*  TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic car | DMSO
In the present study, we evaluated the efficacy of TRC210258, a novel TGR5 agonist, in clinically relevant animal models of ... Patients with diabesity have a significantly increased risk of developing cardiovascular disease. Therefore, therapy addressing ... reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity Shitalkumar Zambad, Davinder Tuli, Anoop ... TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity. ...
  https://www.dovepress.com/trc210258-a-novel-tgr5-agonist-reduces-glycemic-and-dyslipidemic-cardi-peer-reviewed-article-DMSO
*  Genetically Modified Rat Is Promising Model For Alzheimer's | WHQR
The genetically modified rat is the first rodent model to exhibit ... but did not help people with the disease. A lack of good animal ... "The closer the model is to the human condition in representing the disease, the more likely the drug will behave and cure the ... The closer the model is to the human condition in representing the disease, the more likely the drug will behave and cure the ... And as the animals get older, Town says, "they perform even worse, much as you would see in a human being that would have these ...
  http://whqr.org/post/genetically-modified-rat-promising-model-alzheimers
*  Center for Animal Disease Modeling and Surveillance
The Disease BioPortal is operated and maintained by the Center for Animal Disease Modeling and Surveillance (CADMS) at the ... Disease BioPortal: a near-real time platform for the visualization and analysis of local and global information. The Disease ... Contact us , Animal Health Inquiries , Check us out on Facebook, Twitter, & YouTube , Online Donation Form. UC Davis School of ... BioPortal is a web-based system that provides near-real time access to local, regional, and global disease information and data ...
  http://www.vetmed.ucdavis.edu/cadms/slideshow-pages/page-1.cfm.cfm
*  Neuro-immune interactions of neural stem cell transplants: from animal disease models to human trials.
... Giusto E, Donegà M, ... The significant impact in vivo of experimental NPC therapies in animal models of inflammatory CNS diseases has raised great ... on the most recent evidence of therapeutically-relevant neuro-immuneinteractions following NPC transplants in animal models of ... initial idea that stem cell transplants work in vivo via the replacement of endogenous cells lost or damaged owing to disease ...
  http://www.wingsforlife.com/de/aktuelles/neuro-immune-interactions-of-neural-stem-cell-transplants-from-animal-disease-models-to-human-trials-2823/
*  Animal Models of Human Disease | Circulation
Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The ...
  http://circ.ahajournals.org/collection/animal-models-human-disease?page=8
*  Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models - Ujiie - 2012...
Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models. Authors. *. ... with an emphasis on studies using active animal mouse models for these diseases. Previous studies have demonstrated that ... In interpreting the experimental results, the limitations of those animal models should be considered. Further understanding of ... Autoimmune bullous diseases (AIBDs) are characterized by blisters and erosions on the skin and/or mucous membranes, which are ...
  http://onlinelibrary.wiley.com/doi/10.1111/exd.12011/abstract
*  Recent Articles | Animal Models And Disease/Medicine | The Scientist Magazine®| Page 3
Emerging infections provide clues about how pathogens might evolve when farm animals are protected from infection. ... tags: animal models x disease/medicine x The Scientist. » animal models and disease/medicine ...
  https://www.the-scientist.com/?articles.list/tagNo/1275,6/tags/animal-models,disease-medicine/pageNo/3/
*  Kenichi Yamada] Development of fluorescent and mass spectrometry multi-probe for lipid derived radicals and application to...
Furthermore, this method applies to animal disease models. These results will provide valuable information regarding oxidative ... of fluorescent and mass spectrometry multi-probe for lipid derived radicals and application to animal disease models. ... of fluorescent and mass spectrometry multi-probe for lipid derived radicals and application to animal disease models ... Metabolic products of lipid peroxides have been reported to involve in the pathogenesis of various diseases. However, lipid ...
  http://www.jst.go.jp/kisoken/presto/en/project/106sikkan/106Yamada.html
*  Opossum models liver disease | Understanding Animal Research
... allowing them to study the biology of the disease and test potential treatments. ... Animal models are used by scientists to replicate human diseases in another living animal, ... Animal models are used by scientists to replicate human diseases in another living animal, allowing them to study the biology ... A new opossum model has been developed to mimic nonalcoholic steatohepatitis, which resembles alcoholic liver disease but ...
  http://www.understandinganimalresearch.org.uk/news/research-medical-benefits/opossum-models-liver-disease/
*  Balance and movement improved in animal model of Parkinson's disease | UCLA
Balance and movement improved in animal model of Parkinson's disease. UCLA RESEARCH ALERT. Mark Wheeler , June 07, 2017. ... the American Parkinson's Disease Association, and gifts to the Center for the Study of Parkinson's Disease at UCLA. ... The disease is chronic and progressive, and over time can worsen from tremors in a person's hands and slow movements, to ... Parkinson's disease is a nervous system disorder that affects movement. It's estimated that as many as 1 million Americans live ...
  http://newsroom.ucla.edu/releases/movement-restored-in-animal-model-of-parkinsons-disease
*  Revalesio Presents Data Showing RNS60 Alters Disease Progression in Animal Model of Alzheimer's Disease
... ... RNS60 has demonstrated a reduction in inflammatory responses that are linked to numerous diseases, including neurodegenerative ... respiratory and cardiovascular diseases. RNS60 has successfully completed Phase I safety studies and is advancing into Phase II ... impacts Alzheimer's Disease. This research, conducted in partnership with Rush University Medical Center, investigates a new ...
  https://www.nanowerk.com/news2/newsid=31443.php
*  Advances in Neuroprotective Ingredients of Medicinal Herbs by Using Cellular and Animal Models of Parkinson's Disease
... Sandeep ... of the evidence-linked neuroprotective activity of bioactive ingredients of herbal origin in cellular and animal models of PD ... Parkinson's disease (PD) is a multifactorial disorder, which is neuropathologically identified by age-dependent ... but there remain a number of inadequacies in therapeutic strategies for the disease. The pathogenesis of PD remains intricate, ...
  https://www.hindawi.com/journals/ecam/2013/957875/abs/
*  Animal Models of Human Disease for the 21st Century: Ingenta Connect Articles that cite this article
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more ...
  http://www.ingentaconnect.com/content/aalas/cm/1998/00000048/00000006/art00003/citations
*  Use of viral vectors to create animal models for Parkinson's disease
... Löw, Karin; Aebischer, Patrick ... In this review we describe viral animal models for PD, i.e. models that are based on PD-associated mutations, and have been ... To date, viral PD models comprise α-synuclein and LRRK-2-based overexpression models, as well as models that mimic parkin loss ... These viral models provide valuable insights into Parkinson disease mechanisms, help to identify therapeutic targets and may ...
  https://infoscience.epfl.ch/record/173786
*  National Center for Biodefense and Infectious Diseases - Animal Models of Viral Infections
National Center for Biodefense and Infectious Diseases / Research and Facilities / Animal Model Capabilities / Animal Models of ... Animal Models of Viral Infections. The following animal models of viral infections have either been established or are under ... To see the animal model, please click on the animal model description. ... Models Currently Available. Family Genus. Species. Strain. Route of Infection. Animal Model. ...
  https://cos.gmu.edu/ncbid/research-and-facilities/animal-model-capabilities/animal-models-of-viral-infections/
*  Animal Models of Human Disease | Circulation: Genomic and Precision Medicine
Arrhythmogenic CardiomyopathyTransgenic Animal Models Provide Novel Insights Into Disease Pathobiology Kalliopi Pilichou, ... Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The ... Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage ... Reciprocal Transcriptional Regulation of Metabolic and Signaling Pathways Correlates With Disease Severity in Heart Failure ...
  http://circgenetics.ahajournals.org/collection/animal-models-human-disease?page=6
*  Stem Cells in Large Animal Models of Retinal and Neurological Disease
The journal will consider basic, translational, and clinical research, including animal models and clinical trials. ... Stem Cells in Large Animal Models of Retinal and Neurological Disease. Guest Editors: Henry Klassen, Budd A. Tucker, Chee G. ... Stem Cells in Large Animal Models of Retinal and Neurological Disease, Henry Klassen, Budd A. Tucker, Chee G. Liew, Morten La ... Assessment of Hereditary Retinal Degeneration in the English Springer Spaniel Dog and Disease Relationship to an RPGRIP1 ...
  https://www.hindawi.com/journals/sci/si/970239/
*  Cotton Rats as Animal Model for Infectious Diseases | College of Veterinary Medicine
Cotton rats as models of infectious diseases. Cotton rats are an important animal model to study infectious diseases because of ... Diversifying animal models: the use of hispid cotton rats (Sigmodon hispidus in infectious diseases. Laboratory Animals 36: 357 ... Cotton rats (Sigmodon hispidus): an animal model for respiratory tract infections with human pathogens.. Lab Animal, 42, 170- ... Lab Animal 1: 31-36.. Niewiesk, S., F. Völp and V. ter Meulen (1997).. A maintenance and handling device for cotton rat ( ...
  https://vet.osu.edu/cotton-rats-animal-model-infectious-diseases
*  Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's...
Naphthoquinone-tyrptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model.. *Authors ... L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.. * ... cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models.. * ... Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract.. * ...
  https://www.pubfacts.com/detail/21305046/Orally-administrated-cinnamon-extract-reduces-%CE%B2-amyloid-oligomerization-and-corrects-cognitive-impa
*  Animal model of Parkinson s disease reveals striking sensitivity to common environmental toxins
... 07.09.2005 ... The two studies were performed with the fruit fly Drosophila, a widely used model organism for studies of human disease, and ... Past work had shown that one form of familial Parkinson s disease results from a loss of function of a gene called DJ-1. ... Parkinson s disease occurs both sporadically and as a result of inheritance of single gene mutations. One of the most common ...
  http://www.innovations-report.com/html/reports/life-sciences/report-48809.html
*  Genetic Therapy Reverses Nervous System Damage in Animal Model of Inherited Human Disease
Other examples include Tay-Sachs disease, Hunter disease and Pompe disease. In a lysosomal storage disease, cellular debris ... Genetic Therapy Reverses Nervous System Damage in Animal Model of Inherited Human Disease. 10.03.2005 ... Although the disease itself is rare, AMD is one of about 50 lysosomal storage diseases, a class of diseases that accounts for a ... This is the first genetic disease affecting the central nervous system to be successfully treated in an animal larger than mice ...
  http://www.innovations-report.com/html/reports/life-sciences/report-41585.html
*  Epilepsy drug levetiracetam reverses memory loss in animal model of Alzheimer's disease
... that an FDA-approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer's-related impairments in an animal ... Epilepsy drug levetiracetam reverses memory loss in animal model of Alzheimer's disease. August 6, 2012, Gladstone Institutes ... Cholesterol drug shows benefit in animal study of Alzheimer's disease. April 3, 2012 A cholesterol drug commonly prescribed to ... anti-epileptic drug reverses memory loss and alleviates other Alzheimer's-related impairments in an animal model of the disease ...
  https://medicalxpress.com/news/2012-08-epilepsy-drug-levetiracetam-reverses-memory.html
*  Enzyme inhibition protects against Huntington's disease damage in two animal models - Massachusetts General Hospital, Boston, MA
Enzyme inhibition protects against Huntington's disease damage in two animal models. Treatment with SIRT2 inhibitor reduced ... slowed the loss of motor function and extended survival in two animal models of Huntington's disease. The study led by ... protected against neuronal damage in cellular and animal models of HD and Parkinson's disease - both of which are characterized ... Treated animals in this model, which usually die prematurely, lived 13 percent longer than untreated R6/2 mice. In the ...
  http://www.massgeneral.org/about/pressrelease.aspx?id=1526
*  Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease | Journal...
2007) Neuroprotective effect of protein kinase C δinhibitor rottlerin in cell culture and animal models of Parkinson's disease ... Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease. Nikhil ... Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease ... Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease ...
  http://www.jneurosci.org/content/35/27/10058