RCSB PDB - Protein Feature View - Phospholipase A2 crotoxin basic subunit CBb - P0CG56 (PA2BB CRODU)
Heterodimer CA-CB: Crotoxin is a potent presynaptic neurotoxin that possesses phospholipase A2 (PLA2) activity and exerts a ... Multiple variants of each subunit give different crotoxin complexes that can be subdivided into 2 classes: (1) those of high ... At equilibrium, only the CB subunits remain associated with the specific crotoxin receptor. In addition to neurotoxicity, ... crotoxin has been found to exert myotoxicity, nephrotoxicity, and cardiovascular toxicity (PubMed:20109480). Moreover, anti- ...http://www.rcsb.org/pdb/protein/P0CG56
GV (nerve agent) - Wikipedia
Crotoxin. See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Nicotinic acetylcholine ...https://en.wikipedia.org/wiki/GV_
ANTI-LETHAL FACTOR FROM OPOSSUM SERUM IS A POTENT ANTIDOTE FOR ANIMAL, PLANT AND BACTERIAL TOXINS
The results in Table 5 show that TNF neutralizes the lethal toxic effects of various snake venom toxins: crotoxin, cobratoxin, ...http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301999000100005&lng=en&nrm=iso&tlng=en
Toxins | Free Full-Text | Molecular Characterization of Lys49 and Asp49 Phospholipases A2 from Snake Venom and Their Antiviral...
Crotoxin and phospholipases A2 from Crotalus. durissus terrificus showed antiviral activity against dengue and yellow fever ...http://www.mdpi.com/2072-6651/5/10/1780/htm
IUCr) Acta Crystallographica Section F Volume 63, Part 12, December 2007
Crotoxin B is a basic phospholipase A2 found in the venom of C. durissus terrificus and is one of the subunits that constitute ... Preliminary X-ray crystallographic studies of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus ... crotoxin. Here, the crystallization, X-ray diffraction data collection and molecular-replacement solution of a novel tetrameric ... complex formed by two dimers of crotoxin B isoforms are presented. ...http://journals.iucr.org/f/issues/2007/12/00/
Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are...
Effects of chemical modifications of crotoxin B, the phospholipase A2 subunit of crotoxin from Crotalus durissus terrificus ... Crotoxin, a phospholipase A2 neurotoxin from the South American rattlesnake Crotalus durissus terrificus: purification of ... Crotalus d. terrificus crotoxin-B. 15. very low myotoxicityb Gopalakrishnakone et al. (1984) ... Crotalus d. terrificus crotoxin-B. 0. 14.1, myotoxicity. Soares et al. (2001a) ...https://peerj.com/articles/569/
Opiate and acetylcholine-independent analgesic actions of crot...
Opiate and acetylcholine-independent analgesic actions of crotoxin isolated from crotalus durissus terrificus venom.: The venom ... Opiate and acetylcholine-independent analgesic actions of crotoxin isolated from crotalus durissus terrificus venom.. Authors * ... The venom of Crotalus durissus terrificus is reported to have analgesic activity and the administration of Crotoxin (Cro) to ...https://www.mysciencework.com/publication/show/opiate-acetylcholine-independent-analgesic-actions-crotoxin-isolated-from-crotalus-durissus-terrificus-venom-b1330c55
Rattlesnake Venom Compounds Show Activity Against Hepatitis C Virus
When the same experiment was performed using crotoxin, production of viral particles fell 58%.. The second stage of the ... In this case, the results were even more satisfactory: phospholipase blocked 97% of viral cell entry, and crotoxin reduced ... They are found in natura as subunits of the crotoxin protein complex, which the researchers also tested.. In a series of in ... Treatment with crotoxin achieved 50% inhibition of viral release.. According to the researchers, the results of the experiments ...https://www.technologynetworks.com/biopharma/news/isolated-rattlesnake-venom-compounds-show-activity-against-hepatitis-c-virus-297342
Expression of anti human IL-4 and IL-6 scFvs in transgenic tobacco plants, Plant Molecular Biology | 10.1023/A:1023902407855 |...
Neutralizing human anti crotoxin scFv isolated from a nonimmunized phage library. Cardoso, D.F.; Nato, F.; England, P.; ... A monoclonal antibody directed against the non-toxic subunit of a dimeric phospholipase A2 neurotoxin, crotoxin, neutralizes ... Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library ...https://www.deepdyve.com/lp/springer_journal/expression-of-anti-human-il-4-and-il-6-scfvs-in-transgenic-tobacco-eaEau70T4p
Management of strabismus - Wikipedia
Crotoxin appears to act similarly. To weaken an eye muscle, 1 to 12 units (a few nanograms) of toxin are injected directly into ... Crotoxin, a snake neurotoxin, is being developed in Belo Horizonte, Brazil as a potential alternative. Botulinum toxin ... CS1 maint: Uses authors parameter (link) Ribeiro Gde B, Almeida HC, Velarde DT, Sá ML (Oct 2012). "Study of crotoxin on the ... CS1 maint: Uses authors parameter (link) Ribeiro Gde B, Almeida HC, Velarde DT (2012-12-01). "Crotoxin in humans: analysis of ...https://en.wikipedia.org/wiki/Management_of_strabismus
Crotalus simus - Wikipedia
Only venom from neonates contains crotoxin; a constituent typically found in C. durissus venom that produces neurotoxic ...https://en.wikipedia.org/wiki/Crotalus_simus
Spotlight Innovation - Wikipedia
Crotoxin was tested on patients in the George Pompidou University Hospital in Paris. In 2014, Celtic Biotech LTD entered into a ... "Crotoxin Administration for Cancer Treatment and Pain Relief". www.google.com/patents. Google Patents. Retrieved 7 September ... In January, 2015, Celtic Biotech Iowa was granted a patent by the U.S. Patent and Trademark Office entitled Crotoxin ... Celtic Biotech made headlines in 2011 when they announced a clinical trial to test the effectiveness of Crotoxin, a protein ...https://en.wikipedia.org/wiki/Spotlight_Innovation
Snakebite Envenoming in Latin America and the Caribbean | Springer for Research & Development
Cellular and mitochondrial changes induced in the structure of murine skeletal muscle by crotoxin, a neurotoxic phospholipase A ...https://rd.springer.com/referenceworkentry/10.1007/978-94-017-7438-3_14
Datura - Infogalactic: the planetary knowledge core
All Datura plants contain tropane alkaloids such as scopolamine, hyoscyamine, and atropine, primarily in their seeds and flowers. Because of the presence of these substances, Datura has been used for centuries in some cultures as a poison. There can be a 5:1 toxin variation between plants, and a given plant's toxicity depends on its age, where it is growing, and the local weather conditions. These variations makes Datura exceptionally hazardous as a drug.. In traditional cultures, a great deal of experience with and detailed knowledge of Datura was critical to minimize harm. Many tragic incidents result from modern users ingesting Datura. For example, in the 1990s and 2000s, the United States media contained stories of adolescents and young adults dying or becoming seriously ill from intentionally ingesting Datura. There are also several reports in the medical literature of deaths from D. stramonium and D. ferox intoxication. Children are especially ...https://infogalactic.com/info/Datura
Antinociceptive and Anti-Inflammatory Effects of Orally Administrated Denatured Naja Naja Atra Venom on Murine Rheumatoid...
Crotalus durissus terrificus venom, which contains crotoxin as a major active component, significantly inhibited edema and ...https://www.hindawi.com/journals/ecam/2013/616241/
Karl Slotta - Wikipedia
In 1938, Slotta and his brother-in-law Heinz Fraenkel-Conrat isolated crotoxin from venom, the first snake toxin to be isolated ... Their research suggested that the toxicity of crotoxin was due to effects on nerve lipids. He subsequently co-founded a ...https://en.wikipedia.org/wiki/Karl_Slotta
Calumenin - Wikipedia
Hseu MJ, Yen CH, Tzeng MC (1999). "Crocalbin: a new calcium-binding protein that is also a binding protein for crotoxin, a ...https://en.wikipedia.org/wiki/Calumenin
Most recent papers with the keyword Mojave toxin | Read by QxMD
... which protects them against crotoxin, the main toxin of their venom. CICS neutralizes the lethal potency of crotoxin and ... First crotoxin-like phospholipase A(2) complex from a New World non-rattlesnake species: nigroviriditoxin, from the arboreal ... A previous proteomic profiling of its venom revealed the presence of proteins with homology to the A and B subunits of crotoxin ... Crotalus durissus terrificus snakes possess a protein in their blood, named crotoxin inhibitor from Crotalus serum (CICS), ...https://www.readbyqxmd.com/keyword/21001
One of the protein structures in this search is crotoxin B (2QOG), an enzyme (a "phospholipase") that cleaves lipid molecules ...http://blogs.oregonstate.edu/psquared/week-4/
Crotalus durissus - Wikipedia
Bite symptoms are very different from those of Nearctic species due to the presence of neurotoxins (crotoxin and crotamine) ...https://en.wikipedia.org/wiki/Crotalus_durissus
List of dangerous snakes - Wikipedia
Bite symptoms are very different from those of Nearctic species due to the presence of neurotoxins (crotoxin and crotamine) ...https://en.wikipedia.org/wiki/List_of_dangerous_snakes
Grazyna Faure-Kuzminska • Research - Institut Pasteur
Faure G, Saul F, Crystallographic characterization of functional sites of crotoxin and ammodytoxin, potent β-neurotoxins from ... determination of the crystal structures of crotoxin and several neurotoxic phospholipases A2, SPR characterization of the ...https://research.pasteur.fr/en/member/grazyna-faure-kuzminska/
The 15 Most Valuable Body Parts & Fluids On The Underground Market
... it possesses a unique quantity of both toxicity and Crotoxin, which is a valuable mix in the cancer fighting process.. ...https://www.therichest.com/world-money/the-15-most-valuable-body-parts-fluids-on-the-underground-market/
Celecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells |...
... could increase CML cell death with anti-leukemia drugs including crotoxin, SAHA, bafetinib, imatinib and dasatinib. In this ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1012-8
Brazilian Journal of Medical and Biological Research - ISSN: 0100-879X
Crotoxin, the major toxin from the rattlesnake Crotalus durissus terrificus, inhibits 3H-choline uptake in guinea pig ileum ...http://journaldatabase.info/journal/issn0100-879X