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*  Metabolic imaging of the human heart: clinical application of magnetic resonance spectroscopy | Heart
Cardiovascular MRI has earned its place in the field of clinical cardiac imaging. Regularly used techniques include anatomical ... Cardiac energy metabolism. A simplified schematic representation of cardiac energy metabolism and opportunities to assess ... measuring the abundance of metabolites in the myocardium in vivo non-invasively without the use of radiation or external ... Metabolic imaging of the human heart: clinical application of magnetic resonance spectroscopy ...
  http://heart.bmj.com/content/early/2013/07/31/heartjnl-2012-302546
*  IDEALS @ Illinois: Ex vivo proton magnetic resonance spectroscopy (1HMRS) of normal, reactive and malignant canine lymph nodes:...
High field (14.1T) 1HMRS was performed on each lymph node. Choline signal-to-noise ratios (Cho SNR) were calculated and ... Dissertations and Theses - Veterinary Clinical Medicine * Graduate Dissertations and Theses at Illinois Graduate Theses and ... Differentiation of neoplastic tissue from surrounding normal tissue is dependent on variations in cellular metabolism. Choline ... whole body magnetic resonance imaging). Magnetic resonance spectroscopy (MRS) is a non-invasive and non-ionizing technique that ...
  https://www.ideals.illinois.edu/handle/2142/50534
*  Nuclear Magnetic Resonance Assesses Changes in Hippocampal Neurons in Animal Models
... magnetic resonance spectroscopy can quantitatively analyze in vivo abnormalities of biochemical metabolism within brain tissue. ... Compared with 3.0T magnetic resonance spectroscopy, high-field magnetic resonance spectroscopy (≥ 7.0T) exhibits high spatial ... Novel Process Aims to Speed Up Testing of New Clinical Drugs Here's How Fatty Food Like Margarine Can Cause Inflammatory Bowel ... magnetic resonance spectroscopy can quantitatively analyze in vivo abnormalities of biochemical metabolism within brain tissue. ...
  http://www.medindia.net/news/nuclear-magnetic-resonance-assesses-changes-in-hippocampal-neurons-in-animal-models-135642-1.htm
*  Facilities: Advanced Imaging Research Center (AIRC) - UT Southwestern, Dallas, TX
... nuclear magnetic resonance spectroscopy, and computed tomography techniques. ... Core facilities for AIRC include machines for magnetic resonance imaging and spectroscopy, ... Learn more about human metabolism in vivo at 7 tesla.. Chemistry Labs. Chemistry is the core science for development of new ... The 7 Tesla MR scanner, the only ultra-high field MR scanner in the entire Southwest, remains the centerpiece of the AIRC. Two ...
  https://www.utsouthwestern.edu/education/medical-school/departments/airc/airc-facilities/
*  Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial HypertensionClinical Perspective |...
Proton magnetic resonance spectroscopy (MRS) is a noninvasive tool used to quantify in vivo intracellular triglyceride content ... This technique offers a noninvasive means of studying myocardial lipid metabolism and may be a valuable adjunct to clinical ... and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol. 2005;287: ... Human proton magnetic resonance spectroscopy in PAH and controls. Nonfasting in vivo myocardial triglyceride content was ...
  http://circ.ahajournals.org/content/133/20/1936
*  Feasibility of 7-T fluorine magnetic resonance spectroscopic imaging (19F MRSI) for TAS-102 metabolite detection in the liver...
... vivo monitoring of capecitabine metabolism in human liver by fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field ... clinical correlations of in vivo 19F nuclear magnetic resonance spectroscopy pharmacokinetics. J Clin Oncol. 8:1868-1873 ... Biomarkers Colorectal neoplasms Magnetic resonance spectroscopy (MRS) Metabolism Trifluridine/tipiracil (TAS-102) ... Kamm YJL, Heerschap A, van den Bergh EJ et al (2004) 19F-magnetic resonance spectroscopy in patients with liver metastases of ...
  https://link.springer.com/article/10.1186%2Fs41747-018-0043-8
*  Nuclear Magnetic Resonance Spectroscopy » Analytical Toxicology
By far the largest body of work to date using HPLC-NMR and HPLC-NMR-MS is in the field of drug metabolism, in which the ... Finally, NMR spectra can be obtained from living humans and animals and in vivoNMR or magnetic resonance spectroscopy (MRS) has ... which is now widely available in hospitals for clinical diagnosis. ... in the presence of the magnetic field, these provide a fluctuating magnetic field that opposes the main field of the NMR magnet ...
  https://www.analyticaltoxicology.com/en/nuclear-magnetic-resonance-spectroscopy/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... caused by the strong mechanical forces due to the static magnetic field of the MR scanner) constitute a crucial problem when ... Additionally, we provide a literature review on clinical uses of tDCS and its cortical effects measured by EEG techniques. ... as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism ...
  https://www.jove.com/visualize/abstract/19816597/tinnitus-intensity-dependent-gamma-oscillations-contralateral
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... Clinical efficacy and safety of pamidronate therapy on bone mass density in early post-renal transplant period: a meta-analysis ... Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma ... as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism ...
  https://www.jove.com/visualize/abstract/25265508/clinical-efficacy-safety-pamidronate-therapy-on-bone-mass-density
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... This imaging platform records the shadows (i.e., lensless digital holograms) of each cell of interest within its field of view ... These two treatments are currently approved as monotherapy11,12, but their combination has never been evaluated in a clinical ... as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism ...
  https://www.jove.com/visualize/abstract/23840312/rates-factors-associated-with-major-modifications-to-first-line
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... Asking patients to bring visuals of their lives into the clinical interaction can help to illuminate gaps in clinical knowledge ... Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma ... as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism ...
  https://www.jove.com/visualize/abstract/26147736/disruption-white-matter-integrity-adult-survivors-childhood-brain
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... Clinical studies testing the use of metformin in patients with PDAC are currently underway (e.g., NCT01210911, NCT01167738, and ... Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma ... Medicine, Issue 100, Pancreatic ductal adenocarcinoma, cancer stem cells, spheres, metformin (met), metabolism ...
  https://www.jove.com/visualize/abstract/26087013/clonal-evolution-blast-crisis-correlate-with-enhanced-proteolytic
*  Functional magnetic resonance spectroscopy of the brain - Wikipedia
"Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy". Journal of ... imaging Nuclear magnetic resonance spectroscopy Fourier transform spectroscopy Adjusting the homogeneity of a magnetic field ... Unlike in vivo MRS which is intensively used in clinical settings, fMRS is used primarily as a research tool, both in a ... Functional magnetic resonance spectroscopy of the brain (fMRS) uses magnetic resonance imaging (MRI) to study brain metabolism ...
  https://en.wikipedia.org/wiki/Functional_magnetic_resonance_spectroscopy_of_the_brain
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... via the application of localized magnetic field pulses.9 In order to explore the default mode network's propensity towards and ... Over the past decade there has been great clinical interest in improving bone healing by altering the mechanical environment ... as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism ...
  https://www.jove.com/visualize/abstract/25176211/biomechanical-study-influence-stability-for-pedicle-screws-fixation
*  31P-Magnetization Transfer Magnetic Resonance Spectroscopy Measurements of In Vivo Metabolism | Diabetes
Given that many clinical MR scanners now have the capability of performing 31P-MT experiments and the implementation of the ... The duration of the experiment will be dependent on the tissue of interest, species, and field strength of the MR system used. ... Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy. Methods Enzymol 2009;457:373-393pmid: ... 31P-Magnetization Transfer Magnetic Resonance Spectroscopy Measurements of In Vivo Metabolism Message Subject (Your Name) has ...
  http://diabetes.diabetesjournals.org/content/61/11/2669
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... status of ongoing clinical trials using these agonists are discussed as well as Mitch's prediction for areas in the field of ... as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism ... Neuroscience, Issue 93, proton magnetic resonance spectroscopy, transcranial direct current stimulation, primary motor cortex, ...
  https://www.jove.com/visualize/abstract/23342022/urbanization-trace-metal-pollution-malaria-prevalence-house
*  Peter C.M. Van Zijl, Ph.D.
International Society of Cerebral Blood Flow and Metabolism. *International Society of Magnetic Resonance in Medicine ... "In vivo imaging of paraCEST agents using frequency labeled exchange transfer MRI." Magn Reson Med. 2014 Jan;71(1):286-93. doi: ... He is currently working to develop novel technologies for high-field MRI in humans and animals, which includes developing new ... He has developed methods for MR spectroscopy (MRS) and MRS imaging; diffusion tensor imaging (DTI) and axonal mapping; ...
  https://www.hopkinsmedicine.org/profiles/results/directory/profile/4804320/peter-vanzijl
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... Next, we feature three distinct ex vivo recording techniques: extracellular field potential recording, visualized whole-cell ... Asking patients to bring visuals of their lives into the clinical interaction can help to illuminate gaps in clinical knowledge ... as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism ...
  https://www.jove.com/visualize/abstract/24194849/selective-inhibition-matrix-metalloproteinase-9-attenuates-secondary
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... Energy Metabolism, Lipid Metabolism, C. elegans, fluorescent lipid staining, lipids, Nile red, fat, high throughput screening, ... The INTREPID project is aimed to implement a new instrument to treat anxiety-related disorders and to test its clinical ... We anticipate that these techniques will become new standards in the field of C. elegans metabolic research. ...
  https://www.jove.com/visualize/abstract/20376307/depression-anxiety-glucose-metabolism-general-dutch-population-new
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... Glycogen is the main energetic polymer of glucose in vertebrate animals and plays a crucial role in whole body metabolism as ... The model compared the field steering results with single source versus dedicated power source systems on dual 8-contact ... Opioid-induced hyperalgesia and tolerance severely impact the clinical efficacy of opiates as pain relievers in animals and ...
  https://www.jove.com/visualize/abstract/24147079/inhibition-glycogen-synthase-kinase-3-prevents-remifentanil-induced
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo ... This pre-clinical C2 SCI model is a powerful, useful, and reliable pre-clinical model to study various respiratory and non- ... The model compared the field steering results with single source versus dedicated power source systems on dual 8-contact ... as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism ...
  https://www.jove.com/visualize/abstract/24278386/effectiveness-bisphosphonate-analogues-functional-electrical
*  Protocols and Video Articles Authored by David S. Wishart
Interpreting Protein Chemical Shift Data Progress in Nuclear Magnetic Resonance Spectroscopy. Feb, 2011 , Pubmed ID: 21241884 ... The study of metabolism at the global or "-omics" level is a rapidly growing field that has the potential to have a profound ... NMR results have a proven track record of translating in vitro findings to in vivo clinical applications. ... 2008 , Pubmed ID: 19040747 One-dimensional (1D) 1H nuclear magnetic resonance (NMR) spectroscopy is widely used in metabolomic ...
  https://www.jove.com/author/David+S._Wishart
*  Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients - Tabular View - ClinicalTrials.gov
... a magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut. 2005 Jan;54(1):122-7. ... MRS techniques and algorithms and gained extended experience in the field of DM2 related cardiac function and lipid metabolism. ... Given the consistency of the results from animal experiments and clinical observations, this area appears ripe for clinical ... Post conditioning efficacy of GLP-1 was also demonstrated in an ex vivo rat heart. Exendin-4 was shown to diminish infarct size ...
  https://clinicaltrials.gov/ct2/show/record/NCT01761318?view=results
*  Imaging Cancer Metabolism
Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors ... bright field microscopy has been a staple of histological analysis of tumor tissue for decades and is widely used by clinical ... Magnetic resonance imaging and spectroscopy. Magnetic Resonance Imaging (MRI) is based on the physical phenomenon called ... magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), computed tomography (CT) and optical imaging. We ...
  http://www.biomolther.org/journal/view.html?uid=905&vmd=Full
*  Faculty and Staff
... postdoctoral training included the development of hardware and software for high field magnetic resonance systems for clinical ... Her research utilizes advanced noninvasive in vivo magnetic resonance techniques that her team has developed for the detection ... The Harris Lab studies the effectiveness of targeted therapies for TBI using magnetic resonance imaging and spectroscopy, along ... and preclinical research, with emphasis on neural metabolism, at the Center for Magnetic Resonance Research at the University ...
  http://www.kumc.edu/school-of-medicine/hoglund-brain-imaging-center/faculty-and-staff.html