*  KEGG PATHWAY: Base excision repair - Isoptericola variabilis
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from ... BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub- ... Base excision repair - Isoptericola variabilis [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show ... of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a ...
  http://www.genome.jp/kegg-bin/show_pathway?iva03410+Isova_2011
*  H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase :...
Accumulation of DNA repair intermediates by inhibition of DNA repair synthesis resulted in a marked increase of H2AX ... Accumulation of DNA repair.... It has been suggested that phosphorylation of the histone variant H2AX after ultraviolet light ( ... In this study, we show that H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is induced ... In this study, we show that H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is induced ...
  http://oxfordindex.oup.com/view/10.1093/carcin/bgm157
*  Focus Formation of DNA Repair Proteins in Normal and Repair-Deficient Cells Irradiated with High-LET Ions
Molecular biology, DNA damage, DNA repair, DSB, NHEJ, DNA-PK, ionising radiation, high-LET, heat-labile sites, PFGE, ... Focus Formation of DNA Repair Proteins in Normal and Repair-Deficient Cells Irradiated with High-LET Ions. Karlsson, Karin H ... Efficient and correct repair of DNA damage, especially DNA double-strand breaks (DSBs), is vital for the survival of individual ... 1. Role of Non-Homologous End-Joining in Repair of Radiation-Induced DNA Double-Strand Breaks. Open this publication in new ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:169135
*  Inefficient in vivo repair of mismatches at an oncogenic hotspot correlated with lack of binding by mismatch repair proteins...
... are also significantly improved over repair rates at codon 12 in non-synchronous cells, demonstrating that DNA mismatch repair ... demonstrating that mismatch repair mechanisms are active in G1. Repair rates in non-synchronous cells for the same mismatches ... demonstrating that mismatch repair mechanisms are active in G1. Repair rates in non-synchronous cells for the same mismatches ... Repair rates of mismatched nucleotides located at an activating hotspot of mutation, H-ras codon 12, have been analyzed in vivo ...
  http://oxfordindex.oup.com/view/10.1093/carcin/20.8.1417
*  Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC
... Journal. Journal of Cell Science. ... To investigate how the nucleotide excision repair initiator XPC locates DNA damage in mammalian cell nuclei we analyzed the ... DNA-damaging agents retard the mobility of XPC, and UV damage has the most pronounced effect on the mobility of XPC-GFP. XPC ... To avoid excessive DNA probing by the low specificity of the protein, the steady-state level in the nucleus is controlled by ...
  http://dare.uva.nl/search?metis.record.id=298187
*  "Nucleotide Excision Repair Deficiency is Intrinsic in Sporadic Stage I" by Jean J. Latimer, Jennifer M. Johnson et al.
... tested with the functional unscheduled DNA synthesis assay exhibited a significant deficiency of DNA nucleotide excision repair ... Loss of DNA repair capacity, including the complex, damage-comprehensive NER pathway, results in genomic instabil- ity, a ... tested with the functional unscheduled DNA synthesis assay exhibited a significant deficiency of DNA nucleotide excision repair ... Loss of DNA repair capacity, including the complex, damage-comprehensive NER pathway, results in genomic instabil- ity, a ...
  http://nsuworks.nova.edu/hpd_com_faculty_articles/1110/
*  Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC | Journal of Cell Science
Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC ... Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC ... Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC ... Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC ...
  http://jcs.biologists.org/content/121/23/3991
*  Study Reveals How Cells Remove Bits of RNA from DNA Strands
DNA »DNA repair »Escherichia coli »Gates Foundation »NSF »RNA »RNA/DNA »RNase »genetic mutation »genomic DNA »methanol fuel ... Further reports about: , DNA , DNA repair , Escherichia coli , Gates Foundation , NSF , RNA , RNA/DNA , RNase , genetic ... "We were excited to find that a DNA repair mechanism like mismatch repair was activated by RNA/DNA mismatches and could remove ... we plan to test whether other DNA repair mechanisms, such as nucleotide-excision repair and base-excision repair, can also ...
  http://www.innovations-report.com/html/reports/life-sciences/study-reveals-cells-remove-bits-rna-dna-strands-187083.html
*  The development of DNA repair assays which show that dietary carrots stimulate DNA repair activity - Surrey Research Insight...
The development of DNA repair assays which show that dietary carrots stimulate DNA repair activity ... The development of DNA repair assays which show that dietary carrots stimulate DNA repair activity In: 3rd Conference on Food ...
  http://epubs.surrey.ac.uk/824306/
*  Role of nucleotide excision repair factors in genome maintenance in human cells under oxidative stress | ScholarBank@NUS
Other DNA repair proteins including a component of the NER pathway, XPF, have been reported to be involved in telomere dynamics ... The role of nucleotide excision repair (NER) in the maintenance of DNA integrity under oxidative assault has yet to be ... Our findings have implications in the mechanisms of DNA repair in oxidative stress, mutagenesis, carcinogenesis and ageing. ... Although the NER is characterized to be involved in repairing UV-induced damage, it is difficult to attribute all the symptoms ...
  http://scholarbank.nus.edu.sg/handle/10635/16872
*  DNA Repair & Nucleic Acid Enzymology Group
... and its biological roles in base excision DNA repair. This DNA repair pathway protects cells against endogenous DNA lesion ... the study of gap-filling DNA synthesis in DNA repair. To define the biological role of DNA polymerase beta, the group and ... DNA Repair & Nucleic Acid Enzymology Group. Mechanisms of DNA Synthesis. Samuel H. Wilson, M.D. Principal Investigator Tel 984- ... the study of gap-filling DNA synthesis in DNA repair ("/Rhythmyx/assembler/render?sys_contentid=53298&sys_revision=1&sys_ ...
  https://www.niehs.nih.gov/research/atniehs/labs/gisbl/pi/dnarna/
*  DNA Repair
... provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal ... DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal ... DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal ... DNA Repair sponsors GRC DNA Damage, Mutation & Cancer 2018 * 3rd DNA Replication/Repair Structures and Cancer - Fusion ...
  https://www.journals.elsevier.com/dna-repair
*  DNA Repair and Simple Recombination | SpringerLink
... for repairing any damage). Nevertheless, most organisms can undergo some sort of... ... Birge E.A. (1994) DNA Repair and Simple Recombination. In: Bacterial and Bacteriophage Genetics. Springer, New York, NY. * DOI ... and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III. Proceedings of the National Academy of Sciences ... Madiraju, M.V.V.S., Clark, A.J. (1992). Evidence for ATP binding and double-stranded DNA binding by Escherichia coli RecF ...
  https://link.springer.com/chapter/10.1007/978-1-4757-2328-1_5
*  How DNA Repair Helps Prevent Cancer - Redorbit
Feig studies the proteins MutS and MSH2-MSH6, which recognize defective DNA and initiate DNA repair. Natural DNA repair occurs ... "DNA damage occurs frequently and if you couldn't repair your DNA, then you won't live for very long." This is because damaged ... "We believe that DNA bending facilitates the initial recognition of the mismatched base for repair," Feig said. "Normal DNA is ... In these cases, cancer is not a result of damaged DNA, but occurs because of a problem in the DNA repair mechanism itself. ...
  http://www.redorbit.com/news/health/1112926275/how-dna-repair-helps-prevent-cancer/
*  Nobel shows link between DNA repair, diseases
An expert in DNA repair says the amount of damage caused to our DNA each day is astounding - an estimated 50,000 lesions per ... Nobel shows link between DNA repair, diseases An expert in DNA repair says the amount of damage caused to our DNA each day is ... Nobel shows link between DNA repair, diseases An expert in DNA repair says the amount of damage caused to our DNA each day is ... STOCKHOLM (AP) - An expert in DNA repair says the amount of damage caused to our DNA each day is astounding - an estimated ...
  https://www.elpasotimes.com/story/news/national/2015/10/07/nobel-shows-link-between-dna-repair-diseases/73508798/?from=new-cookie
*  DNA repair protein XRCC4 (IPR010585) | InterPro | EMBL-EBI
... the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ... This entry represents the DNA double-strand break repair and V(D)J recombination protein XRCC4, which is found in certain ... XRCC4 binds to DNA, and to DNA ligase IV (LIG4) to form the LIG4-XRCC4 complex [PMID: 11029705]. The LIG4-XRCC4 complex is ... Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro.. Cancer Res. ...
  http://www.ebi.ac.uk/interpro/entry/IPR010585
*  Snapshot of DNA repair
... a crucial interaction for DNA repair, to find a unique interaction. ... The DNA is protected, however, by DNA repair machinery. A new study from scientists at Osaka University and The University of ... Snapshot of DNA repair. (Nanowerk News) Osaka University scientists, in collaboration with The University of Tokyo, describe ... To activate the DNA repair machinery, DSBs stimulate ubiquitylation. RNF168 binds to polyubiquitylated proteins and accumulates ...
  https://www.nanowerk.com/news2/biotech/newsid=49122.php
*  Phys.org - dna repair
DNA repair. DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules ... or one that no longer effectively repairs damage incurred to its DNA, can enter one of three possible states:. The DNA repair ... Snapshot of DNA repair. DNA is like the computer code of the body, and it must be preserved for our bodies to survive. Yet, as ... Consequently, the DNA repair process is constantly active as it responds to damage in the DNA structure. ...
  https://phys.org/tags/dna+repair/
*  Phys.org - dna repair
DNA repair. DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules ... or one that no longer effectively repairs damage incurred to its DNA, can enter one of three possible states:. The DNA repair ... Consequently, the DNA repair process is constantly active as it responds to damage in the DNA structure. ... Researchers find that accurately transcribing DNA overrides DNA repair. A groundbreaking and surprising discovery provides a ...
  https://phys.org/tags/dna+repair/sort/liverank/all/
*  Recent Articles | Dna Repair | The Scientist Magazine®
A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not ... The Role of DNA Base Modifications. By Skirmantas Kriaucionis , September 1, 2017 ... Researchers develop a more-efficient method for rewriting DNA that could hold therapeutic value for HIV and other diseases. ... From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process. ...
  https://www.the-scientist.com/?articles.list/categoryNo/2625/category/The-Scientist/tagNo/110/tags/DNA-repair/
*  DNA Repair in Skin Care
While DNA repair is occurring in our body roughly 100 trillion times every day, we apparently still need more help. There is a ... Our DNA is critical to our health and survival, but does our skin really benefit from this novel ingredient class? ... DNA is information everyone should become familiar with as we move to the next paradigm in skin care. ... delicate balance between oxygen being used a repair and sustain life and the infamous free radical cascade that is often the ...
  http://www.skininc.com/treatments/facial/antiaging/DNA-Repair-in-Skin-care--372234562.html
*  RCSB PDB - Gene View - BRCA1 - BRCA1, DNA repair associated
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
  http://www.rcsb.org/pdb/gene/BRCA1?chromosome=chr17&range=41228505&v=hg19
*  Scientists find DNA repair 'accuracy switch' | Cancer Research UK
UK scientists have shed light on how our cells use two different methods to repair damaged DNA, and how they switch between ... "Up to now, it was unclear how this accurate mechanism for repairing DNA breaks is turned on so we are very pleased with the ... UK scientists have shed light on how our cells use two different methods to repair damaged DNA, and how they switch between ... Cells have two main DNA repair pathways that were thought to function at different stages of a cell's life cycle and protect ...
  http://www.cancerresearchuk.org/about-us/cancer-news/news-report/2009-05-29-scientists-find-dna-repair-accuracy-switch
*  DNA Repair and Mutagen Interaction in Saccharomyces: Theoretical Considerations | SpringerLink
One or more of these pathways are mutagenic, i.e., induce mutations during the process of repair of lesions in DNA.... ... DNA repair pathways have been identified in the yeast Saccharomyces cerevisiae. ... Resnick, M. A., The repair of double-strand breaks in chromosomal DNA of yeast, In: Molecular Mechanisms for Repair of DNA, ... Johnston, L. H., The DNA repair capability of cdc9, the Saccharomyces cerevisiae mutant defective in DNA ligase, Mol. Gen. ...
  https://link.springer.com/chapter/10.1007/978-1-4684-3842-0_10
*  Detailed Look At A DNA Repair Protein In Action - Redorbit
... model of DNA repair, in which MutS proteins are the beads and DNA is the string. In solution, the MutS protein will bind to a ... A new and detailed look at the role of MutS in DNA's mismatch repair (MMR) system has been provided by a team of researchers ... "This is the first time we used this technique to look at a protein-mediated process like DNA repair in solution with multiple ... "The view of DNA as a passive element is at least in part due to a paucity of robust tools for examining dynamic DNA ...
  http://www.redorbit.com/news/science/1112983687/dna-repair-protein-in-action-102413/