US20020098199A1 - Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences -...
The polynucleotide is not administered with a HCV or HBV antigen. Administration of the polynucleotide results in amelioration ... secretion of cytokines, activation or expansion of lymphocyte populations such as NK cells, CD4 + T lymphocytes, CD8+ T ... whereas the Th2 subset functions more effectively as a helper for B-cell activation. The type of immune response to an antigen ... Methods for increasing a cytotoxic t lymphocyte response in vivo CA2405424A1 (en) 2000-04-07. 2001-10-18. The Regents Of The ...https://patents.google.com/patent/US20020098199A1/en
Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes |...
aAPC-expanded TILs undergo numerical expansion of tumor antigen-specific cells, remain amenable to secondary aAPC-based ... To facilitate adoptive immunotherapy, we applied genetically-engineered K562 cell-based artificial antigen presenting cells ( ... Development of a standardized platform for the rapid expansion of tumor-infiltrating lymphocytes (TILs) with anti-tumor ... Alternatively, enrichment for particular T cell subsets, such as cytotoxic CD8+ T cells, may improve overall TIL potency and ...https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-9-131
Frontiers | NFAT2 Regulates Generation of Innate-Like CD8+ T Lymphocytes and CD8+ T Lymphocytes Responses | Immunology
NFAT2 absence did not influence significantly differentiation of CD8+ T cells into cytotoxic effector cells, but reduced theirs ... As reports are mainly focused on the role of NFAT2 in CD4+ T lymphocytes activation and differentiation, we decided to ... As reports are mainly focused on the role of NFAT2 in CD4+ T lymphocytes activation and differentiation, we decided to ... Only the NFAT2-/-/Rag-1-/- chimeric mice model gave insight into the role of NFAT2 transcription factor in T lymphocyte ...https://www.frontiersin.org/articles/10.3389/fimmu.2016.00411/full
Frontiers | Epigenomic Views of Innate Lymphoid Cells | Immunology
The parallelism between ILCs and T cells extends beyond these two cell types and comprises other innate-like T lymphocytes. ... The parallelism between ILCs and T cells extends beyond these two cell types and comprises other innate-like T lymphocytes. ... Beyond the recognition of specialized effector functionalities in diverse lymphocytes, features typical of T cells, such as ... Beyond the recognition of specialized effector functionalities in diverse lymphocytes, features typical of T cells, such as ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.01579/full
SLAMF7 Gene - GeneCards | SLAF7 Protein | SLAF7 Antibody
Novel LY9 (Lymphocyte Antigen 9) Like Protein 3 * CD2-Like Receptor Activating Cytotoxic Cells 3 ... Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin ... In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528). *SLAF7_HUMAN,Q9NQ25 ... Suggested Antigen Peptide Sequences for SLAMF7 Gene. GenScript: Design optimal peptide antigens:. *cDNA FLJ78403, highly ...https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLAMF7&keywords=GH01I160732&prefilter=genomic_location
Innate immunity recovers earlier than acquired immunity during severe postoperative immunosuppression
Lymphocytes, B cells, T cells, T helper cells and cytotoxic T cells from day of surgery before surgery (od) until day 5 after ... The Th2 cytokines IL-4, IL-5 and IL-10 did not show any differences after surgery (Figure 5D, E, F). ... Acquired immune cells und subsets. Lymphocytes showed significant differences from od until pod5 (p = 0.007; Figure 4A) and ... monocytes and T lymphocytes with antigen presentation and consequent T cell response are essential for adequate immune function ...http://www.medsci.org/v15p0001.htm
Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory...
Tr1 cells use multiple suppressive mechanisms, IL-10 and TGF-beta as secreted cytokines, and cytotoxic T lymphocyte antigen 4 ... Healthy and allergic individuals exhibit all three allergen-specific subsets in different proportions, indicating that a change ... Show others and affiliations. 2004 (English)In: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 199, ... Tr1 cells consistently represent the dominant subset specific for common environmental allergens in healthy individuals; in ...http://kth.diva-portal.org/smash/record.jsf?pid=diva2:1088046
EBV-Specific CD8+ T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function |...
Five new cytotoxic T cell epitopes identified within Epstein-Barr virus nuclear antigen 3. J. Gen. Virol. 75: 2489. ... Intracellular cytokines produced by CD8+ lymphocytes were detected by initially incubating PBMCs at room temperature for 30 min ... Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708. ... 8⇓ (left), gated on tetramer-positive CD8+ cells, show that most if not all of the CCR7+ fraction are CD45ROhigh, CD28+ and ...http://www.jimmunol.org/content/167/4/2019
Lymphocyte - Wikipedia
Effector lymphocytes function to eliminate the antigen, either by releasing antibodies (in the case of B cells), cytotoxic ... Some lymphocytes show a clear perinuclear zone (or halo) around the nucleus or could exhibit a small clear zone to one side of ... "Lymphocyte subsets in term and significantly preterm UK infants in the first year of life analysed by single platform flow ... cytokines using intracellular cytokine staining (ICCS)). In order to study the function of a lymphocyte by virtue of the ...https://en.wikipedia.org/wiki/Lymphocyte
Frontiers | Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally...
... dendritic cell subsets in a single vaccine as preclinical studies identified synergistic effects between various antigen- ... Upcoming treatment paradigms aim to include several primary dendritic cell subsets in a single vaccine as preclinical studies ... identified synergistic effects between various antigen-presenting cells. ... Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor ...https://www.frontiersin.org/articles/10.3389/fimmu.2014.00165/full
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity |...
... whilst MyD88-deficient mice show a profound impairment of Th1 cytokines, TLR2-deficient mice show greatly enhanced Th1 and Tc1 ... Human cytotoxic T lymphocyte responses to live attenuated 17D yellow fever vaccine: identification of HLA-B35-restricted CTL ... Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression. J. Exp. Med. 196:1017- ... IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced ...http://jem.rupress.org/content/203/2/413
Frontiers | The Role of Invariant Natural Killer T Cells in Dendritic Cell Licensing, Cross-Priming, and Memory CD8+ T Cell...
... thereby inducing a similar set of costimulatory molecules and cytokines in DC. This form of licensing differs from Th cell help ... thereby inducing a similar set of costimulatory molecules and cytokines in DC. This form of licensing differs from Th cell help ... NKT cells produce a broad spectrum of Th1 and Th2 cytokines, ... NKT cells produce a broad spectrum of Th1 and Th2 cytokines, ... by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int ...https://www.frontiersin.org/articles/10.3389/fimmu.2015.00379/full
US5587302A - T cell growth factor - Google Patents
Monoclonal antibodies to cytotoxic lymphocyte maturation factor US4847201A (en) 1989-07-11. DNA encoding for CSF-1 and ... To investigate whether P40 is elaborated by a particular subset of T lymphocytes, T cells were purified by nylon wool ... The detection of antibody production can be carried out by testing the antisera with appropriately labeled antigen. Lymphocytes ... Cytokines have been recognized which mediate host defense against cancer and/or infection. Such cytokines include the ...https://patents.google.com/patent/US5587302?oq=U.S.+Patent+
Protocols and Video Articles Authored by Huey-Kang Sytwu (Translated to Swedish)
Moreover, we demonstrated using an antigen-specific re-stimulation test to analyze the effector function of lymphocyte subsets ... In general, the Th1-type cytokines and cytotoxic T-cells are detected consistently in a host who is undergoing rejection, ... Together, our data show that in EAE, EPO induction of endogenous HO-1 and modulation of adaptive immunity both centrally and ... Invariant natural killer T (iNKT) cells are a unique subset of lymphocytes that control peripheral tolerance. Mounting evidence ...https://www.jove.com/author/Huey-Kang_Sytwu?language=Swedish
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Immunology, Issue 80, Virus Diseases, Immune System Diseases, HIV, CD4 T cell, CD8 T cell, antigen-presenting cell, Cytokines, ... GB virus C infection is associated with altered lymphocyte subset distribution and reduced T cell activation and proliferation ... The purified infected primary T-cell blasts can then be used as targets in either a degranulation or cytotoxic assay with ... Early studies evaluating NK cell cytolytic responses to primary HIV-infected cells failed to show significant killing of the ...https://www.jove.com/visualize/abstract/23209780/gb-virus-c-infection-is-associated-with-altered-lymphocyte-subset
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy
Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural ... Natural killer cells (NKs) are innate immune cells that, in addition to producing pro-inflammatory cytokines, are cytotoxic ... In vivo, MSCs are also postulated to not only support the viability of naïve, but also more differentiated, B cell subsets in ... DCs take up antigen and during maturation and activation up-regulate MHCs, increase the expression of co-stimulatory molecules ...https://www.wjgnet.com/1948-0210/full/v6/i5/526.htm
Lymphoid Hematopoiesis and Lymphocytes Differentiation and Maturation | IntechOpen
Lymphoid Hematopoiesis and Lymphocytes Differentiation and Maturation , IntechOpen, Published on: 2017-07-12. Authors: Luciana ... In response to distinct antigen challenge and extracellular cytokines signals, each CD4+ T cell subset has distinct abilities ... CD8+ cytotoxic T lymphocytes (CTLs) subsets. Similar to T CD4+ cells, naïve CD8+ T cells differentiate into effector T cells ( ... CD56dimNK cells are mainly in peripheral blood and show potent cytolytic activity and fast release of IFN‐γ and other cytokines ...https://www.intechopen.com/books/lymphocyte-updates-cancer-autoimmunity-and-infection/lymphoid-hematopoiesis-and-lymphocytes-differentiation-and-maturation/
Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in...
Both CD4 and CD8 antigens were originally described as antigen coreceptors on helper and cytotoxic/suppressor T lymphocytes, ... Further analysis of T cell subsets showed that the populations of CD4+ and CD8+ T cells increased significantly (Fig. 5). In ... Cytokines measure. Commercially available rat ELISA kits were used to quantify tissue TNF-α, IL-6, and plasma norepinephrine ( ... In summary, our results show that NLRP3 plays a key role in prehypertensive rats induced by high-salt diet, via an inflammatory ...https://link.springer.com/article/10.1186/s12974-018-1131-7
Treatment of Inflammatory Macular Edema with Humanized Anti-CD11a Antibody Therapy | IOVS | ARVO Journals
... antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J Immunol. 1986;136:4480-4486. [PubMed] ... Human NK cells have typically been identified as CD56+CD3− lymphocytes, with two subsets of human NK cells identified based on ... Laboratory and renal and liver function test results had to be normal or to show mild abnormalities, no worse than those ... higher secretion of downregulatory cytokines, and unique surface receptor expression profile. 14,16 -18 Previous studies have ...http://iovs.arvojournals.org/article.aspx?articleid=2188419
Roles of repressive epigenetic machinery in lineage decision of T cells - Naito - 2013 - Immunology - Wiley Online Library
T lymphocytes develop in the thymus, and thymocyte progenitors give rise to several distinct T-cell subsets under various ... nor the cytotoxic lineage-affiliated genes, suggesting that the deregulated production of high amounts of cytokines is a ... MBD2 knockout mice did not show any significant developmental arrest during T-lymphocyte development. However Mbd2−/− CD4+ ... Previous article in issue: Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity ...http://onlinelibrary.wiley.com/doi/10.1111/imm.12058/full
Frontiers | Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection | Immunology
This function is further pronounced in perforin-deficient mice that show the enhanced NK-cell proliferation and cytokine ... This function is further pronounced in perforin-deficient mice that show the enhanced NK-cell proliferation and cytokine ... Depletion of Lymphocyte Subsets and the Determination of Viral Titers In Vivo. The depletion of NK cells in vivo was performed ... C) On days 1.5 and 4 p.i., serum levels of the indicated cytokines were determined. (D) On days 1.5, 4.5, and 6 p.i., mice were ...https://www.frontiersin.org/articles/10.3389/fimmu.2016.00133/full
CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo | JEM
... the transferred antigen-pulsed DCs are triggered to release IL-12 upon antigen-specific interaction with T lymphocytes in vivo ... 1988) Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275-283. ... it is of major interest to identify the factors that influence the differentiation of distinct Th cell subsets in vivo. We show ... CD95L has been shown to recruit neutrophils and activate their cytotoxic machinery, leading to local inflammation ((29)). As ...http://jem.rupress.org/content/189/3/587?ijkey=6acace1285417cacab63f2402774cab9fef14ef9&keytype2=tf_ipsecsha
Temozolomide for immunomodulation in the treatment of glioblastoma, Neuro-Oncology | 10.1093/neuonc/noy072 | DeepDyve
... checkpoint blockade to create resistance to Treg-induced immunosuppression.60 They found that cytotoxic T lymphocyte antigen 4 ... Serial changes in lymphocyte subsets in patients with newly diagnosed high grade astrocytomas treated with standard radiation ... In addition to direct effects on lymphocytes, temozolomide results in a relatively increased abundance of cytokines and ... Additionally, bevacizumab, which inhibits vascular endothelial growth factor, did not show benefit when added to radiotherapy- ...https://www.deepdyve.com/lp/ou_press/temozolomide-for-immunomodulation-in-the-treatment-of-glioblastoma-X1NdrGHWCL
Protocols and Video Articles Authored by Stuart I. Mannering (Translated to Arabic)
Cytotoxic T-lymphocyte-mediated Killing of Human Pancreatic Islet Cells in Vitro Human Immunology. Sep, 2008 , Pubmed ID: ... Our findings show that pathogenic T cells in celiac disease show limited diversity, and therefore suggest that peptide-based ... Our approach was to prepare spleen extract from the islet donors (allo-antigen) and islet extracts (auto-antigen). To our ... and one plasmacytoid DC subset characterized by CD304 expression. Human DC subsets in spleen were very similar to those in ...https://www.jove.com/author/Stuart+I._Mannering?language=Arabic
Federal Register :: Government-Owned Inventions; Availability for Licensing
TIL are a subset of T cells found within tumors that have high specificity for the antigen(s) expressed by that tumor. ... Description of Technology: Scientists at the National Institutes of Health (NIH) have developed cytotoxic, CD8+ T lymphocyte (T ... However, detection of SDHB-related PHEOs/PGLs can be difficult as up to ten percent do not show elevated stress hormone ... Effective in reducing proinflammatory cytokines than existing agents. Development Stage: *Prototype. *Clinical ...https://www.federalregister.gov/documents/2012/03/28/2012-7420/government-owned-inventions-availability-for-licensing