*  E-box - Wikipedia
These proteins usually contain the basic helix-loop-helix protein structural motif, which allows them to bind as dimers. This ... Ripperger, J A.; Schibler, U. (Mar 2006). "Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp ... Chaudhary, J; Skinner, M K. (May 1999). "Basic helix-loop-helix proteins can act at the E-box within the serum response element ... 2000). "Serine/Threonine Kinases 3pK and MAPK-activated Protein Kinase 2 Interact with the Basic Helix-Loop-Helix Transcription ...
  https://en.wikipedia.org/wiki/E-box
*  Basic helix-loop-helix - Wikipedia
A basic helix-loop-helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing ... 2009: Grove, De Masi et al., identified novel short DNA motifs, bound by a subset of bHLH proteins, which they defined as "E- ... helix-loop-helix". Protein Profile. 2 (6): 621-702. PMID 7553065. Massari ME, Murre C (January 2000). "Helix-loop-helix ... It should not be confused with the helix-turn-helix domain. The motif is characterized by two α-helices connected by a loop. In ...
  https://en.wikipedia.org/wiki/Basic_helix-loop-helix
*  Myc - Wikipedia
... basic helix-loop-helix) structural and LZ (leucine zipper) motifs. Through its bHLH DNA-binding motif, Myc interacts with DNA, ... Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ... Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ... while the leucine zipper TF-binding motif allows the dimerization with its partner Max, another bHLH transcription factor. Myc ...
  https://en.wikipedia.org/wiki/Myc
*  What's hot today: Current papers in developmental biology and gene function
Proneural genes encode basic helix-loop-helix transcription factors that promote the expression of 'core' and subtype-specific ... Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes Dev 28: 888-901 ... The Dntf-2r regulatory region is similar to the known β2 tubulin 14 bp testis motif (β2-UE1). Comparative sequence analyses ... act as testis-specific regulatory motifs in these genes. The Dntf-2r regulatory region is similar to the known β2 tubulin 14 bp ...
  http://www.sdbonline.org/sites/fly/aimain/model-organisms-june2014.htm
*  Protein structure prediction - Wikipedia
An example is the helix-loop-helix motif. Structural motifs are also referred to as supersecondary structures and folds. ... the known protein structures have been classified into hierarchical levels of structural complexity with the fold as a basic ... Examples of sequence motif databases are the Prosite catalog and the Stanford Motifs Database. motif (structural context) a ... fold similar to structural motif, includes a larger combination of secondary structural units in the same configuration. Thus, ...
  https://en.wikipedia.org/wiki/Protein_structure_prediction
*  DNA-binding domain - Wikipedia
The basic helix-loop-helix (bHLH) domain is found in some transcription factors and is characterized by two alpha helices (α- ... A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that ... set of DNA-binding domains to predict transcription factors in all completely sequenced genomes Table of DNA-binding motifs DNA ... helixes) connected by a loop. One helix is typically smaller and due to the flexibility of the loop, allows dimerization by ...
  https://en.wikipedia.org/wiki/DNA-binding_domain
*  SMART: PTB domain annotation
It contains a peptide binding pocket (formed by the beta strand 5 and C-terminal alpha helix) and a highly basic phospholipid ... The structural bases of the interactions are well understood for the few domains now experimentally determined, and ligand- ... The Shc-like PID specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins including ... Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine. ...
  http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=PTB&BLAST=DUMMY
*  Heterogeneous Nuclear Ribonucleoprotein K Binds to the Cytosine-Rich Sequence of the Hypoxia Inducible Factor 1 Alpha Proximal...
Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated ... or long-loop sizes, class II. Class I i-motif structures include the VEGF, RET and Rb i-motifs, which have loop size ... or the pH at which half the structural species consists of i-motif and the other half of non-i-motif folded species) of 5.8, ... Knowing that C15 is in the loop region of the i-motif and is highly brominated when folded in an i-motif and that hnRNP K does ...
  https://www.omicsonline.org/heterogeneous-nuclear-ribonucleoprotein-k-binds-to-the-cytosine-rich-sequence-of-the-hypoxia-inducible-factor-1-alpha-proximal-promoter-that-forms-a-stable-i-motif-at-neutral-ph-2161-0398.S5-001.php?aid=10995
*  CASK | SpringerLink
Therefore, although the structural information provides a basic framework to probe molecular and cellular function of CASK, ... and the LID region composed of a long loop and alpha helix. The LID region of CASK GuK domain has a structure distinct from ... The Hook motif that follows the SH3 domain has been shown to interact with protein 4.1 and effect actin filamentation (Biederer ... 1996); it has also been suggested that besides PDZ-binding motifs, neurexin and syndecan harbor secondary interaction sites for ...
  https://link.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_101833
*  Quint Lab:papers of the month - OpenWetWare
cd- Yi et al.: A basic helix-loop-helix transcription factor controls cell growth and size in root hairs. Nat Gen 2010 ... mq - Yin et al.: Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 16: ... mq - Chung/Howe: A critical role for the TIFY motif in repression of jasmonate signaling by repression of a stabilized splice ... mq - Shoval & Alon: SnapShot: Network Motifs. Cell 143:326e1-2. *mq - Ruschaki et al.: The proteasome antechamber maintains ...
  https://openwetware.org/wiki/?title=Quint_Lab:papers_of_the_month&oldid=478841
*  The Light-Response BTB1 and BTB2 Proteins Assemble Nuclear Ubiquitin Ligases That Modify Phytochrome B and D Signaling in...
... molecular recognition motif necessary for targeting photoactivated phytochrome signaling to specific basic helix-loop-helix ... E3s recognize structural motifs in the target and then catalyze an isopeptide linkage between the C-terminal Gly of Ub and an ... basic helix-loop-helix. BACK. BTB-and-C-terminal-Kelch. NLS. nuclear localization sequence. RT. reverse transcription. Y2H. ... which belong to the basic helix-loop-helix (bHLH) superfamily of transcriptional regulators (Bae and Choi, 2008; Leivar and ...
  http://www.plantphysiol.org/content/160/1/118.full
*  Beta sheet - Wikipedia
A β-helix is formed from repeating structural units consisting of two or three short β-strands linked by short loops. These ... in which case it is called a β-α-β motif. A closely related motif called a β-α-β-α motif forms the basic component of the most ... a program to identify and analyze structural motifs in proteins". Protein Science. 5 (2): 212-20. doi:10.1002/pro.5560050204. ... Individual strands can also be linked in more elaborate ways with longer loops that may contain α-helices. The Greek key motif ...
  https://en.wikipedia.org/wiki/Beta_sheet
*  Structural And Molecular Dynamics Analysis Of The Super Secondary Motifs From TIM Barrel Proteins: Implications For Folding And...
The acquired complex three-dimensional structure of proteins is a culmination of simple structural fragments like α-α, β-Î ... The TIM barrel proteins are made up of a regular repeating βαβ motif resulting in the strands and helices in an alternating ... loop length, loop dynamics, residue preferences in loops, long range side chain main chain interactions etc., to shortlist βαβ ... Thus, tertiary structures can be seen as a combination of basic building block motifs implying that all complex protein ...
  https://www.omicsonline.org/proceedings/structural-and-molecular-dynamics-analysis-of-the-super-secondary-motifs-from-tim-barrel-proteins-implications-for-foldi-72403.html
*  protein facts, information, pictures | Encyclopedia.com articles about protein
The helix-loop-helix motif is a knobby structure, and the zinc finger projects outward like its name. These last two motifs ... Serving as the basic structural molecule of all the tissues in the body, protein makes up nearly 17 percent of the total body ... It is the amino acid sequence that determines the folding pattern, common motifs being the 'alpha helix' and the 'pleated beta ... Combinations of secondary structure form "motifs." A coiled-coil motif is common among proteins that associate with the DNA ...
  https://www.encyclopedia.com/science-and-technology/biochemistry/biochemistry/protein
*  G protein-coupled receptor - Mashpedia Free Video Encyclopedia
... common structural theme among GPCRs is palmitoylation of one or more sites of the C-terminal tail or the intracellular loops. ... the seven-transmembrane helices, is conserved, the relative orientation of the helices differ significantly from that of ... International Union of Basic and Clinical Pharmacology. Retrieved 11 August 2008.. *. "GPCRdb". Data, diagrams and web tools ... Ligand binding disrupts an ionic lock between the E/DRY motif of TM-3 and acidic residues of TM-6. As a result, the GPCR ...
  http://www.mashpedia.com/G-protein_coupled_receptor
*  Unicellular and multicellular Organisms are best explained through design
as illustrated by the basic helix-loophelix (bHLH) protein family involved in diverse cellular developmental processes in ... For example, what if any are the selection barriers to (and the drivers toward) it? Are the motifs in the morphological ... It is now widely accepted, on the basis of structural, biochemical, and molecular evidence, that the five major types of large ... This feature enables sometimes radically different variants of a developmental motif, such as cell-cell adhesion, to achieve ...
  http://reasonandscience.heavenforum.org/t2010-unicellular-and-multicellular-organisms-are-best-explained-through-design
*  Insects | Free Full-Text | Molecular Mechanisms of Transcription Activation by Juvenile Hormone: A Critical Role for bHLH-PAS...
Moore, A.W.; Barbel, S.; Jan, L.Y.; Jan, Y.N. A genomewide survey of basic helix-loop-helix factors in drosophila. Proc. Natl. ... These sequences form secondary structural elements of the PAS fold in a manner analogous to the elements in a PAC motif, but ... MET and GCE possess two conserved PAS motifs, PAS A and PAS B, that are a hallmark feature of bHLH-PAS proteins. PAS domains ... Kewley, R.J.; Whitelaw, M.L.; Chapman-Smith, A. The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. ...
  http://www.mdpi.com/2075-4450/3/1/324/htm
*  The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism
Alba and YhbY domains share a distinct basic loop, bounded by two small residues between the first strand and helix (Figures ​( ... Structural manipulations were carried out using the Swiss-PDB viewer version 3.7 program [48]. Searches of the PDB database, or ... Several members of this family also have long carboxy-terminal tails with repeats of the RGG motif (see below). Members of this ... The majority of archaeal members of the superfamily are clearly distinguished by certain sequence motifs, such as a GXKP ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC328453/?lang=en-ca
*  Natural history of S-adenosylmethionine-binding proteins | BMC Structural Biology | Full Text
Motif IV consists of β-strand 4 and the flanking loops. In this motif again, there is a well-preserved D/E/N residue, located ... Similar duplication of a basic three-stranded unit containing the β-clip structural motif probably occurred also in related SAF ... Motif V corresponds to the helix following the strand with motif IV. In some Rossmann-fold methyltransferases, it serves as a ... Each motif has a clear counterpart at the structural level. Five motifs are arranged in the same linear order in almost all ...
  https://bmcstructbiol.biomedcentral.com/articles/10.1186/1472-6807-5-19
*  HIF1A - Wikipedia
HIF1A contains a basic helix-loop-helix domain near the C-terminal, followed by two distinct PAS (PER-ARNT-SIM) domains, and a ... Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ (Apr 2002). "Structural basis for recruitment of CBP/p300 ... Hansson LO, Friedler A, Freund S, Rudiger S, Fersht AR (Aug 2002). "Two sequence motifs from HIF-1alpha bind to the DNA-binding ... The HIF1A polypeptide also contains a nuclear localization signal motif, two transactivating domains CTAD and NTAD, and an ...
  https://en.wikipedia.org/wiki/HIF1A
*  RNA-binding protein database - Wikipedia
These domains contain a few basic modular units. Comparing with a single motif, RBPs can recognize a much longer stretch of ... the flanking helices, the β-strand and the variable loop between β2 and β3 (type I) or between α2 and β2 (type II) play a very ... The weak interaction surface is largely increased by these motifs. As the result, RBPs can bind RNA with higher specificity and ... The strategy used by zinc figure to distinguish these two type of nucleotides may contain distinct structural arrangement of ...
  https://en.wikipedia.org/wiki/RNA-binding_protein_database
*  Histone acetyltransferase - Wikipedia
It should be noted that there is a seven-stranded β-sheet that is surrounded by α-helices as well as a loop that is involved in ... Human p300 contains a highly basic loop embedded in the middle of its HAT domain that is hyperacetylated in the active form of ... but there are many structural differences in the regions flanking this central core. Overall, the structural data is consistent ... The C motif is found in most GNATs, but it is not present in the majority of other known HATs. The yeast Gcn5 (general control ...
  https://en.wikipedia.org/wiki/Histone_acetyltransferase
*  Protein domain - Wikipedia
EF hand : a helix-turn-helix structural motif found in each structural domain of the signaling protein calmodulin and in the ... For example, the β-hairpin motif consists of two adjacent antiparallel β-strands joined by a small loop. It is present in most ... Structural alignment is an important tool for determining domains. Several motifs pack together to form compact, local, semi- ... Basic Leucine zipper domain (bZIP domain) : is found in many DNA-binding eukaryotic proteins. One part of the domain contains a ...
  https://en.wikipedia.org/wiki/Protein_domain
*  Importin - Wikipedia
A cargo protein can contain either one or two of these motifs, which will bind to the major and/or minor binding sites on ... The release of importin-β frees this region and allows it to loop back and compete for binding with the cargo protein at the ... The basis of their structure is 18-20 tandem repeats of the HEAT motif. Each one of these repeats contains two antiparallel ... Lee SJ, Matsuura Y, Liu SM, Stewart M (June 2005). "Structural basis for nuclear import complex dissociation by RanGTP". Nature ...
  https://en.wikipedia.org/wiki/Importin
*  JAIRO | Basic helix-loop-helix transcription factor DEC1 regulates ...
Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cellsBasic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells ...
  http://jairo.nii.ac.jp/0012/00004633/en
*  Genes | Free Full-Text | A Genome-Wide Identification and Analysis of the Basic ...
The basic helix-loop-helix (bHLH) transcription factors in insects play essential roles in multiple developmental processes including neurogenesis, sterol metabolism, circadian rhythms, organogenesis and formation of olfactory sensory neurons. The identification and function analysis of bHLH family members of the most destructive insect pest of rice, Nilaparvata lugens, may provide novel tools for pest management. Here, a genome-wide survey for bHLH sequences identified 60 bHLH sequences (NlbHLHs) encoded in the draft genome of N. lugens. Phylogenetic analysis of the bHLH domains successfully classified these genes into 40 bHLH families in group A (25), B (14), C (10), D (1), E (8) and F (2). The number of NlbHLHs with introns is higher than many other insect species, and the average intron length is shorter than those of ...
  http://www.mdpi.com/2073-4425/7/11/100
*  Scleraxis: a basic helix-loop-helix protein that prefigures skeletal ...
Members of the basic helix-loop-helix (bHLH) family of transcription factors have been shown to regulate growth and differentiation of numerous cell types. Cell-type-specific bHLH proteins typically form heterodimers with ubiquitous bHLH proteins, such as E12, and bind a DNA consensus sequence known as an E-box. We used the yeast two-hybrid system to screen mouse embryo cDNA libraries for cDNAs encoding novel cell-type-specific bHLH proteins that dimerize with E12. One of the cDNAs isolated encoded a novel bHLH protein, called scleraxis. During mouse embryogenesis, scleraxis transcripts were first detected between day 9.5 and 10.5 post coitum (p.c.) in the sclerotome of the somites and in mesenchymal cells in the body wall and limb buds. Subsequently, scleraxis was expressed at high levels within mesenchymal precursors of ...
  http://dev.biologists.org/content/121/4/1099
*  "Intricate gene regulatory networks of helix-loop-helix (HLH) proteins " by Ying ...
Helix-loop-helix (HLH) transcription factors are key regulators of neurogenesis, myogenesis and osteogenesis. Here the relative contributions of multiple classes of HLH factors to the expression of bone related genes during osteoblast maturation were compared. We examined the expression of a panel of HLH proteins (e.g., Twist1/2, USF1/2, c-Myc, Id1 approximately 4, E12/47, Stra13) and one Zn finger protein (Snail which recognizes a subset of E-boxes), during osteoblast differentiation and their functional contributions to bone phenotypic gene regulation. While expression of Twist1, Stra13, E12/47 and Snail transcripts remains relatively constant, expression of Twist2 as well as the inhibitory factors Id1, Id2, Id3, and Id4 decreases and USF1 is up-regulated during osteoblastic differentiation of MC3T3 cells. Forced expression of selected HLH ...
  http://escholarship.umassmed.edu/gsbs_sp/1567/
*  Differential regulation of granulopoiesis by the basic ...
Inhibitor of DNA binding (Id) proteins function as inhibitors of members of the basic helix-loop-helix family of transcription factors and have been demonstrated to play an important role in regulating lymphopoiesis. However, the role of these proteins in regulation of myelopoiesis is currently unclear. In this study, we have investigated the role of Id1 and Id2 in the regulation of granulopoiesis. Id1 expression was initially up-regulated during early granulopoiesis, which was then followed by a decrease in expression during final maturation. In contrast, Id2 expression was up-regulated in terminally differentiated granulocytes. In order to determine whether Id expression plays a critical role in regulating granulopoiesis, Id1 and Id2 were ectopically expressed in CD34(+) cells by retroviral transduction. Our experiments ...
  https://www.rdm.ox.ac.uk/publications/573060
*  BHLHE41 - Wikipedia
BHLHE41 is a member of the DEC subfamily within the basic helix-loop-helix (bHLH) proteins gene family.[13][15] BHLHE41 was mapped to human chromosome 12: 26,120,026-26-125-127 reverse strand and has a total length of 5,101 base pairs.[16] The gene is also mapped to 6 G2-G3 on the mouse chromosome, and 4q43 distal-q4 on the rat chromosome respectively.[13] BHLHE41 has 3 known splice variants. BHLHE41-002[17] and BHLHE41-003[18] are retained introns and do not code for a protein. BHLHE41-001 contains 5 coding exons, has a transcript length of 3,837 base pairs, and encodes the 482 amino acid BHLHE41 protein.[19][1] BHLHE40 is the paralogue of BHLHE41.[20] BHLHE41 currently has 165 known orthologs.[21][2]. The BHLHE41 protein has a myc-type, basic ...
  https://en.wikipedia.org/wiki/BHLHB3
*  HIF1A - Hypoxia inducible factor 1, alpha subunit (Basic ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
  http://www.uniprot.org/uniprot/A0JND0
*  Plus it
Metastasis is the final and fatal step in the progression of breast cancer. Currently available therapeutic strategies at this stage of cancer progression are often nonspecific, have only marginal efficacy, and are highly toxic. This is in part due to the lack of knowledge about the molecular mechanisms regulating the development of aggressive cancers. Therapeutic approaches targeting only specific mechanisms involved in the development of aggressive breast cancers are urgently need. The expectation would be that this strategy would reduce unwanted toxicities associated with the therapy itself.. We previously showed that the helix-loop-helix protein Id-1, an inhibitor of basic ...
  http://mct.aacrjournals.org/content/6/11/2921
*  Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type...
Basic helix-loop-helix (bHLH) transcription factors are required for proper formation of the vertebrate and invertebrate nervous systems (Bertrand et al., 2002). The vertebrate neural bHLH transcription factors have been classified into subgroups based on their temporal pattern of expression (Lee, 1997) and on their homology to Drosophila proneural genes (Bertrand et al., 2002). The factors Mash1, a homolog of the Drosophila Achaete-scute genes (Johnson et al., 1990), and Math1, a homolog of the Drosophila atonal gene (Akazawa et al., 1995), both belong to the early expressed sub-group of bHLH factors because of their expression in progenitor cells of the developing neural tube, but they reside in distinct sub-classes based on sequence homology (Bertrand et al., 2002). Gene knockout studies have demonstrated essential roles ...
  http://dev.biologists.org/content/131/6/1319
*  HEA798Hu | 低氧诱导因子1α(HIF1a)检测试剂盒(酶联免疫吸附试验法,高敏型) | Homo sapiens (Human,人) USCN(武汉优尔生商贸有限公司)
HEA798Hu, High Sensitive ELISA Kit for Hypoxia Inducible Factor 1 Alpha (HIF1a), 低氧诱导因子1α(HIF1a)检测试剂盒(酶联免疫吸附试验法,高敏型), HIF1-A; MOP1; PASD8; Basic Helix-Loop-Helix Transcription Factor; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78 | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
  http://www.uscnk.cn/uscn/High-Sensitive-ELISA-Kit-for-Hypoxia-Inducible-Factor-1-Alpha-
*  Transcription-factor occupancy at HOT regions quantitatively predicts RNA polymerase recruitment in five human cell lines | BMC...
Motifs in the E-box family are bound by TFs with a basic helix-loop-helix domain, including BHLHE40 [59], MYC-MAX [29], MXI1-MAX [30], TCF12 [60], and USF1/USF2 [33]. Other TFs enriched at E-box sites included ATF3, E2F6, NFE2, and SIN3A; of these, the only previously documented interaction with a E-box-binding TF is between SIN3A and MAD-MAX [61].. Subunits of the AP-1 transcription factor were only weakly enriched at promoters containing motifs for the FOS-JUN heterodimer; however, JUN and JUND, but not FOS, were more strongly enriched at sites with motifs associated with their alternate binding partner ATF3. The ATF3 motifs were also predictive of the occupancy of CEBPB, RFX5, and SRF, none of which are documented to interact with AP-1 directly; however, ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-720
*  Genetic risk expressed in early regulator of gene expression | Genes 2 Brains 2 Mind 2 Me
Image via Wikipedia The basic helix-loop-helix transcription factor, neurogenin-1 is known to regulate neural development and neurite outgrowth. As such, it makes for a particularly interesting point to begin to understand mental illness and its complex developmental origins. The recent paper by Ho et al., 'Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: Effects on illness…
  https://genes2brains2mind2me.com/2009/06/29/genetic-risk-expressed-in-early-regulator-of-gene-expression/
*  WikiGenes - NHLH1 - nescient helix loop helix 1
The world's first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
  https://www.wikigenes.org/e/gene/e/4807.html
*  Anti-NSCL1 (HEN1; Helix-loop-helix protein 1) Polyclonal Antibody, Unconjugated from ...
Anti-NSCL1 (HEN1; Helix-loop-helix protein 1) Polyclonal Antibody, Unconjugated from CHEMICON,Recognizes NSCL1. The molecular weight of the protein is 14,616 Daltons.,biological,biology supply,biology supplies,biology product
  http://www.bio-medicine.org/biology-products/Anti-NSCL1--28HEN1-3B-Helix-loop-helix-protein-1-29-Polyclonal-Antibody--Unconjugated-from-CHEMICON-4104-1/
*  Abstract 14: The Helix-Loop-Helix Transcription Factor nPAS4 Induces Sprouting ...
Introduction: Neuronal PAS4 (nPAS4) -formerly known as LE-PAS- is a helix-loop-helix-PAS (HLH-PAS) transcription factor that has recently been cloned as the vertebrate homologue of the drosophila protein dysfusion (dys). In drosophila, the lack of dys is characterized by impaired midline fusion of tracheal tubes. Forced expression of dys results in aberrant sprouting of tracheal tubes in drosophila. In neurons, nPAS4 plays a role in the formation of GABA-releasing synapses. Based on the morphological similarity between tracheal tube formation and angiogenesis, we aimed to investigate the role of nPAS4 in angiogenesis in vertebrates.. Methods and Results: RT-PCR and Western blotting analyses showed that nPAS4 is expressed at low levels in various endothelial cell lines. The expression of nPAS4 is not upregulated by angiogenic growth factors ...
  http://atvb.ahajournals.org/content/32/Suppl_1/A14
*  Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons |...
Myf5 is a key basic Helix-Loop-Helix transcription factor capable of converting many non-muscle cells into muscle. Together with MyoD it is essential for initiating the skeletal muscle programme in the embryo. We previously identified unexpected restricted domains of Myf5 transcription in the embryonic mouse brain, first revealed by Myf5-nlacZ(+/)(−) embryos (Tajbakhsh, S. and Buckingham, M. (1995) Development 121, 4077-4083). We have now further characterized these Myf5 expressing neurons. Retrograde labeling with diI, and the use of a transgenic mouse line expressing lacZ under the control of Myf5 regulatory sequences, show that Myf5 transcription provides a novel axonal marker of the medial longitudinal fasciculus (mlf) and the mammillotegmental tract (mtt), the earliest longitudinal tracts to be established in the ...
  http://dev.biologists.org/content/127/2/319
*  Gene Expression Literature Detail
J:55991 Brown D, Wagner D, Li X, Richardson JA, Olson EN, Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis. Development. 1999 Oct;126(19):4317-29 ...
  http://www.informatics.jax.org/gxdlit/key/15085
*  anti-HIF1 alpha antibody | GeneTex
HIF1 alpha antibody (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)) for ICC/IF, IHC-Fr, IHC-P, IP, WB, ChIP assay. Anti-HIF1 alpha pAb (GTX127309) is tested in Human, Mouse, Rat, Bovine samples. 100% Ab-Assurance.
  http://www.genetex.com/HIF1-alpha-antibody-GTX127309.html
*  Plus it
The bHLH 3 family of transcription factors have been shown to play important roles in cell growth and differentiation (reviewed in Refs. 1 and 2 ). There are two distinct classes of bHLH proteins. Ubiquitously expressed class A bHLH, often also referred as the "E" proteins, consist of E2-2 (3) , HEB (4) , and the differentially spliced products of the E2A gene, E12 and E47 (5) . The class B proteins represent a large yet expanding group of transcription factors, the expression of which is developmentally regulated, such as MyoD (6) , NeuroD (7) , and Tal1 (8) . These proteins contain an HLH domain, mediating homo- and heterodimerization, which consists of two amphipathic helixes separated by a loop, plus an adjacent DNA-binding region rich in basic amino acids (5) . The bHLH dimers bind to a DNA consensus sequence known as the E-box (CANNTG). E-box sites are present in a wide variety of ...
  http://cancerres.aacrjournals.org/content/60/5/1376
*  jira] [Commented] (MATH-1267) Grid coordinate of 'Neuron' that belongs to a 'NeuronSquareMesh2D'
https://issues.apache.org/jira/browse/MATH-1267?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=14732152#comment-14732152 ] Ole Ersoy commented on MATH-1267: --------------------------------- In NeuronSquareMesh2D the getNeuron(int i, int j) method refers to i and j. I assume this is different from the stuff we are talking about above? , Grid coordinate of "Neuron" that belongs to a "NeuronSquareMesh2D" , ------------------------------------------------------------------ , , Key: MATH-1267 , URL: https://issues.apache.org/jira/browse/MATH-1267 , Project: Commons Math , Issue Type: Wish , Reporter: Gilles , Assignee: Gilles , Priority: Minor , Fix For: 4.0, 3.6 , , Attachments: LocationFinder.java , , , When the network layout is a 2D grid, it useful to be able to retrieve the grid coordinate (row, column) of a a neuron. , I propose to define a new class "LocationFinder" (in package "o.a.c.m.ml.neuralnet.twod.util") that will provide the functionality ...
  http://mail-archives.apache.org/mod_mbox/commons-issues/201509.mbox/%3CJIRA.12861854.1441376694000.265468.1441502746496@Atlassian.JIRA%3E
*  jira] [Updated] (MATH-746) Things to do before releasing 3.0
https://issues.apache.org/jira/browse/MATH-746?page=com.atlassian.jira.plugin.system.issuetabpanels:all-tabpanel ] Gilles updated MATH-746: ------------------------ Description: This issue is meant to contain a list of tasks to be completed before the release. * Remarks to be added to the *release notes*: ** Experimental code: {{BOBYQAOptimizer}} (cf. MATH-621) *** Many code paths untested *** Looking for volunteers to improve the code readability, robustness and performance *** Looking for volunteers to extend the test suite ** {{FastMath}} is not always faster than {{Math}} (issue MATH-740) ** List of new features * Create a "release branch" * Disable CheckStyle scanning of {{BOBYQAOptimizer}} (/) ({{r1244855}}) * Comment out "print" statements in {{BOBYQAOptimizerTest}} (/) ({{r1244975}}) * Remove unit test class {{BatteryNISTTest}} * Remove class {{PivotingQRDecomposition}} * Comment out "print" statement in {{SymmLQTest}} (/) ({{r1244992}}) (removed in {{r1244996}}) * Findbugs: ** ...
  http://mail-archives.apache.org/mod_mbox/commons-issues/201202.mbox/%3C2125077438.6290.1329840757986.JavaMail.tomcat@hel.zones.apache.org%3E
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