*  EC 3.4.21.43
Ser bond in complement component C3 α-chain to form C3a and C3b, and Arg. bond in complement component C5 α-chain to form C5a ... C4b,2a,3b; C42; C5 convertase; C423; C4b,2a,3b; complement C.hivin.4.hivin2; complement C3 convertase. Comments: A complex of ... C2a and C2b are formed by cleavage of proenzyme C2 by complement subcomponent C. . Cleavage of C5 requires complement fragment ... Complement component C2a is in peptidase family S1 (trypsin family). Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, ...
  http://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC3/4/21/43.html
*  Complement C5a desArg ELISA Kits | Biocompare.com
Compare Complement C5a desArg ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews ... Your search returned 190 Complement C5a desArg ELISA ELISA Kit across 11 suppliers. ... We consider that the increase of C5a in our samples is an indication of an increase in inflammation. It is a very accurate kit. ... Mouse Complement C5a ELISA Kit (Sandwich ELISA) *Detection Target: Complement C5a. *Detection Range: 15.6 - 1000 Picograms per ...
  https://www.biocompare.com/pfu/110627/soids/2-12239/Assay_Kit/ELISA_Complement_C5a_desArg
*  Potent Cyclic Antagonists of the Complement C5a Receptor on Human Polymorphonuclear Leukocytes. Relationships between...
Inhibition by C5a (•), 1 (▪), 18 (○), and 38 (□) of binding of 125I-C5a to human PMNLs (A) and C5a-induced myeloperoxidase ... C5a, complement factor 5a; C5aR, C5a receptor; Boc, N-tert-butoxycarbonyl; Fmoc, fluoromethyloxycarbonyl; TOCSY, total ... C5a formation or action is inhibited in vivo by soluble recombinant complement receptor type I (sCR1) (Hill et al., 1992), C5 ... Sustained or aberrant complement activation is associated with tissue damage and inflammatory disease. Elevated levels of C5a ...
  http://molpharm.aspetjournals.org/content/65/4/868
*  Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo | Journal of...
C5a p , 0.03).. Figure 4 C5a mediated protection against glutamate mediated GluR2 depletion in vitro is specific for both C5a ... Complement has long been hypothesized to play a role in neuroinflammation and C5a has been postulated to have several different ... Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo. ... In conclusion we found that the complement C5a protects against apoptotic pathways in neurons in vitro and in vivo through ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-5-5
*  Leukocyte extravasation - Wikipedia
Synthesis of P-selectin can be induced by thrombin, leukotriene B4, complement fragment C5a, histamine, TNFα or LPS. These ... Monk PN, Scola AM, Madala P, Fairlie DP (October 2007). "Function, structure and therapeutic potential of complement C5a ... IL-1, TNFα and C5a cause the endothelial cells of blood vessels near the site of infection to express cellular adhesion ...
  https://en.wikipedia.org/wiki/Leukocyte_extravasation
*  Lung tissue remodeling in the acute respiratory distress syndrome
C5a Complement C5a fragment G-CSF Granulocyte- colony stimulating factor GM-CSF Granulocyte-Macrophage - colony stimulating ... These include lipopolissacaride (LPS), C5a complement fragment (C5a), granulocyte-macrophage colony stimulator factor (G-CSF, ... Immunoglobulins, fibrinogen, surfactant and complement impregnate the hyaline membrane, whereas fibronectin covers minimally ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-35862003000400013&lng=es&nrm=iso
*  C5a receptor - Wikipedia
... structure and therapeutic potential of complement C5a receptors". British Journal of Pharmacology 152 (4): 429-48. PMC 2050825 ... 1998). "Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a ... 1998). "Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated ... Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • ...
  https://sh.wikipedia.org/wiki/C5a_receptor
*  Ronald Pearl | Stanford Medicine Profiles
... complement C5a, and thrombin-cleaved osteopontin. Hydrolysis of bradykinin and C5a and thrombin-cleaved osteopontin peptides by ... Thrombin-activatable fibrinolysis inhibitor (TAFI) regulates activated complement C5a in vivo. 46th Annual Meeting of the ... TAFIa abrogated C5a-induced neutrophil activation in vitro. Jurkat cell adhesion to osteopontin was markedly enhanced by ...
  https://med.stanford.edu/profiles/ronald-pearl
*  Proteins: Recombinant, Native & Peptides | Cell Sciences
Recombinant Human Complement C5a His. 1.0 mg. $9,900.00 BUY CRC188A. Recombinant Human Complement C5a His. 20 μg. $410.00 BUY ... Recombinant Human C5a. 1.0 mg. $9,900.00 BUY CRC188C. ... Recombinant Human Complement C5a His. 100 μg. $1,565.00 BUY 6 ... Recombinant Human C5a. 100 μg. $1,190.00 BUY CRC187C. ... Recombinant Human C5a. 20 μg. $540.00 BUY CRC187B. ...
  https://www.cellsciences.com/proteins?alphabet_bar_name=2283
*  Recombinant Proteins: Cytokines & Chemokines | Cell Sciences
Recombinant Human Complement C5a His. 100 μg. $1,565.00 BUY CRC188C. Recombinant Human Complement C5a His. 1.0 mg. $9,900.00 ... Recombinant Human Complement C5a His. 20 μg. $410.00 BUY CRC188B. ... Recombinant Human C5a. 20 μg. $540.00 BUY CRC188A. ... Recombinant Human C5a. 1.0 mg. $9,900.00 BUY CRC187A. ... Recombinant Human C5a. 100 μg. $1,190.00 BUY CRC187C. ...
  http://www.cellsciences.com/proteins/recombinant?alphabet_bar_name=2283
*  John D. Lambris | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of...
Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects. ... In addition we study the involvement of various complement components with developmental pathways and the role of complement in ... Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation. Scandinavian journal of immunology 86(3): 143-155 ... Reis Edimara S, Mastellos Dimitrios C, Ricklin Daniel, Mantovani Alberto, Lambris John D: Complement in cancer: untangling an ...
  http://www.med.upenn.edu/apps/faculty/index.php/g275/p7993
*  Proteins: Recombinant, Native & Peptides | Cell Sciences
Complement C5a (6) * CPK/Creatine Kinase (2) * Creatine kinase (2) * Creatine Kinase MM Isozyme type 3 (3) ...
  http://www.cellsciences.com/proteins?p=7
*  Proteins: Recombinant, Native & Peptides | Cell Sciences
Recombinant Human Complement C5a His. 100 μg. $1,565.00 BUY CRC188C. Recombinant Human Complement C5a His. 1.0 mg. $9,900.00 ...
  http://www.cellsciences.com/proteins?source=2244&species=369
*  Search results for: 'Moustached monkey'
Protein Name:Complement C5a anaphylatoxin Catalog #:OKCA02322 Type: Kit Reacts with: Monkey ...
  https://www.avivasysbio.com/en/catalogsearch/result/?q=Moustached%20monkey
*  Novel Agents for Intractable Itch
... complement C5a). This biogenic amine acts mainly as a neurotransmitter and plays a major role in skin reactions associated with ...
  http://www.skintherapyletter.com/2008/13.1/2.html
*  Antibody Pairs | ▻ antibodies-online.com
Human Complement C5a ELISA Pair Set Mouse, HRP. Supplier: Log in to see ... Human Complement Component C2 ELISA Pair Set Rabbit, HRP. Supplier: Log in to see ...
  https://www.antibodies-online.com/antibody/antibody-pair/
*  JCI - Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest. 2003;112(11): ... Singh J, Ahmed A, Girardi G. Role of complement component C1q in the onset of preeclampsia in mice. Hypertension. 2011;58(4): ... Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med. 2004;10(11):1222- ...
  https://www.jci.org/articles/view/86957
*  Hepatic expression of inflammatory genes and microRNAs in pigs with high "cholesteryl ester transfer protein" (CETP) activity,...
Complement C5a inhibition reduces atherosclerosis in ApoE−/− mice. Manthey, HD; Thomas, AC; Shiels, IA; Zernecke, A; Woodruff, ... Complement activation products C5a and sC5b-9 are associated with low-grade inflammation and endothelial dysfunction, but not ... The role of complement in inflammatory diseases from behind the scenes into the spotlight ...
  https://www.deepdyve.com/lp/springer_journal/hepatic-expression-of-inflammatory-genes-and-micrornas-in-pigs-with-I93tGXZ0lk
*  Frontiers | Multimodal Regulation of NET Formation in Pregnancy: Progesterone Antagonizes the Pro-NETotic Effect of Estrogen...
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest (2003) 112:1644- ... and activation of circulatory neutrophils via the complement cascade may contribute to PE-like conditions or those associated ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00565/full
*  Immunology and Pregnancy Losses: HLA, Autoantibodies and Cellular Immunity - Madame Curie Bioscience Database - NCBI Bookshelf
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest. 2003;112(11): ... Interaction of complement component 5a (C5a) with its receptor is reported to be necessary for thrombosis of placental ... Complement system on the attack in autoimmunity. J Clin Invest. 2003;112(11):1639-41. [PMC free article: PMC281650] [PubMed: ... Complement activation has been reported to be a central mechanism of pregnancy loss in APS. The fact that F(ab)'2 fragments of ...
  https://www.ncbi.nlm.nih.gov/books/NBK6615/
*  K+ Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+ Signaling | The Journal of Immunology
Complement C5a potentiates uric acid crystal-induced IL-1β production. Eur. J. Immunol. 44: 3669-3679. ... and C5a complement GPCR, which stimulate phospholipase C-mediated increases in cytosolic [Ca2+], have been reported to induce ...
  http://www.jimmunol.org/content/194/8/3937
*  C5a receptor - Wikipedia
It functions as a complement receptor. C5a receptor modulates inflammatory responses, obesity, development and cancers. The C5a ... The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G ... Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500-43. doi:10.1124/pr.111.005223. PMID ... Monk PN, Scola AM, Madala P, Fairlie DP (October 2007). "Function, structure and therapeutic potential of complement C5a ...
  https://en.wikipedia.org/wiki/C5a_receptor