*  A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces...
DNA Damage / drug effects. Drug Screening Assays, Antitumor. HCT116 Cells. High-Throughput Screening Assays*. Humans. Indoles ... Apoptosis / drug effects*. Cell Line, Tumor. Cell Proliferation / drug effects. Cyclin D / metabolism. Cyclin-Dependent Kinase ... Title: Journal of biomolecular screening Volume: 16 ISSN: 1552-454X ISO Abbreviation: J Biomol Screen Publication Date: 2011 ... Previous Document: Comparison of Multivariate Data Analysis Strategies for High-Content Screening.. Next Document: An Improved ...
  http://www.biomedsearch.com/nih/High-Throughput-Screen-with-Isogenic/21335596.html
*  Inhibition of pancreatic adenocarcinoma cell growth by lovastatin.
Cell Survival / drug effects. Cricetinae. Dose-Response Relationship, Drug. Drug Screening Assays, Antitumor. Humans. ... 333026 - An improved plaque assay for mouse myeloma (mopc 315) cells for use in studies of humor.... 11532876 - Areca nut ... 3364936 - Inhibition of invasion activity in vitro by a novel class of antitumor agents: silatran.... 8083436 - Regulation of ...
  http://www.biomedsearch.com/nih/Inhibition-pancreatic-adenocarcinoma-cell-growth/1499946.html
*  Evaluation of Drug Resistance in Patients With Metastatic Breast Cancer - Full Text View - ClinicalTrials.gov
Drug: paclitaxel Other: antitumor drug screening assay Phase 2 Study Type:. Interventional ... Assay to determine probability of drug resistance to paclitaxel. After successful completion of the EDR assay (approximately 7 ... and low drug resistance to paclitaxel using the Extreme Drug Resistance (EDR) Assay in patients with previously treated ... Assessment of the Predictive Value of the Extreme Drug Resistance (EDR) Assay in Patients Receiving Paclitaxel for Metastatic ...
  https://www.clinicaltrials.gov/ct2/show/NCT00003253
*  Distribution and subcellular localization of a water-soluble hematoporphyrin-platinum(II) complex in human bladder cancer cells...
Drug Screening Assays, Antitumor. MESH. Hematoporphyrins/metabolism. MESH. Humans. MESH. Organoplatinum Compounds/chemistry. ...
  https://epub.uni-regensburg.de/4827/
*  The effect of retinoic acid on chemosensitivity of PA-1 human teratocarcinoma cells and its modulation by an activated N-ras...
Drug Interactions. MESH. Drug Screening Assays, Antitumor. MESH. Etoposide/pharmacology. MESH. Female. MESH. ... Combination of chemotherapeutic drugs with agents that induce cell differentiation is a possible means of improving cancer ... Combination of chemotherapeutic drugs with agents that induce cell differentiation is a possible means of improving cancer ... Treatment with RA caused an increase in the cytotoxicity of all 3 drugs to the 2 RA-sensitive cell lines. In contrast, a ...
  https://epub.uni-regensburg.de/15254/
*  Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of...
Cell Proliferation/drug effects. MESH. Drug Screening Assays, Antitumor. MESH. Histone Deacetylases/antagonists & inhibitors. ... Inhibition of Abl kinase in biochemical assays was maintained for most compounds, but in general the kinase selectivity profile ...
  https://epub.uni-regensburg.de/8551/
*  Comparative activity of melarsoprol and arsenic trioxide in chronic B-cell leukemia lines.
We have investigated the effects of the organic arsenical, melarsoprol (a drug used for treatment of trypanosomiasis), upon ... Cell Survival / drug effects. DNA Damage. DNA Fragmentation. Drug Screening Assays, Antitumor. Herpesvirus 4, Human. Humans. ... Apoptosis / drug effects. Arsenic Poisoning*. Arsenicals*. Cell Division / drug effects. Cell Line, Transformed. ... We have investigated the effects of the organic arsenical, melarsoprol (a drug used for treatment of trypanosomiasis), upon ...
  http://www.biomedsearch.com/nih/Comparative-activity-melarsoprol-arsenic-trioxide/9226155.html
*  anal mucinous adenocarcinoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Drug Screening Assays, Antitumor / methods. Paclitaxel / pharmacology. *Genetic Alliance. consumer health - Breast Cancer. ... NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .. *[Source] The source of this record is MEDLINE®, a database of the U.S. ... NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .. *[Source] The source of this record is MEDLINE®, a database of the U.S. ... NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .. *[Source] The source of this record is MEDLINE®, a database of the U.S. ...
  http://www.bmlsearch.com/?kwr=anal+mucinous+adenocarcinoma+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  ZFIN Publication: Santoriello et al., 2012
Drug Screening Assays, Antitumor* (all 22) Animals; Central Nervous System Diseases/drug therapy; Central Nervous System ... Drug Screening Assays, Antitumor*; Eye Diseases/genetics; Female; Genetic Engineering; Heart Diseases/genetics; Heart Diseases/ ... Duchenne/drug therapy; Muscular Dystrophy, Duchenne/genetics; Neoplasms/drug therapy; Neoplasms/genetics; Zebrafish/anatomy & ... Animals; Central Nervous System Diseases/drug therapy; Central Nervous System Diseases/genetics; Disease Models, Animal*; ...
  http://zfin.org/ZDB-PUB-120706-12
*  Targeted Therapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia -...
Antitumor Drug Screening Assay Undergo pre clinical kinase inhibitor activity screening. Other Name: Drug Screening Assays, ... Antitumor Drug Screening Assay Undergo pre clinical kinase inhibitor activity screening. Other Name: Drug Screening Assays, ... Antitumor Drug Screening Assay Undergo pre clinical kinase inhibitor activity screening. Other Name: Drug Screening Assays, ... Antitumor Drug Screening Assay Undergo pre clinical kinase inhibitor activity screening. Other Name: Drug Screening Assays, ...
  https://clinicaltrials.gov/show/NCT01620216
*  urinary tract neoplasms benign drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-minor] Breast Neoplasms / drug therapy. Cell Line, Tumor. Drug Screening Assays, Antitumor. Female. HCT116 Cells. Humans. ... Prostatic Diseases / drug therapy. Prostatic Hyperplasia / drug therapy. Prostatic Neoplasms / drug therapy. Prostatitis / drug ... Urologic Diseases / drug therapy. *[MeSH-minor] Clinical Trials as Topic. Dose-Response Relationship, Drug. Drug Evaluation, ... Prostatic Hyperplasia / drug therapy. Prostatic Neoplasms / drug therapy. Sulfonamides / pharmacology. Urinary Retention / drug ...
  http://www.bmlsearch.com/?kwr=urinary+tract+neoplasms+benign+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
*  a) Single-crystal X-ray structure of 17 f. Ellipsoids a | Open-i
Cell Proliferation/drug effects. *Dose-Response Relationship, Drug. *Drug Screening Assays, Antitumor ... The broad anticancer activity of DHIQ 16 g was confirmed in the NCI 60-cell line assay giving a mean activity of 33 nM. ... The broad anticancer activity of DHIQ 16 g was confirmed in the NCI 60-cell line assay giving a mean activity of 33 nM. ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4114533_cmdc-9-798-f3&req=4
*  Additive antitumor activity of dasatinib and Eto in MDA | Open-i
Additive antitumor activity of dasatinib and Eto in MDA-MB-231 cells. The cells were treated with indicated concentrations of ... Dose-Response Relationship, Drug. *Drug Screening Assays, Antitumor/methods. *Etoposide/pharmacology. *Humans ... Dasatinib enhanced antitumor activity of etoposide in the basal B cell lines. Dasatinib induced a G1-S blockade with a slight ... Dasatinib enhanced antitumor activity of etoposide in the basal B cell lines. Dasatinib induced a G1-S blockade with a slight ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2967550_1471-2407-10-568-6&req=4
*  Reverse transcription quantitative polymerase chain rea | Open-i
Cell Proliferation/drug effects. *Cell Survival/drug effects. *Drug Screening Assays, Antitumor ... Bottom Line: The present study aimed to investigate the antitumor effects of virosecurinine by inducing the apoptosis of ... Bottom Line: The present study aimed to investigate the antitumor effects of virosecurinine by inducing the apoptosis of ... The present study aimed to investigate the antitumor effects of virosecurinine by inducing the apoptosis of leukemic K562 cells ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4214351_MMR-10-05-2365-g07&req=4
*  Effect of IMiDs on the migration and invasion of cells. | Open-i
Dose-Response Relationship, Drug. *Drug Screening Assays, Antitumor. *Female. *Immunoblotting. *Immunohistochemistry. *Mice ... The effect of only 10 μM of each drug was assessed in CMT93 (panel C). Mentions: The effect of IMiDs on the metastatic ... In addition, an in vivo experimental metastasis model also showed that treatment with the drugs resulted in a significantly ... In addition, an in vivo experimental metastasis model also showed that treatment with the drugs resulted in a significantly ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2736839_6605206f3&req=4
*  List of MeSH codes (E05) - Wikipedia
... drug screening assays, antitumor MeSH E05.337.550.200.800 --- tumor stem cell assay MeSH E05.337.550.200.900 --- xenograft ... drug screening assays, antitumor MeSH E05.200.500.388.930 --- tumor stem cell assay MeSH E05.200.500.410 --- electroporation ... multiphasic screening MeSH E05.318.308.250.580.580 --- neonatal screening MeSH E05.318.308.250.580.925 --- vision screening ... model antitumor assays MeSH E05.337.550.200.900.830 --- subrenal capsule assay MeSH E05.337.550.400 --- microbial sensitivity ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(E05)
*  Search of: inv(16) | 'Acute monoblastic leukemia' - List Results - ClinicalTrials.gov
Other: antitumor drug screening assay. *Drug: chemotherapy. *Biological: biological therapy. Interventional. *University of ... Achievability of Performing Individualized Drug Screening and Initiating Therapy Based on the Results of the Drug Screen for ... Treatment for Relapsed/Refractory AML Based on a High Throughput Drug Sensitivity Assay. *Adult Acute Megakaryoblastic Leukemia ... Inhibition of NF-kB target transcripts and/or inhibition of drug efflux in at least 50% of patients ...
  https://clinicaltrials.gov/ct2/results?term=inv%2816%29&cond=%22Acute+monoblastic+leukemia%22
*  Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules. - PubMed - NCBI
Drug Design*. *Drug Screening Assays, Antitumor/economics. *Drug Screening Assays, Antitumor/methods* ... Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules.. Hedvat M1, Emdad ... HeLa cells stably expressing the PEG-3-promoter will be utilized as the primary screen. A hit from the primary screen will be ... Structure-based modeling combined with rational drug design, and high throughput screening approaches offer significant ...
  https://www.ncbi.nlm.nih.gov/pubmed/22931411
*  Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications of dolastatin 10. - PubMed...
Drug Screening Assays, Antitumor. *Humans. *Leukemia P388. *Mice. *Molecular Structure. Substances. *Antineoplastic Agents ... especially to new and useful anticancer drugs. Dolastatin 10 and three analogues, minor structural modifications designated ...
  https://www.ncbi.nlm.nih.gov/pubmed/21534541?access_num=21534541&link_type=MED&dopt=Abstract
*  Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. - Nuffield Department...
... using in silico screening and small library synthesis, a series of 2-alkyl-3-aryl-3-alkoxyisoindolinones has been identified as ... Cell Line, Tumor, Humans, Indoles, Antineoplastic Agents, Drug Screening Assays, Antitumor, Combinatorial Chemistry Techniques ... From a set of weakly potent lead compounds, using in silico screening and small library synthesis, a series of 2-alkyl-3-aryl-3 ...
  https://www.ndorms.ox.ac.uk/publications/649689
*  Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to...
Drug Screening Assays, Antitumor. *Enzyme Inhibitors/pharmacology. *Gene Expression Regulation, Neoplastic*. *Humans ...
  https://www.ncbi.nlm.nih.gov/pubmed/19500021
*  Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition. - PubMed - NCBI
Drug Screening Assays, Antitumor. *Drug Synergism. *Indoles/administration & dosage. *Lymphocyte Activation. *Macrophages/drug ... Lack of superior antitumor activity of PLX3397 and PLX4032 in immunodeficient mice or with CD8+ T-cell depletion. a) Tumor ... Combined antitumor activity of PLX3397 and PLX4032 in murine melanoma SM1 model. a) Schematic of PLX3397 and PLX4032 treatments ... Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.. Mok S1,2, Tsoi J3, Koya RC4 ...
  https://www.ncbi.nlm.nih.gov/pubmed/25939769
*  Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. - PubMed - NCBI
Cell Proliferation/drug effects. *Dose-Response Relationship, Drug. *Drug Screening Assays, Antitumor ... b) Binding affinity of SAH-EZH2 peptides for EED as measured by fluorescence polarization assay. Data represents mean ± s.e.m. ...
  https://www.ncbi.nlm.nih.gov/pubmed/23974116?access_num=23974116&link_type=MED&dopt=Abstract
*  Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population. - PubMed - NCBI
Drug Screening Assays, Antitumor/instrumentation. *Drug Screening Assays, Antitumor/methods*. *Female. *Gene Expression ... The viability of the cells was assessed by a MTT assay. Results are expressed as percentages of cells still viable relative to ... A multifaceted approach is presented as a general strategy to identify new drug targets in a breast cancer stem cell-containing ... 48 h later, cells were incubated with Paclitaxel of Doxorubicin and viability was measured using an MTT assay. Results are ...
  https://www.ncbi.nlm.nih.gov/pubmed/18802034