As cotinine half life is about 20 hours,16 length of time since last working also impacts on cotinine concentrations. This was ... Measuring nicotine intake in population surveys: comparability of saliva cotinine and plasma cotinine estimates. Nicotine Tob ... In bodily fluids, cotinine, with a half life of around 20 hours,16 is a good indicator of exposure to smoke over the previous ... Salivary cotinine-Non-stimulated saliva samples (about 1 ml) were collected according to the protocol used in the Health Survey ...http://www.bmj.com/content/331/7525/1117
Cotinine Feedback as an Intervention to Change Parental/Caregiver Smoking Behavior Around Children With Cancer - Full Text View...
Cotinine Feedback as an Intervention to Change Parental/Caregiver Smoking Behavior Around Children With Cancer. This study has ... Change in urine cotinine level [ Time Frame: 4 weeks after baseline visit ]. The primary objective of this study is to ... Behavioral: Cotinine Education Those randomized to the active intervention will also be provided with education utilizing the ... Cotinine Feedback as an Intervention to Change Parental/Caregiver Smoking Behavior Around Children With Cancer. ...https://clinicaltrials.gov/ct2/show/NCT01828502?term=%22secondhand+smoke%22&recr=Open&rank=7
Maternal smoking during pregnancy and testicular cancer in the sons : A nested case-control study and a meta-analysis.
First trimester sera were retrieved from the 70 index mothers and 519 control mothers and were tested for cotinine level by a ... No statistically significant association between maternal cotinine level and risk of TC in the offspring was found (OR 0.68; 95 ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2:221110
Serum cotinine level as predictor of lung cancer risk. - Oxford Clinical Trial Service Unit & Epidemiological Studies Unit ...
RESULTS: Mean serum cotinine level was higher in cases than in controls. Compared with subjects with a cotinine level of , or ... Serum cotinine level is a predictor of risk of lung cancer among smokers. The reported plateau in risk at high doses is likely ... Serum cotinine was measured with a competitive immunoassay. Regression dilution was corrected for based on repeated measures on ... We found no association between serum cotinine level (range, 0.1-9.9 ng/mL) and lung cancer risk among self-reported nonsmokers ...https://www.ctsu.ox.ac.uk/publications/39963
Cotinine ≥98% | Sigma-Aldrich
Cotinine for your research needs. Find product specific information including CAS, MSDS, protocols and references. ... Cotinine ≥98% Synonym: (S). -. 1-. Methyl-. 5-. (3-. pyridyl). -. 2-. pyrrolidinone, S(−)-1-Methyl-5-(3-pyridyl)-2-pyrrolidone ...https://www.sigmaaldrich.com/catalog/product/sigma/c5923?lang=en®ion=US
Cotinine Summary Report | CureHunter
The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to ... Cotinine. Subscribe to New Research on Cotinine The N-glucuronide conjugate of cotinine is a major urinary metabolite of ... 12/01/2013 - "The goal of the study was to examine the association of cotinine and NNAL with asthma outcomes in the U.S. ". 07/ ... 03/01/2013 - "This study used salivary cotinine to assess the impact of change in smoking exposure on birth weight in full-term ...http://www.curehunter.com/public/keywordSummaryD003367-Cotinine.do
How long is cotinine detectable in the blood? | Reference.com
... cotinine levels fall below the detectable range after two weeks of abstinence, according to Mayo Clinic. This means that the ... The average half-life of nicotine is two hours, while the half-life of cotinine is 15 hours. The range of cotinine in the blood ... Elevated levels of cotinine have been found in individuals exposed to second-hand smoking. Levels as high as 8 nanograms per ... In most heavy smokers, cotinine levels fall below the detectable range after two weeks of abstinence, according to Mayo Clinic. ...https://www.reference.com/health/long-cotinine-detectable-blood-5f1a91bb936a2a4a
Nicotine Information | Cotinine Detection Info
Learn about nicotine drug testing, the difference between nicotine and cotinine, and more. ... Cotinine can also be easily detected with a cotinine saliva drug test such as our iScreen OFD Saliva Cotinine Test Kit, which ... What is cotinine?. Cotinine (COT) is a metabolite synthesized by the body as a byproduct of nicotine. Drug tests for nicotine ... Cotinine remains in the body for an extended period of time as a result of direct or secondhand smoke exposure. Cotinine drug ...https://testcountry.com/pages/faq-nicotine-and-tobacco
Detection of cotinine in newborn dried blood spots.
Cotinine / blood*. Female. Humans. Infant, Newborn. Maternal-Fetal Exchange. Neoplasms / etiology. Predictive Value of Tests. ... Mean cotinine was 29 ng/mL (SD, 7.5), 45 ng/mL (SD, 9.7), and 9 ng/mL (SD, 7.4), respectively, among infants of all smokers, ... 0/Biological Markers; 0/Tobacco Smoke Pollution; 486-56-6/Cotinine From MEDLINE®/PubMed®, a database of the U.S. National ... As proof-of-principle, we examined cotinine in DBS of 20 infants enrolled in a pilot study of pregnancy among low-income women ...http://www.biomedsearch.com/nih/Detection-cotinine-in-newborn-dried/17855712.html
Cotinine and Blood Pressure Levels: Variability Omitted Once Again | Hypertension
Cotinine and Blood Pressure Levels: Variability Omitted Once Again. Costas Thomopoulos, Carolina Lombardi, Gianfranco Parati ... Cotinine and Blood Pressure Levels: Variability Omitted Once Again. Costas Thomopoulos, Carolina Lombardi and Gianfranco Parati ... Cotinine and Blood Pressure Levels: Variability Omitted Once Again. Costas Thomopoulos, Carolina Lombardi and Gianfranco Parati ... Association of serum cotinine levels and hypertension in never smokers. Hypertension 2013;61:304-308. ...http://hyper.ahajournals.org/content/61/4/e41
Metabolism of Nicotine and Cotinine in Pregnant African-American Women - Full Text View - ClinicalTrials.gov
Metabolism of Nicotine and Cotinine in Pregnant African-American Women. The safety and scientific validity of this study is the ... Passive and active maternal smoking as measured by serum cotinine: the effect on birthweight. Am J Public Health. 1995 Mar;85(3 ... Blood, urine, and saliva samples are analyzed for nicotine and cotinine (a product of nicotine metabolism) levels, and DNA will ... 1. Collect DNA for exploratory analyses regarding genetic causes of differences in metabolism of nicotine and cotinine. ...https://clinicaltrials.gov/ct2/show/NCT00341640?term=sleep&spons=NICHD&rank=20
Nicotine and its metabolite cotinine are mitogenic for human vascular smooth muscle cells.
A weak mitogenic effect was observed at a low serum concentration for cotinine but not nicotine. Cotinine at a concentration of ... Cotinine / adverse effects*. Culture Media. DNA / biosynthesis, drug effects. Fetal Blood. Graft Survival. Humans. Hyperplasia ... RESULTS: In the presence of serum both nicotine and cotinine at concentrations of 10(-7) and 10(-8) mol/L were mitogenic for ... This study evaluated the effect of nicotine and its major stable metabolite cotinine on vascular SMC proliferation in vitro. ...http://www.biomedsearch.com/nih/Nicotine-its-metabolite-cotinine-are/9129624.html
The detection of cotinine in hydrolyzed meconium samples. | Base documentaire | BDSP
It was hypothesized that cotinine forms reversible Schiff base bonds with free amino functions on proteins, therefore, ... hydrolysis of meconium would be necessary for the detection of free cotinine. One-hundred-and-two 102 meconium... ... Of the non-hydrolyzed samples, 33% were positive for cotinine, while 79% of the hydrolyzed samples were cotinine-positive. ... The detection of cotinine in hydrolyzed meconium samples. R f. 196231 Article - En anglais ...http://www.bdsp.ehesp.fr/Base/196231/
iScreen OFD Cotinine Saliva Test Kit
iScreen OFD Nicotine/Cotinine saliva test is an easy oral fluid screening test to detect elevated levels of cotinine (nicotine ... iScreen OFD - Nicotine/Cotinine (Saliva) Oral Fluid Test Kit. The iScreen® OFD - Cotinine device is a rapid, oral fluid ... iScreen Cotinine Swab Test Levels and Detection Periods. Drug Name:. Abbr:. Cutoff:. ... The iScreen OFD Cotinine test device is a rapid, oral fluid drug test that can be performed anytime and almost anywhere. The ...https://www.confirmbiosciences.com/products/saliva-drug-tests/iscreen-ofd-nicotine/
Cotinine - Wikipedia
Salivary cotinine concentrations are highly correlated to blood cotinine concentrations, and can detect cotinine in a low range ... At steady state, plasma cotinine levels are determined by the amount of cotinine formation and the rate of cotinine removal, ... Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine. Cotinine is used as a biomarker ... Cotinine was developed as an antidepressant as a fumaric acid salt, cotinine fumarate, to be sold under the brand name Scotine ...https://en.wikipedia.org/wiki/Cotinine
Immunoassay device for determining nicotine or cotinine - Patent EP0916950 - PubChem
EP0916950 chemical patent summaryhttps://pubchem.ncbi.nlm.nih.gov/patent/EP0916950
Interlaboratory comparability of serum cotinine measurements at smoker and nonsmoker concentration levels: A round-robin study ...
Cotinine-conjugated aptamer/anti-cotinine antibody complexes as a novel affinity unit for use in biological assays. : Park,...
Cotinine-conjugated aptamer/anti-cotinine antibody complexes as a novel affinity unit for use in biological assays. ... Cotinine-conjugated aptamer/anti-cotinine antibody complexes as a novel affinity unit for use in biological assays.. Item ... Cotinine-conjugated AS1411/anti-cotinine antibody complexes were successfully applied to immunoblot, immunoprecipitation, and ... Our results show that cotinine-conjugated aptamer/anti-cotinine antibody complexes are an effective alternative and ...https://archive.org/details/pubmed-PMC3465749
QuickStats: Median Serum Cotinine Levels in Nonsmokers, by Age Group --- National Health and Nutrition Examination Survey ...
Cotinine is a metabolite only of nicotine. Among nonsmokers, the presence of cotinine in serum indicates exposure to secondhand ... QuickStats: Median Serum Cotinine Levels in Nonsmokers, by Age Group --- National Health and Nutrition Examination Survey ( ... From 1988--1991 through 2001--2002, median serum cotinine levels decreased by 74% in children aged 4--11 years, 79% in persons ...https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5541a7.htm
Validation of Self-Reported Smoking Status Using Saliva Cotinine: A Rapid Semiquantitative Dipstick Method | Cancer...
Cotinine Analyses. Cotinine is a widely accepted biomarker for tobacco product use and exposure. Cotinine has a longer half- ... Measurement of cotinine, a primary metabolite of nicotine that has a half-life of 16 to 18 h and that can be detected in urine ... Cotinine levels and self-reported smoking status in patients attending a bronchoscopy clinic. Biomarkers 2003;8:218-28. ... Use of cotinine immunoassay test strips for preclassifying urine samples from smokers and nonsmokers prior to analysis by LC-MS ...http://cebp.aacrjournals.org/content/16/9/1858
Urine cotinine measurement
... What is this test?. This test measures the amount of cotinine (a byproduct of nicotine) in urine. ...https://www.allinahealth.org/CCS/doc/Thomson%20Consumer%20Lab%20Database/49/150270.htm
Analysis of [3',3'-d(2)]-nicotine and [3',3'-d(2)]-cotinine by capillary liquid chromatography-electrospray tandem mass...
... d0-cotinine, m/z 177→98 (D), d2-cotinine, m/z 179→100 (E), d3-cotinine, m/z 180→101 (F). Different chromatographic conditions ... cotinine, respectively. The coefficient of variation was 3.7% for d(2)-nicotine and 2.5% for d(2)-cotinine. The method was ... Signal-to-noise comparison between the m/z 179→80 and 179→100 mass transitions for d2-cotinine, obtained from HILIC-ESI MS/MS ... A selective and sensitive LC/MS/MS assay was developed for the quantification of d(2)-nicotine and d(2)-cotinine in plasma of ...https://www.ncbi.nlm.nih.gov/pubmed/17644451?access_num=17644451&link_type=MED&dopt=Abstract
IJERPH | Free Full-Text | Estimation of Saliva Cotinine Cut-Off Points for Active and Passive Smoking during Pregnancy-Polish...
The aim of this study was to determine optimal saliva cotinine cut-off values for smoking during pregnancy. The analyses were ... Saliva cotinine concentrations were assessed by high performance liquid chromatography coupled with tandem mass spectrometry ( ... Significantly more younger, single, and less educated self-reported non-smokers had a cotinine concentration higher than 10 ng/ ... HPLC-ESI + MS/MS). The saliva cotinine cut-off value for active smoking was established at 10 ng/mL (sensitivity 96%, ...http://www.mdpi.com/1660-4601/13/12/1216
Development of simple HPLC/UV with a column-switching method for the determination of nicotine and cotinine in hair samples
As one of the results, the areas of nicotine and cotinine measured by HPLC/UV with column-switching method were 12.9 and 16.9 ... We were able to establish a low-cost method with good sensitivity for measuring nicotine and cotinine in hair. The HPLC/UV with ... The amount of nicotine and cotinine in hair was significantly correlated to number of cigarettes smoked per day (r = 0.228, p ... We then measured amounts of nicotine and cotinine in hair samples collected from the general population, and compared both the ...http://www.scirp.org/journal/PaperInformation.aspx?PaperID=29880
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