*  Vigabatrin for Treatment of Cocaine Dependence - Full Text View - ClinicalTrials.gov
Cocaine-Related Disorders. Substance-Related Disorders. Chemically-Induced Disorders. Mental Disorders. Cocaine. Vigabatrin. ... blocking cocaine-induced increases in dopamine levels represents a valid pharmaceutical approach to the treatment of cocaine ... Cocaine addiction, a serious public health concern associated with significant medical, social, and economic consequences, is ... Visual field and ocular safety during short-term vigabatrin treatment in cocaine abusers. Am J Ophthalmol. 2012 Aug;154(2):326- ...
  https://clinicaltrials.gov/show/NCT00611130
*  Cocaine Treatment: Early Results From Various Approaches
8 Cocaine dependence is the most serious of all the cocaine diagnoses. Clients diagnosed as 'cocaine-dependent' demonstrate ... and others cocaine- heroin and cocaine clients receiving (1994, positive dependence vouchers for cocaine- 1995); Johns urines ... Nearly half of the cocaine-abusing and cocaine-dependent clients (who were also heroin users) given vouchers for cocaine-free ... Wells and Alternative Cocaine was primary drug Average number of days 24 wks. others assignment; of choice of cocaine use cut ...
  http://druglibrary.org/schaffer/GOVPUBS/gao/gao64.htm
*  The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine - Full Text View - ClinicalTrials.gov
Cocaine Addiction Cocaine Abuse Cocaine Dependence Substance Abuse Drug: Placebo Drug: Doxazosin Phase 1 ... Visual-analogue scale ratings of 'any cocaine effect', 'high', 'good effects', 'bad effects', 'like cocaine', 'desire cocaine ... because smoked cocaine reaches brain sites of action as rapidly as does intravenously administered cocaine and smoked cocaine ... Cocaine-Related Disorders. Chemically-Induced Disorders. Mental Disorders. Cocaine. Doxazosin. Anesthetics, Local. Anesthetics ...
  https://clinicaltrials.gov/ct2/show/NCT01062945
*  Upregulation of Bax and Bcl-2 following prenatal cocaine exposure induces apoptosis in fetal rat brain
... cocaine 30 mg/kg/day, and 3) cocaine 60 mg/kg/day. Cocaine HCl was dissolved in saline at 10 mg/ml and injected subcutaneously ... Cocaine and development: mechanism of fetal toxicity and neonatal consequences of prenatal cocaine exposure. Early Hum. Dev. ... Effects of maternal cocaine administration on Bax and Bcl-2 protein expression in fetal rat brain. Cocaine was administered ... Cocaine-induced nucleosomal DNA fragmentation on agarose gels in fetal rat brain. Cocaine was administered subcutaneously to ...
  http://www.medsci.org/v05p0295.htm
*  Cocaine Exposure Results in Formation of Dendritic Varicosity in Rat Primary Hippocampal Neurons | Science Publications
Intriguingly, cocaine exposure of primary neurons in the presence of the neurotoxin-HIV envelope protein gp 120, resulted in ... Results: Cocaine exposure also resulted in decreased expression of the synaptic plasticity gene, Arc as evidenced by Western ... Approach: In present study, we explored the impact of cocaine exposure (I and 10 μM) on the dendritic beading in rat primary ... Conclusion: Taken together these findings imply that cocaine in co-operation with HIV protein exacerbates neuronal damage in ...
  http://thescipub.com/abstract/10.3844/ajidsp.2009.26.30
*  Cocaine Treatment Center Newport RI - cocaine treatment center, Newport RI cocaine detox, Newport RI cocaine rehab, Newport...
Find phone numbers, addresses and information about Cocaine Treatment Center in Newport. ... Cocaine Treatment Center Newport RI. Cocaine Treatment Center in Newport, RI. Find phone numbers, addresses and information ...
  http://articles.directorym.com/Cocaine_Treatment_Center_Newport_RI-p1775068-Newport_RI.html
*  Shirzad Jenab - Hunter College
Sun WL, Zhou L, Quinones-Jenab V and Jenab S. (2009). Cocaine effects on dopamine and NMDA receptors interactions in the ... Quinones-Jenab V and Jenab S. (2012). Influence of sex differences and gonadal hormones on cocaine addiction ILAR J. 53:14-22. ... Wei-Lun Sun WL, Zhou L, Nazarian A, Quinones- Jenab V and Jenab S. (2015). Acute cocaine differentially induces PKA ... Quinones-Jenab V and Jenab S. (2010). Progesterone attenuates cocaine-induced responses. Horm Behav. 58:22-32. ...
  http://www.hunter.cuny.edu/psychology/faculty/biopsychology/jenab
*  "Development of a translational model to screen medications for cocaine" by Amy R. Johnson
Methods Four rhesus monkeys with chronic indwelling intravenous catheters had access to cocaine injections (0, 0.043, 0.14, or ... This study, therefore, sought to establish choice between cocaine and an alternative reinforcer in rhesus monkeys responding ... 0.43 mg/kg/injection) and food (0, 1, 3, or 10 1 g banana-flavored food pellets). During daily 5 h sessions, a single cocaine ... Background Homologous cocaine self-administration procedures in laboratory animals and humans may facilitate translational ...
  https://scholarscompass.vcu.edu/phtx_pubs/44/
*  Spontaneous perinephric haemorrhage and acute renal failure in pregnancy due to cocaine intoxication : Clinical Kidney Journal ...
Cocaine abuse may contribute to the diverse forms of renal injury. We report a case of a pregnant woman who developed a large ... Cocaine abuse may contribute to the diverse forms of renal injury. We report a case of a pregnant woman who developed a large ... This case is unique in that it is the first report of cocaine intoxication in pregnancy complicated by subcapsular haemorrhage ... This case is unique in that it is the first report of cocaine intoxication in pregnancy complicated by... ...
  http://oxfordindex.oup.com/view/10.1093/ndtplus/sfq015
*  Progression of Changes in Dopamine Transporter Binding Site Density as a Result of Cocaine Self-Administration in Rhesus...
The cocaine groups differed according to length of cocaine exposure [5 or 100 d (3.3 months)] and cocaine dose (0.03 or 0.3 mg/ ... Lower cocaine dose. In contrast to the decreases observed in the initial phases, the effects of 3.3 months of cocaine self- ... 1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237:1219-1223. ... Effects of cocaine self-administration. The general pattern of [3H]WIN 35,428 binding in cocaine self-administering monkeys was ...
  http://www.jneurosci.org/content/21/8/2799
*  Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5 ...
... alcohol/cocaine-injected versus water/cocaine-injected; P , 0.0001, alcohol/cocaine-injected versus water/saline-injected, ... Prior cocaine use decreases preference for alcohol.. * fig. S3. Initiation of cocaine self-administration on day 11 resulted in ... Prior cocaine use decreases preference for alcohol.. fig. S3. Initiation of cocaine self-administration on day 11 resulted in ... All groups start cocaine self-administration (0.8 mg/kg per infusion) on day 11. The average alcohol intake during the alcohol- ...
  http://advances.sciencemag.org/content/3/11/e1701682/tab-figures-data
*  Heartland Center for Behavioral Change Cocaine/Crack - Heartland Center for Behavioral Change
About Cocaine/Crack. Cocaine is a powerfully addictive stimulant drug. The powdered form of cocaine can be snorted or dissolved ... Abusing cocaine has a variety of adverse effects on the body. For example, cocaine constricts blood vessels, dilates pupils, ... The street names of cocaine are coke, snow, flake and blow.. Cocaine usually makes the user feel euphoric and energetic, but ... with 1.5 percent of young adults reporting past month cocaine use. Overall, men report higher rates of current cocaine use than ...
  http://heartlandcbc.org/about-addiction/cocainecrack/
*  Cocaine - California - Northern and Eastern Districts Drug Threat Assessment
Cocaine is also seized from air and railway passengers. Operation Jetway Task Force officers seized 1 kilogram of crack cocaine ... Cocaine use in San Francisco is relatively steady. 'Speedballs' (heroin and cocaine sold together for combination use) are ... Crack is the predominant form of cocaine sold in San Francisco public housing. Both powdered cocaine and crack are sold on the ... A significant portion of the powdered cocaine is sold to users who combine the cocaine with heroin to form 'speedballs.' In ...
  https://www.justice.gov/archive/ndic/pubs/653/cocaine.htm
*  Cocaine intoxication - Wikipedia
Cocaine intoxication refers to the immediate and deleterious effects of cocaine on the body. Although cocaine intoxication and ... Cocaine can be snorted, swallowed, injected, or smoked. Most deaths due to cocaine are accidental but may also be the result of ... Cocaine and its metabolites are completely eliminated from the body by 3 days. Cocaine pharmacodynamics involve multiple ... Heat loss is also inhibited by the cocaine-induced vasoconstriction. Cocaine and/or associated hyperthermia may cause muscle ...
  https://en.wikipedia.org/wiki/Cocaine_intoxication
*  Analysis of Cocaine, Benzoylecgonine Ecgonine Methyl Ester, and Ecgonine by High-Pressure Liquid Chromatography-API Mass...
The method was applied to monitor the in vitro degradation of cocaine in plasma. Fresh unpreserved and preserved (0.25 % KF) ... In all samples, degradation of cocaine that was dependent on storage time and temperature and on sample preservation could be ... A method for the determination of cocaine (COC), benzoylecgonine (BE), ecgonine methyl ester (EME), and ecgonine (ECG) in ... A method for the determination of cocaine (COC), benzoylecgonine (BE), ecgonine methyl ester (EME), and ecgonine (ECG) in ...
  http://oxfordindex.oup.com/view/10.1093/jat/25.6.425
*  Prenatal cocaine exposure - Wikipedia
Cocaine causes impaired growth of the fetus's brain, an effect that is most pronounced with high levels of cocaine and ... Prenatal cocaine exposure (PCE), theorized in the 1970s, occurs when a pregnant woman uses cocaine and thereby exposes her ... Most people who were exposed to cocaine in utero are normal or close to it. Cocaine, a small molecule, is able to cross the ... Most women who use cocaine while pregnant use other drugs too; one study found that 93% of those who use cocaine or opiates ...
  https://en.wikipedia.org/wiki/Prenatal_cocaine_exposure
*  Cocaethylene - Wikipedia
Some studies suggest that it may be more cardiotoxic than cocaine and "it also carries an 18- to 25-fold increase over cocaine ... If ethanol is present during the metabolism of cocaine, a portion of the cocaine undergoes transesterification with ethanol, ... Warning of extra heart dangers from mixing cocaine and alcohol Hearn WL, Rose S, Wagner J, Ciarleglio A, Mash DC (June 1991). " ... Jatlow P, McCance EF, Bradberry CW, Elsworth JD, Taylor JR, Roth RH (August 1996). "Alcohol plus cocaine: the whole is more ...
  https://en.wikipedia.org/wiki/Cocaethylene
*  Pardons Granted by President William J. Clinton (1993-2001) | PARDON | Department of Justice
1. Conspiracy to distribute cocaine, 21 U.S.C. § 846. 2. W.D. Ark.. 2. 1985. 2. Distribution of cocaine, 21 U.S.C. § 841(a)(1) ... Conspiracy to distribute cocaine, distribution of cocaine, and using a communications facility to facilitate distribution of ... Conspiracy to possess with intent to distribute and to distribute cocaine, possession with intent to distribute cocaine, use of ... Conspiracy to possess with intent to distribute cocaine and to distribute cocaine, 21 U.S.C. § 846. ...
  https://www.justice.gov/pardon/clinton-pardons
*  Cocaine
... is a highly addictive stimulant drug made from the coca plant grown in the Andean Ridge of South America. Both U.S. ... Cocaine use and its consequences continue to have a significant harmful effect on the security and well-being of our citizens. ... Likewise, U.S. interdiction agencies seized a record amount of cocaine in fiscal year 2016 and are working directly with their ... ONDCP and our Federal, state, and local partners are working to build a comprehensive approach to reduce cocaine availability ...
  https://www.whitehouse.gov/ondcp/key-issues/cocaine/
*  Cocaine Anonymous - Wikipedia
Cocaine Anonymous (January 1993). Hope, Faith and Courage: Stories from the Fellowship of Cocaine Anonymous. Los Angeles, ... While many CA members have been addicted to cocaine, crack, speed or similar substances, identifying specifically as a cocaine ... Cocaine Anonymous (CA) is a twelve-step program for people who seek recovery from drug addiction. CA is patterned very closely ... Co-Anon (formerly CocAnon) is a program for families of cocaine users, analogous to Al-Anon for the friends and family of ...
  https://en.wikipedia.org/wiki/Cocaine_Anonymous
*  Cocaine | FRANK
Charlie, C, Snow… The names are different, but the facts stay the same. Find them out from FRANK and ask any questions you have.
  http://www.talktofrank.com/drug/cocaine
*  Cocaine
... *. The DRCNet Library Cocaine section. *. Cocaine Synthesis from Recreational Drugs: A Complete Guide to Manufacturing ... Cocaine and Methamphetamine *. Cocaine, from Cognito. *The Cocaine Anonymous home page. *. Crackpot Ideas, a Mother Jones ... research into the treatment of cocaine dependence, and research into the diagnosis of cocaine dependence. *Cocaine dependence, ... Abstinence from cocaine use: Are people who start to use cocaine able to stop, or does one line inevitably lead to another, in ...
  http://www.lycaeum.org/~sputnik/Drugs/Cocaine/
*  Biosynthesis of cocaine - Wikipedia
In the biosynthesis of cocaine, however, only the (S)-enantiomer can cyclize to form the tropane ring system of cocaine. The ... Willstätter's synthesis derived cocaine from tropinone. Since then, Robert Robinson and Edward Leete have made significant ... The additional carbon atoms required for the synthesis of cocaine are derived from acetyl-CoA, by addition of two acetyl-CoA ... E. Leete; J. A. Bjorklund; M. M. Couladis & S. H. Kim (1991). "Late intermediates in the biosynthesis of cocaine: 4-(1-methyl-2 ...
  https://en.wikipedia.org/wiki/Biosynthesis_of_cocaine
*  Category:Cocaine - Wikimedia Commons
Cocaine dosage and cocaine addiction'. Wellcome L0016413.jpg 1,122 × 1,674; 1.09 MB. ... Cocaine dosage and cocaine addiction'. Wellcome L0016412.jpg 1,250 × 1,477; 662 KB. ... Cocaine dosage and cocaine addiction'. Wellcome L0016414.jpg 1,250 × 1,460; 713 KB. ... US Navy 080913-N-0000F-071 In this photo released by the U.S. Coast Guard, some of the 37 bales of cocaine are seen in one of ...
  https://commons.wikimedia.org/wiki/Category:Cocaine