*  Frontiers | The Potential Use of DNA Methylation Biomarkers to Identify Risk and Progression of Type 2 Diabetes | Endocrinology
This Mini Review will address the most recent associations between DNA methylation and diabetes-related traits in human tissues ... This Mini Review will address the most recent associations between DNA methylation and diabetes-related traits in human tissues ... Recent data demonstrate highly significant correlations between DNA methylation and the most important risk factors of T2D, ... Also, T2D patients and individuals with increased risk of the disease display differential DNA methylation profiles and ...
  https://www.frontiersin.org/articles/10.3389/fendo.2015.00043/full
*  DNA methylation signatures for breast cancer classification and prognosis | Genome Medicine | Full Text
The DNA methylation reaction is catalyzed by DNA methyltransferases (DNMTs) [9, 10]. DNA methylation is unique among all the ... DNA methylation and cancer. Cancer was the first group of diseases to be associated with DNA methylation and to be considered ... DNA methylation of tumor suppressor genes has been the focus of numerous studies that have aimed to identify DNA methylation ... DNA methylation in breast cancer. DNA methylation of candidate genes in breast cancer. The original concept driving ...
  https://genomemedicine.biomedcentral.com/articles/10.1186/gm325
*  A semi-quantitative assay of overall DNA methylation status using Methyl-CpG binding protein (MBD1) | BMC Research Notes | Full...
Overall DNA methylationMBD1Slot blot assay. Background. DNA methylation of the CpG dinucleotide is one of the most crucial ... Thus, DNA methylation may help explain the pathophysiology of diseases. Furthermore, the aberrant genome-wide DNA methylation ... Changes in the level of genome-wide DNA methylation (also known as overall DNA methylation) are associated with alterations in ... the overall DNA methylation level of kidney is significantly higher than that of liver. But at D1, the DNA methylation level ...
  https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-5-234
*  Scholars' Mine - Undergraduate Research Conference at Missouri S&T: Statistical Analysis of DNA Methylation Data in a Cervical...
DNA methylation levels are measured at cytosines across the genome with Illumina 450K methylation microarrays. After initial ... or other genomic annotations can help researchers better understand the molecular impact of DNA methylation and its connection ... In this research, statistical methods are employed to test for significant differences in methylation levels between HIV ... Previous studies have established links between specific methylation patterns and many diseases. ...
  http://scholarsmine.mst.edu/ugrc/2017/full-schedule/39/
*  Aberrant DNA methylation associated with Alzheimer's disease in the superior temporal gyrus
... wide DNA methylation data by bioinformatics analysis. The genome‑wide DNA methylation data in the STG region of 34 patients ... Aberrant DNA methylation associated with Alzheimer's disease in the superior temporal gyrus. *Authors: *Zhan Gao ... Abnormal DNA methylation patterns have been demonstrated to be associated with the pathogenesis of Alzheimer's disease (AD). ... Gao, Z., Fu, H., Zhao, L., Sun, Z., Yang, Y., Zhu, H.'Aberrant DNA methylation associated with Alzheimer's disease in the ...
  https://www.spandidos-publications.com/etm/15/1/103/abstract
*  DNA methylation levels at chromosome 8q24 in peripheral blood are associated with 8q24 cancer susceptibility loci | Cancer...
... but little is known about the contribution of DNA methylation at 8q24. To evaluate variability in DNA methylation levels at ... DNA methylation levels at chromosome 8q24 in peripheral blood are associated with 8q24 cancer susceptibility loci. Kathryn ... DNA methylation levels at chromosome 8q24 in peripheral blood are associated with 8q24 cancer susceptibility loci ... DNA methylation levels at chromosome 8q24 in peripheral blood are associated with 8q24 cancer susceptibility loci ...
  http://cancerpreventionresearch.aacrjournals.org/content/early/2014/10/14/1940-6207.CAPR-14-0132
*  A variational bayes beta mixture model for feature selection in DNA methylation studies
... to feature selection of DNA methylation profiles should thus be of value to any study undergoing large-scale DNA methylation ... A variational bayes beta mixture model for feature selection in DNA methylation studies. Ma, Zhanyu KTH, School of Electrical ... An increasing number of studies are using beadarrays to measure DNA methylation on a genome-wide basis. The purpose is to ... Feature selection, beta mixture, DNA methylation, variational Bayes National Category Bioinformatics and Systems Biology Signal ...
  http://kth.diva-portal.org/smash/record.jsf?pid=diva2:616502
*  Pharmaceuticals | Free Full-Text | DNA Methylation as Clinically Useful Biomarkers-Light at the End of the Tunnel
... concentrate on the current advances in DNA methylation studies that demonstrate a direct link between abnormal DNA methylation ... It also appears that disease-specific DNA methylation patterns undergo unique changes in response to treatment with a ... In this regard cell-free circulating DNA from blood is especially interesting because it carries methylation markers specific ... Although only a few DNA methylation-based biomarkers have attained clinical relevance, the ongoing efforts to decipher disease- ...
  http://www.mdpi.com/1424-8247/5/1/94
*  Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation | Biology Open
We induced DNA methylation at up to 50% of alleles for targeted CpG dinucleotides. DNA methylation levels peaked within 50 bp ... Targeted DNA methylation approaches have been attempted by fusing DNA methyltransferase enzymes (DNMTs) to DNA-binding proteins ... Induced methylation decreases ARF expression. (A) Locations of the three sgRNA used to induce DNA methylation at the ARF ... While methylation of the entire CGI at the CDKN2A promoter repressed gene expression, inducing DNA methylation of a region 100- ...
  http://bio.biologists.org/content/5/6/866?utm_source=Sub&utm_medium=BiO_DMM&utm_campaign=BiOHomeBox&utm_content=5-866
*  Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes | Epigenetics &...
Dynamics of DNA methylation in mouse, bovine and rabbit zygotes. To compare the developmental dynamics of DNA methylation in ... DNA methylation of sperm and oocyte-derived chromosomes is largely erased. While Southern blot studies of DNA methylation in ... In our studies we therefore analyzed the dynamics of H3K9me2 and H3K4me3 methylation along with DNA methylation alterations in ... Represents a significant loss of DNA methylation in the NT embryo, (C, n = 2) represents a lesser extent of DNA demethylation ...
  https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/1756-8935-1-8
*  DNA Methylation and its Significance in Cancer - QIAGEN
Quantifying DNA methylation is simplified with QIAGEN's predesigned PyroMark CpG Assays, which can be used to validate results ... br /> ,br /> Many studies have shown that tumor emergence and growth are associated with changes in DNA methylation patterns, ... br /> ,br /> For high-throughput discovery of variations in DNA methylation, hybridization arrays are employed. However, the ... using DNA methylation patterns to detect cancer at very early stages, to classify tumors, and to predict and monitor response ...
  https://www.qiagen.com/ar/resources/knowledge-area/cancer-unraveling-the-complexity/dna-methylation-analysis/
*  Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer | Science Translational Medicine
We surveyed the landscape of DNA methylation alterations in gastric cancer by analyzing genome-wide CG dinucleotide (CpG) ... Whereas most methylation-expression correlations were negative, several positively correlated methylation-expression ... Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer Message Subject. (Your Name) has forwarded a page ... Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer. By Hermioni Zouridis, Niantao Deng, Tatiana ...
  http://stm.sciencemag.org/content/4/156/156ra140
*  Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene | Cancer Research
... which is highly reproducible and accurate at measuring small changes in DNA methylation. DNA methylation analysis was repeated ... We used DNA methylation analyses of LINE-1 and AluI repeated sequences to evaluate global methylation. Due to the heavy ... Bisulfite-treated DNA was stored at −20°C until use.. PCR and Pyrosequencing. DNA methylation was quantitated using bisulfite- ... DNA methylation and airborne benzene exposure. LINE-1 and AluI methylation decreased with increasing airborne benzene exposure ...
  http://cancerres.aacrjournals.org/content/67/3/876
*  Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its...
Lung tumor DNA and corresponding blood DNA were evaluated for LINE-1 methylation (surrogate for global methylation levels). The ... Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its ... Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its ... Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its ...
  http://cancerres.aacrjournals.org/content/69/1/243.full
*  DNA methylation sites
... Brian H. Taylor BRIAN at BIO.TAMU.EDU Mon May 10 20:54:06 EST 1993 *Previous message: Poplar Molecular ... I'm wondering if anyone has ever ruled out cytosine methylation at GC dinucleotides (as opposed to CG and CXG) or, for that ... Appropriate controls indicate that I don't have a problem with dirty DNA or bad enzyme or any of the usual trivial explanations ... 292, 860-862), where nearest neighbor analysis was used to show a high level of methylation at CG and CXG. One nonsymmetrical ...
  http://www.bio.net/bionet/mm/plantbio/1993-May/001214.html
*  DNA Methylation in the Human Genome
... ... DNA methylation regulates the expression of genes that guide development and define cell types. In mammals, 70 to 80 percent of ... The DNA methylation signatures, called differentially methylated regions, that the researchers identified can be used to guide ... Charting a dynamic DNA methylation landscape of the human genome. Nature 500(7463):477-481. ...
  https://www.niehs.nih.gov/research/supported/sep/2013/methylation_genome/index.cfm
*  DNA Methylation Research Trends
DNA methylation is probably universal in eukaryotes. In humans, approximately 1% of DNA bases undergo DNA methylation. In adult ... DNA methylation is a type of chemical modification of DNA that can be inherited without changing the DNA sequence. As such, it ... DNA methylation involves the addition of a methyl group to DNA for example, to the number 5 carbon of the cytosine pyrimidine ... DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.In ...
  https://www.novapublishers.com/catalog/product_info.php?products_id=5718
*  DNA methylation and gene expression. - PubMed - NCBI
DNA methylation and gene expression.. Razin A1, Cedar H.. Author information. 1. Department of Cellular Biochemistry, Hebrew ... Although methylation patterns are very stable in somatic cells, the early embryo is characterized by large alterations in DNA ... A large body of evidence demonstrates that DNA methylation plays a role in gene regulation in animal cells. Not only is there a ... Methylation appears to influence gene expression by affecting the interactions with DNA of both chromatin proteins and specific ...
  https://www.ncbi.nlm.nih.gov/pubmed/1943996
*  DNA Methylation Analysis - QIAGEN
Pyrosequencing provides accurate and detailed profiles of DNA methylation patterns underlying cell cycle regulation, ... Now, the recently launched PyroMark Q24 Advanced system makes it easy to quantify methylation at non-CpG (CpN) sites commonly ... To characterize the methylation status of a DNA sequence via Pyrosequencing, the DNA is first incubated with sodium bisulfite. ... Pyrosequencing facilitates accurate DNA methylation analysis by: *Quantifying methylation in explicit sequence context ...
  https://www.qiagen.com/fi/resources/technologies/pyrosequencing-resource-center/pyrosequencing-applications/dna-methylation-analysis/
*  Influence of DNA methylation on transgene expression | SpringerLink
But DNA methylation of transgene usually leads to target gene silencing in plant genetic engineering. In this research,... ... DNA methylation plays an important role in gene expression in eukaryote. ... DNA methylation plays an important role in gene expression in eukaryote. But DNA methylation of transgene usually leads to ... and DNA methylation of promoter region was found. The results indicated that gene silencing might be caused by DNA methylation ...
  https://link.springer.com/article/10.1007/BF03184330
*  Magazine Articles - DNA methylation | The Scientist Magazine®
Plants grown in dry soil produce offspring that are hardier in drought conditions, and DNA methylation appears responsible. ... A long noncoding RNA associated with DNA methylation has the power to regulate colon cancer growth in vitro. ... After initially discovering that DNA methylation represses transcription, Howard Cedar continues to explore how the epigenetic ... The Role of DNA Base Modifications. By Skirmantas Kriaucionis , September 1, 2017 ...
  https://www.the-scientist.com/?articles.list/categoryNo/2902/category/Magazine/tagNo/130/tags/DNA-methylation/
*  DNA Methylation Pattern as Important Epigenetic Criterion in Cancer
... Mehrdad Ghavifekr Fakhr, Majid Farshdousti Hagh, Dariush ... Epigenetic modifications can affect the long-term gene expression without any change in nucleotide sequence of the DNA. ...
  https://www.hindawi.com/journals/gri/2013/317569/abs/
*  Methblast - DNA Methylation and Epigenetics
Top : New Forum Archives (2009-): : DNA Methylation and Epigenetics. Methblast - (Jan/09/2013 ). Hi, Does anyone here used the ...
  http://www.protocol-online.org/biology-forums-2/posts/28101.html
*  DNA methylation may be associated with health inequalities | The BMJ
Most DNA methylation is fixed for life from just a few weeks after conception. Lower levels of methylation have been linked to ... DNA methylation may be associated with health inequalities BMJ 2012; 344 :e722 ... The research focused on DNA methylation, the signalling tool that cells use to control gene expression and that is a crucial ... DNA methylation may be associated with health inequalities. BMJ 2012; 344 doi: https://doi.org/10.1136/bmj.e722 (Published 31 ...
  http://www.bmj.com/content/344/bmj.e722
*  Smoking During Pregnancy Significantly Affects DNA Methylation, Gene Expression - Redorbit
This kind of altered methylation or chemical add-on in as few as six sites in the landscape of methylated genes and DNA can be ... Methylation is a chemical change to DNA that can affect the ways genes are expressed and regulated.) ... In a study that correlated changes in DNA methylation (a chemical change that affects the level of gene expression) to changes ... "Just as we expected from our previous studies in one gene, this dysregulation between DNA methylation and gene expression when ...
  http://www.redorbit.com/news/health/1112427756/smoking-during-pregnancy-significantly-affects-dna-methylation-gene-expression/