Biosynthetic Pathways* / drug effects * Drug Discovery* * Drug Synergism * Drug Therapy, Combination * Energy Metabolism / drug ...

The method has been applied in the combination of anti-cancer drugs, anti-HIV agents, drug-radiation, and traditional Chinese ... and introduced the concept of combination index (CI) for quantitative definition of synergism (CI. 1) using computerized ... The derived combination index equation for two drugs is: C I = ( D ) 1 ( D x ) 1 + ( D ) 2 ( D x ) 2 = ( D ) 1 ( D m ) 1 [ f a ... The DRI is a measure of how many folds the dose of each drug in a synergistic combination may be reduced, at a given effect ...

Combinations of the methanolic extract and antimicrobial drugs resulted in statistically significant synergism.. [24]. ... aureus and its biofilm formation and observed a synergism when the extract was used in combination with antimicrobial drugs. ... The drugs modulatory activity was tested at an initial concentration of 1024 μg/mL.. EO oil showed activity against ... In Silico Drug Design for Purinergic GPCRs: Overview on Molecular Dynamics Applied to Adenosine and P2Y Receptors ...

Since clinical trials involving ibudilast have shown no adverse side effects and the drug readily penetrates the blood brain ... barrier, treatment of GBM with this combination is clinically achievable. ... Ibudilast showed modest anti-proliferative activity however, when combined with TMZ, significant synergism was observed, ... Chou, T. C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination ...

Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of acute hypertensive episode. Avoid combination within ... Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of acute hypertensive episode. Avoid combination within ... DRUG INTERACTIONS: See also How to Use section.Drug interactions may change how your medications work or increase your risk for ... Most commonly, these are "non-preferred" brand drugs.. 4. This drug is available at a higher level co-pay. Most commonly, these ...

... or the combination (10 mg/kg, twice weekly; Materials and Methods); coefficient of drug interaction, CDI ,0.7 (significant ... CDI = 1 indicates additivity whereas CDI , 1 indicates synergism and CDI , 0.7 indicates significant synergy (34, 35). ... or the combination (10 mg/kg, twice weekly; Materials and Methods); coefficient of drug interaction, CDI ,0.7 (significant ... Coefficient of drug interaction (CDI) at termination was calculated using the following formula: z/(x*y), where z equals ratio ...

... for combating drug resistance, and for elucidating fundamental relationships in cell physiology. When drugs are combined... ... Abstract Drug combinations are increasingly important in disease treatments, ... Interaction network for six antibiotics: synergism is red; antagonism, green; suppression, blue; stars show drug combinations ... For all drug pairs and the vast majority of mutants, the growth rates measured at fixed concentration of the drug combination ( ...

The quantification of interaction as a synergism or antagonism was done by the general equation (1) for n-drug combination at x ... The DRI value for each corresponding drug was given for n-drug combinations, Equation (2): (DRI)1 = (Dx)1/(D1); (DRI)2 = (Dx)2 ... Chou, T.C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination ... where n(CI)x is the sum of the dose of n drugs that exerts x % inhibition in a combination. In the denominator (Dx) is for D " ...

Results from this study indicate that a 1599 clarithromycin combination is potentially viable, providing the drug exposures can ... These studies highlight the importance of validating in vitro synergism and the challenge of matching drug exposures to obtain ... These studies highlight the importance of validating in vitro synergism and the challenge of matching drug exposures to obtain ... Results from this study indicate that a 1599 clarithromycin combination is potentially viable, providing the drug exposures can ...

Synergism between antifungals and Cys was observed in C. parapsilosis sensu lato strains. Combinations formed by antifungals ... strengthen the potential of calcineurin inhibition as a promising approach to enhance the efficiency of antifungal drugs. ... Thanks to the combination of alkaline digestion and SBSE, which greatly simplifies sample treatment and limits solvent use to ... Combinations formed by antifungals with Cys were evaluated against mature biofilms in microtitre plates. No differences in the ...

Either increases toxicity of the other by Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Increased risk of ... Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Combination may be used ... Either increases toxicity of the other by Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Increased risk of ... Either increases toxicity of the other by Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Increased risk of ...

Drug, Drug Combinations, Drug Synergism, Drug Therapy, Combination, Flucytosine/*administration & dosage, Male, Mice, Microbial ... by use of the Greco model of drug interaction. The combination was additive, meaning that the experimental effect did not ... by use of the Greco model of drug interaction. The combination was additive, meaning that the experimental effect did not ... by use of the Greco model of drug interaction. The combination was additive, meaning that the experimental effect did not ...

Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat Biotechnol. 2009;27:659-66 ... Quantitative methods for assessing drug synergism. Genes Cancer. 2011;2:1003-8 ... Florea AM, Busselberg D. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side ... As shown in Figure 4A, the AKT protein was not clearly reduced by drug alone or a combination of JIB extract and cisplatin. The ...

... alone and in combination with mitotane. ER-stress markers were monitored by immunoblotting. Drug synergism was quantified using ... ACY241, an HDAC6 selective inhibitor, has shown anti-multiple myeloma (MM) activity in combination with immunomodulatory drugs ... Hsp90 inhibition in adrenocortical carcinoma: Limited drug synergism with mitotane.. Mol Cell Endocrinol. 2019; 480:36-41 [ ... response to drug - response to electrical stimulus - sequence-specific DNA binding - sequence-specific DNA binding ...

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies ... Drug combination studies and their synergy quantification using the Chou-Talalay method ... 6A, top), whereas the combination of KNK437 and curcumin was strongly synergistic in all combinations tested [Fig. 6A (top) and ... The combination of curcumin and KNK437 synergistically inhibits HEI-193 schwannoma cell growth. Because hsp70 protects tumor ...

Avoid or Use Alternate Drug. Coadministration of eplerenone and mdoerate CYP3A4 inhibitor is not recommended. If combination is ... Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with ... Avoid or Use Alternate Drug. Coadministration of eplerenone and mdoerate CYP3A4 inhibitor is not recommended. If combination is ... Most commonly, these are "non-preferred" brand drugs.. 4. This drug is available at a higher level co-pay. Most commonly, these ...

Pharmaceutical researchers recognize the concept of drug synergism but note that clinical trials may be used to investigate the ... as some herbal remedies have the potential to cause adverse drug interactions when used in combination with various ... the bark is used for cancer drugs, paclitaxel); Hoodia (from Namibia, source of weight loss drugs); half of Magnolias (used as ... The word drug itself comes from the Swedish word "druug", which means dried plant. Some examples are inulin from the roots of ...

The combination of trimethoprim and a sulfonamide exemplifies synergism resulting from sequential actions in the same metabolic ... The combination of two drugs noted as "I" or even "R" together can render the drug susceptible. Current C&S techniques do not ... The tube with the lowest concentration of drug that yields no growth on the agar gel contains the MBC of drug. For drugs ... For tissues which concentrate the drug (or if the drug can be applied topically), and for drugs which can be concentrated by ...

Chou, T.C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination ... For the drug combination study, the drug or compounds were first dissolved in solvents at 2,000 times the highest dose tested. ... In combination therapy, two different drugs are used to increase the efficacy of treatment, and the interaction of these drugs ... Combination Treatment against P. falciparum Growth. Working solutions of the drug or compound were mixed in a 1:1 ratio (5 μL ...

In combination with the chemotherapy agents, TCEE treatment further enhanced the tumor suppression efficiency of cisplatin and ... study are to clarify the antitumor effects of TCEE on human hepatocellular carcinoma cells and also evaluate the combination ... drug effects with conventional chemotherapy agents, cisplatin and doxorubicin. In the present study, the TCEE treatment induced ... and computerized simulation of synergism and antagonism in drug combination studies," Pharmacological Reviews, vol. 58, no. 3, ...

Drugs of the so-called targeted therapy operate selectively by either inhibiting receptors and ligands or molecules of the ... The western blots demonstrated an upregulation of HDJ2 by single use of Lonafarnib and combination with Flavopiridol. Relevant ... in BG1-cells evidence for a synergism of Flavopiridol and Lonafarnib was found. This study supports evidence in literature ... No syngergistic effects could be observed in SKOV-3-cells; in BG1-cells combining both drugs led to a rise of necrosis and a ...

Sphingolipid-targeting drugs have been tested alone or in combination with chemotherapy, exhibiting antitumor activity alone as ... exhibiting antitumor activity alone and in synergism with chemotherapy in vitro and in vivo. As a consequence of treatments, ... Sphingolipid-targeting drugs have been tested alone or in combination with chemotherapy, ... Aslthough all these drugs have produced good results in preclinical studies of multiple cancers, the outcomes of clinical ...

The sensitivity of drug-combination treatments is assessed for the synergism achieved in each patient sample. We found a large ... We have estimated the pharmacological sensitivity and synergism of 125 individual patient samples for all drugs and combination ... Background: We have evaluated the ex vivo pharmacology of single drugs and drug combinations in malignant cells of bone marrow ... Título: Prediction of neutropenia-related effects of a new combination therapy with the anticancer drugs BI 2536 (a Plk1 ...

Drug screening was performed as previously described.4 Here ibrutinib demonstrated the strongest synergism with venetoclax, ... The lower part of each panel represents drug serum levels as black dots and drugs given as gray rectangles. Drug levels were ... We employed combinatorial drug screening to identify synergistic combination partners to enhance the efficacy of venetoclax in ... Andersson EI, Pützer S, Yadav B. Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and ...

However, it is unclear whether lycopene can act as an adjuvant to increase the anti-metastatic activity of anticancer drugs. ... Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice ... Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice ... Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of ...

Given the potential synergism between these two drugs, we believe that the combination of seli and rux have the potential to ... including immuno-oncology agents and antibody-drug conjugates across all phases of drug development from I&D filings for Phase ... No, I think when you look at that study in combination with [Inaudible], were running that study in the U.S. and in Europe. ... So this is going to be the Phase 1 portion of the ongoing Phase 1/2 trial that obviously is looking at selinexor in combination ...

... since some drug combinations exhibit pharmacological synergism, translating into lower doses, fewer adverse side effects, and ... Multi-targeted drug therapy holds more promise than single-class drug regimens (Lapchak 2011) ... Combination therapy could extend the current therapeutic time window of t-PA from 4.5 h and reduce adverse effects such as ... Thus, a combination of neuroprotectants is being explored (Connell et al. 2014; Casas et al. 2019), including promoting ...

Synergism; Drug-interaction; Comparative-toxicology ... Body burden of the two solvents in combination was not additive ... The effects of acute exposure to toluene (108883) and methyl-ethyl- ketone (78933) (MEK) singly and in combination were ... Behavior performance was not affected by the combination of toluene and MEK. ...

Title: Interpreting the Mechanism of Synergism for Drug Combinations Using Attention-Based Hierarchical Graph Pooling ... Title: Exploiting Pretrained Biochemical Language Models for Targeted Drug Design Authors: Gökçe Uludoğan, Elif Ozkirimli, ... Title: VDDB: a comprehensive resource and machine learning platform for antiviral drug discovery ... Title: ImDrug: A Benchmark for Deep Imbalanced Learning in AI-aided Drug Discovery ...