*  Genetic Analysis of Resistance to Viral Infection - Bruce Beutler
The present application extends a successful multifaceted investigation of host resistance to viral infection. The strengths of ... Basic scientific discovery in these areas will pave the way to the design of effective anti-viral drugs and vaccines, and has ... Genetic Analysis of Resistance to Viral Infection Beutler, Bruce A. University of Texas Sw Medical Center Dallas, Dallas, TX, ... 2016) Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. Proc Natl Acad Sci U S A 113 ...
  http://grantome.com/grant/NIH/P01-AI070167-06A1
*  Growing Threat Of Drug Resistance Demands Systematic Global Response, Report
The growing threat of drug resistance, which will increasingly leave more and more people vulnerable to diseases that were once ... Spotlight on: MRSA / Drug Resistance. * Antibiotic resistance: how has it become a global threat to public health? ... "Drug resistance is a natural occurrence, but careless practices in drug supply and use are hastening it unnecessarily.". ... Thus the key to slowing down the emergence of drug resistance, is to manage the use of drugs carefully, eg only give them when ...
  https://www.medicalnewstoday.com/articles/192008.php?sr
*  Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo | Clinical Cancer...
... suggesting the emergence of resistance to both classes of drugs. Such acquired resistance is a major cause of cancer drug ... 11 cells develop acquired resistance to the one class of drug, they retain their sensitivity to the second class of drug. In ... Acquired resistance of tumor cells to anticancer drugs is a major cause of the failure of clinical cancer therapy. We have ... RS4;11 and MV4;11 tumors treated with SAR405838 acquire resistance to the drug by mutation of the TP53 gene or compromise of ...
  http://clincancerres.aacrjournals.org/content/21/11/2558
*  MOR/0.2R | Creative Bioarray
MOR/0.2R accumulate lower levels of doxorubicin than the parent line and have been shown to overexpress multi drug resistance ... Expression of a 190kDa membrane protein associated with the degree of drug-resistance has been indicated. Cells grow as easily ... The drug resistant cell line MOR/0.2R has been derived from the parent line, MOR, by continuous exposure to increasing ...
  https://www.creative-bioarray.com/MOR-02R-CSC-C9510J-item-42499.htm
*  What dose of medication is best to prevent the evolution of drug resistance? | Penn State University
... with the highest tolerable dose of anti-microbe medications may not be best for preventing the evolution of drug resistance in ... Day and Read showed that the optimal approach to combatting the evolution of drug resistance will be either to use the highest ... "Killing all of the infecting microbes obviously stops any further evolution of drug resistance, but we can't do this in every ... If a small number of microbes are already resistant to treatment, or if drug resistance arises by chance, high doses of ...
  http://news.psu.edu/story/389559/2016/01/28/research/what-optimal-dose-medication-prevent-evolution-drug-resistan
*  World Health Organization, Amid concern over drug resistance, Mekong countries call for accelerated action to eliminate malaria...
To date, resistance has been detected in five of the six GMS countries. The best way to address the threat posed by drug ... Amid concern over drug resistance, Mekong countries call for accelerated action to eliminate malaria before 2030. SEAR/PR/1673 ... Resistance to antimalarial drugs, unless addressed with urgency, could undermine these gains. Malaria is a life-threatening ... The call comes amid concern over resistance of malaria parasites to antimalarial drugs, including artemisinin-the core compound ...
  http://www.searo.who.int/mediacentre/releases/2017/1673/en/
*  Drug resistance - Wikipedia
Tolerance and Resistance Cosmetics Database HCMV drug resistance mutations tool Combating Drug Resistance - An informative ... "Drug resistance develops naturally, but careless practices in drug supply and use are hastening it unnecessarily." - Center for ... The chances of drug resistance can sometimes be minimized by using multiple drugs simultaneously. This works because individual ... Antibiotic resistance Fecal bacteriotherapy Mass drug administration Multidrug resistance Pharmacoepidemiology Small multidrug ...
  https://en.wikipedia.org/wiki/Drug_resistance
*  Microbial Drug Resistance
The international peer-reviewed journal covering the global spread and threat of multi-drug resistant clones of major pathogens ...
  http://www.liebertpub.com/subscribe/addtocart/microbial-drug-resistance/44/
*  Microbial Drug Resistance
The international peer-reviewed journal covering the global spread and threat of multi-drug resistant clones of major pathogens ... Microbial Drug Resistance (MDR) is an international, peer-reviewed journal that covers the global spread and threat of multi- ... Microbial Drug Resistance is under the editorial leadership of Editor Alexander Tomasz, PhD, The Rockefeller University, ... The Journal addresses the serious challenges of trying to decipher the molecular mechanisms of drug resistance. MDR provides a ...
  http://www.liebertpub.com/MDR/
*  WHO | Responding to antimalarial drug resistance
Resistance to antimalarial medicines is a threat to global efforts to control and eliminate malaria. Protecting the efficacy of ... Preventing and containing antimalarial drug resistance. Several factors influence the emergence and spread of drug resistant ... The Greater Mekong Subregion has long been the epicentre of antimalarial drug resistance. P. falciparum resistance to ... Countries where resistance to artemisinins or to ACT partner drugs is reported need to intensify malaria control in order to ...
  http://www.who.int/malaria/areas/drug_resistance/overview/en/
*  Drug Resistance
An easy-to-use directory for life science and biomedical research products. Find special deals on products, order catalogs and browse product lines from suppliers of reagents, antibodies, laboratory equipment, and more.
  http://www.biosupplynet.com/cfdocs/products/prod_supp.cfm?prod_id=268
*  Drug resistance continued: Malaria | HealthMap
Resistance Open: Battling the 'Post-Antibiotic Era'. November 18, 2015 Doctor, Meet Resistance The origins of Resistance Open ... Drug resistance continued: Malaria. Sep 22, 2011 , Anna Tomasulo , Outbreak News by DFID - UK Department for International ... Antimalarial Drug Resistance in Cambodia. January 27, 2016 An NIH study published in The Lancet Infectious Disease earlier this ... Antimalarial Drug Resistance in Cambodia. An NIH study published in The Lancet Infectious Disease earlier this month indicates ...
  http://www.healthmap.org/site/diseasedaily/article/drug-resistance-continued-malaria-92211
*  Drug resistance and tuberculosis | HealthMap
Antimicrobial Resistance. Antimicrobial resistance is a serious threat: if microbes develop resistance to all the drugs we have ... drug resistance to TB drugs is a man-made problem; wild Mycobacterium tuberculosis is susceptible to anti-TB drugs. Problems ... Resistance to antimicrobial drugs can either occur based on a characteristic of the microbe itself, mutation in the microbe or ... Antimalarial Drug Resistance in Cambodia. January 27, 2016 An NIH study published in The Lancet Infectious Disease earlier this ...
  http://www.healthmap.org/site/diseasedaily/article/drug-resistance-and-tuberculosis-92111
*  HIV Antiretroviral Drug Resistance Testing, Genotypic
... used to determine whether the HIV strain infecting an individual is resistant or has developed resistance to one or more drugs ... HIV antiretroviral drug resistance testing is used to help select a drug regimen that will likely be effective in treating a ... 1995-2012). Test ID: GHIVR HIV-1 Genotypic Drug Resistance Mutation Analysis, with Reflex to Phenotypic Drug Resistance ... is a better indicator of the level of HIV drug resistance.. HIV genotypic resistance testing cannot detect unknown resistance ...
  https://labtestsonline.org/tests/hiv-antiretroviral-drug-resistance-testing-genotypic
*  Transmission of HIV-1 Drug Resistance | SpringerLink
... or primary resistance. As transmitted drug resistance increases the risk... ... Infection with an HIV strain harboring drug resistance-related mutations is referred to as transmitted drug resistance (TDR) ... Resistance Mutation Virological Failure Replicative Capacity Drug Resistance Mutation Acquire Drug Resistance These keywords ... Infection with an HIV strain harboring drug resistance-related mutations is referred to as transmitted drug resistance (TDR) or ...
  https://link.springer.com/referenceworkentry/10.1007/978-1-4939-0667-3_23-1
*  WPRO | Drug Resistance
Antimicrobial resistance is a global public health threat with resistant microorganisms reaching alarming levels in all six WHO ... Resistance occurs when microorganisms become resistant to antimicrobial medicines and the antimicrobials no longer work in ... There is a need for urgent, concerted actions with multiple stakeholders to contain antimicrobial resistance at the national, ... Join the fight against antimicrobial resistance by pledging to use antibiotics responsibly and to promote awareness of ...
  http://www.wpro.who.int/topics/drug_resistance/en/
*  Antibiotic and Drug Resistance - Emergence | Coursera
Many bugs have only survived by evolving resistance to those chemicals.. So drug resistance is often out there in nature anyway ... Antibiotic and Drug Resistance. To view this video please enable JavaScript, and consider upgrading to a web browser that ... And most of the time those bugs evolve resistance.. What are we going to do as drug-resistant bugs become more and more common? ... We'll explore Malaria, and use it as a case study of the evolution of drug resistance. We'll even be looking at social networks ...
  https://www.coursera.org/lecture/epidemics/antibiotic-and-drug-resistance-j60aR
*  Transmitted HIV drug resistance in Asia
Surveillance for transmitted HIV drug resistance is essential to assessing the longer term sustainability and durability of ... Purpose of review: Surveillance for transmitted HIV drug resistance is essential to assessing the longer term sustainability ... However, MSM appear to be at higher risk of transmitted resistance and may benefit from enhanced resistance assessments and ... resistance has primarily been reported to be below WHO thresholds for moderate resistance (i.e. ,5%). However, studies have ...
  http://www.comminit.com/content/transmitted-hiv-drug-resistance-asia-1
*  Drug resistance deadlier than cancer by 2050: Study
... Catherine Boyle , @cboylecnbc Published 4:38 AM ET Thu, 11 Dec 2014 ... Its forecasts, based on research by RAND Europe and KPMG, suggest that drug resistance, which is estimated to have caused ... warned that the developing world would be hardest hit by growth in drug resistance. Countries in particular danger are likely ... "There can be no doubt now that antimicrobial resistance is one of the biggest (risks) that we, all of us, face," Nick Stern, ...
  https://www.cnbc.com/2014/12/11/drug-resistance-to-kill-more-than-cancer-by-2050-study.html
*  Scientists Warn About Malarial Drug Resistance
Malaria could be developing resistance to the most effective type of drug, according to the initial results of studies of ... Drug Toxicity. Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, ... Malaria could be developing resistance to the most effective type of drug, according to the initial results of studies of ... often containing small amounts of the real drug, is thought to be helping nurture resistance. Professor Nick Day, of the ...
  http://www.medindia.net/news/Scientists-Warn-About-Malarial-Drug-Resistance-52193-1.htm
*  Mutations and Drug Resistance | Frontiers Research Topic
Mutation in drug target is a critical mechanism that results in drug resistance. The aim of this topic is to highlight ... resulting in drug resistance. In general, resistant mutations in drug targets are derived from tissue specimen of the patients ... Thus, one way to overcome drug resistance is to develop AR inhibitors that are active against multiple AR mutants. In another ... There are several scenarios under which a mutation could lead to drug resistance. Mutations could reduce the binding affinity ...
  https://www.frontiersin.org/research-topics/2063/mutations-and-drug-resistance
*  HIV Drug Resistance Database
Patterns of Drug-Resistance Mutations. Description , PI , NRTI , NNRTI , INI 2.. Downloadable Reference Dataset. Description , ... of accompanying nonpolymorphic established drug-resistance mutations. Sequences containing electrophoretic mixtures at a drug- ... Sequences containing electrophoretic mixtures at a drug-resistance position are excluded from the results. Median, ... Results are aggregated by the pattern of accompanying nonpolymorphic established drug-resistance mutations. ...
  http://hivdb.stanford.edu/pages/genotype-phenotype.html
*  Rising levels of HIV drug resistance | EurekAlert! Science News
... according to the largest meta-analysis to date on HIV drug resistance, led by researchers at UCL and the World Health ... HIV drug resistance is approaching and exceeding 10 percent in people living with HIV who are about to initiate or reinitiate ... In July 2017, WHO published a new HIV drug resistance report, based on drug resistance national surveys conducted in 11 ... "Many people develop drug resistance after being treated by antiretroviral drugs if they stop taking their medication - often ...
  https://eurekalert.org/pub_releases/2017-11/ucl-rlo112917.php
*  Drug resistance: WHO report 'serious lack of new antibiotics'
... from the WHO reveals that the current scope of new antibiotic development is far from what is needed to tackle drug resistance. ... Drug resistance 'could kill 10 million people annually'. A review suggests that drug resistance could kill 10 million people ... Spotlight on: MRSA / Drug Resistance. * Antibiotic resistance: how has it become a global threat to public health? ... Drug resistance, or antimicrobial resistance, arises when pathogens evolve to evade the harms of antimicrobial therapeutics, ...
  https://www.medicalnewstoday.com/articles/319493.php
*  WHO warns about threat of drug resistance - NHS.UK
for TB, resistance in the UK to first-line drug treatments is seen in less than 8% of cases and resistance to multiple drugs is ... What is antimicrobial resistance?. Antimicrobial resistance occurs when a drug is no longer effective against an infection. ... to improve surveillance of antimicrobial resistance (resistance of all types of infections to drugs) and to measure the health ... to develop standard ways to record antibiotic resistance (resistance of bacteria to drugs) in humans and food-producing animals ...
  https://www.nhs.uk/news/medication/who-warns-about-threat-of-drug-resistance/