*  Clavulanic acid - Wikipedia
... which produces clavulanic acid. Clavulanic acid is biosynthesized from the amino acid arginine and the sugar glyceraldehyde 3- ... Clavulanic acid is an example of a clavam. Clavulanic acid was patented in 1974. For the treatment of pyelonephritis during ... which is the first step of the clavulanic acid biosynthesis. Clavulanic acid was discovered around 1974/75 by British ... This restructures the clavulanic acid molecule, creating a much more reactive species that attacks another amino acid in the ...
  https://en.wikipedia.org/wiki/Clavulanic_acid
*  Amoxicillin/clavulanic acid - Wikipedia
Amoxicillin/clavulanic acid is banned from use in domestic-food animals (cattle, swine, etc.) in both the US and Europe; in the ... Amoxicillin/clavulanic acid, also known as co-amoxiclav, is an antibiotic useful for the treatment of a number of bacterial ... Amoxicillin/clavulanic acid was approved for medical use in the United States in 1984. It is on the World Health Organization's ... Amoxicillin/clavulanic acid is widely used to treat or prevent many infections caused by susceptible bacteria, such as: urinary ...
  https://en.wikipedia.org/wiki/Amoxicillin/clavulanic_acid
*  Ticarcillin/clavulanic acid - Wikipedia
Ticarcillin/clavulanic acid, or co-ticarclav, is a combination antibiotic consisting of ticarcillin, a β-lactam antibiotic, and ... clavulanic acid, a β-lactamase inhibitor. This combination results in an antibiotic with an increased spectrum of action and ...
  https://en.wikipedia.org/wiki/Ticarcillin/clavulanic_acid
*  Amoxicillin - Wikipedia
It may also increase the risk of yeast infections and, when used in combination with clavulanic acid, diarrhea. It should not ... For this reason, it may be combined with clavulanic acid, a β-lactamase inhibitor. This drug combination is commonly called co- ... Use of the amoxicillin/clavulanic acid combination for more than one week has caused mild hepatitis in some patients. Young ... Cundiff j, Joe S.; Joe, S (2007). "Amoxicillin-clavulanic acid-induced hepatitis". Am. J. Otolaryngol. 28 (1): 28-30. doi: ...
  https://en.wikipedia.org/wiki/Amoxicillin
*  Proclavaminate amidinohydrolase - Wikipedia
This enzyme participates in clavulanic acid biosynthesis. Salowe SP, Krol WJ, Iwata-Reuyl D, Townsend CA (1991). "Elucidation ... Townsend CA (2002). "New reactions in clavulanic acid biosynthesis". Curr. Opin. Chem. Biol. 6 (5): 583-9. doi:10.1016/S1367- ... of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis ...
  https://en.wikipedia.org/wiki/Proclavaminate_amidinohydrolase
*  Clavaminate synthase - Wikipedia
Townsend, C.A. (2002). "New reactions in clavulanic acid biosynthesis". Curr. Opin. Chem. Biol. 6: 583-589. doi:10.1016/S1367- ... Clavaminate synthase (EC 1.14.11.21, clavaminate synthase 2, clavaminic acid synthase) is an enzyme with systematic name ... "Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase". Nat. Struct. Biol. 7 (2): 127- ...
  https://en.wikipedia.org/wiki/Clavaminate_synthase
*  carboxyethyl)arginine beta-lactam-synthase - Wikipedia
Townsend CA (2002). "New reactions in clavulanic acid biosynthesis". Curr. Opin. Chem. Biol. 6 (5): 583-9. doi:10.1016/S1367- ... This enzyme participates in clavulanic acid biosynthesis. Miller, M. T.; Bachmann, B. O.; Townsend, C. A.; Rosenzweig, A. C. ( ...
  https://en.wikipedia.org/wiki/(carboxyethyl)arginine_beta-lactam-synthase
*  N2-(2-carboxyethyl)arginine synthase - Wikipedia
Khaleeli N; Li R; Townsend CA (1999). "Origin of the beta-lactam carbons in clavulanic acid from an unusual thiamine ... This enzyme participates in clavulanic acid biosynthesis. As of late 2007, two structures have been solved for this class of ... the first enzyme in the clavulanic acid biosynthesis pathway". J. Biol. Chem. 279 (7): 5685-92. doi:10.1074/jbc.M310803200. ...
  https://en.wikipedia.org/wiki/N2-(2-carboxyethyl)arginine_synthase
*  Ureohydrolase - Wikipedia
Proclavaminate amidinohydrolase is involved in clavulanic acid biosynthesis. Clavulanic acid acts as an inhibitor of a wide ... evolution of a hydrolytic enzyme in clavulanic acid biosynthesis". Biochem. J. 366 (Pt 2): 423. doi:10.1042/BJ20020125. PMC ... Clifton IJ, Elkins JM, Hernandez H (2002). "Oligomeric structure of proclavaminic acid amidino hydrolase: ...
  https://en.wikipedia.org/wiki/Ureohydrolase
*  Clavam - Wikipedia
An example is clavulanic acid, from which this compound class receives its name. "Medscape.com". Retrieved 2008-12-29. Chemical ... Clavulanic Acid Mode of Action and Biosynthesis". Retrieved 2011-07-25. ...
  https://en.wikipedia.org/wiki/Clavam
*  Streptomyces clavuligerus - Wikipedia
Baggaley K, Brown A, Schofield C (1997). "Chemistry and biosynthesis of clavulanic acid and other clavams". Nat Prod Rep. 14 (4 ... Tahlan K, Anders C, Jensen S (2004). "The Paralogous Pairs of Genes Involved in Clavulanic Acid and Clavam Metabolite ... Streptomyces clavuligerus is a species of Gram-positive bacterium notable for producing clavulanic acid. S. clavuligerus ATCC ... Kirk S (2000). "The physiology of clavulanic acid production by Streptomyces clavuligerus (PhD thesis)". University of Surrey, ...
  https://en.wikipedia.org/wiki/Streptomyces_clavuligerus
*  List of antibiotics - Wikipedia
"APO-Amoxycillin and Clavulanic Acid 500mg/125 mg Tablets" (PDF). Retrieved November 27, 2014. Mechanism of Action of Bacitracin ... "Amoxicillin-sulbactam versus amoxicillin-clavulanic acid for the treatment of non-recurrent-acute otitis media in Argentinean ... Fluoroquinolones Piperacillin/tazobactam Ticarcillin/clavulanic acid Antibiotics that cover vancomycin-resistant Enterococcus ( ... Clindamycin Dalbavancin Daptomycin Fusidic acid Linezolid Mupirocin (topical) Oritavancin Tedizolid Telavancin Tigecycline ...
  https://en.wikipedia.org/wiki/List_of_antibiotics
*  Urinary tract infection - Wikipedia
Cephalosporins, amoxicillin/clavulanic acid, or a fluoroquinolone may also be used. However, resistance to fluoroquinolones ...
  https://en.wikipedia.org/wiki/Urinary_tract_infection
*  Beta-glucan - Wikipedia
Mennink-Kersten MA, Warris A, Verweij PE (2006). "1,3-β-D-Glucan in patients receiving intravenous amoxicillin-clavulanic acid ...
  https://en.wikipedia.org/wiki/Beta-glucan
*  Cilastatin - Wikipedia
Thus imipenem/cilastatin, like amoxicillin/clavulanic acid, is a commonly used combination product. Keynan S, Hooper NM, Felici ...
  https://en.wikipedia.org/wiki/Cilastatin
*  ArgJ protein family - Wikipedia
"X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster". Biochem. J. 385 (Pt ...
  https://en.wikipedia.org/wiki/ArgJ_protein_family
*  Proteus penneri - Wikipedia
However, HugA does not affect cephamycins or carbapenems and is inhibited by clavulanic acid. Similar to other Proteus species ... penneri LPS are the amide of D-galacturonic acid with L-lysine α-D-GalA-(L-Lys) (and the amide of D-galacturonic acid with L- ... penneri from the experiment were found to be multiple drug-resistant including resistance to amoxy-clavulanic acid combination ...
  https://en.wikipedia.org/wiki/Proteus_penneri
*  Haemophilus influenzae biogroup aegyptius - Wikipedia
These include ampicillin, chloramphenicol, amoxicillin-clavulanic acid, cefamandole, cefuroxime, cefotaxime, tetracycline, ... "Deoxyribonucleic acid relatedness between Haemophilus aegyptius and Haemophilus influenza," Elsevier, 137B (1986): 155-163. ...
  https://en.wikipedia.org/wiki/Haemophilus_influenzae_biogroup_aegyptius
*  Urofacial syndrome - Wikipedia
Treatment can include amoxicillin-clavulanic acid, intravenous fluid administration and paracetamol oral for pain relief. Other ...
  https://en.wikipedia.org/wiki/Urofacial_syndrome
*  Adenoiditis - Wikipedia
Bacterial adenoiditis may be treated with antibiotics, such as amoxicillin - clavulanic acid or a cephalosporin. In case of ...
  https://en.wikipedia.org/wiki/Adenoiditis
*  British Approved Name - Wikipedia
For example, the BAN Co-amoxiclav is assigned to preparations containing amoxicillin and clavulanic acid. Most other ... "amoxicillin with clavulanic acid". The prefix of "co-" is used for many combination drugs, including opioid with paracetamol or ...
  https://en.wikipedia.org/wiki/British_Approved_Name
*  Park Jong-sei - Wikipedia
"Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC-ESI mass spectrometry". Journal of ...
  https://en.wikipedia.org/wiki/Park_Jong-sei
*  GlaxoSmithKline - Wikipedia
Brown AG (Aug 1986). "Clavulanic acid, a novel beta-lactamase inhibitor--a case study in drug discovery and development". Drug ...
  https://en.wikipedia.org/wiki/GlaxoSmithKline
*  Thienamycin - Wikipedia
Spratt BG, Jobanputra V, Zimmermann W (1977). "Binding of Thienamycin and Clavulanic Acid to the Penicillin-Binding Proteins of ... and l-α-aminoadipic acid by ACV synthetase (ACVS, a nonribsomal peptide synthetase) and then cyclization of this formed ...
  https://en.wikipedia.org/wiki/Thienamycin
*  Ticarcillin - Wikipedia
Ticarcillin is also often paired with a β-lactamase inhibitor such as clavulanic acid (co-ticarclav). In molecular biology, ... One synthesis began by making the monobenzyl ester of 3-Thienylmalonic acid, converting this to the acid chloride with SOCl2, ... and condensing it with 6-Aminopenicillanic acid (6-APA). Hydrogenolysis (Pd/C) completed the synthesis of ticarcillin.. ...
  https://en.wikipedia.org/wiki/Ticarcillin