The human tissue-engineered cornea as a model to study the impact of altering the PI3K/Akt signal transduction pathway on...
... approach were wounded with a 8-mm diameter biopsy punch and deposited on another reconstructed human corneal stroma to allow ... Conclusions : We demonstrated for the first time that corneal wound healing can be monitored in vitro using as a model hTECs ... We hypothesize that ECM remodelling occurring during corneal wound healing causes the activation of very specific signal ... This will certainly lead to progress in the clinical field of corneal blindness. ...http://iovs.arvojournals.org/article.aspx?articleid=2559687
Molecular Vision: A mouse model of lamellar intrastromal femtosecond laser keratotomy: ultra-structural, inflammatory,...
A novel method for generating corneal haze in anterior stroma of the mouse eye with the excimer laser. Exp Eye Res. 2008; 86: ... Corneal injury. A relatively pure model of stromal-epithelial interactions in wound healing. Methods Mol Med. 2003; 78:67-81. [ ... Serial sagittal corneal 8μm sections were cut using a Microm HM550 cryostat (Microm, Walldorf, Germany). Sections were placed ... Corneal stromal cellular responses vary dependent on whether the stromal injury occurs together with an epithelial injury (as ...http://www.molvis.org/molvis/v17/a324/
Expression of VSX1 in Human Corneal Keratocytes during Differentiation into Myofibroblasts in Response to Wound Healing | IOVS ...
After the corneal epithelium was removed, the corneal stroma was sliced into quarters and digested overnight with 2.0 mg/mL ... The corneal stroma is endowed with a significant number of resident dendritic cells. Invest Ophthalmol Vis Sci. 2003;44:581-589 ... Bone marrow-derived cells in normal human corneal stroma. Arch Ophthalmol. 2006;124:62-69. [CrossRef] [PubMed] ... The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin ...http://iovs.arvojournals.org/article.aspx?articleid=2163791
Stroma of cornea - Wikipedia
During development of the embryo, the corneal stroma is derived from the neural crest (a source of mesenchyme in the head and ... At its centre, human corneal stroma is composed of about 200 flattened lamellæ (layers of collagen fibrils), superimposed one ... "Mesenchymal stem cells in the human corneal limbal stroma". Invest Ophthalmol Vis Sci. 53 (9): 5109-16. doi:10.1167/iovs.11- ... Macular corneal dystrophy, associated with the loss of keratan sulfate Oyster, CW (1999). "8". The human eye: structure and ...https://en.wikipedia.org/wiki/Stroma_of_cornea
OSA | Wavelength dependence of femtosecond laser ablation threshold of corneal stroma
Surface ablation of corneal stroma with few-cycle laser pulses at 800 nm L. Hoffart, P. Lassonde, F. Légaré, F. Vidal, N. ... Wavelength dependence of femtosecond laser ablation threshold of corneal stroma G. Olivié, D. Giguère, F. Vidal, T. Ozaki, J.-C ... D. W. Leonard and K.M. Meek, "Refractive indices of the collagen fibrils and extrafibrillar material of the corneal stroma," ... D. W. Leonard and K.M. Meek, "Refractive indices of the collagen fibrils and extrafibrillar material of the corneal stroma," ...https://www.osapublishing.org/vjbo/abstract.cfm?uri=oe-16-6-4121
Exogenous TGFβ3 promotes mouse corneal stroma development | IOVS | ARVO Journals
Exogenous TGFβ3 promotes mouse corneal stroma development Lingling Zhang; Lung-Kun Yeh; Yujin Zhang; Yuka Okada; Yen-Chiao Wang ... Exogenous TGFβ3 promotes mouse corneal stroma development You will receive an email whenever this article is corrected, updated ... Methods : Primary corneal stroma fibroblasts were treated with BMP4, TGFβ3 or PBS (control) and related gene expressions were ... TEM revealed that TGFβ3 promotes mouse corneal stroma maturation by increasing stromal cell density and cell activates (more ER ...http://iovs.arvojournals.org/article.aspx?articleid=2639122
Development of the corneal stroma, and the collagen-proteoglycan associations that help define its structure and function -...
Development of the corneal stroma, and the collagen-proteoglycan associations that help define its structure and function. ... Bin Kong, Shengli Mi, Electrospun Scaffolds for Corneal Tissue Engineering: A Review, Materials, 2016, 9, 8, 614. CrossRef ... Shikha Chawla, Sourabh Ghosh, Establishment of in vitro model of corneal scar pathophysiology, Journal of Cellular Physiology, ... Sunil K. Parapuram, William Hodge, The integrin needle in the stromal haystack: emerging role in corneal physiology and ...http://onlinelibrary.wiley.com/doi/10.1002/dvdy.21579/abstract
Three-Dimensional Distribution of Transverse Collagen Fibers in the Anterior Human Corneal Stroma | IOVS | ARVO Journals
Its primary structural and mechanical element is the corneal stroma, comprising over 90% of corneal thickness. The stroma ... Meek KM Boote C. The organization of collagen in the corneal stroma. Exp Eye Res . 2004; 78: 503-512. [CrossRef] [PubMed] ... A large body of research has been devoted to exploring the structure and biomechanics of the corneal stroma. 1,4-11 However, ... Development of the corneal stroma, and the collagen-proteoglycan associations that help define its structure and function. Dev ...https://iovs.arvojournals.org/article.aspx?articleid=2127457
Retinoic Acid Improves Keratocyte Phenotype in a 3D Model of the Corneal Stroma | IOVS | ARVO Journals
However, the role of this signaling molecule in the corneal stroma has been long overlooked. The purpose of this study was to ... Retinoic Acid Improves Keratocyte Phenotype in a 3D Model of the Corneal Stroma ... Retinoic Acid Improves Keratocyte Phenotype in a 3D Model of the Corneal Stroma ... Retinoic Acid Improves Keratocyte Phenotype in a 3D Model of the Corneal Stroma. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1300 ...https://iovs.arvojournals.org/article.aspx?articleid=2330999
Collagen type I and type V are present in the same fibril in the avian corneal stroma. | JCB
Collagen type I and type V are present in the same fibril in the avian corneal stroma.. D E Birk, J M Fitch, J P Babiarz, T F ... Collagen type I and type V are present in the same fibril in the avian corneal stroma. ...http://jcb.rupress.org/content/106/3/999/tab-article-info
Generation and Characterization of a Novel Mouse Line, Keratocan-rtTA (KeraRT), for Corneal Stroma and Tendon Research | IOVS |...
Ectopic expression of TGF-α in corneal keratocytes caused hyperplasia in the corneal epithelium and stroma. ... of corneal stroma keratocytes lacked expression of GFP (arrows). Ud, upper lid; Ld, lower lid; Co, cornea; Epi, corneal ... of corneal stroma keratocytes lacked expression of GFP (arrows). Ud, upper lid; Ld, lower lid; Co, cornea; Epi, corneal ... of corneal stroma keratocytes lacked expression of GFP (arrows). Ud, upper lid; Ld, lower lid; Co, cornea; Epi, corneal ...https://iovs.arvojournals.org/article.aspx?articleid=2655084
Two-Photon Fluorescence Microscopy for Determination of the Riboflavin Concentration in the Anterior Corneal Stroma When Using...
Baiocchi S, Mazzotta C, Cerretani D, Caporossi T, Caporossi A. Corneal crosslinking: riboflavin concentration in corneal stroma ... Araie M, Maurice D. The rate of diffusion of fluorophores through the corneal epithelium and stroma. Exp Eye Res. 1987 ; 44: 73 ... Hatami-Marbini H, Etebu E, Rahimi A. Swelling pressure and hydration behavior of porcine corneal stroma. Curr Eye Res. 2013; 38 ... From x-ray scattering experiments21 in corneal stroma, we know that primarily the collagen molecule is superficially cross- ...http://iovs.arvojournals.org/article.aspx?articleid=2465331
Impaired Wound Healing In Corneal Stroma Of A Nitric Oxide Synthase Type II -deficient Mouse | IOVS | ARVO Journals
Purpose: To investigate the effects of loss of nitric oxide synthase type II (NOS2) in the healing of an injured corneal stroma ... Methods: The effect of lacking NOS2 on corneal stroma wound healing following an incision injury was evaluated by using NOS2- ... Results: Healing of an incision injury in corneal stroma was delayed with less invasion of macrophages and reduction in ... Appearance of myofibroblasts in the injured corneal stroma was suppressed by lacking NOS2 in vivo, although the loss of NOS2 ...http://iovs.arvojournals.org/article.aspx?articleid=2148694
The Kinetics of Chemically Induced Nonequilibrium Swelling of Articular Cartilage and Corneal Stroma | Journal of Biomechanical...
The Kinetics of Chemically Induced Nonequilibrium Swelling of Articular Cartilage and Corneal Stroma S. R. Eisenberg and A. J. ... The Kinetics of Chemically Induced Nonequilibrium Swelling of Articular Cartilage and Corneal Stroma. ASME. J Biomech Eng. 1987 ... Return to: The Kinetics of Chemically Induced Nonequilibrium Swelling of Articular Cartilage and Corneal Stroma ... To Understand Myopic Alleviation by Conducting Finite Element Structural Analysis of a Cornea With an Intrastromal Corneal Ring ...http://biomechanical.asmedigitalcollection.asme.org/article.aspx?articleid=1397498
Age, refractive index of corneal stroma help improve LASIK predicted outcomes - LinkOPH
Age, refractive index of corneal stroma help improve LASIK predicted outcomes. by Healio ophthalmology • 2013/03/26. • 0 ... Factoring patient age and refractive index of the corneal stroma into the treatment profile improved the predictability of ...http://www.linkoph.com/2013/03/26/age-refractive-index-of-corneal-stroma-help-improve-lasik-predicted-outcomes/
Multipotent Stem Cells in Human C... preview & related info | Mendeley
Stem cells (Dayton, Ohio). Keratocytes of the corneal stroma secrete a specialized extracellular matrix essential for vision. ... Keratocytes of the corneal stroma secrete a specialized extracellular matrix essential for vision. These quiescent cells ... These results demonstrate the presence of a population of cells in the human corneal stroma expressing stem cell markers and ... These cells may be a resource for bioengineering of corneal stroma and for cell-based therapeutics. ...https://www.mendeley.com/research-papers/multipotent-stem-cells-human-corneal-stroma/
Clinical Ophthalmology | Volume 4 - Dove Press Open Access Publisher
Swelling studies of camel and bovine corneal stroma Turki Almubrad, Mohammad Faisal Jamal Khan, Saeed Akhtar ... Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium Ryou Watanabe, ... Corneal cell viability and structure after transcorneal freezing-thawing in the human cornea Joo Youn Oh, Hyun Ju Lee, Sang In ... Observation of posterior corneal vesicles with in vivo confocal microscopy and anterior segment OCT Ryou Watanabe, Toru ...https://www.dovepress.com/clinical-ophthalmology-archive9-v221
Molecular Vision: In vivo observation of Langerhans cells by laser confocal microscopy in Thygeson's superficial punctate...
Corneal stroma and endothelial cells. Some keratocytes had highly reflective cell bodies of irregular size, orientation, and ... Corneal epithelium. Superficial cells of the corneal epithelium showed no substantial changes in cell size, shape, or ... Images of the posterior stroma and corneal endothelium appeared normal in the affected eyes. ... In vivo confocal microscopy for studying corneal diseases and conditions associated with corneal nerve damage. Adv Exp Med Biol ...http://www.molvis.org/molvis/v15/a155/
July 2014 - Volume 33 - Issue 7 : Cornea
Penetration of Silicate Nanoparticles into the Corneal Stroma and Intraocular Fluids. Mohammadpour, Mehrdad; Hashemi, Hassan; ... Correlation of Corneal Endothelial Changes With Different Stages of Keratoconus. El-Agha, Mohamed-Sameh H.; El Sayed, Yasmine M ... Pterygium Is Related to a Decrease in Corneal Endothelial Cell Density. Hsu, Min-Yen; Lee, Hsin-Nung; Liang, Chiao-Ying; More ... Corneal Sensitivity in Chronic Inflammatory Demyelinating Polyneuropathy. Bansal, Surbhi; Myneni, Ajay A.; Mu, Lina; More ...http://journals.lww.com/corneajrnl/Abstract/2014/07000/href
AQP5 Gene - GeneCards | AQP5 Protein | AQP5 Antibody
Keratocytes Corneal Stroma *span" data-trigger="SectionLoaded"> Kidney (Urinary System) * Type B cells Renal Collecting Duct ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP5
POU2F1 Gene - GeneCards | PO2F1 Protein | PO2F1 Antibody
Adult Corneal Superbasal Epithelial Cells Corneal Epithelium * Keratocytes Corneal Stroma * Fetal Corneal Superficial ... Adult Corneal Basal Epithelial Cells Corneal Epithelium * ... Adult Corneal Basal Epithelial Cells Corneal Epithelium * Adult ... Fetal Corneal Superficial Epithelial Cells Corneal Epithelium * Adult Corneal Superficial Epithelial Cells Corneal Epithelium ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=POU2F1&rf=/home/genecards/current/website/carddisp.pl&interactions=91
Descemet's stripping automated endothelial keratoplasty (DSAEK) using corneal donor tissue not acceptable for use in...
Corneal Stroma / pathology. Corneal Transplantation* / methods. Descemet Membrane / surgery*. Donor Selection*. Endothelium, ... Central corneal thickness measurements should be performed before cutting to avoid tissue perforation. The use of ASF tissue ... Corneal topography, pachymetry, and manifest astigmatism were not significantly different between groups.. CONCLUSION: ... Descemet's stripping automated endothelial keratoplasty (DSAEK) using corneal donor tissue not acceptable for use in ...http://www.biomedsearch.com/nih/Descemets-stripping-automated-endothelial-keratoplasty/19654530.html
Patent US5261923 - Method and apparatus for continuous circular capsulorehexis - Google Patents
System for inserting material into corneal stroma. US5846256 *. 5 Jun 1995. 8 Dec 1998. Keravision, Inc.. Device and method for ... Device and method for inserting a biocompatible material into the corneal stroma. ... inserting a biocompatible material into the corneal stroma. US5860994 *. 30 Jul 1996. 19 Jan 1999. Yaacobi; Yoseph. Remotely ...http://www.google.co.uk/patents/US5261923
Search of: Recruiting, Not yet recruiting, Available Studies | 'Corneal Diseases' - List Results - ClinicalTrials.gov
Brillouin frequency shift of corneal stroma. *Change of Brillouin frequency shift from base line in corneas received LASIK ... Effectiveness of Corneal Accelerated Crosslinking for Infectious Keratitis. *Keratitis. *Procedure: Accelerated Corneal Cross- ... Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases. *Hereditary Corneal Dystrophy ... Corneal thickness. 15. All. 18 Years and older (Adult, Senior). NCT02806921. 14620. August 2016. September 2017. May 2018. June ...https://clinicaltrials.gov/ct2/results?recr=Open&cond=%22Corneal+Diseases%22&show_flds=Y
Mechanical strain enhances survivability of collagen micronetworks in the presence of collagenase: implications for load...
1982 The bilaterally asymmetrical architecture of the submammalian corneal stroma resembles a cholesteric liquid crystal. Dev. ... 1983 Morphogenesis of rabbit corneal stroma. Invest. Ophthalmol. Vis. Sci. 24, 543-556. ... who noted the lack of bilateral symmetry in the rotation of the lamellae in chick primary corneal stroma and concluded that ... 1999 Corneal stromal wound healing in refractive surgery: the role of myofibroblasts. Prog. Retin. Eye Res. 18, 311-356. (http ...http://rsta.royalsocietypublishing.org/content/367/1902/3339