*  EC 3.4.21.43
Ser bond in complement component C3 α-chain to form C3a and C3b, and Arg. bond in complement component C5 α-chain to form C5a ... C4b,2a,3b; C42; C5 convertase; C423; C4b,2a,3b; complement C.hivin.4.hivin2; complement C3 convertase. Comments: A complex of ... C2a and C2b are formed by cleavage of proenzyme C2 by complement subcomponent C. . Cleavage of C5 requires complement fragment ... Complement component C2a is in peptidase family S1 (trypsin family). Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, ...
  http://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC3/4/21/43.html
*  Leukocyte extravasation - Wikipedia
Synthesis of P-selectin can be induced by thrombin, leukotriene B4, complement fragment C5a, histamine, TNFα or LPS. These ... Monk PN, Scola AM, Madala P, Fairlie DP (October 2007). "Function, structure and therapeutic potential of complement C5a ... IL-1, TNFα and C5a cause the endothelial cells of blood vessels near the site of infection to express cellular adhesion ...
  https://en.wikipedia.org/wiki/Leukocyte_extravasation
*  C5a receptor - Wikipedia
It functions as a complement receptor. C5a receptor modulates inflammatory responses, obesity, development and cancers. The C5a ... The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G ... Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500-43. doi:10.1124/pr.111.005223. PMID ... Monk PN, Scola AM, Madala P, Fairlie DP (October 2007). "Function, structure and therapeutic potential of complement C5a ...
  https://en.wikipedia.org/wiki/C5a_receptor
*  Complement component 5a - Wikipedia
C5a is a protein fragment released from cleavage of complement component C5 by protease C5-convertase into C5a and C5b ... C5a des-Arg is a much less potent anaphylatoxin. Both C5a and C5a des-Arg can trigger mast cell degranulation, releasing ... C5a, the other cleavage product of C5, acts as a highly inflammatory peptide, encouraging complement activation, formation of ... C5a is also an effective chemoattractant, initiating accumulation of complement and phagocytic cells at sites of infection or ...
  https://en.wikipedia.org/wiki/Complement_component_5a
*  Acylation stimulating protein - Wikipedia
Complement peptide C5a, C4a, and C3a receptors". Pharmacol. Rev. 65 (1): 500-43. doi:10.1124/pr.111.005223. PMID 23383423. ... Complement 3 (C3) through its interaction with factors B and D (adipsin) generates C3a. In the human body, C3a is rapidily ...
  https://en.wikipedia.org/wiki/Acylation_stimulating_protein
*  GPR77 - Wikipedia
Cain SA, Monk PN (2002). "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg ... Complement peptide C5a, C4a, and C3a receptors". Pharmacol. Rev. 65 (1): 500-43. doi:10.1124/pr.111.005223. PMID 23383423. Ohno ... The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host ... 2004). "C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines ...
  https://en.wikipedia.org/wiki/GPR77
*  Formyl peptide receptor 1 - Wikipedia
... the C5a receptor (also termed CD88), which binds and is activated by complement component 5a (C5a) and GPR77, a second C5a ... bacteria-induced complement activation also causes the formation of complement component 3a (C3a) by cleavage from complement ... Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500-43. doi:10.1124/pr.111.005223. PMID ... Li R, Coulthard LG, Wu MC, Taylor SM, Woodruff TM (Mar 2013). "C5L2: a controversial receptor of complement anaphylatoxin, C5a ...
  https://en.wikipedia.org/wiki/Formyl_peptide_receptor_1
*  C3a receptor - Wikipedia
Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500-43. doi:10.1124/pr.111.005223. PMID ... "Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of ... is a G protein-coupled receptor protein involved in the complement system. The receptor binds to complement component C3a, ... Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (October 2013). "Immune cell-derived C3a and C5a costimulate ...
  https://en.wikipedia.org/wiki/C3a_receptor
*  Formyl peptide receptor 3 - Wikipedia
Li R, Coulthard LG, Wu MC, Taylor SM, Woodruff TM (Mar 2013). "C5L2: a controversial receptor of complement anaphylatoxin, C5a ... the C5a receptor (also termed CD88) and GPR77, and a second C5a receptor, C5a2 (C5L2), which has the structure of a G protein ... Bao L, Gerard NP, Eddy RL, Shows TB, Gerard C (Jun 1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP ... "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors ...
  https://en.wikipedia.org/wiki/Formyl_peptide_receptor_3
*  Formyl peptide receptor 2 - Wikipedia
Li R, Coulthard LG, Wu MC, Taylor SM, Woodruff TM (Mar 2013). "C5L2: a controversial receptor of complement anaphylatoxin, C5a ... the G protein-coupled C5a receptor (also termed CD88) and a second C5a receptor, GPR77 (i.e. C5a2 or C5L2), which has the ... Bao L, Gerard NP, Eddy RL, Shows TB, Gerard C (Jun 1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP ... Bao L, Gerard NP, Eddy RL, Shows TB, Gerard C (Jun 1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP ...
  https://en.wikipedia.org/wiki/Formyl_peptide_receptor_2
*  Complement component 4 - Wikipedia
Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500-43. doi:10.1124/pr.111.005223. PMID ... an effect produced by the effector proteins of the complement system in which the C4 partakes). Complement system Complement ... Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human ... All three pathways converge at a step in which complement protein C3 is cleaved into proteins C3a and C3b, which results in a ...
  https://en.wikipedia.org/wiki/Complement_component_4
*  Inflammation - Wikipedia
"Opposing roles for complement component C5a in tumor progression and the tumor microenvironment". Journal of Immunology. 189 (6 ... Plasma derived complement C3b and antibodies that exude into the inflamed tissue during the vascular phase bind to and coat the ... These include the complement system activated by bacteria and the coagulation and fibrinolysis systems activated by necrosis, e ... The complement system, when activated, creates a cascade of chemical reactions that promotes opsonization, chemotaxis, and ...
  https://en.wikipedia.org/wiki/Inflammation
*  List of MeSH codes (D12.776.124) - Wikipedia
... complement c4a MeSH D12.776.124.486.274.024.270 -- complement c5a MeSH D12.776.124.486.274.024.270.255 -- complement c5a, des- ... complement c5 MeSH D12.776.124.486.274.450.250 -- complement c5a MeSH D12.776.124.486.274.450.250.255 -- complement c5a, des- ... complement c6 MeSH D12.776.124.486.274.650 -- complement c7 MeSH D12.776.124.486.274.750 -- complement c8 MeSH D12.776.124.486. ... complement c1r MeSH D12.776.124.486.274.050.290 -- complement c1s MeSH D12.776.124.486.274.150 -- complement c2 MeSH D12.776. ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)
*  L-Ribonucleic acid aptamer - Wikipedia
Spiegelmers have been obtained for the chemokines CCL2 and CXCL12, the complement components C5a and ghrelin. They are ...
  https://en.wikipedia.org/wiki/L-Ribonucleic_acid_aptamer
*  C5a peptidase - Wikipedia
"Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus". Biochem. J. 273: 635-640. PMC ... C5a peptidase (EC 3.4.21.110, streptococcal C5a peptidase, ScpA, ScpB, SCPA) is an enzyme. This enzyme catalyses the following ... Stafslien, D.K.; Cleary, P.P. (2000). "Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent ... C5a peptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal. ...
  https://en.wikipedia.org/wiki/C5a_peptidase
*  Chemotaxis - Wikipedia
Complement 3a (C3a) and complement 5a (C5a) are intermediate products of the complement cascade.[citation needed] Their ... Leukocytes also move toward chemoattractants C5a, a complement component, and pathogen-specific ligands on bacteria. Mechanisms ... The availability of this technology led to the discovery of C5a, a major chemotactic factor involved in acute inflammation. The ... "Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for ...
  https://en.wikipedia.org/wiki/Chemotaxis
*  Anaphylatoxin - Wikipedia
C4a and C5a) that are produced as part of the activation of the complement system. Complement components C3, C4 and C5 are ... C3a works with C5a to activate mast cells, recruit antibody, complement and phagocytic cells and increase fluid in the tissue, ... coded for by a single exon within the complement protein gene. The C3a, C4a and C5a components are referred to as ... "C5a fragment of bovine complement. Purification, bioassays, amino-acid sequence and other structural studies". European Journal ...
  https://en.wikipedia.org/wiki/Anaphylatoxin
*  Complement component 5 - Wikipedia
Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b: C5a plays an important role in ... 1991). "Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus". Biochem. J. 273 (Pt 3 ... Zuiderweg ER, Nettesheim DG, Mollison KW, Carter GW (1989). "Tertiary structure of human complement component C5a in solution ... Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing ...
  https://en.wikipedia.org/wiki/Complement_component_5
*  C3a (complement) - Wikipedia
C3a has a regulatory process and a structure homologous to complement component C5a, with which it shares 36% of its sequence ... 12th European Meeting on Complement in Human Disease12th European Meeting on CHD12th European Meeting on Complement in Human ... "Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells". ... in contrast to C5a and C5a desArg". Protein Science. 22 (2): 204-212. doi:10.1002/pro.2200. ISSN 1469-896X. PMC 3588916 . PMID ...
  https://en.wikipedia.org/wiki/C3a_(complement)
*  Specialized pro-resolving mediators - Wikipedia
... complement components C5a and C3a which are chemotactic factors formed during the activation of the host's blood complement ...
  https://en.wikipedia.org/wiki/Specialized_pro-resolving_mediators
*  Cutaneous small-vessel vasculitis - Wikipedia
C3a and C5a, proteins produced from the complement system, attract neutrophils to the vessels. Once activated, neutrophils then ... immune complexes deposit in vessel walls leading to activation of the complement system. ...
  https://en.wikipedia.org/wiki/Cutaneous_small-vessel_vasculitis
*  Chondroitin sulfate - Wikipedia
In addition, OSCS induced generation of C3a and C5a, potent anaphylatoxins derived from complement proteins. Chondroitin ...
  https://en.wikipedia.org/wiki/Chondroitin_sulfate
*  Eculizumab - Wikipedia
Both C5a and C5b-9 cause the complement-mediated events that are characteristic of PNH and aHUS. The metabolism of eculizumab ... By inhibiting the complement cascade at this point, the normal, disease-preventing functions of proximal complement system are ... Eculizumab specifically binds to the terminal complement component 5, or C5, which acts at a late stage in the complement ... Eculizumab inhibits terminal complement activation and therefore makes people vulnerable to infection with encapsulated ...
  https://en.wikipedia.org/wiki/Eculizumab
*  Arthus reaction - Wikipedia
Activation of complement primarily results in cleavage of soluble complement proteins forming C5a and C3a, which activate ... An Arthus reaction is a local vasculitis associated with deposition of immune complexes and activation of complement. Immune ...
  https://en.wikipedia.org/wiki/Arthus_reaction
*  Type III hypersensitivity - Wikipedia
The cause of damage is as a result of the action of cleaved complement anaphylotoxins C3a and C5a, which, respectively, mediate ... are far more capable of interacting with complement; these medium-sized complexes, formed in the slight excess of antigen, are ... leading to small immune complexes being formed that fix complement and are not cleared from the circulation. It involves ...
  https://en.wikipedia.org/wiki/Type_III_hypersensitivity