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*  PSEN1 - Wikipedia
... and stabilize beta-catenin. Mutant of presenilin-1 that reduces the ability to stabilize beta-catenin complex leads to ... Wnt signaling pathway has been shown to be involved in several critical steps in embryogenesis and development. Presenilin 1 ... with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes ... presenilin-1 was also found to play a role in beta-catenin phosphorylation. Beta-catenin is coupled by presenilin-1 and ...
  https://en.wikipedia.org/wiki/PSEN1
*  Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling...
beta-Catenin mutation and its nuclear localization are confirmed to be frequent causes of Wnt signaling pathway activation in ... Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development ... the activation of target genes usually depends on the binding of β-catenin to the TCF/LEF complex [27]. Using the TOP/FOP flash ... Our results suggest that Lef1 is a critical factor for the maintenance of the normal hair cycle and also might participate in ...
  http://www.medsci.org/v10p0738.htm
*  TIP49, C-terminal (IPR010339) | InterPro | EMBL-EBI
Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways ... The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [PMID ... lik encodes Reptin, a component of a DNA-stimulated ATPase complex. ... they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and ...
  http://www.ebi.ac.uk/interpro/entry/IPR010339
*  Beta-catenin - Wikipedia
... in later stages of development, the downregulation of beta-catenin is required. In cardiac muscle, beta-catenin forms a complex ... an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level ... Cell-cell adhesion complexes are essential for the formation of complex animal tissues. β-catenin is part of a protein complex ... the temporal regulation of beta-catenin by protein degradation mechanisms is critical for normal functioning of beta-catenin in ...
  https://en.wikipedia.org/wiki/Beta-catenin
*  Aaron D. Gitler | Stanford Medicine Profiles
... and we demonstrate active Wnt/beta-catenin signaling in developing endocardial cushions suggesting pathways that have not been ... are most important for driving disease and therefore most critical for considering during the development of therapeutic ... Analysis of COPII Vesicles Indicates a Role for the Emp47-Ssp120 Complex in Transport of Cell Surface Glycoproteins. Traffic ... Mitotic exit in neurons is accompanied by an essential switch in ATP-dependent chromatin regulatory complexes from the neural ...
  https://med.stanford.edu/profiles/aaron-gitler?tab=teaching
*  Epigenetic regulation of aging stem cells EA Pollina and A Brunet REVIEW
... shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development. Cell Stem Cell 1: ... The role of b-catenin in adult stem cell function may be mediated through its activity at chromatin, as b-catenin complexes ... The reverse transcriptase of the telomerase complex, TERT, has also recently been found to act downstream of the WNT pathway ... 2008). New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal 1: ra12. Martin C, ...
  http://spotidoc.com/doc/5992/epigenetic-regulation-of-aging-stem-cells-ea-pollina-and-..
*  Frontiers | A review of hedgehog signaling in cranial bone development | Physiology
As demonstrated from murine studies, expression of both SHH and IHH is critical to the formation and fusion of the cranial ... signaling pathway is essential for mesodermal tissue patterning and differentiation. The Hedgehog family consists of three ... of which two are expressed in the craniofacial complex (IHH and SHH). Dysregulations in HH signaling are well documented to ... As demonstrated from murine studies, expression of both SHH and IHH is critical to the formation and fusion of the cranial ...
  https://www.frontiersin.org/articles/10.3389/fphys.2013.00061/full
*  Zijie Sun | Stanford Medicine Profiles
The Wnt signaling pathway and its key component beta-catenin play critical roles in embryonic development as well as in human ... a similarity of the EOS1 complex to that of the bacterial helix-turn-helix phage lambda and 434 repressor-operator complexes, ... Since mutations in Adenomatous polyposis coli (APC), beta-catenin, and other components of the beta-catenin destruction complex ... beta-Catenin plays a critical role in embryonic development and tumorigenesis through its effects on E-cadherin-mediated cell ...
  https://med.stanford.edu/profiles/zijie-sun
*  Colon Cancer Oncogene Discovered ( CDK8 is frequently amplified in these...)
... critical to regulating the WNT/beta-catenin signaling pathway known to be involved in the bulk of colon cancer cases, and also ... CDK8 is a member of the so-called mediator complex, which bridges distant protein complexes to activate expression of certain ... 14 (HealthDay News) -- Researchers have identified a new genetic player in the development of colon cancer. ... It turns out that kinases tend to play key roles in the biochemical pathways that often go haywire in cancer, so they are ...
  http://www.bio-medicine.org/medicine-news-1/Colon-Cancer-Oncogene-Discovered-26412-1/
*  The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells | Development
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 275,1784 -1787. ... Shen, Q., Zhong, W., Jan, Y. N. and Temple, S. (2002). Asymmetric Numb distribution is critical for asymmetric cell division of ... Immune complexes were then eluted from the beads with a solution containing 10 mM dithiothreitol, 1% SDS and 0.1 M NaHCO3, ... Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275,1787 -1790. ...
  http://dev.biologists.org/content/131/12/2791
*  SMART: PHD domain annotation
... core components of the Wnt signaling pathway that are required for the transcriptional activity of Armadillo/beta-catenin and T ... Pygopus residues required for its binding to Legless are critical for transcription and development. ... crystal structure of PHF2 PHD domain complexed with H3K4Me3 peptide. 3kv4. Structure of PHF8 in complex with histone H3. ... Structure of PHD domain of UHRF1 in complex with H3 peptide. 2lgk. NMR Structure of UHRF1 PHD domains in a complex with histone ...
  http://smart.embl.de/smart/do_annotation.pl?DOMAIN=PHD&START=1325&END=1368&E_VALUE=4.32e-9&TYPE=SMART&BLAST=YCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWECPWHR
*  MamL-1 domain - Wikipedia
... beta-catenin). MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the ... kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex ... Mastermind-like proteins act as critical transcriptional co-activators for Notch signaling. The N-terminal domain of MAML ... "The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development". Blood. 110 (10): 3618- ...
  https://en.wikipedia.org/wiki/MamL-1_domain
*  CDH2 - Wikipedia
Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (May 2003). "N-cadherin-catenin complexes form prior to cleavage of the ... "Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development". ... Knudsen KA, Wheelock MJ (1992). "Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N ... When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway, which ...
  https://en.wikipedia.org/wiki/CDH2
*  Casein kinase 1 - Wikipedia
"Axin-mediated CKI phosphorylation of beta -catenin at Ser 45: A molecular switch for the Wnt pathway". Genes & Development. 16 ... DBT has been shown to physically interact with PER in vitro and in vivo, and to create a stable complex with PER throughout the ... CK1ε has been shown to phosphorylate CRY when both CK1ε and CRY are complexed with PER in vitro, but the functional ... further demonstrating the importance of timely PER degradation as a critical determinant in establishing 24-h rhythmicity. In ...
  https://en.wikipedia.org/wiki/Casein_kinase_1
*  PTPRK - Wikipedia
... activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes ... "Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell ... The authors suggest that the presence of PTPkappa at the plasma membrane in association with the cadherin/catenin complex is ... T cells development was inhibited. PTPkappa likely regulates T-cell development by positively regulating ERK1/2 phosphorylation ...
  https://en.wikipedia.org/wiki/PTPRK
*  N-alpha-acetyltransferase 10 - Wikipedia
"Hypoxia-inducible factor-1alpha obstructs a Wnt signaling pathway by inhibiting the hARD1-mediated activation of beta-catenin ... "An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development". J. Biol. Chem. 278 (41 ... Interestingly, non-complexed (Naa15 unbound) Naa10 adopts a different fold: Leu22 and Tyr26 shift out of the active site of ... "Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation". Cancer Research. ...
  https://en.wikipedia.org/wiki/N-alpha-acetyltransferase_10
*  HER2/neu - Wikipedia
Schroeder JA, Adriance MC, McConnell EJ, Thompson MC, Pockaj B, Gendler SJ (June 2002). "ErbB-beta-catenin complexes are ... "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein ... Huang YZ, Zang M, Xiong WC, Luo Z, Mei L (January 2003). "Erbin suppresses the MAP kinase pathway". The Journal of Biological ... Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression ...
  https://en.wikipedia.org/wiki/HER2/neu
*  Epidermal growth factor receptor - Wikipedia
Schroeder JA, Adriance MC, McConnell EJ, Thompson MC, Pockaj B, Gendler SJ (June 2002). "ErbB-beta-catenin complexes are ... Shilo BZ (March 2003). "Signaling by the Drosophila epidermal growth factor receptor pathway during development". Experimental ... Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J (March 1994). "A complex of Grb2 adaptor protein, Sos exchange ... Qian X, Vass WC, Papageorge AG, Anborgh PH, Lowy DR (February 1998). "N terminus of Sos1 Ras exchange factor: critical roles ...
  https://en.wikipedia.org/wiki/Epidermal_growth_factor_receptor
*  JADE1 - Wikipedia
"Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL". Nature Cell Biology ... JADE1 isoforms assemble at least two different complexes, JADE1L-HBO1-ING4/5 and JADE1S-HBO1 complex. Due to the lack of the C- ... Results of study using in silico microarray algorithm analysis shows, that PHF17 mRNA may play a role in the development of ... "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation ...
  https://en.wikipedia.org/wiki/JADE1
*  Occludin - Wikipedia
"Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by ... Occludin plays a critical role in maintaining the barrier properties of a tight junction. Thus, mutation or absence of occludin ... The phenotypical response of these mice to the lack of occludin suggest that the function of occludin is more complex than ... loss or disruption of occludin and other tight junction proteins leads to initiation of apoptosis through extrinsic pathways. ...
  https://en.wikipedia.org/wiki/Occludin
*  Cyclin D - Wikipedia
"The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway". Proceedings of the National Academy of Sciences of the ... Hence, INK4 binds to cyclin D- dependent CDKs and inactivates the whole complex. Glycogen synthase kinase three beta, GSK3β, ... Additionally, the development of cancer is also enhanced by the fact that retinoblastoma tumor suppressor protein (Rb), one of ... Once the cells reach a critical cell size (and if no mating partner is present in yeast) and if growth factors and mitogens ( ...
  https://en.wikipedia.org/wiki/Cyclin_D
*  Wnt signaling pathway - Wikipedia
In the embryonic differentiation waves model of development Wnt plays a critical role as part a signalling complex in competent ... MacDonald BT, Tamai K, He X (Jul 2009). "Wnt/beta-catenin signaling: components, mechanisms, and diseases". Developmental Cell ... is further controlled with proteins such as wntless and evenness interrupted and complexes such as the retromer complex. Upon ... The canonical Wnt pathway (or Wnt/β-catenin pathway) is the Wnt pathway that causes an accumulation of β-catenin in the ...
  https://en.wikipedia.org/wiki/Wnt_signaling_pathway
*  Survivin - Wikipedia
It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin. Survivin is a member of the IAP family ... involves complex signaling pathways and cascades of molecular events. This process is needed for proper development during ... shows that there exists a link between survivin and p53 that can possibly explain a critical event that contributes to cancer ... To see which subcellular compartments contained the survivin splice variants complexes, fluorescent antibody markers for ...
  https://en.wikipedia.org/wiki/Survivin
*  Mothers against decapentaplegic homolog 3 - Wikipedia
Based on its essential role in TGF beta signaling pathway, SMAD3 has been related with tumor growth in cancer development. The ... The results showed reductions in SMAD3 transcriptional activity and SMAD2-SMAD4 complex formation, underlining the critical ... "Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin". ... These complexes are recruited to sites throughout the genome by cell lineage-defining transcription factors (LDTFs) that ...
  https://en.wikipedia.org/wiki/Mothers_against_decapentaplegic_homolog_3
*  Bone morphogenetic protein 4 - Wikipedia
... and ureteric bud development.[citation needed] In human embryonic development, BMP4 is a critical signaling molecule required ... Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W (May 2001). "beta-Catenin controls hair follicle morphogenesis and ... In the future, researchers is aiming to find out a more complete pathway of whole eye development and hoping one day, they can ... formation of an R-SMAD complex in conjunction with common-partner Smad (co-Smad) occurs where it migrates to the nucleus. This ...
  https://en.wikipedia.org/wiki/Bone_morphogenetic_protein_4