Head and neck cancer - Wikipedia
Cetuximab is also used in the treatment of throat cancer. Docetaxel-based chemotherapy has shown a very good response in ... there has been an emphasis on the use of various induction or concomitant chemotherapy regimens. Surgery as a treatment is ... CO2 laser surgery is also another form of treatment. Transoral laser microsurgery allows surgeons to remove tumors from the ... People with head and neck cancer may experience the following symptoms and treatment side effects: Eating problems Pain ...https://en.wikipedia.org/wiki/Head_and_neck_cancer
In second-line docetaxel treatment, we also analyzed 40 tumors, and those patients who overexpress COX-2 in their tumors had a ... Treatment of humans with the selective COX-2 inhibitor celecoxib augments the antitumor effects of chemotherapy in patients ... or not COX-2 expression is a primary event due to the biology of the tumor or due to induction by treatment with chemotherapy ... depending on whether the expression is a primary effect of tumorigenesis or due to some secondary effect. ...http://clincancerres.aacrjournals.org/content/10/12/4266s
Sequential FDG-PET and induction chemotherapy in locally advanced adenocarcinoma of the Oesophago-gastric junction (AEG): The...
... and after 14 days of standard neoadjuvant therapy as well as after the first cycle of salvage docetaxel/cisplatin chemotherapy ... Tumors must be potentially R0 resectable and must have a sufficient FDG-baseline uptake. Only metabolic non-responders, showing ... It has been recently shown in the MUNICON trials that response-guided treatment algorithms based on early changes of the FDG ... We plan to investigate whether PET can be used as response assessment during radiochemotherapy given as salvage treatment in ...https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-266
Protocols and Video Articles Authored by Irit Ben-Aharon (Translated to German)
Despite progress in treatment in recent years, survival remains poor. Since induction chemotherapy has been associated with ... the effect of Bevacizumab in combination with chemotherapy on overall survival of patients with metastatic solid tumors. ... The Combination of Docetaxel, Cisplatin, and 5-fluorouracil in Advanced Gastric Cancer: a Single-institution Experience Anti- ... Apart from its direct effect on follicles and oocytes, chemotherapy may induce ovarian toxicity via an impact on the entire ...https://www.jove.com/author/Irit_Ben-Aharon?language=German
... systemic treatment options include chemotherapies such as doxorubicin, ifosfamide, dacarbazine, gemcitabine, and docetaxel. ... has been shown to enhance the effects of chemotherapy. We report that flavopiridol potentiates the effects of doxorubicin in ... While these tumors are also associated with chemotherapy responsiveness to anthracyclines, it is possible that doxorubicin was ... This defect in DNA repair then sensitizes tumor cells to p53-dependent induction of apoptosis by irinotecan (12). Flavopiridol ...http://clincancerres.aacrjournals.org/content/18/9/2638
Trial of Chemotherapy Followed by Pulsed Docetaxel and Concurrent Radiation for Non-Small Cell Lung Cancer - Tabular View -...
The side effects of this treatment and your quality of life while on the study will also be studied. Eighteen will participate ... A Phase II Trial of One-Cycle Induction Chemotherapy Followed by Pulsed Docetaxel and Concurrent Radiation for Non-Small Cell ... is conducting a research study at Highland Hospital and Strong Memorial of lung cancer patients whose tumors cannot be ... The usual treatment for this stage of cancer is chemotherapy (treatment with drugs) combined with radiation (chemo-radiation). ...https://clinicaltrials.gov/ct2/show/record/NCT00167401
A Potential Therapeutic Strategy for Malignant Mesothelioma with Gene Medicine
A standard treatment for mesothelioma consists of surgical resection, irradiation, and systemic chemotherapy. A small number of ... Mesothelioma is essentially resistant to cytotoxic chemotherapy. Any regimens including cisplatin, carboplatin, docetaxel, ... The augmented cell death in tumors is due to differential cell proliferation between tumors and normal tissues, and Ad ... consisting of induction chemotherapy, extrapleural pneumonectomy, and adjuvant irradiation, can produce a beneficial outcome to ...https://www.hindawi.com/journals/bmri/2013/572609/
Novel Agents in the Treatment of Lung Cancer: Fourth Cambridge Conference | Clinical Cancer Research
Several conference participants expressed the view that the preclinical work to support additive effects with chemotherapy used ... it is imperative to do more molecular profiling of treatment-sensitive and treatment-resistant tumors, to better understand the ... 18.7 weeks for docetaxel plus 100 mg vandetanib versus 12 weeks for docetaxel alone); a phase III trial of docetaxel plus or ... Down-regulation of PI3K signaling is necessary for the induction of apoptosis by all of the targeted therapies. Agents directly ...http://clincancerres.aacrjournals.org/content/13/15/4583s
... neoadjuvant chemotherapy, or induction chemotherapy.. If a patient has not received chemotherapy before surgery, chemotherapy ... However, normal cells also grow and divide, so the side effects of chemotherapy are due to the treatment's effects on normal ... Treatment for a distant recurrence is most successful when there are a small number of tumors that have spread to the lung that ... Chemotherapy given after surgery is called adjuvant chemotherapy or postoperative chemotherapy.. The side effects of ...https://www.cancer.net/cancer-types/sarcoma-soft-tissue/treatment-options
Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved...
Because we observed positive effects in the docetaxel combination therapy, we used an analogous treatment schedule for ... First-line chemotherapy of non-seminomatous germ cell tumors (NSGCTs). Cancer Treat Rev 2009; 35: 563-569.. *CrossRef , ... can be combined with standard chemotherapeutics such as docetaxel or cisplatin when chemotherapy is applied after the induction ... Combination of docetaxel and recombinant vaccine enhances T-cell responses and antitumor activity: effects of docetaxel on ...http://onlinelibrary.wiley.com/doi/10.1002/jgm.2605/full
Search of: Recruiting, Not yet recruiting, Available Studies | 'Pharyngeal Neoplasms' - List Results - ClinicalTrials.gov
The Role of Adding Concurrent Chemotherapy to IMRT in the Treatment of Stage II Nasopharyngeal Carcinoma. *Effects of ... Primary Purpose: Treatment. *Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 ( ... Device: Chrono-chemotherapy pump:Melodie. *Device: Routine intravenous drip. *Drug: induction Chrono-chemotherapy ... Drug: docetaxel and cisplatin. *Radiation: IMRT. *Biological: Nimotuzumab. Interventional. Phase 2. *The Second People's ...https://clinicaltrials.gov/ct2/results?recr=Open&cond=%22Pharyngeal+Neoplasms%22&show_rss=Y
Antivascular Therapy for Epithelial Ovarian Cancer
They postulated that the lack of additive effect between these 2 drugs in tumors with high VEGF expression might be due to the ... D. Matei, R. E. Emerson, J. Schilder et al., "Imatinib mesylate in combination with docetaxel for the treatment of patients ... Primary surgical cytoreduction followed by platinum-based chemotherapy is the standard treatment for patients with advanced ... Y. Mizukami, W.-S. Jo, E.-M. Duerr et al., "Induction of interleukin-8 preserves the angiogenic response in HIF-1. α. - ...https://www.hindawi.com/journals/jo/2010/372547/
Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice | BMC Cancer |...
The combination of low-dose chemotherapy and anti-angiogenic inhibitors suppresses growth of experimental tumors more ... the combination treatment could obviously decrease VEGF expression and MVD as well as signals of blood flow and PSV in tumors. ... The combination of chemotherapy and anti-angiogenic drugs may be an innovative and promising therapeutic strategy in the ... Necrosis of tumor and signals of blood flow as well as dynamic parameters of arterial blood flow in tumors such as peak ...https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-250
Erlotinib in Combination With Docetaxel in Advanced Hepatocellular and Biliary Tract Carcinomas - Full Text View -...
Treatment. Official Title:. Phase II Trial of Erlotinib in Combination With Docetaxel in Advanced Hepatocellular and Biliary ... Patients may have had ≤ 2 prior chemotherapy regimens.. *Prior radiation therapy allowed to , 25% of the bone marrow at least ... Determine the Response Rate Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0) ... completed at least 30 days prior to being registered for protocol therapy and recovered from the acute toxicity effects of the ...https://clinicaltrials.gov/ct2/show/NCT00532441
Chemotherapy Is More Effective in Patients with Breast Cancer Not Expressing Steroid Hormone Receptors | Clinical Cancer...
In fact, the only demonstrated benefit of preoperative chemotherapy in terms of treatment effects is the achievement of tumor ... Bear HD, Anderson S, Brown A, et al The effect on tumor response of adding sequential preoperative docetaxel to preoperative ... Colleoni M, Minchella I, Mazzarol G, et al Response to primary chemotherapy in breast cancer patients with tumors not ... Sataloff DM, Mason BA, Prestipino AJ, et al Pathological response to induction chemotherapy in locally advanced carcinoma of ...http://clincancerres.aacrjournals.org/content/10/19/6622.long
Chemotherapy - Wikipedia
Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. This type of chemotherapy is used ... Paclitaxel prevents the cell cycle at the boundary of G2-M, whereas docetaxel exerts its effect during S-phase. Taxanes present ... These transporters pump out most chemotherapy drugs, which reduces their efficacy for treatment of brain tumors. Only small ... Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is ...https://en.wikipedia.org/wiki/Chemotherapy
RAD001 With Weekly Cisplatin and Radiation Therapy in Patients With Locally Advanced Head and Neck Cancer
RAD001 (Everolimus) + Docetaxel + Cisplatin as Induction Chemotherapy in Patients With Local-Regional Advanced Head and Neck ... Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly ... when added to docetaxel and cisplatin. We want to find out what effects, good and/... ... Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus ...https://www.bioportfolio.com/resources/trial/68459/RAD001-With-Weekly-Cisplatin-and-Radiation-Therapy-in-Patients-With-Locally-Advanced.html
14 Small-Cap Biotech Stocks to Consider After the Pullback | Equities.com
The company, which is working on the induction of hypoxia in a variety of solid tumors and hematological cancers, is up 16% ... two Phase 3 trials of ganetespib in combination with chemotherapy as front-line treatment of newly diagnosed elderly patients ... Given the side-effect profile and efficacy seen to date, and the potential to secure a partner to help in the clinical ... by year-end of its pivotal Phase 3 SUNRISE trial of bavituximab in combination with docetaxel as second-line treatment of non- ...https://www.equities.com/news/14-small-cap-biotech-stocks-to-consider-after-the-pullback
Treatment with 1,000 mg of abiraterone acetate of a further 33 chemotherapy-naïve patients at our institution and a similar ... III clinical study of abiraterone acetate in docetaxel-treated patients will be followed by clinical studies in chemotherapy- ... and neoadjuvant settings is also warranted due to the high level of activity observed and the low incidence of side effects. ... selected for individual patients on the basis of prior molecular characterization of their tumors which could utilize the ...http://cancerres.aacrjournals.org/content/69/12/4937
Search of: 'Tongue cancer' - List Results - ClinicalTrials.gov
Chemotherapy Effect. *Surgery. *Drug: Induction chemotherapy. *Procedure: Tongue conservation surgery. *Radiation: ... Drug: neoadjuvant docetaxel/cisplatin/fluorouracil. *Drug: No treatment before definitive CCRT. Interventional. Phase 2. * ... Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck. *Recurrent Adenoid Cystic ... Primary Purpose: Treatment. *To determine whether addition of neoadjuvant chemotherapy before definite CCRT increase ...https://clinicaltrials.gov/ct2/results?cond=%22Tongue+cancer%22
Clinical efficacy of transcatheter arterial chemoembolization combined with DC-CIK in the treatment of colorectal cancer with...
Clinical efficacy of transcatheter arterial chemoembolization combined with DC-CIK in the treatment of colorectal cancer with ... liver metastasis and its effect on the survival of pat ... For liver tumors (including primary tumors and metastatic ... The patients in control group were given intravenous chemotherapy combined with DC-CIK treatment. The specific treatment ... Effect of docetaxel combined regimen transarterial interventional therapy on short and long-term survival rate of patients with ...http://www.alliedacademies.org/articles/clinical-efficacy-of-transcatheter-arterial-chemoembolization-combined-with-dccik-in-the-treatment-of-colorectal-cancer-with-liver-7948.html
Frontiers | Combining Radiation Therapy with Immune Checkpoint Blockade for Central Nervous System Malignancies | Oncology
... studies demonstrating potential synergistic effect of RT with ICB in the treatment of primary and metastatic CNS tumors. In ... studies demonstrating potential synergistic effect of RT with ICB in the treatment of primary and metastatic CNS tumors. In ... current the clinical experience of combining RT with ICB in the treatment of multiple primary and metastatic brain tumors. ... current the clinical experience of combining RT with ICB in the treatment of multiple primary and metastatic brain tumors. ...https://www.frontiersin.org/articles/10.3389/fonc.2016.00212/full
Frontiers | Nanodrug delivery in reversing multidrug resistance in cancer cells | Pharmacology
Selective nanocarrier targeting to tumor overcomes dose-limiting side effects, lack of selectivity, tissue toxicity, limited ... effective and promising platforms for treatment of drug resistant cancer cells. Nanocarriers have potential to improve drug ... high drug doses and emergence of multiple drug resistance with conventional or combination chemotherapy. Current review ... Selective nanocarrier targeting to tumor overcomes dose-limiting side effects, lack of selectivity, tissue toxicity, limited ...https://www.frontiersin.org/articles/10.3389/fphar.2014.00159/full
Rabbit polyclonal to EREG - mTOR inhibitors suppress homologous recombination repair
Preliminary Treatment and Evaluation of Response Induction chemotherapy regimens included (a) vincristine, doxorubicin or ... Purpose The purpose of this study was to examine the effect July 22, 2017. by Gavin Berry·Comments Off on Purpose The purpose ... Charts were examined for disease recurrence, including LR, DM, or SP tumors. An LR was defined as a positive biopsy in the area ... docetaxel, and IMRT (70Gcon) on a far more latest UMCC-0221 trial. Several sufferers who didn't take part in the UMCC-0221 ...http://paccon2016.com/tag/rabbit-polyclonal-to-ereg/
Combination chemotherapy is the mainstay of current cancer treatment options. It is well-known that combining regimens with ... and further suggests that ixabepilone may have intrinsic antiangiogenic effects in tumors. Moreover, ixabepilone combined with ... including enhancement of caspase-2 activity and causes p53 to activate the death effector Bax through induction of expression ... A more recent study found that the antimicrotubule agents docetaxel, epothilone B, and vinblastine significantly inhibited ...http://clincancerres.aacrjournals.org/content/14/24/8123