*  cth, cystathionase (cystathionine gamma-lyase) - Creative Biogene
CTH; cystathionase (cystathionine gamma-lyase); cystathionine gamma-lyase; gamma-cystathionase; homoserine deaminase; cysteine desulfhydrase; homoserine dehydratase; cysteine-protein sulfhydrase; MGC9471; MGC9471, CTH; zgc:66001; zgc:85785; wu:fb48e03; wu:fb58d08; fb58d08 ...
  https://www.creative-biogene.com/symbolsearch_cth.html
*  Structure Cluster - 1N8P: Crystal Structure of cystathionine gamma-lyase from yeast 3D Similarity Report Page
1N8P: Determinants of Enzymatic Specificity in the Cys-Met-Metabolism PLP-Dependent Enzymes Family: Crystal Structure of Cystathionine gamma-lyase from Yeast and Intrafamiliar Structural Comparison
  http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1N8P
*  北京大学医学部机构知识库(IR@PKUHSC): Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma
Endogenous hydrogen sulfide (H(2)S) is hypothesized to have an important role in systemic inflammation. We investigated if endogenous H(2)S may be a crucial mediator in airway inflammation and airway remodeling in a rat model of asthma and if endogenous H(2)S may exert its anti-inflammatory effect by inhibiting inducible nitric oxide synthase (iNOS)/NO pathway. Cystathionine-gamma-lyase (CSE; a H(2)S-synthesizing enzyme) was mainly expressed in airway and vascular smooth muscle cells in rat lung tissue. Levels of endogenous H(2)S was decreased in pulmonary tissue in ovalbumin (OVA)-treated rats. Exogenous administration of NaHS alleviated airway inflammation and airway remodeling: peak expiratory flow (PEF) increased, goblet cell hyperplasia and collagen deposition score decreased, with decreased total cells recovered from bronchoalveolar fluid (BALF) and influx of eosinophils and neutrophils. The H(2)S levels of serum and lung tissue were ...
  http://ir.bjmu.edu.cn/handle/400002259/59159
*  Hydrogen sulfide: a new gaseous signal molecule and blood pressure regulator - Zurich Open Repository and Archive
The gas hydrogen sulfide (H2S) is emerging as a novel regulator of important physiologic functions such as arterial diameter, blood flow and leukocyte adhesion. In addition, it may have antiinflammatory and antiapoptotic effects. H2S has recently attracted much interest as a potent vasorelaxative substance that may establish itself alongside another gaseous signal molecule, nitric oxide (NO). In contrast to NO, the major source of H2S in blood may be production by red blood cells or by vascular smooth muscle cells. H2S is produced from cysteine, involving the enzymes cystathionine beta-synthase and cystathionine gamma-lyase (CSE). The importance of CSE was recently demonstrated in a mouse lacking CSE which showed reduced H2S levels and developed hypertension and reduced endothelium-mediated vasorelaxation. These data establish H2S as a new and important biologic signal molecule and as a new ...
  http://www.zora.uzh.ch/id/eprint/18872/
*  British Library EThOS: Roles and mechanisms of action of the L-cysteine cystathionine-gamma-lyase hydrogen sulphide pathway in...
Hydrogen sulphide (H2S) is a naturally occurring gas and originally the primary focus of research was to investigate its toxicity. In 1989 a physiological role of H2S was proposed after endogenous levels were detected in the rat brain and normal human post-mortem tissue. This discovery has led to an explosion of interest in H2S as a biological mediator. Identification of H2S synthesising enzymes in the cardiovascular system has led to a number of studies examining specific regulatory actions of H2S. The hypothesis underlying the studies in this thesis was that H2S synthesising enzymes exist in the myocardium and the resulting H2S provides cardioprotection against ischaemia-reperfusion injury. This was investigated using a broad range of experimental techniques including Langendorff isolated perfused rat heart models, biochemical H2S stimulation and detection assays, PCR, and Western blotting. The principal findings can be summarised as follows: 1. Rat myocardium has the potential to express both ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.584695
*  ICMP 360 Strain Passport - StrainInfo
Xanthomonas axonopodis pv. punicae cystathionine gamma-lyase (metB), o-antigen export system permease protein RfbD, teichoic acid export ATP-binding protein TagH, hypothetical protein, glycosyl transferase, group 2 family protein, hypothetical protein, phytanoyl-CoA dioxygenase, mobile element protein, hypothetical proteins, phytoene desaturase, putative transmembrane oxidoreductase protein, hypothetical proteins, oxidoreductase, short-chain dehydrogenase/reductase family, probable oxidoreductase, integral membrane proteins, and electron transfer flavoprotein, alpha subunit (etfA) genes, complete ...
  http://www.straininfo.net/strains/25770
*  Abstract 2463: Hydrogen Sulifde, A Novel Gasotransmitter, And Ischemic Stroke: Its Protective Role In Cerebral Ischemic -...
Backgoround: Hydrogen sulfide (H2S) has recently been highligted as the third gasotransmitter following its two counterparts, nitric oxide and carbon monoxide. Several lines of evidence have demonstrated that H2S is a potent vasodilator and has a protective role in ischeic-reperfusion injury of several organs, including heart, liver and kidney. In the present study, we examined the protective effect of H2S in rodent cerebral ischemia-reperfusion injury model.. Methods: Ischemia-reperfusion injury model wsa induced by intraluminal middle cerebral artery occlusion (MCAo) for 120 min followed by reperfusion in Male Sprague Dawley rats. Sodium hydrosulfide (NaHS, 1mg/kg and 5mg/kg), the donor of H2S, and normal saline (1mL) was infused via tail vein, immediately after reperfusion. To confirm the protective effect of H2S, we used propargylglycine (PAG)(50mg/kg, intraperitoneal for 7 days befor MCAo). We used Nissl stain to measure infarct sizes, ELISA to determine the levels of IL-1b, IL-6 and TNF-a ...
  http://stroke.ahajournals.org/content/43/Suppl_1/A2463
*  Human cystathionine γ-lyase: developmental and in vitro expression of two isoforms | Biochemical Journal
Cystathionine γ-lyase (CGL) is the last enzyme of the trans-sulphuration pathway, which converts methionine into cysteine. To study the possible differences in enzymic activity of the two human cystathionine γ-lyase isoforms characterized earlier, these were separately expressed in human kidney embryonic 293T cells. Furthermore, developmental changes in the expression of the two mRNA forms as well as the enzymic activity in human liver were studied, as it has been postulated that a change in the relative expression of CGL isoforms causes the postnatal increase in CGL activity. Transfection with the longer isoform increased the CGL activity 1.5-fold, while the activity of the cells transfected with the shorter form did not differ from the basal activity. In human liver samples, CGL activity was only detected in adult tissue (68±9 nmol of cysteine/h per mg of ...
  http://www.biochemj.org/content/347/1/291
*  Most recent papers in the journal Intensive Care Medicine Experimental | Read by QxMD
BACKGROUND: Cystathionine-γ-lyase (CSE) was shown to have a regulatory role in glucose metabolism. Circulatory shock can induce metabolic stress, thereby leading to hyperglycemia and mitochondrial dysfunction. In vitro data suggest an effect of high glucose on CSE expression. Therefore, the aim of this study was to investigate the effects of hyperglycemia on CSE expression in resuscitated murine septic shock. METHODS: Normo- (80-150 mg/dl) and hyperglycemic (,200 mg/dl) male C57/BL6J mice (n = 5-6 per group) underwent cecal ligation and puncture (CLP)-induced polymicrobial sepsis or sham procedure (n = 6 per group) and, 15 h afterwards, were anesthetized again, surgically instrumented and received intensive care treatment, including antibiotics, lung protective mechanical ventilation, circulatory support, and intravenous (i ...
  https://www.readbyqxmd.com/journal/49927
*  Effect of N-acetylcysteine (NAC) on Hydrogen Sulfide (H2S) in Chronic Kidney Disease (CKD) - Full Text View - ClinicalTrials.gov
Cardiovascular morbidity and mortality is high in CKD patients. Nitric oxide (NO) deficiency plays a crucial role in progression of CKD. This leads to endothelial dysfunction, hypertension, and inflammation. Hydrogen sulfide (H2S) could serve as a backup mechanism for NO deficiency in CKD. N-acetylcysteine (NAC) is a derivate of cysteine and this is the main substrate for H2S production. Therefore, NAC should enable us to stimulate H2S production in humans. Our objective is to investigate the effect of NAC on plasma H2S levels and on markers of oxidative stress, inflammation, and endothelial dysfunction in healthy volunteers, CKD patients, and dialysis patients. We hypothesize that there is an increase in H2S levels after treatment with NAC ...
  https://clinicaltrials.gov/show/NCT01232257
*  Publications by: Jennifer L. Scott Also publishes as (J. Scott, J.L. Scott, Jennifer Louise Scott, Jenni L. Scott) -...
Kinobe, Robert T., Van , Dam P., Scott, Jennifer L., Hall, Christine, Blyth, Scott, Reilly, Laurie, and Ross, Anthony (2011) Inhibition of cystathionine-gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity. In: Proceedings of the The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1- 1. From: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 4-9 December 2011, Perth, WA, Australia. Scott, Jennifer L., Ketheesan, Natkunam, and Summers, Phillip M. (2009) Spermatozoa and seminal plasma induce a greater inflammatory response in the ovine uterus at oestrus than dioestrus. Reproduction, Fertility and Development, ...
  https://researchonline.jcu.edu.au/view/all/CCDD7ABB8E6298B391B73F95938C3D3A.html
*  How to Remove Hydrogen Sulfide From Well Water | eHow
Ascertain that the hydrogen sulfide is in the well water and not being produced in your water heater by turning on a cold water faucet to determine if the rotten egg smell is present. If it is, the problem is the well water (or, less likely, in the water distribution system). Sulfur-reducing bacteria are usually responsible for producing hydrogen sulfide. The bacteria use the sulfur in decaying plants, rocks, and soil for their energy source and as a by-product create hydrogen sulfide. These bacteria thrive in oxygen-deficient environments such as deep wells. While faucet-specific filters can remove low concentrations of hydrogen sulfide from your well water before you use it, installing a whole-house treatment is the recommended way to go.. ...
  https://www.ehow.com/how_6359249_remove-hydrogen-sulfide-well-water.html
*  921-01-7 - D-Cysteine, 98% - H62627 - Alfa Aesar
Klaas R. Krijgsheld; Eltjo J. Glazenburg; Egbert Scholtens; Gerard J. Mulder. The oxidation of L- and D-cysteine to inorganic sulfate and taurine in the rat. Biochimica et Biophysica Acta (BBA) - General Subjects. 1981, 677 (1), (13), 7-12.. Kenji Yamaguchi; Shigeki Sakakibara; Juro Asamizu; Iwao Ueda. Induction and activation of cysteine oxidase of rat liver II. The measurement of cysteine metabolism in vivo and the activation of in vivo activity of cysteine oxidase. Biochimica et Biophysica Acta (BBA) - General Subjects. 1973, 297 (1), 48-59.. ...
  https://www.alfa.com/es/catalog/H62627/
*  Hydrogen Sulfide: An Agent of Stability at the Microbiome-Mucosa Interface | Gastrointestinal and Liver Physiology
A diverse range of effects of the intestinal microbiota on mucosal defence and injury has become increasingly clear over the past decade. Hydrogen sulfide (H2S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defence and repair. Hydrogen sulfide is produced gastrointestinal tract tissues and by bacteria residing within the gut, and can influence the function of a wide range of cells. The microbiota also appears to be an important target of hydrogen sulfide. H2S donors can modify the gut microbiota and the gastrointestinal epithelium is a major site of oxidation of microbial-derived H2S. When administered together with nonsteroidal anti-inflammatory drugs, H2S can prevent some of the dysbiosis those drugs induce, possibly contributing to the observed prevention of gastrointestinal damage. Exogenous H2S can also markedly reduce the severity of experimental colitis and plays important roles in modulating epithelial cell-mucus-bacterial ...
  http://ajpgi.physiology.org/content/early/2017/10/02/ajpgi.00249.2017.most-cited
*  D-Cysteine hydrochloride - Creative Peptides
Creative Peptides offers D-Cysteine hydrochloride for your research. We also provide custom peptide synthesis, process development, GMP manufacturing.
  https://www.creative-peptides.com/product/d-cysteine-hydrochloride-item-cp00605-26180.html
*  Health and Human Biology: Hydrogen Sulfide May Reduce Inflammation in Rheumatoid Arthritis
Researchers have found a donor molecule that slowly releases hydrogen sulfide. They believe that this donor molecule could be used as a medication. In lab experiments the hydrogen sulfide released by the donor molecule inhibits the secretions of the inflammatory chemicals produced in arthritic joints. It also inhibits the activity of several enzymes involved in the inflammation. The researchers say that hydrogen sulfide can't stop arthritis from developing but is very successful at reducing inflammation in in lab tests. Clinical tests are needed to see if it works in patients ...
  http://healthbylynne.blogspot.com/2013/04/hydrogen-sulfide-may-reduce.html
*  Bacterial Protection | Science Signaling
Most bacteria are capable of producing hydrogen sulfide and use a trio of enzymes to do so. Classically, this gas was considered a by-product of sulfur metabolism, but knowing that nitric oxide protects Gram-positive bacteria against oxidative stress, Shatalin et al. (see the Perspective by Belenky and Collins) discovered that H2S probably does likewise. When the H2S-producing enzymes were inactivated, bacteria became more susceptible to antibiotics unless supplied with a source of H2S.. K. Shatalin, E. Shatalina, A. Mironov, E. Nudler, H2S: A universal defense against antibiotics in bacteria. Science 334, 986-990 (2011). [Abstract] [Full Text] P. Belenky, J. J. Collins, Antioxidant strategies to tolerate antibiotics. Science 334, 915-916 (2011). [Abstract] [Full Text] ...
  http://stke.sciencemag.org/content/4/200/ec329
*  bmse000033 L-Cystathionine at BMRB
InCHi String: isomeric SMILES: C(CSC[C@H](C(=O)O)N)[C@@H](C(=O)O)N. canonical SMILES: C(CSCC(C(=O)O)N)C(C(=O)O)N. IUPAC: IUPAC openeye: IUPAC systematic ...
  http://bmrb.wisc.edu/metabolomics/mol_summary/?molName=L-cystathionine
*  The message in the air: hydrogen sulfide metabolism in chronic respiratory diseases.
Abstract Hydrogen sulfide (H(2)S) is an important gasotransmitter in the mammalian respiratory system. The enzymes that produce H(2)S - mainly cystathionine-β-synthase and cystath..
  https://www.omicsonline.org/references/the-message-in-the-air-hydrogen-sulfide-metabolism-in-chronic-respiratory-diseases-118349.html
*  PPT - Hydrogen Sulfide Gas PowerPoint Presentation - ID:6763227
Hydrogen Sulfide Gas. Describe H 2 S gas and where it is found:. Hydrogen Sulfide is a highly toxic gas often associated with operations involving decomposing organic material (rotting plant and animal tissues). Slideshow 6763227 by socorro-xovi
  https://www.slideserve.com/socorro-xovi/hydrogen-sulfide-gas
*  Hydrogen Sulfide Scrubber Systems in Hydrometallurgical Application on Environmental XPRT
Article Hydrogen Sulfide Scrubber Systems in Hydrometallurgical Application. Hydrogen Sulfide is a highly toxic and flammable gas. Being heavier than air, it tends to accumulate at the bottom of poorly ventilated spaces. Although very pungent at firs...
  https://www.environmental-expert.com/articles/hydrogen-sulfide-scrubber-systems-in-hydrometallurgical-application-242435
*  D-Cysteine | Phion
Product Number , 47269964. CAS Number , 921-01-7. EC , Molecular Formula , -. Molecular Weight , 121.16. Storage Temp , +20°C. Harmonized Tariff code , 29309013. Signal Word , ...
  http://phionchemicals.com/product/d-cysteine
*  Hydrogen Sulfide | Plant Design and Operations
The material in this post is extracted from Chapter 5 - Chemicals - of the book Plant Design and Operations. Hydrogen Sulfide (H2S) is a highly toxic chemical compound that is found in a wide variety of oil processing operations. High concentrations of H2S may be present in crude oil, molten sulfur, tank and pit-bottom…
  https://plantdesignoperations.wordpress.com/2014/06/03/hydrogen-sulfide/
*  30 CFR 250.604 - Hydrogen sulfide. | US Law | LII / Legal Information Institute
When a well-workover operation is conducted in zones known to contain hydrogen sulfide (H2S) or in zones where the presence of H2S is unknown (as defined in § 250.490 of this part), the lessee shall take appropriate precautions to protect life and property on the platform or rig, including but not limited to operations such as blowing the well down, dismantling wellhead equipment and flow lines, circulating the well, swabbing, and pulling tubing, pumps and packers. The lessee shall comply with the requirements in § 250.490 of this part as well as the appropriate requirements of this subpart. ...
  https://www.law.cornell.edu/cfr/text/30/250.604