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Trade Name: Decadron, Dexasone, Diodex, Hexadrol, Maxidex. For which conditions is this drug approved? Dexamethasone is used in combination with other agents for the treatment of myeloma and lymphomas. Dexamethasone may also be used to help prevent or reduce nausea and vomiting, to reduce swelling and related pressure, or as an anti-inflammatory agent. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.. What is the mechanism of action? Dexamethasone is referred to as a glucocorticoid or corticosteroid. Dexamethasone may produce anti-cancer effects through several speculated mechanisms. One such mechanism may be the inhibition of inflammatory agents in the body, ...http://cancer.unm.edu/2009/04/28/dexamethasone-sodium-phosphate/
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Dexamethasone sodium phosphate / dexamethasone sodium phosphate NDA 040572 international drug patent coverage, generic...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...https://www.drugpatentwatch.com/p/NDA/040572
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Enhanced dexamethasone resistance in cystic fibrosis cells: potential use for heterozygote detection and prenatal diagnosis |...
Cultured skin fibroblasts from patients with cystic fibrosis (CF) are more resistant to dexamethasone toxicity than are normal cells. We now report that, when fibroblasts cultured from obligate CF heterozygotes are exposed to dexamethasone, they have an intermediate survival compared to normal and homozygous CF cells. When dexamethasone survival was tested on cells from four patients undergoing amniocentesis, cells from a woman at risk of producing a child with CF showed significant dexamethasone resistance, similar to that of fibroblasts derived from lnown CF homozygotes; the other amniotic cell specimens showed dexamethasone sensitivity similar to that of normal skin fibroblasts. These data suggest that the dexamethasone resistance previously observed in skin fibroblasts may also be useful in the prenatal diagnosis of CF. ...http://science.sciencemag.org/content/201/4351/180
Study of Pomalidomide and Low Dose Dexamethasone With or Without Pembrolizumab (MK-3475) in Refractory or Relapsed and...
The purpose of this study is to compare the efficacy of pomalidomide and low dose dexamethasone with pembrolizumab (MK-3475) to that of pomalidomide and low dose dexamethasone without pembrolizumab in terms of Progression-Free Survival (PFS) in participants with refractory or relapsed and refractory multiple myeloma (rrMM) who have undergone at least 2 lines of prior treatment ...https://clinicaltrials.gov/ct2/show/NCT02576977
Effects of neonatal dexamethasone treatment on hypothalamo-pituitary adrenal axis and immune system of the rat.
Synthetic glucocorticoids (GC) are widely used drugs, also in the prevention of diseases that occur in the preterm newborn. Previously we have found that GC treatment of pregnant rats resulted in a persistent increase in the ratio of AVP over CRH inhttp://www.biomedsearch.com/nih/Effects-neonatal-dexamethasone-treatment-hypothalamo/9119981.html
Dexamethasone Regimens Alter Spatial Memory and Anxiety Levels in Mice
Acute and sub chronic effects of oral dexamethasone on anxiety and memory in mice were evaluated using the elevated plus maze, Y maze and radial arm maze. Adult male Swiss albino mice assigned to five groups were given vehicle (normal saline), a standard drug (Diazepam or Scopolamine) or one of three selected doses of dexamethasone (0.5, 1.0 and 1.5 mg/kg) daily for a period of 14 days. Behavioral tests were carried out on days 1 and 14 after administration. Results were analysed using a one-way ANOVA followed by a posthoc test (Student-Newman-Keul) and expressed as mean ± S.E.M. Elevated plus maze test showed a significant reduction in the time spent in the open arm and in the number of open arm entries compared to control. Results of radial arm and Y maze tasks showed an improvement in spatial memory following dexamethasone administration. Y maze locomotor activity was significantly increased, although radial arm maze exploration did not increase ...http://www.scirp.org/journal/PaperInformation.aspx?paperID=44698
Determining the Long-Term Effects of Prenatal Dexamethasone Treatment in Children With 21-Hydroxylase Deficiency and Their...
CAH is a genetic steroidogenesis disorder. The most common form, 21OHD, leads to cortisol deficiency and, in turn, an excess of androgen, a hormone that promotes the development and maintenance of male sex characteristics. As a result of this androgen excess, prepubescent males and newborn, prepubescent, and grown females exhibit mature masculine characteristics. Prenatal treatment with dexamethasone, a corticosteroid that decreases androgen levels, has been shown to prevent the development of abnormal genitalia in female infants. The long-term effects of this treatment, however, have not been evaluated. This study will determine whether prenatal dexamethasone treatment causes any long-term side effects by examining children and young adults who received dexamethasone as fetuses and their mothers, who were exposed to dexamethasone while pregnant.. This study has three parts. In Part 1 of the study, participants will provide written consent ...https://clinicaltrials.gov/ct2/show/NCT00617292?term=CAH&rank=11
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Analgesic Effect of Preoperative Dexamethasone in Gynecological Laparotomies - a Dose-ranging Study - Full Text View -...
The objective of the study is to examine the effect of the addition of intravenous dexamethasone 1.5 hours prior to induction of anesthesia on the post-operative opioid consumption, pain scores, fatigue, and recovery in patients undergoing gynecological surgery with laparotomy under general anesthesia.. This is a dose finding study with two different doses (0.1 mg/kg vs. 0.2 mg/kg) of dexamethasone to find out the optimal efficacious dose of dexamethasone with minimal side effects.. Dexamethasone has anti-inflammatory, immunomodulatory, and analgesic effects; and is superior to placebo in providing post-operative pain control, lower analgesic consumption, prevention of postoperative nausea and vomiting, lesser post-operative fatigue, and better recovery profile. No dose response study has been done. The investigators hypothesize that a higher dose of dexamethasone may have an incremental beneficial effect. ...https://clinicaltrials.gov/ct2/show/NCT01022528?recr=Open&cond=%22Uterine+Myomectomy%22&rank=14
Dexamethasone for Symptom Burden in Advanced Cancer Patients - Tabular View - ClinicalTrials.gov
Dexamethasone decreases inflammation and also suppresses the immune system.. If you are found to be eligible for this study, you will be randomly assigned (as in the toss of a coin) to receive either dexamethasone or a placebo by mouth in the morning and at night with food every day for 14 days. A placebo is a substance that looks like the study drug but which has no active ingredients. You will have an equal chance of being placed in either of the 2 groups. You, the medical staff, and researchers will not know to which group you have been assigned.. Beginning on Day 15 [± 3 days], regardless of if you were assigned to the dexamethasone or placebo group during the first 14 days, you will begin receiving the dexamethasone. On Days 15-21, you will receive dexamethasone 2 times a day. On Days 22-28 you will continue to take dexamethasone 2 times a day, but it will be at a lower dose level.. If you develop ...https://clinicaltrials.gov/ct2/show/record/NCT00489307
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Evaluation of Ixazomib, Lenalidomide, Dexamethasone Induction and extended Consolidation followed by Lenalidomide Maintenance...
The purpose of this study is to evaluate the sCR rate of the combination of Ixazomib, Lenalidomide with and without dexamethasone as induction and extendedhttp://adisinsight.springer.com/trials/700274011
Hypercortisolism revealed by the dexamethasone suppression test in patients [corrected] with acute ischemic stroke. | Stroke
Using the dexamethasone suppression test, we studied the activity of the hypothalamic-pituitary-adrenal axis within the first week after onset in 62 patients with acute ischemic stroke. Compared with two control groups (one comprising 25 elderly patients with various acute medical disorders and the other comprising 33 80-year-old volunteers), stroke patients had higher postdexamethasone cortisol levels (p = 0.08 and p = 0.001, respectively). By multiple regression analysis, high postdexamethasone cortisol levels in the stroke patients were significantly associated with proximity of the lesion to the frontal pole of the brain (p = 0.008) and with disorientation (p = 0.03), whereas no association with major depression was seen. Many stroke patients are exposed to hypercortisolism, which may have negative consequences upon organ functions. The extent to which dexamethasone administration suppresses cortisol levels seems to be determined mainly ...http://stroke.ahajournals.org/content/20/12/1685
Use of dexamethasone and prednisone in acute asthma exacerbations in pediatric patients | The College of Family Physicians of...
Few trials compare oral dexamethasone head-to-head with oral prednisone. In 2001, Qureshi et al14 compared 2 days of dexamethasone (0.6 mg/kg daily; maximum 16 mg/d) to 5 days of prednisone (1 mg/kg daily; maximum 60 mg/d). Dexamethasone had a similar efficacy as measured by relapse rates (7.4% vs 6.9%, P = .84), hospitalization rates (11% vs 12%), and the persistence of symptoms at 10 days (22% vs 21%). The patients treated with dexamethasone had increased compliance (99.6% vs 96%, P = .004) and fewer side effects, such as vomiting (0.3% vs 3%, P = .008). Part of the increased compliance in the dexamethasone group was believed to be owing to patients being discharged from EDs with the medication, whereas prednisone required a prescription to be filled at a pharmacy. Although dispensing medication is feasible in some EDs, it is often not an option in the ambulatory practice setting. Furthermore, ...http://www.cfp.ca/content/55/7/704.full
Systematic review and meta-analysis of early postnatal dexamethasone for prevention of chronic lung disease
Outcomes at School Age after Postnatal Dexamethasone Therapy for Lung Disease of Prematurity. Yeh, Tsu F.; Lin, Yuh J.; Lin, Hung C.; Huang, Chao C.; Hsieh, Wu S.; Lin, Chyi H.; Tsai, Cheng H. // New England Journal of Medicine;3/25/2004, Vol. 350 Issue 13, p1304 Background: We studied the outcomes at school age in children who had participated in a double-blind, placebo-controlled trial of early postnatal dexamethasone therapy (initiated within 12 hours after birth) for the prevention of chronic lung disease of prematurity. Methods: Of the 262 children... ...http://connection.ebscohost.com/c/articles/67245708/systematic-review-meta-analysis-early-postnatal-dexamethasone-prevention-chronic-lung-disease
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