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*  Frontiers | Fragile X mental retardation protein: from autism to neurodegenerative disease | Frontiers in Cellular Neuroscience
... synaptic dysfunction and behavioral phenotypes in fragile X syndrome (Wang et al., 2012; Sidorov et al., 2013; Suhl et al., ... More and more potential FMRP mRNA targets and interacting proteins have been identified in the mammalian brain, supporting the ... is a RNA binding protein, the absence of which due to silencing of the FMR1 gene causes fragile X syndrome, an X-linked ... critical roles of FMRP in neurodevelopment, synaptic plasticity and other neurological disorders apart from fragile X syndrome ...
  https://www.frontiersin.org/articles/10.3389/fncel.2015.00043/full
*  SYNGAP1 Gene - GeneCards | SYGP1 Protein | SYGP1 Antibody
Protein Coding), Synaptic Ras GTPase Activating Protein 1, including: function, proteins, disorders, pathways, orthologs, and ... The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be ... Synaptic Ras GTPase activating protein 1 homolog (Rat) (B1AZX6_HUMAN). *Synaptic Ras GTPase-activating protein 1 (SYGP1_HUMAN) ... Protein Symbol:. Q96PV0-SYGP1_HUMAN. Recommended name:. Ras/Rap GTPase-activating protein SynGAP Protein Accession:. Q96PV0. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=SYNGAP1&rf=/home/genecards/current/website/carddisp.pl&origene_ab_prot=3
*  PSD93 Regulates Synaptic Stability at Neuronal Cholinergic Synapses | Journal of Neuroscience
... and the synaptic Ras-GTPase activating protein SynGAP (Chen et al., 1998; Kim et al., 1998). Furthermore, the GK domain of ... domains, an Src homology 3 (SH3) domain, and an enzymatically inactive guanylate kinase-like (GK) domain. These domains ... Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM ... guanylate kinase domain-associated protein/synapse-associated protein-associated protein) and Shank/ProSAP family proteins, are ...
  http://www.jneurosci.org/content/24/2/378
*  Signaling pathways involved in enhanced NMDA receptor-dependent excitotoxicity in a mouse model of Huntington disease - UBC...
Synaptic RAS GTPase-activating protein (SynGAP) is another abundant PSD protein that binds to PSD-95 (Bezprozvanny and Hayden, ... SAP102 is a member of the PSD-95 family of MAGUK proteins and shows high homology with PSD-95 in the SH3 as well as PDZ domains ... 1 SPN Supernatant Src Sarcoma STEP Striatal-enriched protein tyrosine phosphatase SynGAP Synaptic RAS GTPase-activating protein ... Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II. J Biol ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0072317
*  Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia | Journal of Neuroinflammation | Full Text
To further examine the impact of inflammatory changes on synaptic plasticity, the effect of CD200Fc on Aβ-induced impairment of ... whereas activation of the receptor by CD200 fusion protein (CD200Fc) ameliorates inflammatory changes which are evident in the ... Ras GTPase activating protein. SHIP: SH2-containing inositol phosphatase. SHP: Src homology 2 domain containing phosphatase ... This study highlights the negative effect that activated microglia exert on synaptic plasticity but, importantly, it identifies ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-107
*  RAPGEF4 - Wikipedia
... consists of a CDC25 homology domain (CDC25-HD), a Ras exchange motif (REM) domain, and a Ras association (RA) domain. Epac2B is ... "Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus". ... Epac2 functions as a guanine nucleotide exchange factor for the Ras-like small GTPase Rap upon cAMP stimulation. Epac2 is ... also known as exchange protein directly activated by cAMP 2 (EPAC2) is a protein that in humans is encoded by the RAPGEF4 gene ...
  https://en.wikipedia.org/wiki/RAPGEF4
*  Neurofibromin 1 - Wikipedia
NF1 encodes the protein neurofibromin, a GTPase-activating protein, which primarily regulates the protein Ras. NF1 is located ... neurofibromin also contains a Sec14 homology-like region as well as a pleckstrin homology-like (PH) domain. Sec14 domains are ... Neurofibromin is also believed to be involved in the synaptic ATP-PKA-cAMP pathway, through modulation of adenylyl cyclase. It ... a GTPase-activating protein that negatively regulates RAS/MAPK pathway activity by accelerating the hydrolysis of Ras-bound GTP ...
  https://en.wikipedia.org/wiki/Neurofibromin_1
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
A key regulator of mitogenic signaling is Grb2, a modular protein composed of an internal SH2 (Src Homology 2) domain flanked ... Grb2 is constitutively associated with the GTPase Son-Of-Sevenless (SOS) via its N-terminal SH3 domain. The SH2 domain of Grb2 ... Plasma membrane receptors that bind Grb2 such as activated Epidermal Growth Factor Receptor (EGFR) recruit GFP-Grb2 to the ... This principle of selective innervation of neuronal targets raises the question as to how the appropriate synaptic partners ...
  https://www.jove.com/visualize/abstract/21731601/specific-syndecan-1-domains-regulate-mesenchymal-tumor-cell-adhesion
*  AGAP3 and Arf6 Regulate Trafficking of AMPA Receptors and Synaptic Plasticity | Journal of Neuroscience
SynGAP contains a Ras GTPase activating protein domain (RasGAP) and plays an important role in linking NMDA receptors to Ras/ ... AGAP3 contains multiple signaling domains, a GTPase-like domain, a pleckstrin homology domain, and an ArfGAP domain, and exists ... 1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20:895-904, doi:10.1016/S0896- ... GTPase domain, and ArfGAP domain, respectively. What is the relationship between AGAP3 GTPase domain and ArfGAP domain? These ...
  http://www.jneurosci.org/content/33/31/12586.full
*  CALM2 calmodulin 2 [Homo sapiens (human)] - Gene - NCBI
... organism-specific biosystemIQGAPs constitute a family of scaffolding proteins characterized by a calponin homology (CH) domain ... RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream ... Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for ... The synapse involves a pre-synaptic neuron and a post-synaptic neuron,... ...
  https://www.ncbi.nlm.nih.gov/gene/805
*  Plus it
In contrast to citron, p135 SynGAP, an abundant synaptic Ras GTPase-activating protein that can bind to all three PDZ domains ... Sequences related to citron. A, Domain structure of citron. Ring-H2, Ring-H2 finger domain; PH, pleckstrin homology domain;CMG ... 1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II. Neuron 20:895-904. ... and the synaptic Ras GTPase-activating protein SynGAP (Chen et al., 1998) and can phosphorylate the NR2A and NR2B subunits of ...
  http://www.jneurosci.org/content/19/1/96
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
A key regulator of mitogenic signaling is Grb2, a modular protein composed of an internal SH2 (Src Homology 2) domain flanked ... Grb2 is constitutively associated with the GTPase Son-Of-Sevenless (SOS) via its N-terminal SH3 domain. The SH2 domain of Grb2 ... This directed trafficking is of fundamental importance to deliver, maintain or remove synaptic proteins. Super-ecliptic ... Plasma membrane receptors that bind Grb2 such as activated Epidermal Growth Factor Receptor (EGFR) recruit GFP-Grb2 to the ...
  https://www.jove.com/visualize/abstract/21556374/unconventional-secretion-tissue-transglutaminase-involves
*  Frontiers | SynProt: A Database for Proteins of Detergent-Resistant Synaptic Protein Preparations | Frontiers in Synaptic...
For a comprehensive understanding of synaptic networks the entire ensemble of synaptic proteins has to be considered. To ... For a comprehensive understanding of synaptic networks the entire ensemble of synaptic proteins has to be considered. To ... Both pre- and postsynaptic protein networks represent the molecular substrates for synaptic plasticity. Their function can be ... Both pre- and postsynaptic protein networks represent the molecular substrates for synaptic plasticity. Their function can be ...
  https://www.frontiersin.org/articles/10.3389/fnsyn.2012.00001/full
*  Gene Report for G00001924 - Genes2Cognition Neuroscience Research Programme
... and negligible with the SH3 domains of p21(ras) GTPase-activating protein and COOH-terminal Grb2. Distinct sites in the proline ... Amphiphysin (Amph) is a src homology 3 domain-containing protein that has been implicated in synaptic vesicle endocytosis as a ... Many important protein-protein interactions are mediated by peptide recognition modular domains, such as the Src homology 3 ( ... calmodulin-dependent protein kinase II or mitogen-activated protein kinase modulated the binding to the SH3 domains of ...
  http://www.genes2cognition.org/db/Gene/G00001924
*  RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1)
Ras protein-specific guanine nucleotide-releasing factor 1), Authors: Fernando Calvo, Piero Crespo. Published in: Atlas Genet ... On the other hand, Ras-GRF1 acts as a Rac-GEF when activated in a Gβγ-dependent fashion. Another Rho-family GTPase, Cdc42, ... Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.. ... regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction regulation of synaptic ...
  http://atlasgeneticsoncology.org/Genes/GC_RASGRF1.html
*  The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits
Domain abbreviations: RapGAP, Rap-specific GTPase-activating protein domain. (B) Our structure of Gαi1 (green with translucent ... All three proteins possess an RGS-box N-terminal to DH (Dbl-homology) and PH (pleckstrin-homology) domains that, as a tandem, ... The RGS12 PTB domain binds the synprint ("synaptic protein interaction") region of the N-type calcium channel (Cav2.2); this ... With the ability to interact with a multitude of proteins by virtue of its PDZ, PTB, and Ras-binding domains, along with Gα ...
  http://www.ijbs.com/v01p0051.htm
*  RAB3A - Wikipedia
"Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP". J. Biol. Chem. ... "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem ... Geppert M, Goda Y, Stevens CF, Südhof TC (1997). "The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle ... Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered ...
  https://en.wikipedia.org/wiki/RAB3A
*  Calm1 calmodulin 1 [Rattus norvegicus (Norway rat)] - Gene - NCBI
Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for ... Conserved Domain Search Service (CD Search). *Genome ProtMap. *HomoloGene. *Protein Clusters. *All Homology Resources... ... Title: Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ... RHO GTPase Effectors, organism-specific biosystem (from REACTOME) RHO GTPase Effectors, organism-specific biosystem ...
  https://www.ncbi.nlm.nih.gov/gene/24242
*  Rap1a RAS-related protein 1a [Mus musculus (house mouse)] - Gene - NCBI
Conserved Domains (1) summary. cd04175. Location:3 → 167. Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms. ... MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved ... Homology *Homologs of the Rap1a gene: The Rap1a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, ... negative regulation of synaptic vesicle exocytosis IGI Inferred from Genetic Interaction. more info ...
  https://www.ncbi.nlm.nih.gov/gene/?term=109905
*  C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH? | Journal of Cell Science
Yamaguchi, A., Urano, T., Goi, T. and Feig, L. A. (1997). An Eps homology (EH) domain protein that binds to the Ral-GTPase ... Some EHD proteins (e.g. Reps1 and POB1) regulate actin microfilaments by interacting with GTPase-activating proteins (GAPs) for ... All mammalian C-terminal EHD proteins contain a putative P-loop motif, an ATP/GTP-binding site found in Ras-family proteins, ... retrieval of synaptic vesicle components in neurons, and the regulated expression of signaling receptors and adhesion molecules ...
  http://jcs.biologists.org/content/118/18/4093
*  gq g11 gtp binding protein alpha subunits
Research Grants about gq g11 gtp binding protein alpha subunits ... of the Dbl homology-associated pleckstrin homology domain. ... Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein ... Differential contribution of GTPase activation and effector antagonism to the inhibitory effect of RGS proteins on Gq-mediated ... This modulation and its blockade by atypical neuroleptics could have wide-ranging effects on synaptic integration and long-term ...
  https://www.labome.org/topics/chemicals/and/peptides/intracellular/heterotrimeric/gtp/gq-g11-gtp-binding-protein-alpha-subunits-12352.html
*  Tobias Meyer | Stanford Medicine Profiles
Here, we show that 21 small GTPase homologs activate PI3K. Using a microscopy-based binding assay, we show that K-Ras, H-Ras, ... and other processes by recruiting proteins with pleckstrin homology (PH) domains and possibly other domains to the plasma ... We show here that a regulated interaction of the endocytic adaptor RalBP1 with two synaptic proteins, the small GTPase RalA and ... Cysteine-rich domains (Cys-domains) are approximately 50-amino acid-long protein domains that complex two zinc ions and include ...
  https://med.stanford.edu/profiles/tobias-meyer
*  GNB2 G protein subunit beta 2 [Homo sapiens (human)] - Gene - NCBI
... isoforms are activated by G-protein beta:gamma in the order PLCB3 , PLCB2 , PLCB1. Gbeta:gamma binds to the pleckstrin homology ... Conserved Domains (2) summary. cd00200. Location:48 → 340. WD40; WD40 domain, found in a number of eukaryotic proteins that ... Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for ... The synapse involves a pre-synaptic neuron and a post-synaptic neuron,... ...
  https://www.ncbi.nlm.nih.gov/gene/2783
*  Gene Report for G00001918 - Genes2Cognition Neuroscience Research Programme
RLIP76 is a modular protein that was identified as a putative effector of Ral, a GTPase activated during Ras signaling. To ... It binds directly to the ear domain of gamma-adaptin and it contains an Eps15 homology (EH) domain, although the EH domain is ... Amphiphysin is an SH3 domain protein that has been implicated in synaptic vesicle endocytosis. We have recently cloned a second ... terminal homology domain, ENTH domain) found in a variety of other proteins of the data base. The multiple DPW motifs, typical ...
  http://www.genes2cognition.org/db/Gene/G00001918
*  NUS Department of Physiology
Here, we demonstrate that RASAL2, which encodes a RAS-GTPase-activating protein (RAS-GAP), is a functional target of anti- ... Of note, the identification of specific domains within the Bcl-2 family of proteins (Bcl-2 homology domains; BH domains) has ... synaptic capture, whereby the synaptic tag interacts with newly synthesized plasticity-related proteins (PRPs). Much of the ... Here, we identify Rho GTPase activating protein 29 (ARHGAP29) as a transcriptional target of YAP in a human gastric cancer cell ...
  http://medicine.nus.edu.sg/phys/Research_Highlights.html