DNA adducts are researched in laboratory settings. A typical experimental design for studying DNA adducts is to induce them ... forming DNA adducts, and inducing double-strand breaks (DSBs). In regards to DNA adduct formation, this analysis was conducted ... Ongoing research on DNA adducts seeks to overcome these complications. It is the hope that in future medical practices DNA ... In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing chemical. This process could lead to the ...

DNA adducts are a form of DNA damage caused by covalent attachment of a chemical moiety to DNA. Adducts that are not removed by ... The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair New data show that the HMCES ... DNA damage during chromothripsis is caused by deoxyinosine formation on accumulated RNA-DNA hybrids in micronuclei that are ... Repair of topoisomerase 1 (TOP1) DNA protein crosslinks (DPC) limits the efficacy of the TOP1 inhibitor irinotecan in cancer ...

"DNA Adducts" by people in Harvard Catalyst Profiles by year, and whether "DNA Adducts" was a major or minor topic of these ... Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be ... Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A. Biochem ... "DNA Adducts" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ...

... the types and abundances of NA-DNA adducts in circulating leukocytes will at least partly reflect adduct formation in the lung ... The objective of this study is to identify and quantify NA-DNA adducts in mouse lung as well as mouse and human blood to enable ... In Aim 1, I will Identify and quantitate NA-DNA adducts formed in wild-type (WT) mice following NA inhalation exposure, with ... This project will provide direct evidence for the formation of NA-DNA adducts in vivo, lay the foundation for future studies of ...

2. Correlation between DNA adduct formation and biological effect. Most chemicals induce more than one type of DNA adduct. The ... adducts in specific DNA sequences. There is evidence that the distribution of DNA adducts over the genome immediately after ... and characterization of monoclonal antibodies against DNA containing specific DNA adducts or against a purified DNA adduct ... determination of DNA adducts in the same gene to be used for mutation analysis will allow a direct correlation between DNA ...

Sequence- and Region-Specificity of Oxaliplatin Adducts in Naked and Cellular DNA. Jan M. Woynarowski, William G. Chapman, ... Sequence- and Region-Specificity of Oxaliplatin Adducts in Naked and Cellular DNA. Jan M. Woynarowski, William G. Chapman, ... Sequence- and Region-Specificity of Oxaliplatin Adducts in Naked and Cellular DNA. Jan M. Woynarowski, William G. Chapman, ... Sequence- and Region-Specificity of Oxaliplatin Adducts in Naked and Cellular DNA ...

Our preliminary results show that analysis of DNA adducts following ex vivo drug treatment is a feasible approach towards a ... DNA adducts. Measurement of these adducts prior to therapy could be of value to improve cisplatin based cancer therapy. ... Conclusion: Our preliminary results show that analysis of DNA adducts following ex vivo drug treatment is a feasible approach ... The potential of plantinum-DNA adduct determination in ex vivo treated tumor fragments for the prediction of sensitivity to ...

DNA interaction. Comparative DNA binding experiments indicate that 57% of 2 and 33% of 3 were converted into DNA adducts, ... 15, 187-197]. The majority of DNA adducts with 3 are those from the trans- or cis-opening of the epoxide at C5a by the ... indicating the importance of the secondary structure of DNA for both adduct formation and chemical selectivity. The T-shape ... The structures of nine DNA adducts and two racemic tetraols derived from 3 have been determined spectroscopically. Similar ...

Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo. Title. Dibenzo[a,l]pyrene induced DNA adduct formation ... Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo ...

Bao Y, Bacon J, Williamson G. Effect of phytochemicals on phIP-DNA adduct formation in human HepG2 cells and hepatocytes. In ... Effect of phytochemicals on phIP-DNA adduct formation in human HepG2 cells and hepatocytes. / Bao, Y; Bacon, J; Williamson, G. ... Bao, Y ; Bacon, J ; Williamson, G. / Effect of phytochemicals on phIP-DNA adduct formation in human HepG2 cells and hepatocytes ... Bao, Y., Bacon, J., & Williamson, G. (2001). Effect of phytochemicals on phIP-DNA adduct formation in human HepG2 cells and ...

Reduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technology. Title. Reduction in tamoxifen- ... Reduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technology ...

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint ...

We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more ...

DNA adducts have been detected at low levels in human endometrium, and there is much interest in determining whether DNA damage ... DNA adducts have been detected at low levels in human endometrium, and there is much interest in determining whether DNA damage ... DNA adducts have been detected at low levels in human endometrium, and there is much interest in determining whether DNA damage ... DNA adducts have been detected at low levels in human endometrium, and there is much interest in determining whether DNA damage ...

DNA adducts and AHH activity were determined by the 32P-postlabelling technique and the fluorometric method, respectively. The ... DNA adducts and AHH activity were determined by the 32P-postlabelling technique and the fluorometric method, respectively. The ... DNA adducts and AHH activity were determined by the 32P-postlabelling technique and the fluorometric method, respectively. The ... DNA adducts and AHH activity were determined by the 32P-postlabelling technique and the fluorometric method, respectively. The ...

Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo. Title. Dibenzo[a,l]pyrene induced DNA adduct formation ... Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo ...

Leukocyte DNA adducts were analyzed blindly using 32P postlabeling technique. Adducts were associated with the subsequent risk ... Besides, the association of DNA adduct levels with O 3 indicates a possible role for photochemical smog in determining DNA ... DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition ( ... Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. ...

title = "Solution Conformation of the (-)-trans-anti-Benzo[c]phenanthrene-dA ([BPh]dA) Adduct opposite dT in a DNA Duplex: ... Solution Conformation of the (-)-trans-anti-Benzo[c]phenanthrene-dA ([BPh]dA) Adduct opposite dT in a DNA Duplex: Intercalation ... Solution Conformation of the (-)-trans-anti-Benzo[c]phenanthrene-dA ([BPh]dA) Adduct opposite dT in a DNA Duplex: Intercalation ... Solution Conformation of the (-)-trans-anti-Benzo[c]phenanthrene-dA ([BPh]dA) Adduct opposite dT in a DNA Duplex: Intercalation ...

Modulation of novel DNA adducts during human uterine cervix cancer progression. Srivani Ravoori, Manicka V. Vadhanam, Diane D. ... Dive into the research topics of Modulation of novel DNA adducts during human uterine cervix cancer progression. Together ...

... and DNA in vitro. The chemical structures of the DNA adducts were confirmed by accurate mass values, collision-induced ... and DNA in vitro. The chemical structures of the DNA adducts were confirmed by accurate mass values, collision-induced ... and DNA in vitro. The chemical structures of the DNA adducts were confirmed by accurate mass values, collision-induced ... and DNA in vitro. The chemical structures of the DNA adducts were confirmed by accurate mass values, collision-induced ...

Ultimately, the complex problem of the role of the protein or enzyme environment in PAH-DNA adduct conformation and function ... Ultimately, the complex problem of the role of the protein or enzyme environment in PAH-DNA adduct conformation and function ... Ultimately, the complex problem of the role of the protein or enzyme environment in PAH-DNA adduct conformation and function ... Ultimately, the complex problem of the role of the protein or enzyme environment in PAH-DNA adduct conformation and function ...

DNA adduct. fibroblast/human. 100 µmol/L. CRNGDP 12,1483,1991. DNA adduct. lymphocyte/mammal (species unspecified). 58 gm/L/3H ... DNA adduct. /Escherichia coli. 286 nmol/L. ARTODN 46,277,1980. ... DNA Damage. other cell types/rat. 30 mmol/L. ARTODN 58,67,1985 ... DNA inhibition. intraperitoneal/rat. 500 µg/kg. BICMBE 53,243,1971. DNA inhibition. lymphocyte/mammal (species unspecified). 80 ... DNA Damage. other cell types/human. 30 µmol/L. CNREA8 48,1717,1988. ...

Methods: We investigated levels of N 2-ethylidene-dGuo, the major DNA adduct of acetaldehyde, in DNA from human oral cells at ... Methods: We investigated levels of N 2-ethylidene-dGuo, the major DNA adduct of acetaldehyde, in DNA from human oral cells at ... Methods: We investigated levels of N 2-ethylidene-dGuo, the major DNA adduct of acetaldehyde, in DNA from human oral cells at ... Methods: We investigated levels of N 2-ethylidene-dGuo, the major DNA adduct of acetaldehyde, in DNA from human oral cells at ...

I. Polycyclic aromatic hydrocarbon DNA adducts. Cancer Epidemiol Biomarkers Prev. 2002 Aug. 11(8):677-85. [Medline]. ...

... among which two dA and three dG adducts were detected in reactions of AA IVa with calf thymus DNA (CT DNA). However, no DNA ... Ácidos Aristolóquicos/toxicidade Adutos de DNA/efeitos dos fármacos Dano ao DNA/efeitos dos fármacos DNA/efeitos dos fármacos ... Aristolochic acid IVa forms DNA adducts in vitro but is non-genotoxic in vivo.. Wan, Jingjing; Chen, Ruixue; Yang, Zhou; Xi, ... The competitive reaction of AA I and AA IVa with CT DNA, with adducts levels varying with pH of reaction revealed that AA IVa ...

The adduct levels in DNA were 9630 (dGI), 240 (dCI), 83 (dAI), 6 (dAII), and 28 (TI) pmol/mg DNA, respectively. The preferred ... Identification of adducts derived from reactions of (1-chloroethenyl)oxirane with nucleosides and calf thymus DNA. Lookup NU ... and calf thymus DNA have been studied in aqueous buffered solutions. The adducts from the nucleosides were isolated by reversed ... oxirane with calf thymus DNA gave all of the adducts observed from the individual nucleosides except dGII and dGIII. However, ...

One major adduct and seven minor adducts were formed from each dihy-drodiol-epoxide. The major adduct was, in each case, ... One major adduct and seven minor adducts were formed from each dihy-drodiol-epoxide. The major adduct was, in each case, ... One major adduct and seven minor adducts were formed from each dihy-drodiol-epoxide. The major adduct was, in each case, ... One major adduct and seven minor adducts were formed from each dihy-drodiol-epoxide. The major adduct was, in each case, ...

Recent technological developments have facilitated the identification of multiple DNA adducts in a single experiment. Only a ... A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, ... chemically reactive substances bind to DNA and form DNA adducts. Certain DNA adducts may impede accurate DNA replication and ... Quantities of DNA adducts in tumor and nontumor sites. Box plots of the molar ratio of DNA adducts in tumor or nontumor sites ...