*  gyrA - DNA gyrase subunit A - Staphylococcus aureus (strain USA300) - gyrA gene & protein
DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling ... Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. ... favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation ... DNA gyrase subunit AUniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ...
  http://www.uniprot.org/uniprot/Q2FKQ0
*  sbmC - DNA gyrase inhibitor - Escherichia coli (strain K12) - sbmC gene & protein
Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells ... Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in ... against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double- ... Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells ...
  http://www.uniprot.org/uniprot/P33012
*  gyrB - DNA gyrase subunit B - Mycobacterium smegmatis - gyrB gene & protein
DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, also catalyzes the ... Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed:12000834). ... Supercoils relaxed DNA in an ATP-dependent manner (PubMed:8574396). A type II topoisomerase that negatively supercoils closed ... interconversion of other topological isomers of double-stranded DNA rings, including catenanes (PubMed:12000834). At comparable ...
  http://www.uniprot.org/uniprot/P0C559
*  Energy-saving bacteria resist antibiotics
The researchers found that when MurI binds to DNA gyrase, it takes gyrase away from substrate DNA. Because of this, antibiotics ... Anthrax »DNA »DNA gyrase »E. coli »Energy-saving »Glutamate racemase »MRSA »Meningitis »MurI »Nagaraja »antibiotics »bacteria » ... Further reports about: , Anthrax , DNA , DNA gyrase , E. coli , Energy-saving , Glutamate racemase , MRSA , Meningitis , MurI ... DNA gyrase is involved in DNA replication, which happens when bacteria reproduce. A family of antibiotics called ...
  http://www.innovations-report.com/html/reports/life-sciences/energy-saving-bacteria-resist-antibiotics-117321.html
*  Study of Mutations in the DNA gyrase gyrA Gene of Escherichia coli
In E. coli the major target for quinolones is DNA gyrase. This enzyme is composed of two subunits, GyrA and GyrB encoding by ... these sites are also essential for DNA gyrase activity. ... the major target for quinolones is DNA gyrase (2, 5, 6). DNA ... coli is DNA gyrase. Mutations in both gyrA and gyrB encoding subunits of DNA gyrase lead to resistance to these agents. The ... Quinolones bind to gyrase-DNA complex, called cleavable complex due to the presence of DSB, and form gyrase-quinolone-DNA ...
  http://ijpr.sbmu.ac.ir/article_834.html
*  All Faculty and Research Staff Publications | UW-Madison Department of Chemistry
... and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase. Med. Chem. Commun. 2017 ;8:942-951.*DOI ...
  http://www.chem.wisc.edu/publications?page=4&f%5Bauthor%5D=21615
*  What is DNA gyrase? | Reference.com
... closed-circular DNA, according to the Critical Review of Biochemical and Molecular Biology.... ... DNA gyrase is a bacterial enzyme that catalyzes the ATP-dependent negative supercoiling of double-stranded, ... Where can DNA be found?. A: The majority of DNA is located in the cell nucleus, where it is called nuclear DNA. A small amount ... Why do we need DNA?. A: Without DNA, life would not be able to perpetuate itself. DNA is needed as it is the blueprint of life ...
  https://www.reference.com/science/dna-gyrase-1841d721a5cc5aa5
*  Microbiology Society Journals | Occurrence of qnrB1 and qnrB12 genes, mutation in gyrA and ramR, and expression of efflux pumps...
For the DNA sequencing, six isolates (K3-A2, K12-A2, K25-A2, K27-A2, K19-A2 and K3-C2) were selected and the qnrB1 and qnrB12 ... gyrB and parC were performed by PCR followed by DNA sequencing. Results. Among the isolates analysed, 73.3 % (n=22) presented ... 3. Nam YS, Cho SY, Yang HY, Park KS, Jang JH et al. Investigation of mutation distribution in DNA gyrase and topoisomerase IV ... 37. Zhang Z, Meng X, Wang Y, Xia X, Wang X et al. Presence of qnr, aac(6′)-Ib, qepA, oqxAB, and mutations in gyrase and ...
  http://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000452
*  British Library EThOS: Molecular interactions between DNA gyrase and the quinolone antibacterials
Following on from the finding that the complex of quinolone and gyrase on DNA results in truncated mRNAs in vitro, the results ... DNA gyrase is an essential bacterial topoisomerase with a central role in many cellular processes. Its lack of homology to ... The quinolone antibacterials have previously been shown to "poison" DNA gyrase of Escherichia coli, resulting in rapid ... This process appears similar to the degradation of chromosomal DNA that occurs during apoptosis of some eukaryotic cells. The ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642096
*  Difference between revisions of "BISC209: Lab5" - OpenWetWare
But the presence of your 16S rRNA gene insert has disrupted the ccdB gene and turned off the protein that inhibits DNA gyrase, ... But the presence of your 16S rRNA gene insert has disrupted the ccdB gene and turned off the protein that inhibits DNA gyrase, ... But the presence of your 16S rRNA gene insert has disrupted the ccdB gene and turned off the protein that inhibits DNA gyrase, ... LAB 5: Getting the 16S rRNA genes from the Soil Genomic DNA in the E. coli clones ready to send away for DNA sequencing. ...
  https://openwetware.org/wiki/?title=BISC209:_Lab5&diff=398273&oldid=394721
*  Escherichia coli DNA Gyrase | SpringerLink
The role of DNA gyrase -a type II topoisomerase- had been speculated about for a long time before the discovery of the enzyme. ... Orr E., Lother H., Lurz R., Wahle E. (1984) Escherichia coli DNA Gyrase. In: Proteins Involved in DNA Replication. Advances in ... all dependent on the DNA template. DNA gyrase has now become a most promiscuous protein, participating in different molecular ... The role of DNA gyrase -a type II topoisomerase- had been speculated about for a long time before the discovery of the enzyme. ...
  https://link.springer.com/chapter/10.1007/978-1-4684-8730-5_41
*  RCSB PDB - Protein Feature View - DNA gyrase subunit A - Q8DPM2 (GYRA STRR6)
DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling ... In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB ... Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. UniProt ... favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation ...
  http://www.rcsb.org/pdb/protein/Q8DPM2
*  DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences. - PubMed - NCBI
We have identified DNA gyrase [DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3] as one of the REP-binding proteins. Gyrase has ... DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences.. Yang Y1, Ames GF. ... DNase I footprinting shows that gyrase protects 205 base pairs on a REP-containing DNA fragment enclosing the REP sequences. In ... Binding effectiveness correlates directly with the number of REP sequences in the DNA. ...
  https://www.ncbi.nlm.nih.gov/pubmed/2848243
*  DNA gyrase - Wikipedia
Upon binding to DNA (the "Gyrase-DNA" state), there is a competition between DNA wrapping and dissociation, where increasing ... whose single circular DNA is cut by DNA gyrase and the two ends are then twisted around each other to form supercoils. Gyrase ... "The Intrinsic ATPase of DNA Gyrase". Journal of Biological Chemistry. 255 (13). Reece, Richard (1991). "DNA Gyrase: Structure ... DNA gyrase, or simply gyrase, is an enzyme within the class of topoisomerase (Type II topoisomerase) that relieves strain while ...
  https://en.wikipedia.org/wiki/DNA_gyrase
*  Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase - MedChemComm (RSC...
Bacterial DNA gyrase is an essential type II topoisomerase that enables cells to overcome topological barriers encountered ... In vitro studies demonstrate that the new analogs are potent inhibitors of the DNA supercoiling activity of DNA gyrase (IC50s ... Bacterial DNA gyrase is an essential type II topoisomerase that enables cells to overcome topological barriers encountered ... Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase K. A. Hurley, T. M ...
  http://pubs.rsc.org/en/content/articlelanding/2017/md/c7md00012j
*  RCSB PDB - 1VL4: CRYSTAL STRUCTURE OF A PUTATIVE MODULATOR OF A DNA GYRASE (TM0727) FROM THERMOTOGA MARITIMA MSB8 AT...
Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold ... CRYSTAL STRUCTURE OF A PUTATIVE MODULATOR OF A DNA GYRASE (TM0727) FROM THERMOTOGA MARITIMA MSB8 AT 1.95 A RESOLUTION. *DOI: ...
  http://www.rcsb.org/pdb/explore/explore.do?structureId=1VL4
*  RCSB PDB - 4GGL: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and...
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual ... Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual ... Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and ... The bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) are essential enzymes that control the topological ...
  https://www.rcsb.org/structure/4GGL
*  3D View - 4GEE: Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery...
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and ... Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual ...
  http://www.rcsb.org/pdb/explore/jmol.do?structureId=4GEE&bionumber=1
*  RCSB PDB - 4HYM: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided...
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and ... Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual ...
  http://www.rcsb.org/pdb/explore/explore.do?structureId=4HYM
*  Buy Ofloxacin Tablets | Wholesaler, Supplier, Distributors, Exporters At Tissuepharma.com
Bactericidal - Inhibits the super coiling activity of bacterial DNA gyrase, halting DNA replication. ... Moxifloxacin Tablets works by inhibiting enzymes involved in DNA processes. Detailed information related to Moxifloxacin ...
  http://tissuepharma.com/product/ofloxacin-tablets-2/
*  Reuter VC Strain Passport - StrainInfo
Lactobacillus gasseri strain LMG 18176 DNA gyrase subunit A (gyrA) gene, partial cds. LMG 18176 ... Lactobacillus gasseri strain LMG 18176 DNA gyrase subunit B (gyrB) gene, partial cds. LMG 18176 ...
  http://www.straininfo.net/strains/44089
*  Systemic Inflammatory Response Syndrome
Clinical Context: Levofloxacin, a second-generation quinolone, acts by interfering with deoxyribonucleic acid (DNA) gyrase in ...
  http://misc.medscape.com/pi/android/medscapeapp/html/A168943-business.html
*  protein - Everything2.com
DNA polymerase (n). *DNA glycosylase. *DNA gyrase. *DNA helicase. *integrase. *klenow fragment ...
  https://everything2.com/title/PROTEIN