Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone...
All information about the latest scientific publications of the Clínica Universidad de Navarra. Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cellshttp://www.cun.es/en/research/scientific-publications/chemokine-stromal-cell-derived-factor-1alpha-modulates-vla-4-integrin-dependent-adhesion-fibronectin-vcam-1-bone-marrow-hematopoietic-progenitor-cells
C-X-C Chemokine Receptor Type 2 Market is expected to grow at high CAGR during the forecast period, H1 2016 | Healthcare
Before It's News). Summary. Publisher's, 'C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin-8 Receptor B or IL-8 Receptor Type 2 or CD182 or CXCR2) - Pipeline Review, H1 2016′, provides in depth analysis on C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin-8 Receptor B or IL-8 Receptor Type 2 or CD182 or CXCR2) targeted pipeline therapeutics. The report provides comprehensive information on the C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin-8 Receptor B or IL-8 Receptor Type 2 or CD182 or CXCR2), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the ...http://beforeitsnews.com/healthcare/2016/11/c-x-c-chemokine-receptor-type-2-market-is-expected-to-grow-at-high-cagr-during-the-forecast-period-h1-2016-2487352.html
Braun M et al. (2002), Xenopus laevis Stromal cell-derived factor 1: c... - Xenbase Paper
Transmembrane signaling of the CXC chemokine stromal cell-derived factor-1 (SDF-1) is mediated by CXCR4, a G protein-coupled receptor initially identified in leukocytes and shown to serve as a coreceptor for the entry of HIV into lymphocytes. Characterization of SDF-1- and CXCR4-deficient mice has revealed that SDF-1 and CXCR4 are of vital developmental importance. To study the role of the SDF-1/CXCR4-chemokine/receptor system as a regulator of vertebrate development, we isolated and characterized a cDNA encoding SDF-1 of the lower vertebrate Xenopus laevis (xSDF-1). Recombinant xSDF-1 was produced in insect cells, purified, and functionally characterized. Although xSDF-1 is only 64-66% identical with its mammalian counterparts, it is indistinguishable from human (h)SDF-1alpha in terms of activating both X. laevis CXCR4 and hCXCR4. Thus, both xSDF-1 and hSDF-1alpha promoted CXCR4-mediated activation of heterotrimeric G(i2) in a cell-free system and induced release of ...http://www.xenbase.org/literature/article.do?method=display&articleId=7595
C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin 8 Receptor A or IL8 Receptor Type 1 or CD181 or CXCR1) -...
[45 Pages Report] Check for Discount on C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin 8 Receptor A or IL8 Receptor Type 1 or CD181 or CXCR1) - Pipeline Review, H2 2017 report by Global Markets Direct. According to the recently published report 'C-X-C Chemokine...http://www.reportsnreports.com/reports/1222415-c-x-c-chemokine-receptor-type-1-cdw128a-or-high-affinity-interleukin-8-receptor-a-or-il8-receptor-type-1-or-cd181-or-cxcr1-pipeline-review-h2-2017.html
Circulating progenitor cells
Particular populations of stem cells in the bone marrow harbors the membrane receptor CXCR4 which is a specific receptor for chemokine stromal cell-derived factor (SDF-1). In addition, the presence of CXCR4 identifies cells showing expression of early cardiac, muscle and endothelial markers. In mice experiments it was shown that bone marrow contains pools of cells that express early cardiac lineage markers (Nkx2.5/Csx, GATA-4, and MEF2C) and the population can be mobilised by inducing the myocardial infarction. This is the first proof that postnatal bone marrow contains nonhematopoietic population of cells that express markers for cardiac differentiation [4-6]. The peak expression of cardiac markers was found at the same time as most significant increase of stem cells number was measured . A Similar phenomenon seems to occur in humans in the setting of AMI . The SDF-1/CXCR-4 axis seems particularly important in stem/progenitor cell homing, chemotaxis, engrafment and ...https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-4/Circulating-progenitor-cells-Title-Circulating-progenitor-cells
Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF-κB pathways and promotes osteoclastogenesis in human oral...
Oral squamous cell carcinoma (SCC) has a striking tendency to invade to bone. The chemokine stromal cell-derived factor-1 (SDF-1) is constitutively secreted by osteoblasts and plays a key role in homing of hematopoietic cells to the bone marrow. Interleukin (IL)-6 plays an important role in osteoclastogenesis. Herein, we found that SDF-1α increased the secretion of IL-6 in cultured human SCC cells, as shown by reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay. SDF-1α also increased the surface expression of chemokine receptor 4 (CXCR4) in SCC cells. CXCR4-neutralizing antibody, CXCR4-specific inhibitor (AMD3100) or small interfering RNA against CXCR4 inhibited SDF-1α-induced increase IL-6 production. The transcriptional regulation of IL-6 by SDF-1α was mediated by phosphorylation of extracellular signal-regulated kinases (ERKs) and activation of the nuclear factor-kappa B (NF-κB) components p65 and p50. The binding of p65 ...http://oxfordindex.oup.com/view/10.1093/carcin/bgn045
AID 612006 - Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxis -...
BioAssay record AID 612006 submitted by ChEMBL: Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxis.https://pubchem.ncbi.nlm.nih.gov/bioassay/612006
RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis...
The interaction of multiple myeloma (MM) cells with the bone marrow (BM) milieu plays a crucial role in MM pathogenesis. Stromal cell-derived factor-1 (SDF1) regulates homing of MM cells to the BM. In this study, we examined the role of RhoA and Rac1 GTPases in SDF1-induced adhesion and chemotaxis of MM. We found that both RhoA and Rac1 play key roles in SDF1-induced adhesion of MM cells to BM stromal cells, whereas RhoA was involved in chemotaxis and motility. Furthermore, both ROCK and Rac1 inhibitors reduced SDF1-induced polymerization of actin and activation of LIMK, SRC, FAK, and cofilin. Moreover, RhoA and Rac1 reduced homing of MM cells to BM niches. In conclusion, we characterized the role of RhoA and Rac1 GTPases in SDF1-induced adhesion, chemotaxis, and homing of MM cells to the BM, providing the framework for targeting RhoA and Rac1 GTPases as novel MM ...http://ktisis.cut.ac.cy/handle/10488/7344
A STROMAL CELL-DERIVED FACTOR-1 RELEASING MATRIX ENHANCES THE PROGENITOR CELL RESPONSE AND BLOOD VESSEL GROWTH IN ISCHAEMIC...
Although many regenerative cell therapies are being developed to replace or regenerate ischaemic muscle, the lack of vasculature and poor persistence of the therapeutic cells represent major limiting factors to successful tissue restoration. In response to ischaemia, stromal cell-derived factor-1 (SDF-1) is up-regulated by the affected tissue to stimulate stem cell-mediated regenerative responses. Therefore, we encapsulated SDF-1 into alginate microspheres and further incorporated these into an injectable collagen-based matrix in order to improve local delivery. Microsphere-matrix impregnation reduced the time for matrix thermogelation, and also increased the viscosity reached. This double-incorporation prolonged the release of SDF-1, which maintained adhesive and migratory bioactivity, attributed to chemotaxis in response to SDF-1. In vivo, treatment of ischaemic hindlimb muscle with microsphere-matrix led to increased mobilisation of bone marrow-derived ...http://liu.diva-portal.org/smash/record.jsf?pid=diva2:453975
Novel Stromal Cell-Derived Factor-1 Polypeptides, Polynucleotides, Modulators Thereof and Methods of Use - diagram, schematic,...
Novel Stromal Cell-Derived Factor-1 Polypeptides, Polynucleotides, Modulators Thereof and Methods of Use - diagram, schematic, and image 01 ...http://www.patentsencyclopedia.com/imgfull/20090010946_01
C-X-C chemokine receptor type 1
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008 ...https://pharos.nih.gov/idg/targets/P25024
Platelet-Derived Stromal Cell-Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34+ Cells to...
Thank you for your interest in spreading the word on Circulation.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...http://circ.ahajournals.org/content/early/2007/12/17/CIRCULATIONAHA.107.714691
ActoFactor™ Recombinant Mouse Chemokine (C-X-C motif) ligand 12 (alpha) | Creative Bioarray
Recombinant Murine Stromal Cell-Derived Factor-1 alpha (rMu SDF-1 alpha) is a recently discovered protein belonging to the alpha-chemokine (C-X-C) family of cytokines. Creative Bioarrays recombinant murine SDF-1 alpha is a 7.9 kDa protein containing 68 amino acid residues ...https://www.creative-bioarray.com/ActoFactor-Recombinant-Mouse-Chemokine-C-X-C-motif-ligand-12-alpha-CSC-CTK0778-item-4104.htm
Human CXCR4/Galpha15 Stable Cell Line-Chem-1 - Creative Biogene
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It actshttps://www.creative-biogene.com/Human-CXCR4-Galpha15-Stable-Cell-Line-Chem-1-CSC-RG0642-195540-11.html
OriGene - Cxcl12 (NM 001033883) cDNA Clone
Cxcl12 - Cxcl12 (untagged ORF) - Rat chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) (Cxcl12), transcript variant 3, (10 ug) available for purchase from OriGene - Your Gene Company.http://www.origene.com/Rat_cDNA/RN200482.aspx
OP0215 Endothelial Progenitor Cells Recruitment and NT-ProBNP Release is Related Severity and Progression of Asymptomatic...
Results Mean age was 48.28±3.88 for controls and 49.48±9.88 for patients (p=0.19); 53 controls (95%) and 97 patients (97%) were women (p=0.23). Diastolic dysfunction was present in 1 control (1.7%) and 61 SSc patients (61%) (p=0.0003). NT-proBNP levels were 22.24 pg/ml ±8.48 for controls, 50.51 pg/ml (12-253) for patients without DD and 336.15 pg/ml (17-2250) for patients with DD (p=0.0001). CD309/34+ EPC was 0.84 cels/ml (0.1-3.1) for controls, 1.71 cels/ml (0.1-5.5) for patients without DD and 0.86 cels/ml (0.01-5.5) for patients with DD (p=0.0001); same tendency was observed with other two subtypes of EPC. Subanalysis showed that EPC was different (p=0.0001) among mild, moderate and severe DD. ...http://ard.bmj.com/content/74/Suppl_2/152.2
Two distinct CXCR4 antagonists mobilize progenitor cells in mice by different mechanisms | Blood Advances
HPCs may be mobilized in response to blood-borne chemokines that form a chemotactic gradient across the BM sinusoidal endothelium. Thus CCL11, CXCL8, and CXCL2 all induce a rapid mobilization of HPCs when injected into animals.31⇓-33 The chemokine CXCL12 is produced constitutively in the BM, and there is now an extensive literature that is consistent with the notion that the CXCR4:CXCL12 chemokine axis is critical for HPC retention in the BM.34 Thus, for example, circadian variations in levels of CXCL12 in the BM have been shown to correlate with retention and egress of HPCs,35 and sustained overexpression of CXCL12 using an adenovirus and other drugs that are CXCR4 agonists have been shown to mobilize HPCs into the blood.36⇓-38 CXCL12 is produced locally in damaged tissues and is reported to be critical for the mobilization and recruitment ...http://www.bloodadvances.org/content/1/22/1934?sso-checked=true
The experiments described in this study suggest that the chemokine SDF-1 acts as a neurotransmitter in the DG. The evidence supporting this supposition is similar to that available for GABA, certainly a well-established neurotransmitter. Thus, both GABA and SDF-1 are localized in synaptic vesicles within DG nerve terminals. Both GABA and SDF-1 produce similar electrophysiological effects on nestin-EGFP and DCX-EGFP-expressing cells in the SGZ. Moreover, it appears that both GABA and SDF-1 are tonically released in the DG. Thus, addition of both GABAA and CXCR4 receptor blockers elicited an outward current, suggesting that GABA and SDF-1 normally exert a tonic influence on type 2 progenitor cells. It also appears that the effects of GABA and SDF-1 are linked in some way because the observed effects of SDF-1 are sensitive to both GABAA and CXCR4 blockers.. SDF-1 and its receptor CXCR4 have been shown to be widely expressed throughout the developing and adult nervous systems (Stumm et al., ...http://www.jneurosci.org/content/28/26/6720
CXCL1 - Википедија, слободна енциклопедија
CXCL1 izlučuju ljudske ćelije melanoma. On ima mitogene osobine i učestvuje u patogenezi melanoma. CXCL1 izražavaju makrofage, neutrofili i epitelske ćelije, i dejstvuje kao neutrofilni hemoatraktant. CXCL1 igra ulogu u razvoju kičmene moždine putem inhibicije migracije oligodendrocit prekursora, i učestvuje u procesima angiogeneze, inflamacije, zarastanja rana, i tumorigeneze.. Ovaj hemokin dejstvuje putem signaliziranja kroz hemokin receptor CXCR2. Gen za CXCL1 je lociran na ljudskom hromozomu 4 među genima za drugih CXC hemokina. Jedna početna studija na miševima je proizvela evidenciju da CXCL1 umanjuje težinu multiple skleroze i da možda može da ima neuroprotektivnu ulogu.. ...https://sr.wikipedia.org/wiki/CXCL1
CXCL5 Gene - GeneCards | CXCL5 Protein | CXCL5 Antibody
Complete information for CXCL5 gene (Protein Coding), C-X-C Motif Chemokine Ligand 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendiumhttp://www.genecards.org/cgi-bin/carddisp.pl?gene=CXCL5
CXCL9 Gene - GeneCards | CXCL9 Protein | CXCL9 Antibody
Complete information for CXCL9 gene (Protein Coding), C-X-C Motif Chemokine Ligand 9, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendiumhttp://www.genecards.org/cgi-bin/carddisp.pl?gene=CXCL9
CXCL9 Gene - GeneCards | CXCL9 Protein | CXCL9 Antibody
Complete information for CXCL9 gene (Protein Coding), C-X-C Motif Chemokine Ligand 9, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendiumhttp://www.genecards.org/cgi-bin/carddisp.pl?gene=CXCL9&ace=95
sdf 1 alpha recombinant human sdf 1 alpha Gentaur Molecular Products
sdf 1 alpha recombinant human sdf 1 alpha | order sdf 1 alpha recombinant human sdf 1 alpha | How to use: sdf 1 alpha recombinant human sdf 1 alpha | support help forhttp://www.clonagen.com/product_description.php?id=8088&product_name=recombinant%20human%20sdf%201%20alpha
Aortic and plasma expression levels of IL-18 and CXCL16 | Open-i
Aortic and plasma expression levels of IL-18 and CXCL16.(A) Reduced aortic mRNA expression of IL-18 and CXCL16, but no change in the expression of IFN-γ is obshttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2962638_pone.0013539.g007&req=4
The aim of the present study was to characterize the defect in chemokine-induced αLβ2 activation that we have previously identified in α4β1+ CLL cells ( 3, 4).. Because many CLL clones express little or no α4β1 ( 3, 5), we started the present studies by examining chemokine-induced αLβ2 clustering on these cells. The αL of α4− CLL cells also failed to undergo polar clustering or αLβ2-dependent motility when incubated on ligand in the presence of chemokine. Because the αLβ2 of normal B cells becomes clustered under these conditions ( 4), this indicates that defective αL clustering in response to chemokine is a feature of CLL cells, regardless of their expression of α4β1.. We next found that the αLβ2 of CLL cells tested directly ex vivo is in an activated conformation, but the degree of activation varied among cases, with α4− clones expressing the high-affinity, fully activated form of αLβ2; furthermore, these cells were able to bind ICAM-1. In ...http://cancerres.aacrjournals.org/content/68/20/8429