Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity -...
The disappearance of intestinal parasites from humans in developed countries may be responsible for the upsurge in many diseases including Celiac Disease, Crohn's, ulcerative colitis, asthma and hay fever. A parasite's survival relies on its ability to interfere with the host's immune response. The mechanisms employed to do this are similar to those required by a person to regulate against the so-called autoimmune disorders, diseases in which the system turns on itself. The investigators suspect that when parasites are excluded from the environment, some individuals become sufficiently self-reactive to develop an autoimmune disease. American researchers have successfully treated patients with Crohn's and ulcerative colitis using a pig whipworm (Trichuris suis). The investigators have undertaken a similar preliminary study using a human hookworm in Crohn's patients.. Using a small group of healthy people with celiac disease, the investigators will test if a human hookworm, Necator ...https://clinicaltrials.gov/show/NCT00671138
Epidemiological evidence for a differential effect of hookworm species, Ancylostoma duodenale or Necator americanus, on iron...
Background The hookworms, Ancylostoma duodenale and Necator americanus, cause significant gastrointestinal blood loss. In clinical studies, greater blood losses have been reported with A. duodenale. However, there has been no evidence that endemic A. duodenale infection has greater impact than N. americanus infection on the iron status of...http://www.bdsp.ehesp.fr/Base/171879/
Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity - No...
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... ...https://clinicaltrials.gov/ct2/show/results/NCT00671138?show_desc=Y
Study of Na-ASP-2 Human Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm Infection - Tabular View -...
There is an urgent need for new tools to control human hookworm infection and to reduce its burden of disease in developing countries. This is especially true for children and women of reproductive age who represent populations that are highly vulnerable to the effects of hookworm disease. Up to 65,000 deaths annually have been attributed to human hookworm infection. However, the mortality estimates of hookworm pale in comparison to global disease burden estimates.. The primary approach to hookworm control worldwide has been the frequent and periodic use of benzimidazole anthelminthics for school-age children. However, school-based anthelminthic chemotherapy programs miss populations highly vulnerable to hookworm, including adolescent and adult women. In addition, high rates of hookworm re-infection occur within 4-12 months following anthelminthic chemotherapy, and there is evidence for diminished efficacy of benzimidazoles with frequent and periodic use, possibly because of emerging drug ...https://clinicaltrials.gov/ct2/show/record/NCT00120081
Publications by: Jason Mulvenna Also publishes as (J. Mulvenna, Jason P. Mulvenna) - ResearchOnline@JCU
Tang, Yat T., Gao, Xin, Rosa, Bruce A., Abubucker, Sahar, Hallsworth-Pepin, Kymberlie, Martin, John, Tyagi, Rahul, Heizer, Esley, Zhang, Xu, Bhonagiri-Palsikar, Veena, Minx, Patrick, Warren, Wesley C., Wang, Qi, Zhan, Bin, Hotez, Peter J., Sternberg, Paul W., Dougall, Annette, Gaze, Soraya Torres, Mulvenna, Jason, Sotillo, Javier, Ranganathan, Shoba, Rabelo, Elida M., Wilson, Richard K., Felgner, Philip L., Bethony, Jeffrey, Hawdon, John M., Gasser, Robin B., Loukas, Alex, and Mitreva, Makedonka (2014) Genome of the human hookworm Necator americanus. Nature Genetics, ...https://researchonline.jcu.edu.au/view/all/F258D411055548D59F9C854AED91288A.html
Soil-transmitted helminthiasis - Wikipedia
Soil-transmitted helminthiasis (STH) is a type of helminth infection (helminthiasis) caused by different species of roundworms. It is caused specifically by those worms which are transmitted through soil contaminated with faecal matter and are therefore called soil-transmitted helminths. Three types of soil-transmitted helminthiasis can be distinguished: ascariasis, hookworm infection and whipworm infection. These three types of infection are therefore caused by the large roundworm A. lumbricoides, the hookworms Necator americanus or Ancylostoma duodenale and by the whipworm Trichuris trichiura. It has become the most common parasitic disease of humans worldwide. Approximately two billion people (about a third of global population) are infected as of the latest estimate, and four billion at risk, surpassing even the all-time most prevalent parasitic disease, malaria. The largest numbers of cases occur in impoverished rural areas of ...https://en.wikipedia.org/wiki/Soil-transmitted_helminthiasis
Clinical trial of human hookworm vaccine begins at Children's National Medical Center | EurekAlert! Science News
Today, the Sabin Vaccine Institute, in partnership with the George Washington University and the Children's National Medical Center, began vaccinating participants for a Phase 1 clinical trial of a novel human hookworm vaccine. The trial will investigate the Na-GST-1 antigen developed by the Sabin Vaccine Institute Product Development Partnership to prevent hookworm infections in endemic areas.https://www.eurekalert.org/pub_releases/2012-06/svi-cto061312.php
The American Journal of Tropical Medicine and Hygiene | Basophil Competence during Hookworm (Necator americanus) Infection
A popular hypothesis to explain parasite survival in the presence of a pronounced T helper 2 phenotype in helminth-parasitized populations has been FcϵRI blockade by parasite-induced polyclonal IgE. To begin to test the hypothesis that FcϵRI-bearing cells would be refractory to activation in parasitized populations, we investigated basophil function in 43 individuals from a hookworm endemic area. Study individuals had high levels of total IgE and eosinophilia and a mean hookworm burden of 2,257 epg. Basophils from all members of this parasitized population were shown to release histamine to a number of agonists, including anti IgE and a hookworm allergen, calreticulin. These data would indicate that FcϵRI blockade at the level of the basophil did not occur in this parasitized population despite the presence of possible immunologic blocking agents. This would suggest that this effector arm of the T helper 2 phenotype remains operative in infected populations.http://www.ajtmh.org/content/journals/10.4269/ajtmh.2007.77.860
Hookworms Are Dangerous Parasites, But They Could Also Cure Disease - Redorbit
By Julia Stuart David Pritchard's wife thought he was barking. In the interests of science, the professor of parasite immunology agreed for a plaster bearing 50 hookworms to be stuck on to his skin. They burrowed into his flesh, crawled up his arm, travelled to his lungs and arrived in his gut, where they attached themselves and started to suck out his blood. "My wife said, 'What the hell are you doing? You've got a young family," he says. Mrs Pritchard had already had to put up with her husband disappearing to Papua New Guinea every summer for the past 10 years to study the parasite, a species known as Necator americanus. He and his team from the University of Nottingham established that while in intimate contact with the immune system, the hookworm was never rejected by it. They worked out that the worm was manipulating it to survive. Professor Pritchard then published a speculative article arguing that the worms could actually be good for you. Necator ...http://www.redorbit.com/news/health/897207/hookworms_are_dangerous_parasites_but_they_could_also_cure_disease/
ARCA: Enterocolites na infância
Microscopic and bacteriological examination of fecal contents of the intestines, as well as their histopathological study, were performed in 118 consecutive autopsies of children ( 1 day to 6 years old, 97 cases under 2 years), admitted to the Instituto Fernandes Figueira, Rio de Janeiro. In 50 cases (42.4%) one single enterobacteria has been isolated, as follows: Shigella dysenteriae 2; Flexner group 2; Shigella sonnei 5; Providence group 2; Alkalescens-dispar group 10; Salmonella derby 1; Proteus morgani 20. Microscopic examination revealed helminthic ova or protozoa in 18 cases (15.2%): Ascaris lumbricoides 4; Trichurus trichiura 3; Necator americanus 2; Strongyloides stercoralis 1; Giardia lamblia 1; Entamoeba histolytica 1; Trichomonas hominis 1; Ascaris lumbricoides and Strongyloides stercoralis 2; Ascaris lumbricoides and Trichurus trichiura 2; Trichurus trichiura and Necator americanus 1. Microscopic and bacteriological examinations ...https://www.arca.fiocruz.br/handle/icict/3315
Pathogen Safety Data Sheets: Infectious Substances - Necator americanus - Canada.ca
These Pathogen Safety Data Sheets, regulated under Workplace Hazardous Materials Information System (WHMIS) legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious micro-organisms.https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/pathogen-safety-data-sheets-risk-assessment/necator-americanus.html
... necatoriasis ne·ca·to·ri·a·sis (nĭ-kā'tə-rī'ə-sĭs) n. Infestation with the hookworm Necator americanus, whose adults attach to villi in the small intestinehttp://definithing.com/define-dictionary/necatoriasis/
Desensitising Celiac Disease Patients With the Human Hookworm - Study Results - ClinicalTrials.gov
Single arm, vertical. Necator americanus: Subjects were inoculated with 20 3rd stage Na larvae (10 + 10 over 4-8 weeks). After hookworm colonization, a micro-dose gluten challenge of 10 mg daily for 6 weeks, followed by 50 mg daily for 6 weeks was completed. After this, a detailed assessment including histology was performed to establish it safe for the participant to proceed to a low-dose gluten challenge of 25 mg daily and 1 G (15-20 G of pasta) twice weekly for 12 weeks. After low-dose challenge, a further evaluation was undertaken before inviting participants to undertake a gluten challenge of 3 G daily over for 2 weeks (preceded by a micro-dose 2 week lead-in ...https://clinicaltrials.gov/ct2/show/results/NCT01661933?sect=X056&view=results
Updates on Vaccine Research & Development | Sabin
Schistosomiasis (Bilharzia) is the second most lethal parasitic worm disease, infecting approximately 207 million people and causing 280,000 deaths annually worldwide. Thanks to generous donations from Mort and Chris Hyman and Mr. Len Blavatnik, trustee at the Blavatnik Charitable Foundation, the Schistosomiasis Vaccine Program is becoming a reality. The program will utilize and leverage existing programmatic and technical infrastructure from the Human Hookworm Vaccine Initiative (HHVI) with the goal of developing a cost-effective schistosomiasis vaccine.. Currently, the Sabin research team has identified an efficient expression system in its George Washington University labs, and is prepared to conduct process development, pilot manufacture, and preclinical testing of the Sm-TSP-2 schistosomiasis vaccine in preparation for a Phase 1 clinical trial in adults in Brazil.. Steady Progress with Hookworm Vaccine Development. Now in its eighth year, the Human Hookworm Vaccine Initiative's scientific ...http://www.sabin.org/updates/news/updates-vaccine-research-development?language=fr
Gambaran Infeksi Kecacingan Pada Pekerja Perkebunan Kelapa Sawit Di PT. Asam Jawa Di Afdeling II Kabupaten Labuhan Batu Tahun...
Telah dilakukan penelitianan infeksi kecacingan pada pekerja perkebunan kelapa sawit PT. Asam Jawa di Afdeling II Kabupaten Labuhan Batu. Penelitian dilakukan pada bulan maret 2004. Jenis penelitian ini adalah penelitian deskriptif, dengan memanfaatkan data primer yang diperoleh dengan wawancara dan pemeriksaan tinja pada pekerja. Pekerja yang sesuai dengan kriteria pemilihan sampel ada sebanyak 50 orang, terbagi dalam dua jenis pekerjaan yaitu: pemanen buah kelapa sawit sebanyak 30 orang dan perawatan kebun kelapa sawit sebanyak 20 orang. Analisa data dilakukan dengan melihat angka persentase dari setiap tabel distribusi frekuensi. Dari hasil penelitian diketahui prevalensi kecacingan pada pekerja perkebunan kelapa sawit sebesar 80%. Jenis-jenis cacing yang menginfeksi pekerja adalah cacing Ascaris lumbricoides, cacing Trichuris trichiura, cacing Necator americanus dan Ancylostoma duodenale. Menurut karakteristik pekerja diketahui bahwa ...http://repository.usu.ac.id/handle/123456789/32517
Suillus americanus - Wikipedia
Suillus americanus is a species of fungus in the Suillaceae family of mushrooms. Commonly known as the chicken fat mushroom, the American slippery Jack (or slipperycap), or the American suillus, it grows in a mycorrhizal association with eastern white pine and can be found where this tree occurs in eastern North America and China. The mushroom can be recognized by the bright yellow cap with red to reddish-brown scales embedded in slime, the large yellow angular pores on the underside of the cap, and the narrow yellow stem marked with dark reddish dots. Molecular phylogenetics analysis suggests that S. americanus may be the same species as S. sibiricus, found in western North America and western and central Asia. Suillus americanus is edible, although opinions vary as to its palatability; some susceptible individuals may suffer a contact dermatitis after touching the fruit bodies. The fruit bodies contain a beta glucan carbohydrate shown in laboratory tests ...https://en.wikipedia.org/wiki/Suillus_americanus
Testing the Hygiene Hypothesis: "Celiac Disease? Take 15 Hookworms and call me in the morning"
Enter Necator americanus, the hookworm. Responsible for chronic anemia and failure to thrive in millions of people, but, apparently, small numbers are harmless in healthy humans. Just so you know, the eggs hatch in the soil, the small larvae attach to the skin of your foot, these larvae migrate into the skin, then lymphatics and bloodstream, rupture into the lung, are coughed up through the windpipe and swallowed into your stomach and become adults in your bowel where they live for years, the females laying about 10,000 eggs a day, which go, well, you know where…. Hey, (thinks) wouldn't it be great to infect people with this parasite and see if it helped their autoimmune disease… How do we infect them? Well, Juergen Landmann infected himself both orally and via the skin with Ancylostoma caninum, a closely-related hookworm, and reported his observations in the MJA in 2003. The 'Acknowledgements' section of the paper states: "Vicki Whitehall, the first ...https://asthmaallergieschildren.com/testing-the-hygiene-hypothesis-celiac-disease-take-15-hookworms-and-call-me-in-the-morning/
Health and Human Biology: Hookworms and the Treatment of Celiac Disease
Twelve brave people with celiac disease volunteered to eat gluten in a research study at James Cook University in Australia. The researchers infected each of the patients with twenty larvae of a hookworm (Necator americanus) at the start of a year long experiment. The patients were then given increasing amounts of gluten to eat. The once-a-day servings started with a single piece of spaghetti less than one inch long and ended with seventy-five pieces of spaghetti, or one bowl. A bowl of spaghetti would normally trigger horrible symptoms in someone with celiac disease, but the patients who completed the study experienced no unpleasant effects ...http://healthbylynne.blogspot.com/2014/09/hookworms-and-treatment-of-celiac.html
For the skeptics. Parasites: Fact. NOT fiction. at Parasites Debate Forum, topic 1360512
I m new in this forum--for only 2 months. At first, I could not believe all the things I was reading about parasites residing in our bodies, so I began doing my own research. For all those skeptics out there, there are easy research one can do, these are the ones that I found than can confirm the fact that parasites are causing alot of health issues here in the U.S.: 1. Pub Med s Main Page: http://www.ncbi.nlm.nih.gov or a expecific web site about the Necator americanus American hookworm at Pub Med: http://www.ncbi.nlm.nih.gov/pubmed/15023017?ordinalpos= ...http://www.curezone.org/forums/am.asp?i=1360512
Lecture 16 Ploidy 2010-1 - Ploidy February 19th 2010 Three specimens of Odontophrynus O americanus male 4x =4 Artificial hybrid...
View Notes - Lecture_16_Ploidy_2010-1 from BIOL 202 at UNC. Ploidy February 19th, 2010 Three specimens of Odontophrynus: O. americanus male, 4x =4 Artificial hybrid young, 3x=33 (b); O. cultripeshttps://www.coursehero.com/file/5802258/Lecture-16-Ploidy-2010-1/
Microsatellites of the self-compatible nemerteanProsorhochmus americanus(Hoplonemertea) | SpringerLink
Thousands of microsatellite loci were identified in the nemertean Prosorhochmus americanus through enrichment-isolation and next-generation sequencing protocols. We tested 48 loci for amplification and subsequently genotyped 17 loci in 30 individuals from three North American populations. Most loci were polymorphic within and across populations; six were monomorphic. The number of alleles per locus ranged from 1 to 9 (mean 4.35, SD 2.37). Cross-species amplification in four nemertean species revealed extended marker utility. These loci will enable investigations of colonization potential and natural history in this selfing, putatively introduced species. ...https://link.springer.com/article/10.1007/s12686-014-0380-8
Eastern American Toad - Anaxyrus americanus - Overview - Encyclopedia of Life
Anaxyrus americanus has a short, stout body, with a short broad head bearing large parotoid glands and having a broadly circular snout. The back is covered with different-sized warts and the venter is granular. There are three or four pairs of dark spots down the back, each accompanied by one large wart. Eyes are prominent. The arms and legs are tubular and warty. They are generally olive in color, with a brown crest (Wright and Wright 1949). Males are roughly 54-85 mm in length. The back, sides and tympana are a dull citrine color with olive-citrine or yellow olive color on their hind legs and forelegs. The pectoral region is covered with scattered black spots, and these spots occur over the entire venter except for the throat and the center of the posterior venter. There is some apricot-yellow color across the arm insertion. The pupil is rimmed with citron yellow (Wright and Wright 1949). Females are roughly 56-110 mm in length. The back is a light brownish or buffy olive. The bigger warts ...http://eol.org/pages/1019159/overview
KIT - Food Process Engineering - Staff - Synergism of antifreeze protein type III (macrozoarces americanus) and hydrocolloids...
Synergism of antifreeze protein type III (macrozoarces americanus) and hydrocolloids on recrystallization inhibition of ice in sucrose ...http://lvt.blt.kit.edu/english/21_1720.php
Study Says Pregnant Women in India Are Gravely Underweight | Sabin
The New York Times reports on a new study which reveals that 42 percent of Indian mothers are underweight. The article shares that intestinal parasites contribute to anemia and malnutrition in mothers -- an issue that Dr. Peter Hotez and Remko van Leeuwen are addressing through a human hookworm vaccine. "Mothers also suffer from the same sewage-borne infections that so often kill their babies, made endemic by the primitive sanitation in much of the country, Ms. Coffey said. ...http://www.sabin.org/updates/news/study-says-pregnant-women-india-are-gravely-underweight