*  E2F and p53 Induce Apoptosis Independently during Drosophila Development but Intersect in the Context of DNA Damage
However, dE2F and dp53 converge in the context of a DNA damage response. Both dE2F1/dDP and dp53 are required for DNA damage- ... This sensitivity differs from DNA damage-induced apoptosis in wild-type discs (and from dE2F/dDP-induced apoptosis in un- ... dp53 is required for dE2F-dependent apoptosis in the response to DNA damage, but it is not required for dE2F-dependent ... DNA damage Is the Subject Area "DNA damage" applicable to this article? Yes. No. ...
  http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000153
*  Biomolecules | Free Full-Text | Targeting the Checkpoint to Kill Cancer Cells
Upon DNA damage, cells stop proliferation at cell cycle checkpoints, which provides them time for DNA repair. Inhibiting the ... Importantly, as cancer cells exhibit increased levels of endogenous DNA damage due to an excessive replication stress, ... checkpoint allows entry to mitosis despite the presence of DNA damage and can lead to cell death. ... Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging DNA of cancer cells. ...
  http://www.mdpi.com/2218-273X/5/3/1912
*  Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor
Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour ... Conclusions/Significance Taken together, our results uncover a negative role for Dot1L and H3K79 methylation in the DNA damage ... 2011) Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour ... we generated cells in which the Dot1L gene is disrupted to examine the function and focal recruitment of the 53Bp1 DNA damage ...
  https://aran.library.nuigalway.ie/handle/10379/1936
*  HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation ...
The increased levels of DNA damage sensitised Huwe1‐deficient tumours to DNAdamaging agents and to deletion of the anti‐ ... Importantly, this increased DNA damage phenotype sensitises Huwe1‐deficient tumours to treatment with DNAdamaging agents and ... alongside mediating DNA damage response, a recent paper has identified a mechanism via which Huwe1 loss can drive DNA damage ... DNA damage accumulates and, similar to our own findings, cells show increased sensitivity to DNAdamaging agents. This is in ...
  http://d3gz45kfcn01zz.cloudfront.net/content/9/2/181
*  Biomolecules | Free Full-Text | The RNA Splicing Response to DNA Damage
Although descriptions of molecular mechanisms remain limited, an emerging trend is that DNA damage disrupts the coupling of ... sites of DNA damage. The first steps of the DDR promote the post-translational modification of splicing factors to affect their ... The number of factors known to participate in the DNA damage response (DDR) has expanded considerably in recent years to ... constitutive and alternative splicing with the transcription of genes involved in DNA repair, cell-cycle control and apoptosis ...
  http://www.mdpi.com/2218-273X/5/4/2935
*  Oxidative DNA base damage and its repair in kidneys and livers of nickel(II)-treated male F344 rats. : Carcinogenesis - oi
The results reveal a tissue specific response to Ni(II)-mediated oxidative DNA base damage with apparently faster DNA repair in ... Ten different damaged bases were quantified. No damage was found in either organ 12 h after Ni(II) treatment. The damage became ... Ten different damaged bases were quantified. No damage was found in either organ 12 h after Ni(II) treatment. The damage became ... DNA base damage was assayed using gas chromatography/ mass spectrometry with selected ion monitoring (GC/MS-SIM) in renal and ...
  http://oxfordindex.oup.com/view/10.1093/carcin/18.2.271
*  Elledge Lab
An elaborate DNA damage response (DDR) pathway exists in the cell to ameliorate the effects of DNA damage by promoting DNA ... DNA damage and replication stress. In nearly all tumor cell types, the rate of spontaneous DNA damage and the degree of ... The presence of oncogenes can also elicit substantial DNA damage (Halazonetis et al., 2008). DNA damage stress can be exploited ... DNA damage and DNA replication stress. Based on karyotypic and mutational analyses, it is clear that tumors, especially solid ...
  http://elledgelab.med.harvard.edu/?page_id=305
*  Replication protein A 32 kDa subunit
In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through ... Termination of translesion DNA synthesis 31 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template ... Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. ... Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required ...
  https://pharos.nih.gov/idg/targets/P15927
*  The E3 Ubiquitin Ligase EDD Regulates S-Phase and G(2)/M DNA Damage Checkpoints | Garvan Institute of Medical Research
S and intra S phase DNA damage checkpoint activation and for the maintenance of G(2)/M arrest after double strand DNA breaks. ... S and intra S phase DNA damage checkpoint activation and for the maintenance of G(2)/M arrest after double strand DNA breaks. ... ligase EDD have been observed in a number of carcinomas and we recently reported that EDD modulates activity of the DNA damage ... ligase EDD have been observed in a number of carcinomas and we recently reported that EDD modulates activity of the DNA damage ...
  https://www.garvan.org.au/research/publications/2251
*  Plus it
To investigate this in more detail, we compared the DNA damage response in nontumor forming neural progenitor cells (NPC) and ... Recent evidence suggests that glioma-initiating cells play a central role in radioresistance through DNA damage checkpoint ... cell-cycle defects in the G1-S and S-phase checkpoints were observed by determining entry into S-phase and radioresistant DNA ...
  http://mct.aacrjournals.org/content/early/2012/08/27/1535-7163.MCT-11-1044
*  The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development...
Cells of metazoan organisms respond to DNA damage by arresting their cell cycle to repair DNA, or they undergo apoptosis. Two ... Animals, Apoptosis, Ataxia Telangiectasia Mutated Proteins, Blotting, Northern, Cell Cycle Proteins, DNA Damage, DNA-Binding ... The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development ... mediates the response to ionizing radiation and to spontaneous DNA damage during development. Curr Biol, 14 (15). pp. 1354-1359 ...
  http://epubs.surrey.ac.uk/828295/
*  DNA Damage & Repair - QIAGEN
DNA Damage Signaling Pathway RT2 Profiler PCR Array The Rat DNA Damage Signaling RT² Profiler PCR Array profiles the expression ... DNA Damage Signaling Pathway RT2 Profiler PCR Array The Human DNA Damage Signaling RT² Profiler PCR Array profiles the ... DNA Damage Signaling Pathway RT2 Profiler PCR Array The Mouse DNA Damage Signaling RT² Profiler PCR Array profiles the ... DNA Damage Signaling Pathway EpiTect ChIP qPCR Array The Human DNA Damage Signaling Pathway EpiTect ChIP qPCR Array profiles ...
  https://www.qiagen.com/au/shop/genes-and-pathways/complete-biology-list/dna-damage-and-repair/
*  Nutrients that Prevent DNA Damage and Promote Their Repair In Order to Protect Against Disease - BioFoundations
These remaining DNA damages accumulate in the tissues.. There are a number of sources that contribute to DNA damage. DNA damage ... Most of these damages to DNA from naturally occurring metabolism are repaired. However, there may remain some DNA damage ... DNA damage occurs when there is an alteration in the chemical structure of DNA through: ... Mismatch of bases, due to errors in DNA replication, in which the wrong DNA base is stitched into place in a newly forming DNA ...
  https://biofoundations.org/nutrients-that-prevent-dna-damage-and-promote-their-repair-in-order-to-protect-against-disease/
*  British Library EThOS: Analysis of the relationship between pluripotency and DNA damage tolerance recombination in mammalian...
One of the most threatening DNA lesions to the cell is DNA doublestrand break {DSB}. The repair of these DNA lesions in mouse ... Accumulation of DNA damage at this stage of development would affect multiple / all lineages of the embryo which may poses ... The repair of DNA DSBs or stalled DNA replication fork is often mediated by the formation of Holliday junctions {HJs}. The ... Analysis of the relationship between pluripotency and DNA damage tolerance recombination in mammalian stem cells ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612608
*  DNA damage | Open Library
DNA damage, DNA repair, DNA Repair, Congresses, DNA Damage ... DNA damage by Biochemical Society (Great Britain). Symposium; 1 ... DNA damage from causes to cures organised and edited by Richard P. Bowater, Rhonda H. Borts and Malcolm F. White Published 2009 ... Based on papers presented at the 2008 Biochemical Society Annual Symposium entitled "DNA damage: from causes to cures", held at ... Citation ,publisher = Portland Press ,ol = 24382592M ,isbn = 9781855781733 ,publication-place = London ,title = DNA damage , ...
  https://openlibrary.org/works/OL15412262W/DNA_damage
*  DNA Damage and Carcinogenesis | SpringerLink
They indicate that damage to DNA can lead to cancer and hence one should be... ... Setlow R.B. (1981) DNA Damage and Carcinogenesis. In: Seeberg E., Kleppe K. (eds) Chromosome Damage and Repair. NATO Advanced ... They indicate that damage to DNA can lead to cancer and hence one should be concerned about environmental agents that react ... Nevertheless, there are arguments against this point of view (1) and, even if damage to DNA is the important element in cancer ...
  https://link.springer.com/chapter/10.1007/978-1-4684-7956-0_70
*  DNA Damage, Neurodegeneration, and Synaptic Plasticity
... Guest Editors: Daniela Merlo, Inmaculada C. Ibañez, Rosanna Parlato, ... DNA Damage, Neurodegeneration, and Synaptic Plasticity, Daniela Merlo, Inmaculada Cuchillo-Ibañez, Rosanna Parlato, and Gerhard ... The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease, Laura Narciso, Eleonora Parlanti, Mauro Racaniello, ...
  https://www.hindawi.com/journals/np/si/386321/
*  Signalling DNA Damage | IntechOpen
Signalling DNA Damage. By Andres Joaquin Lopez-Contreras and Oscar Fernandez-Capetillo ... Andres Joaquin Lopez-Contreras and Oscar Fernandez-Capetillo (September 6th 2012). Signalling DNA Damage, Protein ... Andres Joaquin Lopez-Contreras and Oscar Fernandez-Capetillo (September 6th 2012). Signalling DNA Damage, Protein ... www.intechopen.com/embed/protein-phosphorylation-in-human-health/signalling-dna-damage' /,. Embed this code snippet in the HTML ...
  https://www.intechopen.com/books/protein-phosphorylation-in-human-health/signalling-dna-damage/
*  DNA Damage & Repair - QIAGEN
DNA Damage Signaling Pathway RT2 Profiler PCR Array The Rat DNA Damage Signaling RT² Profiler PCR Array profiles the expression ... DNA Damage Signaling Pathway RT2 Profiler PCR Array The Human DNA Damage Signaling RT² Profiler PCR Array profiles the ... DNA Damage Signaling Pathway RT2 Profiler PCR Array The Mouse DNA Damage Signaling RT² Profiler PCR Array profiles the ... DNA Damage Signaling Pathway EpiTect ChIP qPCR Array The Human DNA Damage Signaling Pathway EpiTect ChIP qPCR Array profiles ...
  https://www.qiagen.com/qa/shop/genes-and-pathways/complete-biology-list/dna-damage-and-repair/
*  More on Oxidative DNA Damage Repair
DNA Finger Printing. DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, identity ... DNA repair mechanism decodedTogether with the University of Oxford, Enni Markkanen, a veterinarian in the working group of Prof ... We expect that the DNA repair mechanism discovered here will lead to less invasive approaches in cancer therapy and that it ... In the recent years epigenetics represents inheritable changes in gene expression that do not include DNA alterations. ...
  http://www.medindia.net/news/More-on-Oxidative-DNA-Damage-Repair-95438-1.htm
*  Underground air might cause DNA damage
Particularly damaging to our cellular DNA are the particles from the underground system in Stockholm, Sweden, according to a ... Underground air might cause DNA damage. 15.12.2006. Our everyday environments are full of airborne particles that are harmful ... Free radicals are highly reactive molecules that can prove harmful to the cell's DNA; although such damage can often be ... The damage is caused when these particles enter the body and form free radicals in the body's cells. ...
  http://www.innovations-report.com/html/reports/medicine-health/report-76017.html
*  Environmental DNA Damage May Drive Human Mutation - Scientific American
... chemical book of DNA. Now Japanese researchers have shown how environmentally damaged letters lead to transcription flaws and, ... When lurking in the area during DNA replication, it bonds with adenine and causes the latter to pair with thymine rather than ... Subtle changes in the pairing of the chemical letters of DNA--adenine, cytosine, guanine and thymine--produce new cells with ... And that means Nakabeppu and his colleagues may have shown how environmental damage leads to cellular mutation, for good and ...
  https://www.scientificamerican.com/article/environmental-dna-damage/
*  DNA damage response inhibition - BioPortfolio.com
Dr Massimini speaks with ecancer at WIN 2017 about novel drugs suitable as monotherapy or in combination to inhibit DNA repair ... Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks ... More From BioPortfolio on "DNA damage response inhibition". *Related Companies *Related Events *Related Clinical Trials * ... DNA repair pathways in tumours. He highlights VX970 / M6620, a novel drug affecting the ATR kinase pathway of DNA repair, as ...
  https://www.bioportfolio.com/news/article/3218689/DNA-damage-response-inhibition.html
*  Complex Response to DNA Damage | Science Signaling
... effects of DNA damage by activating a checkpoint mechanism to prevent proliferation of cells that contain damaged DNA. The ... forms MRN complexes with two other proteins that participate in DNA repair, Mre11 and Rad50 (Mre11-Rad50-Nbs1, hence, MRN). Nbs ...
  http://stke.sciencemag.org/content/2004/227/tw128
*  Mechanistic Studies of Radiation-Induced DNA Damage | SpringerLink
The reactions involved have been studied on a model level: DNA and DNA components in... ... the damage caused by ionizing radiation is mainly due to free-radical-induced alterations of their DNA. ... Mechanistic Studies of Radiation-Induced DNA Damage. In: Dizdaroglu M., Karakaya A.E. (eds) Advances in DNA Damage and Repair. ... C. von Sonntag (1994) Topics in free-radical-mediated DNA damage: purines and damage amplification - super-oxide reactions - ...
  https://link.springer.com/chapter/10.1007/978-1-4615-4865-2_33