Togaviridae - Wikipedia
... virus O'nyong-nyong virus Pixuna virus Rio Negro virus Ross River virus Salmon pancreas disease virus Semliki Forest virus ... The genome is linear, non-segmented, single-stranded, positive sense RNA that is 10,000-12,000 nucleotides long. The 5'- ... Early 19th century-Rubella is identified as a distinct disease 1930-Western Equine Encephalitis virus is first isolated in the ... Togaviridae is a family of viruses. Humans, mammals, birds, and mosquitoes serve as natural hosts. There are currently 32 ...https://en.wikipedia.org/wiki/Togaviridae
Frontiers | A Novel Mechanism Underlying the Innate Immune Response Induction upon Viral-Dependent Replication of Host Cell...
... a process known as virus-host cell co-evolution. Positive-single stranded RNA (+sRNA) viruses are an important group of viral ... a process known as virus-host cell co-evolution. Positive-single stranded RNA (+sRNA) viruses are an important group of viral ... A common feature shared by these viruses is their ability to rearrange cellular membranes to serve as platforms for genome ... A common feature shared by these viruses is their ability to rearrange cellular membranes to serve as platforms for genome ...https://www.frontiersin.org/articles/10.3389/fcimb.2017.00005/full
PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response
Alphaviruses are single-stranded, positive-sense, enveloped RNA viruses with a genome of approximately 11.5 kb with a 5′ cap ... Alphaviruses (family Togaviridae) produce disease in a variety of animals and replicate in invertebrates, birds and mammals. In ... bcl-2 acts early to restrict Semliki Forest virus replication and delays virus-induced programmed cell death. J Virol 71, 1583- ... PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2885058/
Chikungunya - Wikipedia
It is a member of the Semliki Forest virus complex and is closely related to Ross River virus, O'nyong'nyong virus, and Semliki ... It was first isolated in 1953 in Tanzania and is an RNA virus with a positive-sense single-stranded genome of about 11.6kb. ... small mammals, and mosquitos between human outbreaks. During outbreaks, due to the high concentration of virus in the blood of ... This emergence and spread beyond Africa may have started as early as the 18th century. Currently, available data does not ...https://en.wikipedia.org/wiki/Chikungunya
Most recent papers in the journal Mammalian Genome: Official Journal of the International Mammalian Genome Society | Read by...
Alphaviruses, members of the positive-sense, single-stranded RNA virus family Togaviridae, represent a re-emerging public ... chikungunya virus, Ross River virus, and Semliki Forest virus) or encephalomyelitis (eastern equine encephalitis virus, western ... Early immunosenscence in devils appears to decrease anti-tumour immunity in older animals compared to younger animals, which ... Male reproductive anomalies are widely distributed among mammals, and male factors are estimated to contribute to approximately ...https://www.readbyqxmd.com/journal/30620
METHODS OF TREATING CARDIOMYOPATHY - Patent application
0081] Alphavirus-based vectors, such as those made from semliki forest virus (SFV) and sindbis virus (SIN) might also be used ... The DNA can be double-stranded or single-stranded, and if single-stranded may be the coding (sense) strand or non-coding (anti- ... Use of alphaviruses is described in Lundstrom, K., Intervirology 43:247-257, (2000) and Perri et al., Journal of Virology 74: ... HSV vectors deleted of one or more immediate early genes (1E) are advantageous because they are generally non-cytotoxic, ...http://www.patentsencyclopedia.com/app/20130072549
METHODS OF TREATING ALZHEIMER'S DISEASE AND OTHER TAUOPATHIES WITH INHIBITORS OF MICROTUBULE AFFINITY REGULATING KINASE - THE...
Semliki Forest virus (SFV), and Venezuelan Equine Encephalitis virus (VEE), will also find use as viral vectors for delivering ... a signal which allows the plasmid construct to exist as single stranded DNA (e.g., a M13 origin of replication), at least one ... a CMV promoter such as the CMV immediate early promoter, the mouse mammary tumor virus LTR promoter, the adenovirus major late ... domestic mammals such as dogs and cats; laboratory animals including rodents such as mice, rats and guinea pigs; birds, ...http://www.freepatentsonline.com/y2016/0030510.html
Hapten-Carrier Conjugates and Uses Thereof - Patent application
Triniti virus, Una virus, Western equine encephalomyelitis virus, Whataroa virus, Sindbis virus (SIN), Semliki forest virus ( ... viruses infecting bacteria, preferably to single-stranded positive-sense RNA viruses infecting bacteria.  Self antigen: ... Rev., 58:491-562 (1994). Examples of alphaviruses include Aura virus, Bebaru virus, Cabassou virus, Chikungunya virus, Easter ... viruses infected mammals that alignment of the proteins is difficult. However, both viruses retain the ability to form core ...http://www.patentsencyclopedia.com/app/20130142821
TUMOR AND INFECTIOUS DISEASE THERAPEUTIC COMPOSITIONS - Patent application
0115]Alphavirus-based vectors, such as those made from semliki forest virus (SFV) and sindbis virus (SIN), might also be used ... in either single stranded form, or a double-stranded helix. Double stranded DNA-DNA, DNA-RNA and RNA-RNA helices are possible. ... Use of alphaviruses is described in Lundstrom, K., Intervirology 43:247-257, 2000 and Perri et al., Journal of Virology 74:9802 ... The study will be double blinded, with the stipulation that the study will be unblinded if one group shows an early advantage ...http://www.patentsencyclopedia.com/app/20100183685
US9072766B2 - Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT) - Google Patents
... vectors based on the influenza A virus), and alphaviruses, for example the Sinbis and semliki forest viruses. ... Complementarity between two single-stranded molecules may be "partial" in which only some of the nucleic acids bind, or it may ... Any suitable means for introducing polynucleotides into cells or mammals (human or non-human) may be adapted to the practice of ... As shown earlier, pharmacological inhibition of NNMT with N-methylnicotinamide stimulated oxygen consumption in cultured ...https://patents.google.com/patent/US9072766B2/en
CYCLIC AMP PHOSPHODIESTERASE 4D7 ISOFORMS AND METHODS OF USE - Memory Pharmaceuticals Corporation
Sindbis virus vectors, Semliki forest virus (ATCC VR-67; ATCC VR-1247), Ross River virus (ATCC VR-373; ATCC VR-1246) and ... The DNA may be triplex, double-stranded or single-stranded, and if single stranded, may be the coding strand or non-coding ( ... Eukaryotic promoters include CMV immediate early, HSV thymidine kinase, early and late SV40, adenovirus promoters, LTRs from ... Such vectors can be constructed from a wide variety of alphaviruses, including, for example, ...http://www.freepatentsonline.com/y2005/0289660.html
HIV polynucleotides and polypeptides derived from Botswana MJ4 - Patent application
Such replicon vectors have been derived from alphaviruses that include, for example, Sindbis virus, Semlild Forest virus, and/ ... The single stranded cDNA may then be amplified by PCR (see U.S. Pat. Nos. 4,683,202, 4,683,195 and 4,800,159, see also PCR ... Semliki Forest, and Venezuelan Equine Encephalitis viruses, will also find use as viral vectors for delivering the ... such as the CMV immediate early promoter (a CMV promoter can include intron A), RSV, HIV-Ltr, the mouse mammary tumor virus LTR ...http://www.patentsencyclopedia.com/app/20090208530