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*  Glycine receptor subunit alpha-1
Ion channel. *Neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family ... in a phenylalanine to leucine amino acid change in position 235 and for a T-to-C base transition resulting in a cysteine to ... Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by ... GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY].. 26079326. 2015. Length of the TM3-4 loop of the glycine receptor ...
  https://pharos.nih.gov/idg/targets/P23415
*  Ligand-gated ion channel - Wikipedia
The cys-loop receptors are named after a characteristic loop formed by a disulfide bond between two cysteine residues in the N ... In contrast to ligand-gated ion channels, there are also receptor systems in which the receptor and the ion channel are ... If these receptors are ligand-gated ion channels, a resulting conformational change opens the ion channels, which leads to a ... GABAA receptors are ligand-gated ion channels. GABA (gamma-aminobutyric acid), the endogenous ligand for these receptors, is ...
  https://en.wikipedia.org/wiki/Ligand-gated_ion_channel
*  Closed-loop control of zebrafish behaviour in three dimensions using a robotic stimulus.
Cysteine Loop Ligand-gated Ion Channel Receptors. A subfamily of ligand-gated ion channel receptors that share a characteristic ... These receptors typically contain five subunits with the cysteine-loop occurring near an N-terminal extracellular domain. ... Closed-loop versus open-loop.. The aim of this review is to evaluate whether open-loop or closed-loop neocortical electrical ... Closed-loop Glucose Control for Automated Management of Type 1 Diabetes. We hypothesize that our integrated closed-loop glucose ...
  https://www.bioportfolio.com/resources/pmarticle/1938949/Closed-loop-control-of-zebrafish-behaviour-in-three-dimensions-using-a-robotic.html
*  Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of...
... a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility. J Biol Chem ... 2011) Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC. PLoS Biol 9:e1001101. ... Reversal of ion-charge selectivity renders the pentameric ligand-gated ion channel GLIC insensitive to anaesthetics ... The Role of Intracellular Linkers in Gating and Desensitization of Human Pentameric Ligand-Gated Ion Channels ...
  https://www.pnas.org/content/109/16/6331.long
*  Recent questions and answers in Receptors, Biogenic Amine - lookformedical.com
Cysteine Loop Ligand-Gated Ion Channel Receptors (0) * Folate Receptors, GPI-Anchored (0) ... I don't understand why blocking endorphin receptors with LDN helps aleviate Parkinson's symptoms. ... Receptors, Artificial (0) * Receptors, Autocrine Motility Factor (0) * Receptors, Biogenic Amine (1) * Receptors, Catecholamine ...
  https://lookformedical.com/answers/en/chemicals-and-drugs/amino-acids-peptides-and-proteins/proteins/membrane-proteins/receptors-cell-surface/receptors-biogenic-amine
*  No questions in Receptors, Urokinase Plasminogen Activator - lookformedical.com
An extracellular receptor specific for UROKINASE-TYPE PLASMINOGEN ACTIVATOR. It is attached to the cell membrane via a ... Cysteine Loop Ligand-Gated Ion Channel Receptors (0) * Folate Receptors, GPI-Anchored (0) ...
  https://lookformedical.com/answers/en/chemicals-and-drugs/amino-acids-peptides-and-proteins/proteins/membrane-proteins/receptors-cell-surface/receptors-urokinase-plasminogen-activator
*  No questions in Receptors, Serotonin, 5-HT3 - lookformedical.com
The cation channels are formed from 5 receptor subunits. When stimulated the receptors allow the selective passage of SODIUM; ... A subclass of serotonin receptors that form cation channels and mediate signal transduction by depolarizing the cell membrane. ... Cysteine Loop Ligand-Gated Ion Channel Receptors (0) * Folate Receptors, GPI-Anchored (0) ... Receptors, Biogenic Amine (1) * Receptors, Catecholamine (1) * Receptors, Histamine (0) * Receptors, Serotonin (1) * Receptors ...
  https://lookformedical.com/answers/en/chemicals-and-drugs/amino-acids-peptides-and-proteins/proteins/membrane-proteins/receptors-cell-surface/receptors-biogenic-amine/receptors-serotonin/receptors-serotonin-5-ht3
*  Receptors, Nicotinic | Colorado PROFILES
Ligand-Gated Ion Channels [D12.776.157.530.400.400]. *Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400 ... Ligand-Gated Ion Channels [D12.776.543.550.425.500]. *Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.425.500 ... Ligand-Gated Ion Channels [D12.776.543.585.400.500]. *Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500 ... Below are MeSH descriptors whose meaning is related to "Receptors, Nicotinic".. *Cysteine Loop Ligand-Gated Ion Channel ...
  https://profiles.ucdenver.edu/display/222364
*  Frontiers | Identification of Glycine Receptor α3 as a Colchicine-Binding Protein | Pharmacology
In this study, by using IFPTarget and ligand similarity ensemble approach (SEA), we show that the glycine receptor alpha 3 ( ... we show that the glycine receptor alpha 3 (GlyRa3), which play a key role in the processing of inflammatory pain, is a ... In this study, by using IFPTarget and ligand similarity ensemble approach (SEA), ... GlyRα3 is a member of the cysteine loop (Cys-loop) superfamily of ligand-gated ion channels and has been identified to have ...
  https://www.frontiersin.org/articles/10.3389/fphar.2018.01238/full
*  Multiple Pharmacophores for the Selective Activation of Nicotinic α7-Type Acetylcholine Receptors | Molecular Pharmacology
5HT3 receptors are members of the cysteine-loop superfamily of ligand-gated ion channels, and, like α7 nAChR, 5HT3 receptor ... functional groups of the receptor-bound drugs may interfere with the conformational changes required for channel gating, and ... including muscle-type receptors. In contrast to the heteromeric receptors, for the homomeric α7 receptors of the brain, choline ... Mazurov A, Hauser T, and Miller CH (2006) Selective alpha7 nicotinic acetylcholine receptor ligands. Curr Med Chem 13: 1567- ...
  http://molpharm.aspetjournals.org/content/74/6/1496
*  Cys-loop receptor - Wikipedia
... as well as non-Cys-loop eukaryotic receptors, and is referred to as "pentameric ligand-gated ion channels", or "Pro-loop ... is because this type of receptors possess a characteristic loop formed by 13 highly conserved amino acids between two cysteine ... Jaiteh M, Taly A, Hénin J (2016). "Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors". PLoS One. 11 (3): ... the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels ...
  https://en.wikipedia.org/wiki/Cys-loop_receptor
*  GABA receptor - Wikipedia
Fast-responding GABA receptors are members of a family of Cys-loop ligand-gated ion channels. Members of this superfamily, ... GABAA receptors, glycine and 5-HT3 receptors, possess a characteristic loop formed by a disulfide bond between two cysteine ... GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein- ... Chebib M, Johnston GA (April 2000). "GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology". J. ...
  https://en.wikipedia.org/wiki/GABA_receptor
*  Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors. | Laboratoire de Biochimie Théorique
... some of which are metazoan-like Cys-loop receptors, and others devoid of Cys-loop cysteines, like their prokaryotic relatives. ... Pro-Loop Receptors.. By jhenin 28 / Mar / 2017 Title. Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors.. ... Pentameric ligand-gated ion channels (pLGICs) are ubiquitous neurotransmitter receptors in Bilateria, with a small number of ... "Pro loop" for that motif, and "Pro-loop receptors" for the superfamily. The infered molecular phylogeny shows a Cys-loop and a ...
  http://www-lbt.ibpc.fr/node/2359
*  Neuromuscular junction - Wikipedia
... which is a ligand-gated ion channel. Each subunit of this receptor has a characteristic "cys-loop," which is composed of a ... The two cysteine residues form a disulfide linkage which results in the "cys-loop" receptor that is capable of binding ... nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can ... acetylcholine and other ligands. These cys-loop receptors are found only in eukaryotes, but prokaryotes possess ACh receptors ...
  https://en.wikipedia.org/wiki/Neuromuscular_junction
*  Agonist-Driven Conformational Changes in the Inner β-Sheet of α7 Nicotinic Receptors | Molecular Pharmacology
Cys-loop ligand-gated ion channels assemble as pentameric proteins, and each monomer contributes two structural elements: an ... transmembrane ion channel domain; AChBP, acetylcholine binding protein; SCAM, substituted-cysteine accessibility method; MTSEA ... The two major structural elements of these receptors are the ligand binding site and the ion channel. The ligand binding site ... Targeted molecular dynamics study of c-loop closure and channel gating in nicotinic receptors. PLoS Comput Biol 2: 1173-1184. ...
  http://molpharm.aspetjournals.org/content/71/5/1312
*  Molecular characterization of binding loop E in the nematode cys-loop GABA receptor | Molecular Pharmacology
Nematodes exhibit a vast array of cys-loop ligand-gated ion channels with unique pharmacological characteristics. However, many ... In this study, we examined each amino acid in one of the main agonist binding loops (loop E) via the substituted cysteine ... Molecular characterization of binding loop E in the nematode cys-loop GABA receptor. Ariel Kwaka, Mohammad H Khatami, Joshua ... Molecular characterization of binding loop E in the nematode cys-loop GABA receptor. Ariel Kwaka, Mohammad H Khatami, Joshua ...
  http://molpharm.aspetjournals.org/content/early/2018/09/07/mol.118.112821
*  Molecular Characterization of Binding Loop E in the Nematode Cys-Loop GABA Receptor | Molecular Pharmacology
Nematodes exhibit a vast array of cys-loop ligand-gated ion channels with unique pharmacologic characteristics. However, many ... In this study, we examined each amino acid in one of the main agonist binding loops (loop E) via the substituted cysteine ... Molecular Characterization of Binding Loop E in the Nematode Cys-Loop GABA Receptor. Ariel Kwaka, Mohammad Hassan Khatami, ... The nematode cys-loop GABA receptor uncoordinated 49 (UNC-49) is an important receptor found at neuromuscular junctions that ...
  http://molpharm.aspetjournals.org/content/94/5/1289
*  Functional group interactions of a 5-HT3R antagonist | BMC Biochemistry | Full Text
The cysteine-loop family of ligand gated ion channels (LGIC) is comprised of receptors with pentameric quaternary structure and ... Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels. J Membr. Biol,. 1993 ... The region of this protein homologous to loop E and loop D of the 5-HT3A receptor suggests a loop structure from Y140 to Y152 ... Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor superfamily. Nature. 1987, 328: 221-227 ...
  https://bmcbiochem.biomedcentral.com/articles/10.1186/1471-2091-3-16
*  Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the...
The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function. Biochem Soc Trans. 2004;32 ... cysteine-cysteine-glycine) motif in the large extracellular loop 2. Part b The example here, MS4A2, is one of the two ... Evolutionary history of the ligand-gated ion-channel superfamily of receptors. Trends Neurosci. 1995;18:121-7.View Article ... Ligand-gated ion channels: new insights into neurological disorders and ligand recognition. Chem Rev. 2012;112:6285-318.View ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2592-7
*  Three-finger toxin - Wikipedia
... a family of ligand-gated ion channels. 3FTx binding interferes with cholinergic intercellular signaling particularly at ... Some, such as irditoxin, are heterodimers linked by cysteines in loops I and II. Others, such as alpha-cobrotoxin, can form ... a family of G-protein-coupled receptors. Muscarinic toxins can be either receptor agonists or receptor antagonists, and in some ... "Black mamba venom peptides target acid-sensing ion channels to abolish pain". Nature. 490 (7421): 552-555. doi:10.1038/ ...
  https://en.wikipedia.org/wiki/Three-finger_toxin
*  Drosophila Rdl protein Summary Report | CureHunter
... receptor gene; amino acid sequence given in first source ... Cysteine Loop Ligand-Gated Ion Channel Receptors: 3*GABA-A ... Ligand-Gated Ion Channels: 82*Cysteine Loop Ligand-Gated Ion Channel Receptors: 3*GABA-A Receptors: 2016*Drosophila Rdl protein ... Ligand-Gated Ion Channels: 82*Cysteine Loop Ligand-Gated Ion Channel Receptors: 3*GABA-A Receptors: 2016*Drosophila Rdl protein ... Cysteine Loop Ligand-Gated Ion Channel Receptors: 3*GABA-A Receptors: 2016*Drosophila Rdl protein ...
  http://www.curehunter.com/public/keywordSummaryC082030-Drosophila-Rdl-protein.do
*  Anti-LGICZ1/zacn antibody (ab103664)
... ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels. There are 3 ... Ligand gated ion channel receptor L2 antibody. *Ligand gated ion channel zinc activated 1 antibody ...
  https://www.abcam.com/lgicz1-antibody-ab103664.html
*  GABRB3 - Wikipedia
GABRB3 encodes a member of the ligand-gated ion channel family. The encoded protein is one of at least 13 distinct subunits of ... structure of the human β3 homopentamer revealed unique qualities that are only observed in eukaryotic cysteine-loop receptors. ... GABAA receptor function is inhibited by zinc ions. The ions bind allosterically to the receptor, a mechanism that is critically ... a ligand-gated ion channel. The beta-3 subunit is expressed at different levels within the cerebral cortex, hippocampus, ...
  https://en.wikipedia.org/wiki/GABRB3