*  gyrA - DNA gyrase subunit A - Staphylococcus aureus (strain USA300) - gyrA gene & protein
DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling ... Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. ... favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation ... DNA gyrase subunit AUniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ...
  http://www.uniprot.org/uniprot/Q2FKQ0
*  gyrB - DNA gyrase subunit B - Mycobacterium smegmatis - gyrB gene & protein
DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, also catalyzes the ... Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed:12000834). ... Supercoils relaxed DNA in an ATP-dependent manner (PubMed:8574396). A type II topoisomerase that negatively supercoils closed ... interconversion of other topological isomers of double-stranded DNA rings, including catenanes (PubMed:12000834). At comparable ...
  http://www.uniprot.org/uniprot/P0C559
*  Energy-saving bacteria resist antibiotics
The researchers found that when MurI binds to DNA gyrase, it takes gyrase away from substrate DNA. Because of this, antibiotics ... Anthrax »DNA »DNA gyrase »E. coli »Energy-saving »Glutamate racemase »MRSA »Meningitis »MurI »Nagaraja »antibiotics »bacteria » ... Further reports about: , Anthrax , DNA , DNA gyrase , E. coli , Energy-saving , Glutamate racemase , MRSA , Meningitis , MurI ... DNA gyrase is involved in DNA replication, which happens when bacteria reproduce. A family of antibiotics called ...
  http://www.innovations-report.com/html/reports/life-sciences/energy-saving-bacteria-resist-antibiotics-117321.html
*  Study of Mutations in the DNA gyrase gyrA Gene of Escherichia coli
In E. coli the major target for quinolones is DNA gyrase. This enzyme is composed of two subunits, GyrA and GyrB encoding by ... these sites are also essential for DNA gyrase activity. ... the major target for quinolones is DNA gyrase (2, 5, 6). DNA ... coli is DNA gyrase. Mutations in both gyrA and gyrB encoding subunits of DNA gyrase lead to resistance to these agents. The ... Quinolones bind to gyrase-DNA complex, called cleavable complex due to the presence of DSB, and form gyrase-quinolone-DNA ...
  http://ijpr.sbmu.ac.ir/article_834.html
*  What is DNA gyrase? | Reference.com
... closed-circular DNA, according to the Critical Review of Biochemical and Molecular Biology.... ... DNA gyrase is a bacterial enzyme that catalyzes the ATP-dependent negative supercoiling of double-stranded, ... Where can DNA be found?. A: The majority of DNA is located in the cell nucleus, where it is called nuclear DNA. A small amount ... Why do we need DNA?. A: Without DNA, life would not be able to perpetuate itself. DNA is needed as it is the blueprint of life ...
  https://www.reference.com/science/dna-gyrase-1841d721a5cc5aa5
*  Difference between revisions of "BISC209: Lab5" - OpenWetWare
But the presence of your 16S rRNA gene insert has disrupted the ccdB gene and turned off the protein that inhibits DNA gyrase, ... But the presence of your 16S rRNA gene insert has disrupted the ccdB gene and turned off the protein that inhibits DNA gyrase, ... But the presence of your 16S rRNA gene insert has disrupted the ccdB gene and turned off the protein that inhibits DNA gyrase, ... LAB 5: Getting the 16S rRNA genes from the Soil Genomic DNA in the E. coli clones ready to send away for DNA sequencing. ...
  https://openwetware.org/wiki/?title=BISC209:_Lab5&diff=398273&oldid=394721
*  sbmC - DNA gyrase inhibitor - Escherichia coli (strain K12) - sbmC gene & protein
Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells ... Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in ... against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double- ... Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells ...
  http://www.uniprot.org/uniprot/P33012
*  British Library EThOS: Molecular interactions between DNA gyrase and the quinolone antibacterials
Following on from the finding that the complex of quinolone and gyrase on DNA results in truncated mRNAs in vitro, the results ... DNA gyrase is an essential bacterial topoisomerase with a central role in many cellular processes. Its lack of homology to ... The quinolone antibacterials have previously been shown to "poison" DNA gyrase of Escherichia coli, resulting in rapid ... This process appears similar to the degradation of chromosomal DNA that occurs during apoptosis of some eukaryotic cells. The ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642096
*  DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences. - PubMed - NCBI
We have identified DNA gyrase [DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3] as one of the REP-binding proteins. Gyrase has ... DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences.. Yang Y1, Ames GF. ... DNase I footprinting shows that gyrase protects 205 base pairs on a REP-containing DNA fragment enclosing the REP sequences. In ... Binding effectiveness correlates directly with the number of REP sequences in the DNA. ...
  https://www.ncbi.nlm.nih.gov/pubmed/2848243
*  DNA gyrase - Wikipedia
Upon binding to DNA (the "Gyrase-DNA" state), there is a competition between DNA wrapping and dissociation, where increasing ... whose single circular DNA is cut by DNA gyrase and the two ends are then twisted around each other to form supercoils. Gyrase ... "The Intrinsic ATPase of DNA Gyrase". Journal of Biological Chemistry. 255 (13). Reece, Richard (1991). "DNA Gyrase: Structure ... DNA gyrase, or simply gyrase, is an enzyme within the class of topoisomerase (Type II topoisomerase) that relieves strain while ...
  https://en.wikipedia.org/wiki/DNA_gyrase
*  RCSB PDB - 1VL4: CRYSTAL STRUCTURE OF A PUTATIVE MODULATOR OF A DNA GYRASE (TM0727) FROM THERMOTOGA MARITIMA MSB8 AT...
Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold ... CRYSTAL STRUCTURE OF A PUTATIVE MODULATOR OF A DNA GYRASE (TM0727) FROM THERMOTOGA MARITIMA MSB8 AT 1.95 A RESOLUTION. *DOI: ...
  http://www.rcsb.org/pdb/explore/explore.do?structureId=1VL4
*  RCSB PDB - 4GGL: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and...
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual ... Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual ... Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and ... The bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) are essential enzymes that control the topological ...
  https://www.rcsb.org/structure/4GGL
*  RCSB PDB - 4HYM: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided...
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and ... Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual ...
  http://www.rcsb.org/pdb/explore/explore.do?structureId=4HYM
*  Leicester Research Archive: DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs
DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs. ... We have analysed the DNA cleavage reaction of DNA gyrase using oligonucleotides annealed to a singlestranded M13 derivative ... is determined by drug-DNA interactions whereas with longer fragments the positioning effect of the DNA wrap around gyrase ... We find that gyrase can cleave duplexes down to ∼20 bp in size in the presence of the quinolone drugs ciprofloxacin and ...
  https://lra.le.ac.uk/handle/2381/31858
*  Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones. - Semantic Scholar
Instability of type II topoisomerase-DNA complexes may be a general phenomenon that can be exploited to kill cells. ... The ability of changes in both gyrase and quinolone structure to enhance protein synthesis-independent lethality and chromosome ... However, only fluoroquinolones fragmented purified nucleoids when incubated with gyrase purified from wild-type cells. A GyrA ... The GyrA variation also facilitated immunoprecipitation of DNA fragments by GyrA antiserum following nalidixic acid treatment ...
  https://www.semanticscholar.org/paper/Lethal-fragmentation-of-bacterial-chromosomes-medi-Malik-Zhao/b245a0da929623afee125fbcc27bb20c23a7b1e0
*  Ciprofloxacin, DNA Gyrase Inhibitor, Topo IV Poison
Ciprofloxacin Control Poison Inhibitor of DNA Gyrase and Topo IV Available from TopoGEN ... A control poison/inhibitor of DNA Gyrase and Topo IV. This is also included in the Topo IV/Gyrase Drug Screening Kits. ... This short video describes our new Cell Based Screening Systems for DNA Repair. Mouse and human cell line kits are available, ... This short video describes our new Cell Based Screening Systems for DNA Repair. Mouse and human cell line kits are available, ...
  https://www.topogen.com/inhibitors-and-poisons/inhibitors-and-poisons/ciprofloxacin.html
*  Marbofloxacin | CAS#115550-35-1 | bacterial DNA gyrase inhibitor | bacterial growth suppressor | MedKoo
Marbofloxacin is a bacterial DNA gyrase inhibitor. It suppresses growth of Staphylococus, Escherichia, Actinobacillus, ... Description: Marbofloxacin is a bacterial DNA gyrase inhibitor. It suppresses growth of Staphylococus, Escherichia, ...
  https://www.medkoo.com/products/15532
*  DNA reverse gyrase: Definition with DNA reverse gyrase Pictures and Photos
Definition of DNA reverse gyrase with photos and pictures, translations, sample usage, and additional links for more ... DNA primase. DNA primers. DNA probe. DNA probes. DNA profiling. DNA puff. DNA rearrangement. DNA renaturation. DNA repair. DNA ... DNA sequences. DNA sequencing. DNA shearing. DNA snippet. DNA snippets. DNA supercoiling. DNA synaptase. DNA synthesis. DNA ... DNA replication. DNA restriction-modification enzymes. DNA restriction enzymes. DNA reverse gyrase (current term). DNA sequence ...
  http://lexic.us/definition-of/DNA_reverse_gyrase
*  Overview of Quinolones (Example) - MindMeister
2.1.1. inhibit DNA gyrase. 2.2. Gm +ve. 2.2.1. inhibit topoisomerase IV. 3. Pharmacokinetics. 3.1. Long half-life of new ...
  https://www.mindmeister.com/164425379/overview-of-quinolones
*  The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.
DNA topoisomerases. Annu Rev Biochem. 1985;54:665-697. [PubMed]. *Wang JC. DNA topoisomerases: why so many? J Biol Chem. 1991 ... The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.. S ... Brill SJ, DiNardo S, Voelkel-Meiman K, Sternglanz R. Need for DNA topoisomerase activity as a swivel for DNA replication for ... Brill SJ, Sternglanz R. Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants. Cell. 1988 Jul 29;54(3): ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC359378/
*  Buy Ofloxacin Tablets | Wholesaler, Supplier, Distributors, Exporters At Tissuepharma.com
Bactericidal - Inhibits the super coiling activity of bacterial DNA gyrase, halting DNA replication. ... Moxifloxacin Tablets works by inhibiting enzymes involved in DNA processes. Detailed information related to Moxifloxacin ...
  http://tissuepharma.com/product/ofloxacin-tablets-2/
*  Reuter VC Strain Passport - StrainInfo
Lactobacillus gasseri strain LMG 18176 DNA gyrase subunit A (gyrA) gene, partial cds. LMG 18176 ... Lactobacillus gasseri strain LMG 18176 DNA gyrase subunit B (gyrB) gene, partial cds. LMG 18176 ...
  http://www.straininfo.net/strains/44089
*  R-8764 Strain Passport - StrainInfo
Streptomyces caeruleus DNA gyrase subunit B (gyrB-Rn) gene, complete cds. NCIB 11891 T ... S.sphaeroides genes for gyrase A and gyrase B (novobiocin-sensitive). NCIB 11891 T ...
  http://www.straininfo.net/strains/75970