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*  Alterations in the DNA topoisomerase IV grlA gene responsible...
A 4.2-kb DNA fragment conferring quinolone res ... Alterations in the DNA topoisomerase IV grlA gene responsible ... These results suggest that both DNA gyrase and DNA topoisomerase IV may be targets of quinolones and that the quinolone ... Alterations in the DNA topoisomerase IV grlA gene responsible for quinolone resistance in Staphylococcus aureus.. Authors * J ... A 4.2-kb DNA fragment conferring quinolone resistance was cloned from a quinolone-resistant clinical isolate of Staphylococcus ...
  https://www.mysciencework.com/publication/show/alterations-in-the-dna-topoisomerase-iv-grla-gene-responsible-for-quinolone-resistance-in-staphylococcus-aureus
*  OFLOXACIN TABLETS 200 mg, 300 mg, and 400 mg718071817182Rx only
... action of ofloxacin and other fluoroquinolone antimicrobials involves inhibition of bacterial topoisomerase IV and DNA gyrase ( ... unscheduled DNA Repair (UDS) using human fibroblasts, dominant lethal assays, or mouse micronucleus assay. Ofloxacin was ... both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination. ...
  https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=42896
*  Escherichia coli DNA Gyrase | SpringerLink
The role of DNA gyrase -a type II topoisomerase- had been speculated about for a long time before the discovery of the enzyme. ... Orr E., Lother H., Lurz R., Wahle E. (1984) Escherichia coli DNA Gyrase. In: Proteins Involved in DNA Replication. Advances in ... all dependent on the DNA template. DNA gyrase has now become a most promiscuous protein, participating in different molecular ... The role of DNA gyrase -a type II topoisomerase- had been speculated about for a long time before the discovery of the enzyme. ...
  https://link.springer.com/chapter/10.1007/978-1-4684-8730-5_41
*  What is DNA gyrase? | Reference.com
... closed-circular DNA, according to the Critical Review of Biochemical and Molecular Biology.... ... DNA gyrase is a bacterial enzyme that catalyzes the ATP-dependent negative supercoiling of double-stranded, ... Where can DNA be found?. A: The majority of DNA is located in the cell nucleus, where it is called nuclear DNA. A small amount ... Why do we need DNA?. A: Without DNA, life would not be able to perpetuate itself. DNA is needed as it is the blueprint of life ...
  https://www.reference.com/science/dna-gyrase-1841d721a5cc5aa5
*  DNA gyrase legal definition of DNA gyrase
What is DNA gyrase? Meaning of DNA gyrase as a legal term. What does DNA gyrase mean in law? ... Definition of DNA gyrase in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... DNA gyrase legal definition of DNA gyrase https://legal-dictionary.thefreedictionary.com/DNA+gyrase ... dna. (redirected from DNA gyrase). Also found in: Dictionary, Thesaurus, Medical, Encyclopedia, Wikipedia.. Related to DNA ...
  http://legal-dictionary.thefreedictionary.com/DNA+gyrase
*  DNA gyrase | definition of DNA gyrase by Medical dictionary
DNA gyrase explanation free. What is DNA gyrase? Meaning of DNA gyrase medical term. What does DNA gyrase mean? ... Looking for online definition of DNA gyrase in the Medical Dictionary? ... Related to DNA gyrase: Topoisomerase, Quinolones. DNA gyrase. (ji´rās) a type II DNA topoisomerase.. DNA gyrase. an enzyme that ... DNA gyrase , definition of DNA gyrase by Medical dictionary https://medical-dictionary.thefreedictionary.com/DNA+gyrase ...
  http://medical-dictionary.thefreedictionary.com/DNA+gyrase
*  gyrB - DNA gyrase subunit B - Mycobacterium smegmatis - gyrB gene & protein
DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, also catalyzes the ... Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed:12000834). ... Supercoils relaxed DNA in an ATP-dependent manner (PubMed:8574396). A type II topoisomerase that negatively supercoils closed ... interconversion of other topological isomers of double-stranded DNA rings, including catenanes (PubMed:12000834). At comparable ...
  http://www.uniprot.org/uniprot/P0C559
*  RCSB PDB - Protein Feature View - DNA gyrase subunit A - Q8DPM2 (GYRA STRR6)
DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling ... In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB ... Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. UniProt ... favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation ...
  http://www.rcsb.org/pdb/protein/Q8DPM2
*  sbmC - DNA gyrase inhibitor - Escherichia coli (strain K12) - sbmC gene & protein
Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells ... Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in ... against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double- ... Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells ...
  http://www.uniprot.org/uniprot/P33012
*  gyrA - DNA gyrase subunit A - Staphylococcus aureus (strain USA300) - gyrA gene & protein
DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling ... Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. ... favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation ... DNA gyrase subunit AUniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ...
  http://www.uniprot.org/uniprot/Q2FKQ0
*  British Library EThOS: Molecular interactions between DNA gyrase and the quinolone antibacterials
Following on from the finding that the complex of quinolone and gyrase on DNA results in truncated mRNAs in vitro, the results ... DNA gyrase is an essential bacterial topoisomerase with a central role in many cellular processes. Its lack of homology to ... The quinolone antibacterials have previously been shown to "poison" DNA gyrase of Escherichia coli, resulting in rapid ... This process appears similar to the degradation of chromosomal DNA that occurs during apoptosis of some eukaryotic cells. The ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642096
*  DNA gyrase - Wikipedia
Upon binding to DNA (the "Gyrase-DNA" state), there is a competition between DNA wrapping and dissociation, where increasing ... whose single circular DNA is cut by DNA gyrase and the two ends are then twisted around each other to form supercoils. Gyrase ... "The Intrinsic ATPase of DNA Gyrase". Journal of Biological Chemistry. 255 (13). Reece, Richard (1991). "DNA Gyrase: Structure ... DNA gyrase, or simply gyrase, is an enzyme within the class of topoisomerase (Type II topoisomerase) that relieves strain while ...
  https://en.wikipedia.org/wiki/DNA_gyrase
*  DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences. - PubMed - NCBI
We have identified DNA gyrase [DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3] as one of the REP-binding proteins. Gyrase has ... DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences.. Yang Y1, Ames GF. ... DNase I footprinting shows that gyrase protects 205 base pairs on a REP-containing DNA fragment enclosing the REP sequences. In ... Binding effectiveness correlates directly with the number of REP sequences in the DNA. ...
  https://www.ncbi.nlm.nih.gov/pubmed/2848243
*  Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase - MedChemComm (RSC...
Bacterial DNA gyrase is an essential type II topoisomerase that enables cells to overcome topological barriers encountered ... In vitro studies demonstrate that the new analogs are potent inhibitors of the DNA supercoiling activity of DNA gyrase (IC50s ... Bacterial DNA gyrase is an essential type II topoisomerase that enables cells to overcome topological barriers encountered ... Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase K. A. Hurley, T. M ...
  http://pubs.rsc.org/en/content/articlelanding/2017/md/c7md00012j
*  Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes - MedChemComm (RSC...
DNA gyrase plays indispensable roles in DNA replication, and both its GyrA and GyrB subunits are clinically validated ... Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes X. Huang, J. Guo, Q. Liu ... Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes ... bind to this pocket were shown to inhibit the ATPase activity as well as the DNA topological transition activity of DNA gyrase ...
  https://pubs.rsc.org/en/content/articlelanding/2018/md/c8md00148k
*  RCSB PDB - 1VL4: CRYSTAL STRUCTURE OF A PUTATIVE MODULATOR OF A DNA GYRASE (TM0727) FROM THERMOTOGA MARITIMA MSB8 AT...
Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold ... CRYSTAL STRUCTURE OF A PUTATIVE MODULATOR OF A DNA GYRASE (TM0727) FROM THERMOTOGA MARITIMA MSB8 AT 1.95 A RESOLUTION. *DOI: ...
  http://www.rcsb.org/pdb/explore/explore.do?structureId=1VL4
*  RCSB PDB - 4GGL: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and...
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual ... Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual ... Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and ... The bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) are essential enzymes that control the topological ...
  https://www.rcsb.org/structure/4GGL
*  3D View - 4GEE: Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery...
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and ... Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual ...
  http://www.rcsb.org/pdb/explore/jmol.do?structureId=4GEE&bionumber=1
*  RCSB PDB - 4HYM: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided...
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and ... Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual ...
  http://www.rcsb.org/pdb/explore/explore.do?structureId=4HYM
*  Leicester Research Archive: DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs
DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs. ... We have analysed the DNA cleavage reaction of DNA gyrase using oligonucleotides annealed to a singlestranded M13 derivative ... is determined by drug-DNA interactions whereas with longer fragments the positioning effect of the DNA wrap around gyrase ... We find that gyrase can cleave duplexes down to ∼20 bp in size in the presence of the quinolone drugs ciprofloxacin and ...
  https://lra.le.ac.uk/handle/2381/31858
*  AID 1272956 - Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by...
Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by electrophoresis ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/1272956
*  The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action
The DNA topoisomerases are excellent targets for chemotherapy, and DNA gyrase in particular is a well-validated target for ... The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. Karkare, Shantanu; Chung, Terence ... The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. Login ... tuberculosis gyrase and other gyrases. Our evidence strongly suggests that the compounds bind to the N-terminal domain of GyrB ...
  https://repository.up.ac.za/handle/2263/21873
*  Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones. - Semantic Scholar
Instability of type II topoisomerase-DNA complexes may be a general phenomenon that can be exploited to kill cells. ... The ability of changes in both gyrase and quinolone structure to enhance protein synthesis-independent lethality and chromosome ... However, only fluoroquinolones fragmented purified nucleoids when incubated with gyrase purified from wild-type cells. A GyrA ... The GyrA variation also facilitated immunoprecipitation of DNA fragments by GyrA antiserum following nalidixic acid treatment ...
  https://www.semanticscholar.org/paper/Lethal-fragmentation-of-bacterial-chromosomes-medi-Malik-Zhao/b245a0da929623afee125fbcc27bb20c23a7b1e0
*  The DNA cleavage reaction of DNA gyrase. Comparison of stable...
The DNA cleavage reaction of DNA gyrase. Comparison of stable ternary complexes formed with enoxacin and CcdB protein.: The ... The DNA cleavage reaction of DNA gyrase. Comparison of stable ternary complexes formed with enoxacin and CcdB protein.. Authors ... CcdB binds gyrase-DNA complexes but does not influence enzymatic activity directly. 2) Complexes that produce DNA cleavage with ... the F plasmid both inhibit bacterial growth by attacking DNA gyrase and by stimulating enzyme-induced breaks in bacterial DNA. ...
  https://www.mysciencework.com/publication/show/dna-cleavage-reaction-dna-gyrase-comparison-stable-ternary-complexes-formed-enoxacin-ccdb-protein-ba76fcb1