Head and neck cancer - Wikipedia
Cetuximab is also used in the treatment of throat cancer. Docetaxel-based chemotherapy has shown a very good response in ... there has been an emphasis on the use of various induction or concomitant chemotherapy regimens. Surgery as a treatment is ... CO2 laser surgery is also another form of treatment. Transoral laser microsurgery allows surgeons to remove tumors from the ... People with head and neck cancer may experience the following symptoms and treatment side effects: Eating problems Pain ...https://en.wikipedia.org/wiki/Head_and_neck_cancer
In second-line docetaxel treatment, we also analyzed 40 tumors, and those patients who overexpress COX-2 in their tumors had a ... Treatment of humans with the selective COX-2 inhibitor celecoxib augments the antitumor effects of chemotherapy in patients ... or not COX-2 expression is a primary event due to the biology of the tumor or due to induction by treatment with chemotherapy ... depending on whether the expression is a primary effect of tumorigenesis or due to some secondary effect. ...http://clincancerres.aacrjournals.org/content/10/12/4266s
Protocols and Video Articles Authored by Irit Ben-Aharon (Translated to German)
Despite progress in treatment in recent years, survival remains poor. Since induction chemotherapy has been associated with ... the effect of Bevacizumab in combination with chemotherapy on overall survival of patients with metastatic solid tumors. ... The Combination of Docetaxel, Cisplatin, and 5-fluorouracil in Advanced Gastric Cancer: a Single-institution Experience Anti- ... Apart from its direct effect on follicles and oocytes, chemotherapy may induce ovarian toxicity via an impact on the entire ...https://www.jove.com/author/Irit_Ben-Aharon?language=German
... systemic treatment options include chemotherapies such as doxorubicin, ifosfamide, dacarbazine, gemcitabine, and docetaxel. ... has been shown to enhance the effects of chemotherapy. We report that flavopiridol potentiates the effects of doxorubicin in ... While these tumors are also associated with chemotherapy responsiveness to anthracyclines, it is possible that doxorubicin was ... This defect in DNA repair then sensitizes tumor cells to p53-dependent induction of apoptosis by irinotecan (12). Flavopiridol ...http://clincancerres.aacrjournals.org/content/18/9/2638
Trial of Chemotherapy Followed by Pulsed Docetaxel and Concurrent Radiation for Non-Small Cell Lung Cancer - Tabular View -...
The side effects of this treatment and your quality of life while on the study will also be studied. Eighteen will participate ... A Phase II Trial of One-Cycle Induction Chemotherapy Followed by Pulsed Docetaxel and Concurrent Radiation for Non-Small Cell ... is conducting a research study at Highland Hospital and Strong Memorial of lung cancer patients whose tumors cannot be ... The usual treatment for this stage of cancer is chemotherapy (treatment with drugs) combined with radiation (chemo-radiation). ...https://clinicaltrials.gov/ct2/show/record/NCT00167401
A Potential Therapeutic Strategy for Malignant Mesothelioma with Gene Medicine
A standard treatment for mesothelioma consists of surgical resection, irradiation, and systemic chemotherapy. A small number of ... Mesothelioma is essentially resistant to cytotoxic chemotherapy. Any regimens including cisplatin, carboplatin, docetaxel, ... The augmented cell death in tumors is due to differential cell proliferation between tumors and normal tissues, and Ad ... consisting of induction chemotherapy, extrapleural pneumonectomy, and adjuvant irradiation, can produce a beneficial outcome to ...https://www.hindawi.com/journals/bmri/2013/572609/
... neoadjuvant chemotherapy, or induction chemotherapy.. If a patient has not received chemotherapy before surgery, chemotherapy ... However, normal cells also grow and divide, so the side effects of chemotherapy are due to the treatment's effects on normal ... Treatment for a distant recurrence is most successful when there are a small number of tumors that have spread to the lung that ... Chemotherapy given after surgery is called adjuvant chemotherapy or postoperative chemotherapy.. The side effects of ...https://www.cancer.net/cancer-types/sarcoma-soft-tissue/treatment-options
Novel Agents in the Treatment of Lung Cancer: Fourth Cambridge Conference | Clinical Cancer Research
Several conference participants expressed the view that the preclinical work to support additive effects with chemotherapy used ... it is imperative to do more molecular profiling of treatment-sensitive and treatment-resistant tumors, to better understand the ... 18.7 weeks for docetaxel plus 100 mg vandetanib versus 12 weeks for docetaxel alone); a phase III trial of docetaxel plus or ... Down-regulation of PI3K signaling is necessary for the induction of apoptosis by all of the targeted therapies. Agents directly ...http://clincancerres.aacrjournals.org/content/13/15/4583s
Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved...
Because we observed positive effects in the docetaxel combination therapy, we used an analogous treatment schedule for ... First-line chemotherapy of non-seminomatous germ cell tumors (NSGCTs). Cancer Treat Rev 2009; 35: 563-569.. *CrossRef , ... can be combined with standard chemotherapeutics such as docetaxel or cisplatin when chemotherapy is applied after the induction ... Combination of docetaxel and recombinant vaccine enhances T-cell responses and antitumor activity: effects of docetaxel on ...http://onlinelibrary.wiley.com/doi/10.1002/jgm.2605/full
Search of: Recruiting, Not yet recruiting, Available Studies | 'Pharyngeal Neoplasms' - List Results - ClinicalTrials.gov
The Role of Adding Concurrent Chemotherapy to IMRT in the Treatment of Stage II Nasopharyngeal Carcinoma. *Effects of ... Primary Purpose: Treatment. *Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 ( ... Device: Chrono-chemotherapy pump:Melodie. *Device: Routine intravenous drip. *Drug: induction Chrono-chemotherapy ... Drug: docetaxel and cisplatin. *Radiation: IMRT. *Biological: Nimotuzumab. Interventional. Phase 2. *The Second People's ...https://clinicaltrials.gov/ct2/results?recr=Open&cond=%22Pharyngeal+Neoplasms%22&show_rss=Y
Antivascular Therapy for Epithelial Ovarian Cancer
They postulated that the lack of additive effect between these 2 drugs in tumors with high VEGF expression might be due to the ... D. Matei, R. E. Emerson, J. Schilder et al., "Imatinib mesylate in combination with docetaxel for the treatment of patients ... Primary surgical cytoreduction followed by platinum-based chemotherapy is the standard treatment for patients with advanced ... Y. Mizukami, W.-S. Jo, E.-M. Duerr et al., "Induction of interleukin-8 preserves the angiogenic response in HIF-1. α. - ...https://www.hindawi.com/journals/jo/2010/372547/
Erlotinib in Combination With Docetaxel in Advanced Hepatocellular and Biliary Tract Carcinomas - Full Text View -...
Treatment. Official Title:. Phase II Trial of Erlotinib in Combination With Docetaxel in Advanced Hepatocellular and Biliary ... Patients may have had ≤ 2 prior chemotherapy regimens.. *Prior radiation therapy allowed to , 25% of the bone marrow at least ... Determine the Response Rate Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0) ... completed at least 30 days prior to being registered for protocol therapy and recovered from the acute toxicity effects of the ...https://clinicaltrials.gov/ct2/show/NCT00532441
Chemotherapy Is More Effective in Patients with Breast Cancer Not Expressing Steroid Hormone Receptors | Clinical Cancer...
In fact, the only demonstrated benefit of preoperative chemotherapy in terms of treatment effects is the achievement of tumor ... Bear HD, Anderson S, Brown A, et al The effect on tumor response of adding sequential preoperative docetaxel to preoperative ... Colleoni M, Minchella I, Mazzarol G, et al Response to primary chemotherapy in breast cancer patients with tumors not ... Sataloff DM, Mason BA, Prestipino AJ, et al Pathological response to induction chemotherapy in locally advanced carcinoma of ...http://clincancerres.aacrjournals.org/content/10/19/6622.long
RAD001 With Weekly Cisplatin and Radiation Therapy in Patients With Locally Advanced Head and Neck Cancer
RAD001 (Everolimus) + Docetaxel + Cisplatin as Induction Chemotherapy in Patients With Local-Regional Advanced Head and Neck ... Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly ... when added to docetaxel and cisplatin. We want to find out what effects, good and/... ... Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus ...https://www.bioportfolio.com/resources/trial/68459/RAD001-With-Weekly-Cisplatin-and-Radiation-Therapy-in-Patients-With-Locally-Advanced.html
Treatment with 1,000 mg of abiraterone acetate of a further 33 chemotherapy-naïve patients at our institution and a similar ... III clinical study of abiraterone acetate in docetaxel-treated patients will be followed by clinical studies in chemotherapy- ... and neoadjuvant settings is also warranted due to the high level of activity observed and the low incidence of side effects. ... selected for individual patients on the basis of prior molecular characterization of their tumors which could utilize the ...http://cancerres.aacrjournals.org/content/69/12/4937
Search of: 'Tongue cancer' - List Results - ClinicalTrials.gov
Chemotherapy Effect. *Surgery. *Drug: Induction chemotherapy. *Procedure: Tongue conservation surgery. *Radiation: ... Drug: neoadjuvant docetaxel/cisplatin/fluorouracil. *Drug: No treatment before definitive CCRT. Interventional. Phase 2. * ... Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck. *Recurrent Adenoid Cystic ... Primary Purpose: Treatment. *To determine whether addition of neoadjuvant chemotherapy before definite CCRT increase ...https://clinicaltrials.gov/ct2/results?cond=%22Tongue+cancer%22
Rabbit polyclonal to EREG - mTOR inhibitors suppress homologous recombination repair
Preliminary Treatment and Evaluation of Response Induction chemotherapy regimens included (a) vincristine, doxorubicin or ... Purpose The purpose of this study was to examine the effect July 22, 2017. by Gavin Berry·Comments Off on Purpose The purpose ... Charts were examined for disease recurrence, including LR, DM, or SP tumors. An LR was defined as a positive biopsy in the area ... docetaxel, and IMRT (70Gcon) on a far more latest UMCC-0221 trial. Several sufferers who didn't take part in the UMCC-0221 ...http://paccon2016.com/tag/rabbit-polyclonal-to-ereg/
Chemotherapy - Wikipedia
Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. This type of chemotherapy is used ... Paclitaxel prevents the cell cycle at the boundary of G2-M, whereas docetaxel exerts its effect during S-phase. Taxanes present ... These transporters pump out most chemotherapy drugs, which reduces their efficacy for treatment of brain tumors. Only small ... Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is ...https://en.wikipedia.org/wiki/Chemotherapy
Combination chemotherapy is the mainstay of current cancer treatment options. It is well-known that combining regimens with ... and further suggests that ixabepilone may have intrinsic antiangiogenic effects in tumors. Moreover, ixabepilone combined with ... including enhancement of caspase-2 activity and causes p53 to activate the death effector Bax through induction of expression ... A more recent study found that the antimicrotubule agents docetaxel, epothilone B, and vinblastine significantly inhibited ...http://clincancerres.aacrjournals.org/content/14/24/8123
Botanical Therapy in Treating Mucositis in Patients With Head and Neck Cancer Who Have Undergone Chemoradiation Therapy - Full...
Induction chemotherapy (with up to 3 cycles of docetaxel and cisplatin based regimens) is allowed ... Since emphasis is placed on the accurate estimation of treatment effect for use in the planning of a future confirmatory trial ... techniques for patients with intact tumors, and 60 Gy - 66 Gy in 2 Gy per fraction using IMRT for post-operative patients ... Up to 3 months after completion of study treatment ]. The 2 treatment groups will be compared using the Mantel-Haenszel test, ...https://clinicaltrials.gov/ct2/show/NCT01674374?recr=Open&cond=%22Tongue+Diseases%22&rank=16
Frontiers | Nanodrug delivery in reversing multidrug resistance in cancer cells | Pharmacology
Selective nanocarrier targeting to tumor overcomes dose-limiting side effects, lack of selectivity, tissue toxicity, limited ... effective and promising platforms for treatment of drug resistant cancer cells. Nanocarriers have potential to improve drug ... high drug doses and emergence of multiple drug resistance with conventional or combination chemotherapy. Current review ... Selective nanocarrier targeting to tumor overcomes dose-limiting side effects, lack of selectivity, tissue toxicity, limited ...https://www.frontiersin.org/articles/10.3389/fphar.2014.00159/full
Heat Shock Protein 27 Increases after Androgen Ablation and Plays a Cytoprotective Role in Hormone-Refractory Prostate Cancer |...
Effect of Hsp27 ASO treatment on PC-3 tumor growth and chemosensitivity in vivo. A and B, Mice bearing PC-3 tumors were ... Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy. Int J Cancer, ... Docetaxel (taxotere) in the treatment of prostate cancer. Expert Rev Anticancer Ther, 2003; 3: 261-8, ... Hsp27 ASO Treatment Inhibits PC-3 Tumor Progression and Enhances Chemotherapy In vivo.. We next evaluated the effects of Hsp27 ...http://cancerres.aacrjournals.org/content/64/18/6595?ijkey=fdc575d466d3f29c5c3ad9a00b0d692578e0a2ec&keytype2=tf_ipsecsha
News for Medical Independent Sales Representatives and Medical Distributors: New ASTRO Guideline Establishes Standard of Care...
New ASTRO Guideline Establishes Standard of Care for Curative Treatment of Oropharyngeal Cancer with Radiation Therapy ... the integration of chemotherapy with RT and the role of induction chemotherapy.. Oropharyngeal squamous cell cancer (OPSCC) is ... "Radiation therapy is the most commonly used curative option for the primary treatment of oropharynx tumors," said Avraham ... long-term and potentially lifelong side effects which become even more salient as this patient population trends younger.". " ...http://salesandmarketingnetwork.com/news_release_bs.html?pipe=0000ac177000191&ID=2042396
Resistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity | Cancer Research
It is feasible, however, to enhance the effects of paclitaxel treatment in clinical practice by applying agents that reduce ... Cell cycle specific induction of apoptosis and necrosis by paclitaxel in the leukemic U937 cells. Life Sci 2005; 76: 1623-39. ... Our results imply that tumor sensitivity to paclitaxel chemotherapy in a clinical setting might be predictable if total ... Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its ...http://cancerres.aacrjournals.org/content/65/18/8455?ijkey=7846fdcef81302dfadeb2b51f1be84207bab1fed&keytype2=tf_ipsecsha
Tumor-related interleukins: old validated targets for new anti-cancer drug development
Other anti-IL-6 mAbs are in development and have shown promising effect in the treatment of several cancer type (Table 2). mAb ... of a meta-analysis of randomized studies support the use of IL-2 in combination with conventional chemotherapy in solid tumors ... No adverse effects were observed in a phase I study of prostate cancer  and its use in combination with docetaxel appears ... later proved that IL-1β increases the invasiveness of TNBC cells in vitro [89, 90] through MMP-3 induction as well as an IL-1β ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5606116/