Frontiers | Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally...
... focused on vaccines that make use of primary dendritic cells. Though rare in the blood, these naturally circulating dendritic ... focused on vaccines that make use of primary dendritic cells. Though rare in the blood, these naturally circulating dendritic ... Upcoming treatment paradigms aim to include several primary dendritic cell subsets in a single vaccine as preclinical studies ... Upcoming treatment paradigms aim to include several primary dendritic cell subsets in a single vaccine as preclinical studies ...https://www.frontiersin.org/articles/10.3389/fimmu.2014.00165/full
Swartz MA[au] - PubMed - NCBI
... facilitates adipose tissue inflammation and distribution of antigen to lymph node-homing adipose tissue dendritic cells. ... Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance ... Nat Cell Biol. 2015 Sep;17(9):1193-204. doi: 10.1038/ncb3228. Epub 2015 Aug 24. Erratum in: Nat Cell Biol. 2015 Oct;17(10):1370 ... Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia. ...https://www.ncbi.nlm.nih.gov/pubmed?access_num=Swartz+MA&link_type=AUTHORSEARCH&cmd=search&term=Swartz+MA%5Bau%5D&dispmax=50
KAKEN - Research Projects | Analyzes on artifical induction of antigen-specific immunological tolerance (KAKENHI-PROJECT...
Publications] Inaba,K.: 'The tissue distribution of the B7-2 costimulator in mice:abundant expression on dendritic cells in ... The tissue distribution of the B7-2 costimulator in mice : abundant expression on dendritic cells in situ and during maturation ... Publications] Inaba K.: 'The tissue distribution of the B7-2 costimulator in mice : abundant expression on dendric cells in ... Publications] Seino,K.: 'CD86 (B70/B7-2) on endothelial cells costimulates allogeneic CD4^+ T cells.' Int. Immunol.7. 1331-1337 ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05454211/
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17...
Tissue distribution analysis. For assays determining tissue distribution of transferred Vβ13+ T-cell subsets, mice with B16F10 ... B, relative infiltration of donor pmel-1 Tc17 cells compared with host CD8+ T cells, host CD4+ T cells, or host NK cells within ... Preterminal host dendritic cells in irradiated mice prime CD8+ T cell-mediated acute graft-versus-host disease. J Clin Invest ... T cells by depleting immunosuppressive host cells, such as myeloid-derived suppressor cells (MDSC), regulatory T cells (Treg), ...http://clincancerres.aacrjournals.org/content/21/11/2546
Development and Functional Characterization of Murine Tolerogenic Dendritic Cells | Protocol
... we present a protocol to develop and characterize tolerogenic dendritic cells (TolDCs) and evaluate their immunotherapeutic... ... I. Morphology, quantitation, tissue distribution. J Exp Med. 137, (5), 1142-1162 (1973). ... T cell proliferation assay. Pan Dendritic Cell Biotin-Antibody Cocktail. Miltenyi Biotec Inc.. 130-100-875. T cell ... Resuspend the cell pellet in 350 μl of MACS buffer, 50 μl of FcR Blocking Reagent, and 100 μl of Pan Dendritic Cell Biotin- ...https://www.jove.com/video/57637/development-functional-characterization-murine-tolerogenic-dendritic
What's the future in transdermal devices in swine? | National Hog Farmer
Figure 2: The distribution of dendritic cells in the epidermis, dermis and subcutaneous tissue in the pig. Dendritic cells are ... Vaccinations made at more acute or oblique angles will affect the distribution of the vaccine in the tissue. In addition, ... where they are recognized by Langerhans cells. C)Topical application of vaccines delivers vaccines to the epidermis, where they ... dose required for intramuscular vaccines because of the higher antigen dispersion and contact with the antigen presenting cells ...https://www.nationalhogfarmer.com/animal-health/what-s-future-transdermal-devices-swine
Regulatory Dendritic Cells for Immunotherapy in Immunologic Diseases
Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J ... Overview of Dendritic Cell Biology. In general, dendritic cells express MHCII but lack T cell (CD3), B cell (CD19), and NK cell ... Langerin+ migratory skin dendritic cells (i.e., CD103+ dermal dendritic cells and Langerhans cells) can promote T cell ... cells; the CD103+ cells are bona fide dendritic cells while the latter CD103− cells are now thought to be resident tissue ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3907717/
Frontiers | Dendritic cell-based vaccination in cancer: therapeutic implications emerging from murine models | Immunology
... there has been a surge of interest in exploiting these cells as a therapeutic option for the treatment of tumors of diverse ... there has been a surge of interest in exploiting these cells as a therapeutic option for the treatment of tumors of diverse ... Dendritic cells (DCs) play a pivotal role in the orchestration of immune responses, and are thus key targets in cancer vaccine ... Dendritic cells (DCs) play a pivotal role in the orchestration of immune responses, and are thus key targets in cancer vaccine ...https://www.frontiersin.org/articles/10.3389/fimmu.2015.00243/full
The Division of Biology & Biomedical Sciences
... facilitates adipose tissue inflammation and distribution of antigen to lymph node-homing adipose tissue dendritic cells. J. ... Through our studies on the migration of monocyte-derived dendritic cells and other dendritic cells through lymphatic vessels, ... Our research integrates the study of monocytes, monocyte-derived cells, and dendritic cells with vascular and lymphatic vessel ... My laboratory's research integrates the study of monocytes, monocyte-derived cells, and dendritic cells with vascular and ...http://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=6323
Cd11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells | JEM
I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137:1142-1162, pmid:4573839.. ... 1997) Dendritic cell ontogenya human dendritic cell lineage of myeloid origin. Proc. Natl. Acad. Sci. USA. 94:12551-12556, pmid ... 2000) Differentiation of myeloid dendritic cells into CD8alpha-positive dendritic cells in vivo. Blood. 96:1865-1872, pmid: ... 1997) Dendritic cells in the T-cell areas of lymphoid organs. Immunol. Rev. 156:25-37, pmid:9176697.. ...http://jem.rupress.org/content/194/8/1171
Human dendritic cell subsets.
Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also ... Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. ... The distribution of major human dendritic cell (DC) subsets in blood, epithelial tissues and lymph nodes. Broken arrows ... dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong TH17/TH1 T-cell responsesJ Allergy Clin ...http://www.biomedsearch.com/nih/Human-dendritic-cell-subsets/23621371.html
Table of Contents - June 01, 2015, 194 (11) | The Journal of Immunology
Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node-Homing Adipose Tissue Dendritic Cells Emma L ... Allogeneic Mature Human Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in the Presence of IL-15 Nicolle H. R ... T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells Madelene W. Dahlgren, ... Early Effector Cells Survive the Contraction Phase in Malaria Infection and Generate Both Central and Effector Memory T Cells ...http://www.jimmunol.org/content/194/11/
Infection of Dendritic Cells by Lymphocytic Choriomeningitis Virus | Springer for Research & Development
... comprise the major antigen-presenting cells (APCs) of the host, uniquely programmed to stimulate immunologically naïve T ... Distribution of extracellular matrix components and their receptors in human lymphoid tissue and B-cell non-Hodgkin lymphomas. ... Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 154 5071-5079PubMed ... Infection of Dendritic Cells by Lymphocytic Choriomeningitis Virus. In: Steinkasserer A. (eds) Dendritic Cells and Virus ...https://rd.springer.com/chapter/10.1007/978-3-662-06508-2_6
Literature: CXC chemokine receptor 3 (IPR004070) | InterPro | EMBL-EBI
CXCR3 chemokine receptor distribution in normal and inflamed tissues: expression on activated lymphocytes, endothelial cells, ... and dendritic cells.. Garcia-Lopez MA, Sanchez-Madrid F, Rodriguez-Frade JM, Mellado M, Acevedo A, Garcia MI, Albar JP, ... Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis.. Frigerio S, Junt T, Lu B, Gerard C, Zumsteg U ... Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.. Panzer U, Steinmetz ...http://www.ebi.ac.uk/interpro/entry/IPR004070/literature
Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing | JEM
A similar distribution of CD103+ DCs has been reported in the mouse (20). We also confirm the findings of Kilshaw (20) that ... T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J. Exp. Med. ... LP dendritic cells are potent in generating CCR9+α4β7+ CD8+ T cells. OT-I cells were activated in vitro with SIINFEKL peptide- ... Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. Bengt Johansson- ...http://jem.rupress.org/content/202/8/1063
Altered dendritic cell distribution pattern and increased tissue cyclooxygenase-2 mRNA level in colorectal adenoma and ... Distinct changes of dendritic cell number and IL-12 mRNA level in adjacent mucosa throughout the colorectal adenoma-carcinoma ... particularly in adjust dendritic cell function. Co-laboration with other projects in the research lab: PhD projects cand med ... In this subproject, cytokines and immune cell populations will be examined by molecular biological techniques pre- and post- ...https://forskningsprosjekter.ihelse.net/prosjekt/SFP%2044-04
Presence and phenotype of dendritic cells in uveal melanoma
... dendritic morphology. Moreover, their distribution suggests that they can actively migrate within the tissue and concentrate in ... positive cells were absent in residual normal eye tissue. FXIIIa‐positive cells were present deep within the tumour tissue, and ... Expression of dendritic cell markers in uveal melanoma. The photographs (×200) show the typical distribution of (A) CD68‐ ... 0.0027, paired ANOVA). Cells expressing HLA‐DR were slightly more dendritic than CD68, but far less than FXIIIa‐positive cells ...http://pubmedcentralcanada.ca/pmcc/articles/PMC1955657/
Frontiers | Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation | Physiology
pDCs also contribute to the proinflammatory activation of effector T cells, cytotoxic T cells, and conventional DCs. However, ... pDCs also contribute to the proinflammatory activation of effector T cells, cytotoxic T cells, and conventional DCs. However, ... through down-regulation of function and proliferation of proinflammatory T cell subsets and induction of regulatory T cells ... through down-regulation of function and proliferation of proinflammatory T cell subsets and induction of regulatory T cells ...https://www.frontiersin.org/articles/10.3389/fphys.2014.00279/full
In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination | JEM
Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. II. Expression in situ in ... In vivo depletion of CD11c+ dendritic cells abrogation priming of CD8+ T cells by exogenous cell-associated antigens. Immunity. ... Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194:769-780. ... Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal ...http://jem.rupress.org/content/199/6/815
Humanized mice | JEM
Development and activation of human dendritic cells in vivo in a xenograft model of human hematopoiesis. Stem Cells. 23:264-278 ... with appropriate tissue distribution and function. Deep lung viremia and production of inflammatory cytokines result after ... dendritic cells, peripheral blood monocytes, or liver cell lines, which can support virus infection and growth. Joseph Blaney ( ... Human dendritic cell subsets in NOD/SCID mice engrafted with CD34+ hematopoietic progenitors. Blood. 102:3302-3310. ...http://jem.rupress.org/content/202/10/1307
Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via...
Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. I. Expression on dendritic ... dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells. J. Immunol. 166: 5327-5330. ... T cells in an inflammatory context is required. Only dendritic cells (DC) as professional APCs can prime naive CD8+ T cells to ... dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα. ...http://www.jimmunol.org/content/194/3/1069
Intracerebral Dendritic Cells Critically Modulate Encephalitogenic versus Regulatory Immune Responses in the CNS | Journal of...
1999) Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and ... 2005) Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells. J Immunol 174:3941- ... injections of stimulatory dendritic cells. The accumulation of activated neuroantigen-specific T cells in the nervous tissue is ... Numbers in quadrants indicate percent positive cells. C, Absolute number of CD4+ Vβ11+LFA-1highCFSElow T cells in brain tissue ...http://www.jneurosci.org/content/29/1/140
Two Cases of Solitary Fibrous Tumor Involving Urinary Bladder and a Review of the Literature
... which express CD34 and have generalized distribution in tissues, a feature that helps to recognize them in other organs [2, 3]. ... they do not derive from the mesothelium but rather from dendritic interstitial cells, ... The tumor consisted of irregularly dispersed cells in a so-called patternless. The cells were rounded and spindle-shaped with ... The tumor cells were immunoreactive to CD34, CD99, c-kit, and Bcl-2 and they were negative for CD117 (c-kit), anaplastic ...https://www.hindawi.com/journals/criu/2016/5145789/
Mouse Cell Surface Antigens: Nomenclature and Immunophenotyping | The Journal of Immunology
The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus. Cell. ... The anti-Ly-71 (F4/80) mAb has been used extensively in determining the distribution and function of mouse tissue macrophages ( ... Limiting dilution analysis of CD45Rhi and CD45Rlo T cells: further evidence that CD45Rlo cells are memory cells. Cell. Immunol. ... The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375: ...http://www.jimmunol.org/content/160/8/3861
Dendritic cell - Wikipedia
"Identification of a Novel Cell Type in Peripheral Lymphoid Organs of Mice : I. Morphology, Quantitation, Tissue Distribution". ... Dendritic cells have also been found in chickens and turtles. A dendritic cell Play media A well-resolved dendritic cell drags ... concurrent interaction of all three cell types, namely CD4+ T helper cells, CD8+ T cells and dendritic cells, seems to be ... The morphology of dendritic cells results in a very large surface-to-volume ratio. That is, the dendritic cell has a very large ...https://en.wikipedia.org/wiki/Dendritic_cell