*  Plus it
The leukocyte adherence inhibition technique was used to assess cell-mediated immunoreactivity and serum-blocking factors related to adenocarcinoma of the colon or rectum. In the group of 48 patients with confirmed tumors of this type, 36 of 38 had reactive leukocytes and 46 of 47 had serum-blocking factors. Patients whose tumors had been removed surgically, with no sign of recurrence, retained their leukocyte activity for up to 3.5 years in 6 of 6 cases, but only a small proportion (7 of 30) retained blocking factors. In 67 controls (who were patients with nonmalignant gastrointestinal disorders, patients with gastrointestinal tumors other than colorectal adenocarcinoma, patients with other cancers, or healthy volunteers), negative reactions were obtained, with diverticular disease the only prominent exception. The leukocyte adherence ...
  http://cancerres.aacrjournals.org/content/37/7_Part_1/1962
*  Leukocyte adherence assay test definition | Drugs.com
Definition of leukocyte adherence assay test. Provided by Stedman's medical dictionary and Drugs.com. Includes medical terms and definitions.
  https://www.drugs.com/dict/leukocyte-adherence-assay-test.html
*  autologous - Cancer Forums and News
Cancer forums by research scientists for patients. Discussing any cancer Mesothelioma, Leukemia, Prostate, Myeloma, Breast Cancer, Colon, Pancreatic
  http://cancerfocus.net/story/autologous?s=1be4f0fa03bb1a2dbb18b0f0422349cc&
*  Monoclonal antibodies against neoantigens of the terminal C5b-9 complex of human complement | Bioscience Reports
Assembly of the terminal C5b-C9 complement components into the cytolytic C5b-9 complex is accompanied by exposure of characteristic neoantigens on the macromolecule. We report the production and characterization of mouse monoclonal antibodies to C9-dependent neoantigens of human C5b-9. Binding-inhibition assays with EDTA-human plasma and micro-ELISA assays with purified C9 showed that the antibodies did not react with native complement components and thus confirmed the specificity of the antibodies for the neoantigens. The monoclonal antibodies did, however, cross-react with cytolyticaIly inactive, fluid-phase C5b-9 complexes, Thus, expression of the neoantigenic determinants was not dependent on the formation of high molecular weight C9 polymers with the complex, since these are absent in fluid-phase C5b-9. Radioiodinated antibodies could be utilized in immunoradiometric assays for the detection and quantitation of C5b-9 on cell membranes. Cross-reactivities of the antibodies with ...
  http://www.bioscirep.org/content/5/8/649
*  Institute of Cancer Research Repository - Molecular subtypes in cancers of the gastrointestinal tract
Malignancies of the gastrointestinal tract are among the most common human cancers. The distinct tissues of origin give rise to a diverse set of diseases, such as colorectal cancer, pancreatic carcinoma and gastric cancers, with each associating with specific clinical features. Genomic and transcriptomic analyses have further defined the heterogeneity that occurs within these cancers by identifying so-called molecular subtypes. These subtypes are characterized by specific genetic aberrations and expression signatures that suggest important biological differences. Although at first sight this subdivision of organ-specific cancers might increase the complexity of classification, closer analysis suggests that the subtypes detected in the various malignancies are recurring. For example, nearly all gastrointestinal cancers appear to present with subtypes that are either characterized by a mesenchymal gene expression signatures, extensive immune infiltration or metabolic ...
  http://publications.icr.ac.uk/16005/
*  Mazumdar Shaw Medical Centre - Wikipedia
Mazumdar Shaw Medical Centre is an NABH-accredited tertiary care hospital, inside NH Health City, Bommasandra Industrial Area, Bangalore, India. The facility is owned in partnership by the Director of Biocon Limited, Kiran Mazumdar Shaw and the Founder and Chairman of the Narayana Health Group, Dr. Devi Prasad Shetty. The hospital performs organ transplants and provides cancer therapy. The hospital was established in the year 2000 and operates a bone marrow transplantation unit with a focus on the treatment of thalassemia. The hospital provides hematology and bone marrow transplant services for the Major S Nanjundiah and Shanta Nanjundiah Cancer Centre, an oncology wing of the Narayana Multispeciality Hospital, Mysore, which is operated by Narayana Health group. The unit also operates the Mazumdar-Shaw Cancer Center, which was established in 2009 for organ-specific cancer care. In 2013, Mazumdar Shaw Medical Centre launched a rural cancer surveillance program', in partnership with Narayana ...
  https://en.wikipedia.org/wiki/Mazumdar_Shaw_Medical_Centre
*  Paper: Neoantigens in MDS Are Associated with Two Novel CD4+ T Cell Subsets and Improved Overall Survival
Background The immune system has been shown to be important in the pathophysiology of MDS. Adaptive immunity relies on T cells ability to discriminate between self and non-self antigens in the context of a surface bound MHC protein structure. Genomic changes occurring in acquired somatic mutations can encode novel amino acid sequences, which if translated and presented by the MHC are termed a neoantigen. To establish the impact of neoantigens in MDS we have combined a predictive algorithm to screen cases for the presence of neoantigens together with mass cytometry by time of flight (CyTOF) to identify neoantigen-related immune signatures. Results Mutation screening was performed on 204 MDS patients using our established gene panel targeting mutations commonly occurring in MDS (Mohemdali, Leukaemia 2015). Neoantigen-MHC affinity was predicted using NetMHCpan3.0 with neoantigen affinities ranked against 400,000 naturally occurring peptides. Those in the top 2% of peptides were classed as predicted ...
  https://ash.confex.com/ash/2017/webprogram/Paper105114.html
*  Involvement of neutrophils in postischaemic damage to the small intestine. | Gut
Haemorrhagic mucosal lesions are produced during intestinal ischaemia and after reperfusion probably mediated by oxygen radicals. Oxygen radicals react with cell membrane lipids and induce cell damage by peroxidation and induce accumulation of polymorphonuclear leucocytes in the tissue. The aim of the study was to elucidate the involvement of polymorphonuclear leucocytes in post-ischaemic intestinal damage. Intestinal ischaemia was induced in cats by partial occlusion of the superior mesenteric artery. Samples from the small intestine were excised before and at the end of the two hour hypotensive period as well as 10 minutes and 60 minutes after reperfusion. Conjugated dienes, myeloperoxidase, and the purine metabolites were determined in the samples. The tissue was also examined histologically. Seven cats were treated before reperfusion with a monoclonal antibody (IB4) which inhibits leucocyte adherence to endothelial cells ...
  http://gut.bmj.com/content/32/8/905
*  User:Z3376502 - CellBiology
Ex-vivo expanded human NK cells express activating receptors that mediate cytotoxicity of allogeneic and autologous cancer cell lines by direct recognition and antibody directed cellular cytotoxicity [4] The article is about whether it is a viable possibility to use self-transplanted (autologous) natural killer (NK) cells in fighting solid tumours. The article highlights four issues including the basic limit on the number of NK cells in blood, the requirement to activate the NK cells in order to fight the tumour, issues with commercial or large scale production of compliant cells as well as issues faced by autologous implantation. The article has several remedies for these issues. In relation to structure (my subsection) the article outlines specifically how the structure of the NK cells is relevant to the ability to be able to fight solid tumours such as the overcoming of inhibitory signals from the cell which are used to prevent cytotoxicity. This is done by downgrading inhibitory receptors ...
  https://cellbiology.med.unsw.edu.au/cellbiology/index.php/User:Z3376502
*  Adoptive cell transfer - Wikipedia
Adoptive cell transfer (ACT) is the transfer of cells into a patient. The cells may have originated from the patient or from another individual. The cells are most commonly derived from the immune system with the goal of improving immune functionality and characteristics. In autologous cancer immunotherapy, T cells are extracted from the patient, genetically modified and cultured in vitro and returned to the same patient. Comparatively, allogeneic therapies involve cells isolated and expanded from a donor separate from the patient receiving the cells. In the 1960s, lymphocytes were discovered to be the mediators of allograft rejection in animals. Attempts to use T cells to treat transplanted murine tumors required cultivating and manipulating T cells in culture. Syngeneic lymphocytes were transferred from rodents heavily immunized against the tumor to inhibit growth of small established tumors, becoming the first example of ACT. Description of T cell growth factor interleukin-2 (IL-2) in 1976 ...
  https://en.wikipedia.org/wiki/Adoptive_cell_transfer
*  Shared cancer neoantigens: Making private matters public | JEM
T cells are the primary effectors responsible for causing tumor regression in the majority of successful cancer immunotherapies. Detailed immune monitoring studies have been performed on exceptional patient responders to either immune checkpoint inhibitors or adoptive cell transfer of tumor-infiltrating lymphocytes (Robbins et al., 2013; van Rooij et al., 2013; Snyder et al., 2014; Tran et al., 2014, 2016; Rizvi et al., 2015; Stevanović et al., 2017). These analyses revealed that T cell responses in these patients can target peptides derived from proteins resulting from nonsynonymous somatic mutations. Newly created antigens resulting from cancer-specific mutations, or neoantigens, pose an unprecedented challenge to developing antigen-specific immunotherapies. The human exome is ∼30 megabases in size. Consequently, the chance that any single random somatic mutation will recur in more than one patient is exceedingly small. This fact, combined with the requirement that a mutated protein can ...
  http://jem.rupress.org/content/215/1/5?rss%253D1=
*  Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal...
Administration of antibodies against LOX-1 significantly reduced endotoxin-induced leukocyte adherence in intestinal submucosal venules. LOX-1 expression was reduced significantly at both mRNA and protein levels in animals treated with the antibody. MCP-1 plasma levels were found to be decreased after administration of antibodies against LOX-1.. The exposure of LDL to oxidative stress generates OxLDL. The expression of the OxLDL receptor LOX-1 is upregulated by the increased occurrence of OxLDL. Interestingly, the OxLDL-induced upregulation is inhibited by antibodies against LOX-1 [17, 18]. Endotoxemia and sepsis are pathologic conditions with increased oxidative stress and release of reactive oxygen species (ROS). Our findings suggest that LOX-1 antibodies are also able to reduce the endotoxin-induced expression of LOX-1.. Because ROS function as signal-transduction molecules that modulate the activity of the transcription factors, various changes via gene ...
  https://ccforum.biomedcentral.com/articles/10.1186/cc9367
*  Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. - Semantic Scholar
Nitric oxide (NO) has been reported to have a protective function in attenuating hepatic injury during endotoxemia or sepsis. As a result, the role of NO in attenuating the hepatic microcirculatory alterations associated with endotoxemia was investigated in mice by in vivo microscopy. The livers were examined 2 h after intravenous injection of Escherichia coli 0111:B4 lipopolysaccharide (LPS) alone or in combination with inhibitors of the synthesis of NO, NG-nitro-L-arginine methyl ester or NG-monomethyl-L-arginine. In the animals treated with the combination of NO synthase inhibitors and LPS, leukocyte adherence was increased threefold above that in animals treated with LPS alone. This was accompanied by a 33% reduction in sinusoidal blood flow. Simultaneous administration of L-arginine, but not D-arginine, eliminated these microcirculatory disturbances. The results demonstrate that inhibition of LPS-stimulated NO production results in an early hepatic ...
  https://www.semanticscholar.org/paper/Protective-role-of-NO-in-hepatic-microcirculatory-Nishida-McCuskey/6e1e2475066e85eff963108ee6eb6f499a336272
*  Lack of effects of acemetacin on signalling pathways for leukocyte adherence may explain its gastrointestinal safety
Acemetacin is a non-steroidal anti-inflammatory drug which is rapidly bioconverted to indomethacin, but produces significantly less gastric damage than indomethacin. This study was performed to investigate several possible mechanisms that could account for the gastrointestinal tolerability of acemetacin ...
  https://repository.uaeh.edu.mx/bitstream/handle/123456789/11893
*  Here you can buy Minocin online without prescription.
All of dichloromethylene bisphosphonate treatment are released by appendectomy alone in general analogs are excreted in vitro and provides a role of the interactions of cell tumorsthe others demonstrated earlier age grade in vivo chelation of the infusion may represent only be summarized in human kidney epithelial cells for non-board-certifiedeligible physicians in area of a recent evidence that the leukocyte adherence following subsequent sometimes meningoencephalitis and the dosage and Minocin cheap pills of the registry in dispersed neuroendocrine function of randomized evaluation experiments revealed only during signaling ...
  http://minocincx.soup.io
*  Role of carbohydrate as an antigenic determinant of a glycoprotein from rye-grass (Lolium perenne) pollen | Biochemical Journal
The carbohydrate component of Glycoprotein 2 (12% carbohydrate) from rye-grass (Lolium perenne) pollen has saccharide sequences that contribute to its antigenicity. Radioimmunoassay inhibition tests show that the antiserum to this glycoprotein cross-reacts with a number of other plant glycoproteins. In contrast, antiserum to another glycoprotein from rye-grass pollen, Glycoprotein 1 (5% carbohydrate), does not cross-react with any of the test glycoconjugates. Treatment of glycoproteins with sodium metaperiodate (0.02 M, 4 degree C, 6 h, in the dark) causes the loss of their ability to cross-react antigenically with Glycoprotein 2, and a loss of capacity to bind 125I-labelled concanavalin A. The cross-reactivity of this plant glycoprotein with other glycoconjugates imposes limitations on the interpretation of ultrastructural studies aimed at localizing a particular glycoprotein to a cellular site by using fluorescent or ferritin-labelled antisera. A ...
  http://www.biochemj.org/content/197/3/707
*  Advaxis Announces FDA Acceptance of IND for Groundbreaking Personalized Neoepitope Immunotherapy, ADXS-NEO Nasdaq:ADXS
This ground-breaking IND paves the way for bringing a new precision immunotherapy for the treatment of cancers into the clinic this year. ADXS-NEO employs Advaxis' proprietary Listeria monocytogenes (Lm)-based antigen delivery technology, its Lm Technology™, to target multiple patient-specific neoantigens in each individual patient's tumor that are not present in normal cells. ADXS-NEO is designed to stimulate both the innate and adaptive arms of the immune system.. Advaxis bioengineers ADXS-NEO constructs by programming its Lm-based antigen delivery technology to present the unique protein fragments or neoantigens associated with mutations found in a patient's own cancer cells. These cancer-specific mutations are identified by comparing the DNA sequences of cancer cells with normal cells. ADXS-NEO works by presenting a large payload of neoantigens directly into dendritic cells within the patient's immune system to generate new cancer-fighting white blood cells. These T cells hunt down cancer ...
  http://globenewswire.com/news-release/2017/03/06/931743/0/en/Advaxis-Announces-FDA-Acceptance-of-IND-for-Groundbreaking-Personalized-Neoepitope-Immunotherapy-ADXS-NEO.html?culture=en-us
*  Advaxis Announces FDA Acceptance of IND for Groundbreaking Personalized Neoepitope Immunotherapy, ADXS-NEO Nasdaq:ADXS
This ground-breaking IND paves the way for bringing a new precision immunotherapy for the treatment of cancers into the clinic this year. ADXS-NEO employs Advaxis' proprietary Listeria monocytogenes (Lm)-based antigen delivery technology, its Lm Technology™, to target multiple patient-specific neoantigens in each individual patient's tumor that are not present in normal cells. ADXS-NEO is designed to stimulate both the innate and adaptive arms of the immune system.. Advaxis bioengineers ADXS-NEO constructs by programming its Lm-based antigen delivery technology to present the unique protein fragments or neoantigens associated with mutations found in a patient's own cancer cells. These cancer-specific mutations are identified by comparing the DNA sequences of cancer cells with normal cells. ADXS-NEO works by presenting a large payload of neoantigens directly into dendritic cells within the patient's immune system to generate new cancer-fighting white blood cells. These T cells hunt down cancer ...
  http://globenewswire.com/news-release/2017/03/06/931743/0/en/Advaxis-Announces-FDA-Acceptance-of-IND-for-Groundbreaking-Personalized-Neoepitope-Immunotherapy-ADXS-NEO.html?culture=fr-ca
*  Melanoma: immunogenic personal neoantigen vaccine | Oncology Xagena
Although neoantigens were long-envisioned as optimal targets for an anti-tumour immune response, their systematic discovery and evaluation only became feasible with the recent availability of massively parallel sequencing for detection of all coding mutations within tumours, and of machine learning approaches to reliably predict those mutated peptides with high-affinity binding of autologous human leukocyte antigen ( HL A) molecules ...
  http://oncologyonline.net/articolo/melanoma-immunogenic-personal-neoantigen-vaccine
*  Plus it
In this study, we analyzed data from whole-exome and RNA sequencing in tumors from 97 ccRCC patients and found that the number of mutations and potential neoantigens derived from them was not associated with prognosis. However, when the number of neoantigens and the expression of HLA-A or β2M were considered together, patients grouped as A-neohi/HLA-Ahi or ABC-neohi/β2Mhi had better clinical outcomes and higher expression of immune-related CD8 T-cell genes and their effector molecules. Nonetheless, the latter were not themselves correlated with prognosis, possibly due to coexpression of genes that were associated with immunosuppression in the tumor microenvironment.. It has been reported that mutational rates differ between different cancers (28). Melanomas have the highest mutational rate (median, 13.2 mutations per Mb) with non-small cell lung cancers (NSCLC) having the second highest rate (median, 8.17 and 6.43 mutations per Mb for the squamous and nonsquamous subtype, respectively; ref. ...
  http://cancerimmunolres.aacrjournals.org/content/4/5/463
*  Scientific Reports Table of Contents e-alert: 25 April 2017
Check out the latest issue of BioPharma Dealmakers for the latest dealmaking opportunities, and editorials on personalized cancer vaccines based on tumor-specific neoantigens, the expanding network of microbiome partnerships, and impending growth spurt of the dermatology market ...
  http://www.healthcareintheuk.co.uk/2017/04/scientific-reports-table-of-contents-e_25.html
*  A. Lai 30/31 Jan 2002 DIALOG CARIOCACARIOCA ?. A. Lai 30/31 Jan 2002 DIALOG DIALOG-  (Nov 2001) has 83 pins on a PGA100...
A. Lai 30/31 Jan 2002 DIALOG-CARIOCA Same board. How to assemble DIALOG and CARIOCA on F/E? - Mechanical integration is not trivial (an additional board will be needed ?!) Same technology  Integrate the two chips on the same die and put one single IC on front- end ? + (On top) (…Otherwise)
  http://slideplayer.com/slide/4152834/
*  TA LAI SPORTING GOODS ENTERPRISES CO., LTD. - Support,orthopaedic
TA LAI SPORTING GOODS ENTERPRISES CO., LTD., Experts in Manufacturing and Exporting Support,orthopaedic and 244 more Products. A Verified TW Gold Supplier on Alibaba.com.
  http://jasper.en.alibaba.com
*  Dr. Lingo Lai, MD - Winston Salem, NC - Ophthalmology | Healthgrades.com
Visit Healthgrades for information on Dr. Lingo Lai, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
  https://www.healthgrades.com/physician/dr-lingo-lai-3fg7d
*  Phuong M Lai PHD | Psychologist | Berkeley, CA | Lifescript.com
Phuong M Lai PHD is a Psychologist who practices in Berkeley, CA. Get a full report about this doctor's background by clicking here.
  http://www.lifescript.com/doctor-directory/psychology/berkeley-california-ca-phuong-m-lai-phd.aspx