*  Differential effects of the antidepressant mirtazapine on amphetamine- and dizocilpine-induced PPI deficits. | Scholars@Duke
Differential effects of the antidepressant mirtazapine on amphetamine- and dizocilpine-induced PPI deficits.'s profile, publications, research topics, and co-authors
*  Deric's MindBlog: Ocytocin reverses amphetamine-induced deficits in social bonding.
Drug addiction has devastating consequences on social behaviors and can lead to the impairment of social bonding. Accumulating evidence indicates that alterations in oxytocin (OT) and dopamine (DA) neurotransmission within brain reward circuitry may be involved. We investigated this possibility, as well as the therapeutic potential of OT for drug-induced social deficits, using the prairie vole (Microtus ochrogaster)-a socially monogamous rodent that forms enduring pair bonds between adult mates. We demonstrate that repeated exposure to the commonly abused psychostimulant amphetamine (AMPH) inhibits the formation of partner preferences (an index of pair bonding) in female prairie voles. AMPH exposure also altered OT and DA neurotransmission in regions that mediate partner preference formation: it decreased OT and DA D2 receptor immunoreactivity in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAcc), respectively, and increased NAcc DA levels. Administration of OT directly into ...
*  Staying awake: truck drivers' vulnerability in Rio Grande do Sul, Southern Brazil
DISCUSSION. The conditions for being a professional truck driver are possibly related to the use of stimulants. The majority of the interviewees did not report the use of any substances to stay awake, but almost one fourth mentioned the use of some substance, mainly amphetamine.. The high use of amphetamines among truck drivers has been indicated in other studies. Souza et al17 found a prevalence of 11.1% among Brazilian truck drivers, findings that are similar similar to ours (12.4%). Leyton et al7 tested urine samples and found a prevalence of 5.8% for amphetamines among truck drivers on the highways of the State of São Paulo. In the present study, 16.6% of the interviewees stated having used amphetamines at least once in their lives, and 7.5% reported regular use of amphetamines to stay awake. Silva et al14 detected the presence of amphetamines in truck drivers' urine in Southeast, Northeast and South of ...
*  Conditioned saccharin avoidance induced by infusion of amphetamine in the Nucleus Accumbens shell and morphine in the Ventral...
Drugs of abuse possess the seemingly paradoxical property of conditioning rats to avoid from drinking a saccharin solution that had been predictively paired with their systemic administration (conditioned saccharin avoidance, CSA). CSA is dependent upon an intact dopamine (DA) transmission but the locus, central or peripheral, and eventually the brain area from which this effect originates and its relationship with the rewarding properties of the drug is debated. In order to clarify this issue we tested the ability of amphetamine and morphine to induce CSA after infusion at the same dose-range and in the same areas from which these drugs induce conditioned place preference (CPP). Drugs were infused intracerebrally immediately after saccharin drinking in two acquisition trials and CSA was tested on a two bottle saccharin/water choice. Amphetamine (10 and 20μg/0.5μl) induced CSA after infusion in the NAc shell but was ineffective in the NAc core. Morphine (0.5 and 1μg/0.5μl) ...
*  AMPHU - Overview: Amphetamines Confirmation, Urine
AMPHU : Confirming drug exposure involving amphetamines such as amphetamine and methamphetamine, phentermine, methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methylenediaoxyethylamphetamine (MDEA)
*  Propylamphetamine - Wikipedia
Propylamphetamine is a psychoactive drug and research chemical of the phenethylamine and amphetamine chemical classes which acts as a stimulant. It was first developed in the 1970s, mainly for research into the metabolism of, and as a comparison tool to, other amphetamines. A study in rats found propylamphetamine to be 1/4 as potent as amphetamine. Amphetamine Ethylamphetamine Isopropylamphetamine Methamphetamine Nazarali, A. J.; Baker, G. B.; Coutts, R. T.; Pasutto, F. M. (1983). "Amphetamine in rat brain after intraperitoneal injection of N-alkylated analogues". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 7 (4-6): 813-816. doi:10.1016/0278-5846(83)90073-8. PMID 6686713. Valtier, S.; Cody, J. T. (1995). "Evaluation of internal standards for the analysis of amphetamine and methamphetamine". ...
*  Ruiz suspended 25 games for using amphetamine | MLB.com
PHILADELPHIA -- Major League Baseball announced Tuesday that Phillies catcher Carlos Ruiz has been suspended 25 games for using an amphetamine. The suspension begins at the beginning of the 2013 season, which means Ruiz is unable to play until April 28 against the Mets at Citi Field.. "I am sincerely regretful for my mistake in taking a prohibited stimulant," Ruiz said in a statement. "I apologize to my teammates, the Phillies organization and the Philadelphia fans. ... I look forward to returning to the field and working toward bringing a championship back to Philadelphia in 2013." Losing Ruiz for most of the first month of the season will make that pursuit a little more difficult. Ruiz, who will forfeit about $770,000 of his $5 million salary, had a career season in 2012, hitting .325 with 32 doubles, 16 home runs, 68 RBIs, a .394 on-base percentage, a .540 slugging percentage and a .935 on-base-plus-slugging percentage.. This is the second time Ruiz has tested positive for an ...
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*  Iran's Health Ministry addresses the problem of amphetamine use | UNDP in Iran
One of the activities under piloting prevention programmes for amphetamine users was the organization of training workshops, one of which is currently being held in Ahvaz from 23 to 25 February.
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*  Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like...
Background: Amphetamine and amphetamine derivatives are suggested to induce an immunosuppressive effect. However, knowledge of how amphetamines modulate intracellular signaling pathways in cells of the immune system is limited. We have studied phosphorylation of signal transduction proteins (Akt, CREB, ERK1/2, NF-κB, c-Cbl, STAT1/3/5/6) and stress sensors (p38 MAPK, p53) in human leukocyte subsets following in vitro treatment with the natural amphetamine cathinone, the cathinone derivatives cathine and norephedrine, in comparison with a defined extract of the psychostimulating herb khat (Catha edulis Forsk.). Intracellular protein modifications in single cells were studied using immunostaining and flow cytometry, cell viability was determined by Annexin V-FITC/Propidium Iodide staining, and T-lymphocyte proliferation was measured by 3H-thymidine incorporation.. Results: Cathinone, cathine and norephedrine generally reduced post-translational ...
*  Atomoxetine - Antidepressants, Central Nervous System Agents, ATC:N06BA09
Atomoxetine is an amphetamine used to treat ADD/ADHD in children and adults. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. It increases motor activity and mental alertness, and reduces drowsiness and a sense of fatigue, decreasing motor restlessness and improves one's ability to focus. Peripheral actions include elevation of systolic and diastolic blood pressures and weak bronchodilator and respiratory stimulant action. There is neither specific evidence which clearly establishes the mechanism whereby amphetamine produces mental and behavioral effects in children, nor conclusive evidence regarding how these effects relate to the condition of the central nervous system. Atomoxetine activates the brain stem arousal system and cortex to produce its stimulant effect ...
*  Amphetamines | Goldfrank's Toxicologic Emergencies, 10e | AccessEmergency Medicine | McGraw-Hill Medical
In the 1980s, use of methylenedioxy derivatives of amphetamine and methamphetamine surfaced and were able to circumvent existing regulations. The best known of these derivatives were 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyethamphetamine (MDEA).46 Since the late 1980s, a dramatic resurgence of methamphetamine abuse has spread throughout much of the United States. A high purity preparation of methamphetamine hydrochloride was marketed in a large crystalline form termed "ice" by abusers.7,49 From 1991 to 1994, the number of methamphetamine-related deaths in the United States reported by medical examiners tripled from 151 to 433, with a disproportional distribution from the Los Angeles, San Diego, San Francisco, and Phoenix metropolitan areas. Methamphetamine use is particularly prevalent among men who have sex with men in New York City.74 Because of the ...
*  A pivotal trial of amphetamine (HLD-100) for the treatment of attention deficit hyperactivity disorder - AdisInsight
This pivotal trial will investigate the efficacy and safety of extended release amphetamine [HLD-100; Highland Therapeutics] in the treatment of Attention
*  Addictive Nature of Crystal Methamphetamine Beaver Dam WI - crystal methamphetamine, Beaver Dam WI amphetamine side effects,...
There are two things that are common in addictive drugs. Initially they produce a pleasurable effect, followed by a rebound unpleasant effect. Through its stimulant effects, an amphetamine produces a positive feeling, but when it wears off it leaves a person with the conflicting feelings. This is because of the suppression by the drug of the normal production of adrenaline.
*  Determination of amphetamine, methamphetamine and desmethyldeprenyl in human plasma by gas chromatography/negative ion chemical...
A sensitive and specific assay for the quantitative determination of amphetamine, methamphetamine and desmethyldeprenyl in human plasma specimens is described. Electron capture/negative ion chemical ionization gas chromatography/mass spectrometry is used to determine the extracted plasma concentrati...
*  Crystal Meth and Other Amphetamines (Book) | Logan City Council Libraries | BiblioCommons
Crystal Meth and Other Amphetamines (Book) : Fitzhugh, Karla : This series addresses key lifestyle areas that affect adolescent students with an initial focus on drugs and drug abuse. By recognising the conflicting pressures and information faced by teenagers, these books will help readers make intelligent decisions about their behaviour. This book: includes viewpoints from both sides of the debate about key topics and issues; looks closely at areas with which readers can identify, such as what is happening in schools, clubs and on the streets; and is backed up by case studies from a range of people including users, counsellors and medical professionals.
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*  Amphetamine pollution in Baltimore streams | Sciforums
Pharmaceutical and illicit drugs are present in streams in Baltimore, Maryland. At some sites, amphetamine concentrations are high enough to alter the...
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*  Police allege Newmarket woman sold amphetamines to officers - *GJ FOSTERS NEWS - fosters.com - Dover, NH
EXETER - A 26-year-old Newmarket woman has been indicted on charges alleging she sold amphetamines to undercover police.Christine Tucker allegedly sold quantities of the drug to police three times during the summer. Police claim the sales took place in Exeter on July 11, Aug. 16 and Aug. 27, according to indictments handed up by a grand jury in Rockingham County this month.Tucker, whose last known address was on Bennett Way in Newmarket, faces three Class B felony drug sales charges. She
*  Dextroamphetamine and Amphetamine Tablets Information - Drugs.com
Easy to read patient leaflet for Dextroamphetamine and Amphetamine Tablets. Includes indications, proper use, special instructions, precautions, and possible side effects.
*  Insight - War turns Syria into major amphetamines producer, consumer | Reuters
Syria has become a major amphetamines exporter and consumer as the trauma of the country's brutal civil war fuels demand and the breakdown in order creates opportunity for producers.
*  Amphetamine Reptile Records - Wikipedia
Amphetamine Reptile Records (ou AmRep) é uma gravadora nacionalmente renomada que foi fundada em 1986 pelo fuzileiro naval dos Estados Unidos Tom Hazelmyer em Washington, EUA. Riemenschneider, Chris (3 de outubro de 2005). «A new Atmosphere for local music label». Star Tribune. Consultado em 20 de agosto de 2007 Página oficial Lita de lançamentos na Allmusic. ...
*  War turns Syria into major amphetamines producer, consumer - World - CBC News
Syria has become a major amphetamines exporter and consumer as the trauma of the country's brutal civil war fuels demand and the breakdown in order creates opportunity for producers.