*  Glycine receptor subunit alpha-1
Ion channel. *Neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family ... in a phenylalanine to leucine amino acid change in position 235 and for a T-to-C base transition resulting in a cysteine to ... Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by ... GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY].. 26079326. 2015. Length of the TM3-4 loop of the glycine receptor ...
  https://pharos.nih.gov/idg/targets/P23415
*  Receptors, Nicotinic | Colorado PROFILES
Ligand-Gated Ion Channels [D12.776.157.530.400.400]. *Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400 ... Ligand-Gated Ion Channels [D12.776.543.550.425.500]. *Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.425.500 ... Ligand-Gated Ion Channels [D12.776.543.585.400.500]. *Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500 ... Below are MeSH descriptors whose meaning is related to "Receptors, Nicotinic".. *Cysteine Loop Ligand-Gated Ion Channel ...
  https://profiles.ucdenver.edu/display/222364
*  Multiple Pharmacophores for the Selective Activation of Nicotinic α7-Type Acetylcholine Receptors | Molecular Pharmacology
5HT3 receptors are members of the cysteine-loop superfamily of ligand-gated ion channels, and, like α7 nAChR, 5HT3 receptor ... functional groups of the receptor-bound drugs may interfere with the conformational changes required for channel gating, and ... including muscle-type receptors. In contrast to the heteromeric receptors, for the homomeric α7 receptors of the brain, choline ... Mazurov A, Hauser T, and Miller CH (2006) Selective alpha7 nicotinic acetylcholine receptor ligands. Curr Med Chem 13: 1567- ...
  http://molpharm.aspetjournals.org/content/74/6/1496
*  Cys-loop receptor - Wikipedia
... as well as non-Cys-loop eukaryotic receptors, and is referred to as "pentameric ligand-gated ion channels", or "Pro-loop ... is because this type of receptors possess a characteristic loop formed by 13 highly conserved amino acids between two cysteine ... Jaiteh M, Taly A, Hénin J (2016). "Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors". PLoS One. 11 (3): ... the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels ...
  https://en.wikipedia.org/wiki/Cys-loop_receptor
*  Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors. | Laboratoire de Biochimie Théorique
... some of which are metazoan-like Cys-loop receptors, and others devoid of Cys-loop cysteines, like their prokaryotic relatives. ... Pro-Loop Receptors.. By jhenin 28 / Mar / 2017 Title. Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors.. ... Pentameric ligand-gated ion channels (pLGICs) are ubiquitous neurotransmitter receptors in Bilateria, with a small number of ... "Pro loop" for that motif, and "Pro-loop receptors" for the superfamily. The infered molecular phylogeny shows a Cys-loop and a ...
  http://www-lbt.ibpc.fr/node/2359
*  GABA receptor - Wikipedia
Fast-responding GABA receptors are members of a family of Cys-loop ligand-gated ion channels. Members of this superfamily, ... GABAA receptors, glycine and 5-HT3 receptors, possess a characteristic loop formed by a disulfide bond between two cysteine ... GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein- ... Chebib M, Johnston GA (April 2000). "GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology". J. ...
  https://en.wikipedia.org/wiki/GABA_receptor
*  Agonist-Driven Conformational Changes in the Inner β-Sheet of α7 Nicotinic Receptors | Molecular Pharmacology
Cys-loop ligand-gated ion channels assemble as pentameric proteins, and each monomer contributes two structural elements: an ... transmembrane ion channel domain; AChBP, acetylcholine binding protein; SCAM, substituted-cysteine accessibility method; MTSEA ... The two major structural elements of these receptors are the ligand binding site and the ion channel. The ligand binding site ... Targeted molecular dynamics study of c-loop closure and channel gating in nicotinic receptors. PLoS Comput Biol 2: 1173-1184. ...
  http://molpharm.aspetjournals.org/content/71/5/1312
*  Neuromuscular junction - Wikipedia
... which is a ligand-gated ion channel. Each subunit of this receptor has a characteristic "cys-loop," which is composed of a ... The two cysteine residues form a disulfide linkage which results in the "cys-loop" receptor that is capable of binding ... nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can ... acetylcholine and other ligands. These cys-loop receptors are found only in eukaryotes, but prokaryotes possess ACh receptors ...
  https://en.wikipedia.org/wiki/Neuromuscular_junction
*  Functional group interactions of a 5-HT3R antagonist | BMC Biochemistry | Full Text
The cysteine-loop family of ligand gated ion channels (LGIC) is comprised of receptors with pentameric quaternary structure and ... Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels. J Membr. Biol,. 1993 ... The region of this protein homologous to loop E and loop D of the 5-HT3A receptor suggests a loop structure from Y140 to Y152 ... Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor superfamily. Nature. 1987, 328: 221-227 ...
  https://bmcbiochem.biomedcentral.com/articles/10.1186/1471-2091-3-16
*  Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the...
The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function. Biochem Soc Trans. 2004;32 ... cysteine-cysteine-glycine) motif in the large extracellular loop 2. Part b The example here, MS4A2, is one of the two ... Evolutionary history of the ligand-gated ion-channel superfamily of receptors. Trends Neurosci. 1995;18:121-7.View Article ... Ligand-gated ion channels: new insights into neurological disorders and ligand recognition. Chem Rev. 2012;112:6285-318.View ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2592-7
*  Three-finger toxin - Wikipedia
... a family of ligand-gated ion channels. 3FTx binding interferes with cholinergic intercellular signaling particularly at ... Some, such as irditoxin, are heterodimers linked by cysteines in loops I and II. Others, such as alpha-cobrotoxin, can form ... a family of G-protein-coupled receptors. Muscarinic toxins can be either receptor agonists or receptor antagonists, and in some ... "Black mamba venom peptides target acid-sensing ion channels to abolish pain". Nature. 490 (7421): 552-555. doi:10.1038/ ...
  https://en.wikipedia.org/wiki/Three-finger_toxin
*  Ligand-gated ion channel - Wikipedia
The cys-loop receptors are named after a characteristic loop formed by a disulfide bond between two cysteine residues in the N ... In contrast to ligand-gated ion channels, there are also receptor systems in which the receptor and the ion channel are ... If these receptors are ligand-gated ion channels, a resulting conformational change opens the ion channels, which leads to a ... GABAA receptors are ligand-gated ion channels. GABA (gamma-aminobutyric acid), the endogenous ligand for these receptors, is ...
  https://en.wikipedia.org/wiki/Ligand-gated_ion_channel
*  Drosophila Rdl protein Summary Report | CureHunter
... receptor gene; amino acid sequence given in first source ... Cysteine Loop Ligand-Gated Ion Channel Receptors: 3*GABA-A ... Ligand-Gated Ion Channels: 82*Cysteine Loop Ligand-Gated Ion Channel Receptors: 3*GABA-A Receptors: 2016*Drosophila Rdl protein ... Ligand-Gated Ion Channels: 82*Cysteine Loop Ligand-Gated Ion Channel Receptors: 3*GABA-A Receptors: 2016*Drosophila Rdl protein ... Cysteine Loop Ligand-Gated Ion Channel Receptors: 3*GABA-A Receptors: 2016*Drosophila Rdl protein ...
  http://www.curehunter.com/public/keywordSummaryC082030-Drosophila-Rdl-protein.do
*  Determinants of Zinc Potentiation on the α4 Subunit of Neuronal Nicotinic Receptors | Molecular Pharmacology
Zinc Potentiation Sites Are Not Related to Zinc Binding Sites of Other Ligand-Gated Ion Channels. Other Cys-loop receptors also ... 2B, Table 2). The α4-2β4 receptor (which lacks the C-terminal cysteine) displayed an increase in potentiation, suggesting ... Davies PA, Wang W, Hales TG, and Kirkness EF (2003) A novel class of ligand-gated ion channel is activated by Zn2+. J Biol Chem ... Le Novere N and Changeux J-P (2001) LGICdb: the ligand-gated ion channel database. Nucleic Acids Res 29: 294-295. ...
  http://molpharm.aspetjournals.org/content/69/1/27
*  Analogs of α-Conotoxin MII Are Selective for α6-Containing Nicotinic Acetylcholine Receptors | Molecular Pharmacology
... and glycine receptors (Changeux, 1993). These different ligand-gated ion channels show considerable sequence and structural ... that is cysteine 1 to cysteine 3 and cysteine 2 to cysteine 4. The first and third cysteine residues were protected with acid- ... Because all of the above residues are found in the putative "C" loop of the α subunit, it seems possible that interaction in ... nAChRs activated by the endogenous neurotransmitter acetylcholine belong to the superfamily of ligand-gated ion channels that ...
  http://molpharm.aspetjournals.org/content/65/4/944
*  GABRB3 - Wikipedia
GABRB3 encodes a member of the ligand-gated ion channel family. The encoded protein is one of at least 13 distinct subunits of ... structure of the human β3 homopentamer revealed unique qualities that are only observed in eukaryotic cysteine-loop receptors. ... GABAA receptor function is inhibited by zinc ions. The ions bind allosterically to the receptor, a mechanism that is critically ... a ligand-gated ion channel. The beta-3 subunit is expressed at different levels within the cerebral cortex, hippocampus, ...
  https://en.wikipedia.org/wiki/GABRB3
*  Research Areas
Cysteine Loop Ligand-Gated Ion Channel Receptors. Receptors, Nicotinic , Receptors, GABA-A , Neuropharmacology ... Receptors, GABA-A. GABA Modulators , Cannabis , Cannabinoids , Cannabidiol Cannabis. GABA Modulators , Cannabis , Cannabinoids ... Calcium Channels, L-Type. Neurophysiology , Neuropharmacology Psychopharmacology. Neurotransmitter Transporters , Cocaine , ... Calcium Channels. Molecular Sensory Physiology (retina) , Drugability of Protein Interactions in LTCCs , Channelopathies , ...
  http://cluster.meduniwien.ac.at/mnc/research/research-areas/
*  P2RX1 - Wikipedia
Receptors Channels. 3 (4): 283-9. PMID 8834001. "Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1". ... Ennion SJ, Evans RJ (2002). "Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide ... This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and ... 2003). "The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen". Thromb. Haemost. 86 (5 ...
  https://en.wikipedia.org/wiki/P2RX1
*  ALCOHOL REPORTS: The Basic Property of Lys385 Is Important for Potentiation of the Human α1 Glycine Receptor by Ethanol
Ethanol alters the function of several members of the Cys-loop ligand-gated ion channel superfamily. Recent studies have shown ... Experiments using dynamic cysteine substitution with a methanethiosulfonate reagent and homology modeling indicate that the ... The Basic Property of Lys385 Is Important for Potentiation of the Human α1 Glycine Receptor by Ethanol ... is critical for ethanol potentiation of the receptor.. Read Full Article (PDF) ...
  http://alcoholreports.blogspot.com/2013/05/the-basic-property-of-lys385-is.html
*  Epithelial sodium channel - Wikipedia
It has been suggested that it may be a ligand-gated ion channel. ENaC is also expressed in the skin epidermal layers. In the ... "ATP-gated P2X Receptor Cation Channel (P2X Receptor) Family". Functional and Phylogenetic Classification of Membrane Transport ... Each of the subunits consists of two transmembrane helices and an extracellular loop. The amino- and carboxy-termini of all ... In most ENaC proteins studied to date, the extracellular domains are highly conserved and contain numerous cysteine residues, ...
  https://en.wikipedia.org/wiki/Epithelial_sodium_channel
*  Frontiers | The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel |...
... is an excitatory ion channel involved in pain, inflammation and itching. This channel gates in response to many irritant and ... and the conformational dynamics of the first extracellular flexible loop may govern the voltage-dependence of multimodal gating ... is an excitatory ion channel involved in pain, inflammation and itching. This channel gates in response to many irritant and ... the structure and function of TRPA1 and offer new insights into the gating mechanism of TRPA1 and related channels. ...
  https://www.frontiersin.org/articles/10.3389/fnmol.2017.00016/full
*  rice.txt
ORYSJ Glutamate receptor 3.1 precursor (Ligand-gated ion channel 3.1) [GLR3.1] [LOC_Os04g49570] [OSJNBa0013K16.8] Os04g0590900 ... ORYSJ Cysteine-rich receptor-like protein kinase 6 precursor (EC 2.7.11.-) (Cysteine-rich RLK6) [CRK6] [LOC_Os07g35690] [OJ1008 ... Basic helix-loop-helix protein 142) (OsbHLH142) (Basic helix-loop-helix protein TIP2) (TDR INTERACTING PROTEIN2) [TIP2] [ ... ORYSJ Probable ion channel CASTOR (OsCASTOR) (Probable ion channel DMI1-like) [LOC_Os03g62650] [OSJNBa0032G11.8] Os03g0847600 ...
  http://www.uniprot.org/docs/rice
*  Cyclic nucleotide-gated ion channel - Wikipedia
... a two-looped β helix. Changes induced by ligand binding occur in α helices (αA, αB, and αC and PBC helix). The β roll only ... However, a receptor-type GC in mammalian sperm has yet to be identified. Mouse sperm express other channels such as CatSper1. ... The specific cysteine residue C481 on the C-linker region is located only a few amino acids away from the binding domain. In ... Cyclic nucleotide-gated ion channels or CNG channels are ion channels that function in response to the binding of cyclic ...
  https://en.wikipedia.org/wiki/Cyclic_nucleotide%E2%80%93gated_ion_channel
*  Marine Drugs | Free Full-Text | Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. | HTML
The peptides were screened on nAChRs, NaV and KV channels depending on their cysteine framework and proposed classification. No ... Lo6/7a and Lo6/7b were retrieved from C. longurionis and have a cysteine framework VI/VII. Lo6/7b has an exceptional amino acid ... These receptors are mainly voltage- and ligand-gated ion channels. Some components act on G-protein coupled receptors and ... Moreover, when the O-superfamily is compared with the U-superfamily, there is little similarity in the intercysteine loop ...
  http://www.mdpi.com/1660-3397/14/11/199/htm
*  Plus it
As seen for other studies of potentiation of ligand-gated ion channels, the amount of potentiation of the human α4β2 receptor ... in the cysteine-cysteine loop), at the C-terminal end of the M3 membrane spanning region, and in the middle of the main ... Steroids and ligand-gated ion channels. Transmitter-gated ion channels have been shown to be one target responsible for the ... ligand-gated ion channel. The physiological actions of steroids are typically associated with initiation of gene transcription ...
  http://www.jneurosci.org/content/21/17/6561