*  The Molecular Immunology of Complex Carbohydrates | SpringerLink
... of complex carbohydrates has been found to be involved in important interactions of immunological specificity of antigens and ... The carbohydrate pathogenesis moieties of cell surface glycoconjugates (glycoproteins and glycolipids) of mammals are the sites ... Glycoconjugates as Cancer/or Tumor Antigens. * Tumor-Associated Blood Group Antigen Expressions and Immunoglobulins Associated ... Structural Analysis of Hapten Moiety of Complex Carbohydrate Antigens. * Structural Elucidation of Complex Carbohydrates ...
  https://link.springer.com/book/10.1007%2F978-1-4613-1663-3
*  The Molecular Immunology of Complex Carbohydrates
... of complex carbohydrates has been found to be involved in important interactions of immunological specificity of antigens and ... www.MOLUNA.de The Molecular Immunology of Complex Carbohydrates [4191473] - During the past three decades, the sugar moiety ... III-4 Glycolipids and Glycoproteins in Plasma Membrane of Hepatocellular Cancer.- III-5 Cancer-Associated Carbohydrate Antigens ... Glycoconjugates as Cancer/or Tumor Antigens.- III-l Tumor-Associated Blood Group Antigen Expressions and Immunoglobulins ...
  https://www.moluna.de/buch/4191473-the+molecular+immunology+of+complex+carbohydrates/
*  PAR-17-206: Alliance of Glycobiologists for Cancer Research: Translational Tumor Glycomics Laboratories (U01)
B. Carbohydrate Analytical Expertise. Thorough characterization of the complex carbohydrates to be investigated requires ... Many well-known tumor-associated antigens are glycolipids or glycoproteins that contain aberrant glycan structures. In ... Complex carbohydrates represent one such set of molecules that play major roles in oncogenesis, but their roles in promoting ... Complex Carbohydrates and Cancer Biomarkers. The majority of research on cancer biomarkers has focused on cancer-specific ...
  https://grants.nih.gov/grants/guide/pa-files/PAR-17-206.html
*  KAKEN - Research Projects | Molecular mechanisms for maintenance of the integrity of nervous tissues by glycosphingolipids ...
Presentation] Regulatory mechanisms of malignant phenotypes of human cancers by tumor-associated carbohydrate antigens in the ... Presentation] Involvement of complex carbohydrates in the cancer phenotypes and therapeutic application.2012. *. Author(s). K. ... Presentation] Roles of globo-series glycolipids in the regulation of LPS-TLR4 signals.2012. *. Author(s). K. Furukawa. ... Presentation] Novel functions and mechanisms of complex carbohydrates elucidated by glycosyltransferase gene knockout2015. *. ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23110008/
*  What Makes a Cancer Cell a Cancer Cell? - Holland-Frei Cancer Medicine - NCBI Bookshelf
Tumor-associated carbohydrate antigens can be classified into three groups38: (1) epitopes expressed on both glycolipids and ... The catalytic component of this complex is a reverse transcriptase, hTERT, that uses the RNA contained in the complex as a ... is the multiantennary branches of N-linked carbohydrates and the alterations of O-linked carbohydrate chains seen in some ... Tumor-associated carbohydrate antigens can also be classified by the cell types expressing them as those (1) expressed on only ...
  https://www.ncbi.nlm.nih.gov/books/NBK12516/
*  Structural glycobiology of antibody recognition in xenotransplantation and cancer immunotherapy
... glycolipids or glycoproteins). For example, many tumor-associated carbohydrate antigens are broadly expressed at very high ... Recent progress in bioinformatics, synthesis of complex carbohydrates and analysis of their interactions with proteins [ ... Often the minimal carbohydrate epitopes are located at the terminal end of more complex oligosaccharide chains, which result in ... Carbohydrate antigens recognized by "natural" or preformed and elicited antibodies are central to transplantation/transfusion ...
  https://espace.curtin.edu.au/handle/20.500.11937/17581
*  Patent US4977286 - Glycolipids - Google Patents
... activated carbohydrate residues in stereoselective glycosidic fashion to provide glycolipids in substantially pure ... C-18 azido alcohols and protected fluoroglycosides and are employed as antigens in the production of antibodies useful, for ... Many such tumor-associated antigens have been identified as glycosphingolipids; recent immunological studies have shown that ... Preferred carbohydrates include lactose, galactose, and α-D-galactose-(1-4)-β-D-galactose-(1-4)-β-D-glucose(hereinafter, pk ...
  http://www.google.com.au/patents/US4977286
*  Thomsen-Friedenreich and Tn Antigens in Nipple Fluid: Carbohydrate Biomarkers for Breast Cancer Detection | Clinical Cancer...
Therefore, it was of interest to explore antigens that have been more closely associated with breast cancer, in terms of tumor ... Both TF and Tn are expressed on cell-surface glycoproteins and glycolipids. Nipple aspirate fluid (NAF) is concentrated in ... Washed wells were incubated with avidin/peroxidase complex and peroxidase activity was measured by incubation in 2,2-azino-bis( ... The finding that TF and Tn carbohydrates are present on both epithelial cell surface proteins and lipids (6) prompted us to ...
  http://clincancerres.aacrjournals.org/content/11/19/6868
*  Patent US5935804 - Method for detecting eubacteria in biological samples with catalytically ... - Google Patents
... with a single defined epitope in a complex carbohydrate structure of a particular serotype of bacteria. Cross-reactivity of ... and decreases background reactivity with complex carbohydrates synthesized by mammalian cells, e.g., erythrocytes, leukocytes, ... However, the array of different antigens in bacteria and fungi that are available as potential targets for development of ... tissue cells, tumor cells and the like. Representative periodate solutions include sodium periodate at a concentration of about ...
  http://www.google.com/patents/US5935804?dq=7125605
*  Frontiers | Molecular Recognition of Gangliosides and Their Potential for Cancer Immunotherapies | Immunology
Through both mechanisms, tumor-associated gangliosides may affect malignant progression, which makes them attractive targets ... Gangliosides perform important functions through carbohydrate-specific interactions with proteins, for example as receptors in ... Through both mechanisms, tumor-associated gangliosides may affect malignant progression, which makes them attractive targets ... Gangliosides perform important functions through carbohydrate-specific interactions with proteins, for example as receptors in ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00325/full
*  Enzymatic process for producing a galactosyl.beta.1,3glycal disaccaride using .beta.-galactosidase - Patent # 5403726 -...
Distler et al., Complex Carbohydrates, Edited by Victor Ginsburg, Methods in Enzymology, pp. 514-520, 1978... Leppanen et al., ... tumor associated antigens, and the ligands of adhesion molecules. [Hakomori, Adv. Cancer Res., 52:257 (1981); Fenzi, Nature, ... Karz et al., Carbohydrate Research, 93(1981), C14-C20... Nilsson, Carbohydrate Research, 167, 1987, pp. 95-103... Nilsson, Ann ... and fucose-containing terminal structures found on glycoproteins and glycolipids. These ligandsinclude the naturally occurring ...
  http://www.patentgenius.com/patent/5403726.html
*  Review glyco-diagnostics - Current Molecular Medicine 2007 7 397-416 397 Clinical Laboratory Testing in Human Medicine Based on...
Mainly Detected Via Histology on Tumor Tissue T-Glycotope Probably the best-known family of tumor antigens of carbohydrate ... n tio Glycolipids u rib Polysaccharides Glycosylation Machinery t is D r o F ot Glycoproteins N O O-glycans N-glycans N Fig. (1 ... Defects in these biosynthetic steps towards fully processed complex-type N-glycans most often result in a lower degree of ... MS-based approaches have certainly shown their merit for sensitive and detailed characterisation of carbohydrates, but the ...
  https://www.coursehero.com/file/5902953/Review-glyco-diagnostics/
*  Patent US7829735 - Universal phosphoramidite for preparation of modified biomolecules and surfaces - Google Patents
... and complex lipids such as lipoproteins and glycolipids. Lipids are generally liquid at room temperature and are more soluble ... The term "carbohydrate," as used herein, refers to a molecule having one or more sugar residues. Multiple sugar residues of a ... Carbohydrates composed of multiple sugar residues can vary in the type and location of the linkage between each residue. Sugar ... Nonlimiting examples of target compounds include polynucleotides, antigens, antibodies, polypeptides, ionic compounds, metals, ...
  http://www.google.com.au/patents/US7829735
*  Oligosaccharide - Wikipedia
Glycoproteins are relevant as cell-surface receptors, cell-adhesion molecules, immunoglobulins, and tumor antigens. Glycolipids ... Glycoproteins and glycolipids are by definition covalently bonded to carbohydrates. They are very abundant on the surface of ... Protein-Carbohydrate bonding is often mediated by hydrogen bonding and van der Waals forces.[citation needed] Mixed feeding of ... Human milk contains many complex oligosaccharides that carry multiple Lewis antigen glycans. These human milk oligosaccharides ...
  https://en.wikipedia.org/wiki/Oligosaccharide
*  Tumors: Too sweet to remember? | Molecular Cancer | Full Text
... all so far detected tumor-specific antibodies belong to the natural immunity. In this review we try to explain why malignant ... Membrane bound carbohydrate antigens can be categorized into two major groups: (i) glycolipids such as GM2, GD2, GD3, and ... Chen S, Fukuda M: Cell type-specific roles of carbohydrates in tumor metastasis. Methods Enzymol. 2006, 416: 371-380. 10.1016/ ... Sugars (oligosaccharides and polysaccharides) existing either in free form or in covalent complexes with proteins or lipids are ...
  https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-6-78
*  Frontiers | Extracellular Galectin-3 in Tumor Progression and Metastasis | Oncology
This lectin is found in the tumor stroma, suggesting a role for microenvironmental galectin-3 in tumor progression. Galectin-3 ... This lectin is found in the tumor stroma, suggesting a role for microenvironmental galectin-3 in tumor progression. Galectin-3 ... it can be considered a target in tumor therapies. In conclusion, this review aims to describe the processes of tumor ... Finally, galectin-3 seems to play a relevant role in orchestrating distinct cell events in tumor microenvironment and for this ...
  https://www.frontiersin.org/articles/10.3389/fonc.2014.00138/full
*  EXTRACELLULAR TARGETED DRUG CONJUGATES - Patent application
To overcome the problem of immune tolerance to tumor-associated carbohydrate antigens, non-naturally occurring antigenic sugars ... The agent and targeting moiety may bind to different targets in a "target complex", where "target complex" refers to two or ... and other carbohydrates including glucose, mannose, or dextrins; chelating agents such as EDTA; sugars such as sucrose, ... glycolipids, and glycosaminoglycans (see Anticancer Agents Med Chem 2008; 8(1):2-21, incorporated herein by reference). ...
  http://www.patentsencyclopedia.com/app/20130336994
*  Frontiers | Fungal glycans and the innate immune recognition | Cellular and Infection Microbiology
Recognition of these carbohydrate-containing molecules by the innate immune system triggers inflammatory responses and ... Recognition of these carbohydrate-containing molecules by the innate immune system triggers inflammatory responses and ... and O-linked carbohydrates are the major components of fungal surfaces. The fungal cell wall is an excellent target for the ... and O-linked carbohydrates are the major components of fungal surfaces. The fungal cell wall is an excellent target for the ...
  https://www.frontiersin.org/articles/10.3389/fcimb.2014.00145/full
*  North American Pharmacal
On a healthy cell ABO antigens are clearly visible, but in diseased cells (like cancer cells), ABO antigens often disappear. ... is a potent inhibitor of tumor cell invasion, with modest anti-tumor activity. As such, consumption of bladderwrack might offer ... The complex sugar structures and other compounds found in bladderwrack have anti-HIV activity. Some of the mechanisms of its ... Carbohydrate induced modulation of cell membrane. IV: Interaction with mucin and fucoidan totally immobilizes the human ...
  http://www.dadamo.com/B2blogs/blogs/index.php?blog=26&paged=4
*  Structure and Biological Roles of Mucin-type O-glycans at the Ocular Surface
30 Larger carbohydrate epitopes, including blood group ABH- and Lewis-related carbohydrate antigens, have also been localized ... Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid. Invest Ophthalmol Vis Sci. 2000;41: ... Application of lectins for detection of goblet cell carbohydrates of the human conjunctiva. Exp Eye Res. 1984;38:439-47. [ ... could be attributed to changes in glycolipids and N-linked glycans present in the tear film, as no sialyl-Lewis a has been ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2847370/