where the ratio Dy,1/Dy,2 is called the relative potency of drug 2 versus drug 1. Thus, the growth inhibition produced by drug ... Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells. Clin Cancer Res ... C) for three drugs can be described as. d. 1. D. y. ,. 1. +. d. 2. D. y. ,. 2. +. d. 3. D. y. ,. 3. =. 1. (C)where (d1, d2, d3 ... Results of drug interaction analyses in the Emax model and semiparametric model supported the conclusion that drug combinations ...http://cancerpreventionresearch.aacrjournals.org/content/3/8/917
Adjuvants, Pharmaceutic | CTD
Agents that aid or increase the action of the principle drug (DRUG SYNERGISM) or that affect the absorption, mechanism of ... action, metabolism, or excretion of the primary drug (PHARMACOKINETICS) in such a way as to enhance its effects.. ...http://ctdbase.org/detail.go?type=chem&acc=D000277
Systematic exploration of synergistic drug pairs | Molecular Systems Biology
Jawetz E, Gunnison JB (1953) Antibiotic synergism and antagonism; an assessment of the problem. Pharmacol Rev 5: 175-192. ... Another model of drug synergy proposes that drugs may exhibit synergy if a drug's action helps a second drug's availability in ... Drug synergy allows a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when drugs ... all observed drug synergies. When two drugs acted synergistically, we attributed the drug synergy to the drug with the highest ...http://msb.embopress.org/content/7/1/544
Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS - Full Text View ...
Drug Evaluation. Acquired Immunodeficiency Syndrome. Cachexia. Drug Synergism. Additional relevant MeSH terms: ...https://clinicaltrials.gov/show/NCT00000646?order=69
Interleukin-2 and a T cell hybridoma (MP6) derived B cell-stimulatory factor act synergistically to induce proliferation and...
Cell Division / drug effects. DNA / biosynthesis*. Dose-Response Relationship, Drug. Drug Synergism. Humans. Interleukin-2 / ... Cell Cycle / drug effects. Cell Differentiation / drug effects. ... and act in strong synergism with induction of simultaneous high ...http://www.biomedsearch.com/nih/Interleukin-2-T-cell-hybridoma/2787454.html
Topical nitrates potentiate the effect of botulinum toxin in the treatment of patients with refractory anal fissure.
Drug Synergism. Drug Therapy, Combination. Female. Fissure in Ano / drug therapy*. Humans. Isosorbide Dinitrate / therapeutic ...http://www.biomedsearch.com/nih/Topical-nitrates-potentiate-effect-botulinum/11156644.html
Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA.
Drug Synergism. Female. Fetal Development / drug effects, physiology. Gene Expression Regulation, Developmental / drug effects ... Microsomes, Liver / drug effects, enzymology. Plant Extracts / pharmacology*. Pregnancy. RNA, Messenger / drug effects*, ... Abnormalities, Drug-Induced*. Animals. Aryl Hydrocarbon Hydroxylases / biosynthesis*, genetics. Camellia sinensis / chemistry* ...http://www.biomedsearch.com/nih/Green-tea-extract-increases-cyclophosphamide/19103281.html
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Experimental study of new cerebral protective substances--functional recovery of severe, incomplete ischemic brain pretreated...
Brain Ischemia (drug therapy, physiopathology) *Cerebrovascular Circulation. *Dogs. *Drug Synergism. *Drug Therapy, Combination ... After pretreatment with the drugs, blood flow was reduced via the pump to 1/10 of the normal flow volume and 1 hr later, return ... Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find ... Subsequent changes in electrical activity were observed and the effects of the drugs evaluated. In the control group, no ...http://www.curehunter.com/public/pubmed6792553.do
Drug synergism: its detection and applications. J Pharmacol Exp Ther 2001;298:865-72. ... Only 40% of mice treated with the combination of both drugs did not develop any peritoneal disease, and in the ones who did, ... Huynh H, Soo KC, Chow PK, Panasci L, Tran E. Xenografts of human hepatocellular carcinoma: a useful model for testing drugs. ... It would be attractive to consider therapy with this combination of drugs in a palliative setting, where absence of ascites and ...http://mct.aacrjournals.org/content/6/11/2959
Indole-3-carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines.
Cell Membrane / drug effects, metabolism. Cell Movement / drug effects. Cell Proliferation / drug effects*. Drug Synergism. ... Apoptosis / drug effects. Cadherins / biosynthesis. Cell Cycle / drug effects. Cell Line, Tumor. ...http://www.biomedsearch.com/nih/Indole-3-carbinol-enhances-anti/18358454.html
2001) Drug synergism: its detection and applications. J Pharmacol Exp Ther 298:865-872. ... 2012) Emerging drugs for chronic obstructive pulmonary disease. Expert Opin Emerg Drugs 17:61-82. ... Analysis of Synergism Studies.. Analysis of the potential synergism between RPL554 plus salbutamol, RPL554 plus atropine, or ... Preparation of Drugs. The following drugs were used: acetylcholine (ACh), histamine, salbutamol, atropine, glycopyrrolate, ...http://jpet.aspetjournals.org/content/346/3/414
Drug synergism: its detection and applications. J Pharmacol Exp Ther 2001;298:865-72 [review].. ... each drug should show a dose-effect relationship, at least three data points are required for each single drug effect, and the ... we chose only to analyze concurrent exposures because in patients treated with these drugs, continuous therapeutic drug levels ... Schedule-dependent synergism between raltitrexed and irinotecan in human colon cancer cells in vitro. Clin Cancer Res 1998;4: ...http://clincancerres.aacrjournals.org/content/11/9/3597
Superbugs & Superdrugs USA : Pharmaceuticals : All
11:40 The novel strategy to fight multidrug resistance by multiple drugs synergism, based on docking in drug design and TRIZ. ... Drug Discovery Today is one of the most cited review journals in the field of drug discovery, with an impact factor of 6.422.. ... DRUG DISCOVERY: Enable antibiotic drug development through novel approaches in treating gram-negative infections. TARGETING ... Drug Discovery Today is one of the most cited review journals in the field of drug discovery, with an impact factor of 6.422.. ...http://www.smi-online.co.uk/pharmaceuticals/archive/11-2016/conference/superbugs-superdrugs-usa?o=login&dl=cc&p1=5152&p2=619
Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: modeling...
Revisiting the isobole and related quantitative methods for assessing drug synergism. Tallarida, RJ ... Possible pharmacotherapy of the opioid kappa receptor agonist for drug dependence. Hasabe, K; Kawai, K; Suzuki, T; Kawamura, K ... Kappa-opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug naïve rats and mice ... Assessment of the kappa opioid agonist, salvinorin a, as a punisher of drug self-administration in monkeys ...https://www.deepdyve.com/lp/springer_journal/effects-of-nalfurafine-on-the-reinforcing-thermal-antinociceptive-and-F1d6PeGeko
Interferon gamma (IFN-γ) production by peripheral bloo | Open-i
Drug Synergism. *Escherichia coli/genetics/metabolism. *Female. *Gene Expression. *Interferon-gamma/biosynthesis/secretion ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4109786_1756-0500-7-460-5&req=4
Similar pattern of CCL18 production by IL-4 vs. IL-13 c | Open-i
Drug Synergism. *Humans. *Interleukin-10/pharmacology. *Interleukin-13/pharmacology. *Interleukin-4/pharmacology ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC1590050_1471-2172-7-23-2&req=4
Cytotoxicity of polyene-loaded antifungal fiber mats ag | Open-i
Cell Survival/drug effects. *Diffusion. *Drug Synergism. *Electroplating/methods. *Nanocapsules/administration & dosage/ ... In this article, the efficacy of five different US Food and Drug Administration-approved antifungal-loaded (amphotericin B, ... In this article, the efficacy of five different US Food and Drug Administration-approved antifungal-loaded (amphotericin B, ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4043707_ijn-9-2439Fig10&req=4
Evaluation of proliferation of canine peripheral blood | Open-i
Drug Synergism. *Escherichia coli/genetics/metabolism. *Female. *Gene Expression. *Interferon-gamma/biosynthesis/secretion ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4109786_1756-0500-7-460-3&req=4
A model depicting gating of GIRK channels by the combin | Open-i
Drug Synergism. *Electric Conductivity. *G Protein-Coupled Inwardly-Rectifying Potassium Channels. *Guanosine 5'-O-(3- ... O) Channel open state, gating molecules in the presence of membrane PIP2 can activate the channel and show synergism. Mentions: ... O) Channel open state, gating molecules in the presence of membrane PIP2 can activate the channel and show synergism. ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2230539_JGP8035.f8&req=4
Inhibitors of Metabolite Synthesis: How Sulfa Drugs Work - Video & Lesson Transcript | Study.com
... it is called synergism. Sulfa drugs and trimethoprim are a great example of drug synergism. ... Sulfa Drugs. Sulfa drugs are a class of synthetic drugs that all have a sulfonamide chemical group. These drugs have many ... Synergism With Trimethoprim. That's why sulfa drugs are often administered in combination with trimethoprim, which is another ... Sulfa drugs like Sulfamethoxazole inhibit the enzyme that catalyzes the first step of this pathway. Sulfa drugs are competitive ...https://study.com/academy/lesson/inhibitors-of-metabolite-synthesis-how-sulfa-drugs-work.html
Table of Contents - December 01, 2015, 11 (12) | Molecular Systems Biology
drug synergism. *high‐content imaging. *isogenic cell lines. *systems pharmacology. Mol Syst Biol. (2015) 11: 846 ... The PGPC can be explored to predict compound mode of action and off‐target effects, pathway crosstalk and effective drug ... We used high‐content screening and automated image analysis to measure genotype‐specific effects of 1,280 drugs on complex ... Our approach provided increased coverage for gene-drug interaction mapping as compared to strategies that solely rely on cell ...http://msb.embopress.org/content/11/12
Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines.
However, recent investigations on gambogic acid have focused mainly on mono-drug therapy, and its potential role in cancer ... Cell Proliferation / drug effects. Colorectal Neoplasms / drug therapy*, genetics, metabolism. Drug Synergism. Herb-Drug ... Determination of synergism and antagonism Synergism or antagonism after drug treatments was quantitated with the median-effect ... drug resistance or side effects derived from the various drugs. Accumulating evidence suggests that certain natural ...http://www.biomedsearch.com/nih/Synergistic-anti-proliferative-effects-gambogic/22546220.html
In vitrosynergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells | Breast Cancer Research |...
Tallarida RJ: Drug synergism: its detection and applications. J Pharmacol Exp Ther. 2001, 298: 865-872.PubMedGoogle Scholar. ... The ratio of the combined drug IC50 and IC75 values to the separate IC50 and IC75 values for each drug alone were calculated ... Anticancer Drugs. 2005, 16: 845-854. 10.1097/01.cad.0000175582.01446.6f.View ArticlePubMedGoogle Scholar. ... From these curves, the combined drug IC50 and 75% growth inhibition (IC75) values (e.g. 75% of maximum effect, 25% remaining) ...https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1543
Morphine in Combination with Metabotropic Glutamate Receptor Antagonists on Schedule-Controlled Responding and Thermal...
Loewe S (1953) The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 3: 285-290. ... Tallarida RJ (2000) Drug Synergism and Dose-Effect Data Analysis, Chapman & Hall/CRC Press, Boca Raton, FL. ... Drug Interactions across Behavioral Endpoints. Previous research suggests that interactions between two drugs may depend on the ... For time course determinations, a single injection of a drug or drug mixture was administered i.p., and antinociceptive ...http://jpet.aspetjournals.org/content/324/2/732.long
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