DA was concurrently oxidized to , produce a threefold increase in free radicals, as measured by the , redox-sensitive dye ... AMPH-evoked LPO was only slightly reduced by these , compounds. It is concluded that AMPH enhances ACH release through ... sulfhydryl (SH)-protected] exposed to NO is returned to , full activity by thiol reduction with DTT. The inactivation of native ... drug-induced production of reactive oxygen species (ROS) and nitric oxide , (NO). The cellular effects of ROS or NO cannot be ...http://www.bio.net/bionet/mm/neur-sci/2003-May/054567.html
Patente US5811449 - Treatment for atherosclerosis and other cardiovascular and inflammatory diseases - Google Patentes
... also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox- ... interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox ... A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 ... fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method ...http://www.google.es/patents/US5811449?dq=flatulence
Sauvignon blanc wine: Contribution of ageing and oxygen on aromatic and non-aromatic compounds and sensory composition - A...
... are sulphur-containing compounds possessing a sulfhydryl group (-SH). Various sulphur-containing compounds occur in wine and ... lower redox potentials, such as other phenolic molecules, SO2 and thiol-containing compounds, including glutathione and amino ... However, yeast extracts (which contain GSH) are claimed to preserve the freshness and increase the mouthfeel, as well as the ... Sauvignon blanc wine: Contribution of ageing and oxygen on aromatic and non-aromatic compounds and sensory composition - A ...http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S2224-79042015000300012&lng=en&nrm=iso&tlng=en
Detox Supplement - Complete Detoxification Kit - SHOP.COM
... and helps limit liver damage as a result of disrupted oxygen supply. Milk thistle contains a compound called silymarin, a ... Antioxidants and Redox Signaling. 8(3-4): 395-403, 2006. * Shen, G., et al. Modulation of nuclear factor E2-related factor 2- ... It is claimed that red clover can balance moods, support healthy sleeping patterns, reduce hot flashes, improve libido, support ... NAC cleaves disulfide bonds by converting them to two sulfhydryl groups. This results in the breakup of mucoproteins in lung ...https://www.shop.com/Complete+Detoxification+Kit+-742827918-p+.xhtml
Sub-chronic toxicopathological study of lantadenes of Lantana camara weed in Guinea pigs | SpringerLink
... which are essential for endogenous antioxidative defense system to scavenge reactive oxygen species and maintain cellular redox ... In: Handbook of natural Toxins,Toxicology of plant and fungal compounds R. Keeler, and T. Anthony, eds. Marcel Dekker, Inc. N Y ... Estimation of total, protein-bond and non-protein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968;25:192- ... Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. ...https://link.springer.com/article/10.1186/s12917-018-1444-x
Patent US7262306 - Chemiluminescent compounds and their use - Google Patents
... to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these ... compounds or conjugates thereof in chemiluminescence based assays, especially in immunoassays. ... The present invention relates to novel chemiluminescent compounds, ... claim 4. wherein the H2O2 or a reactive oxygen species is generated by an enzymatic reaction. ...http://www.google.com/patents/US7262306?dq=645576
Nutrients | Free Full-Text | Selenium in Bone Health: Roles in Antioxidant Protection and Cell Proliferation | HTML
All of the enzymatically characterized seleoproteins catalyze not only redox reactions at sulfhydryl groups/disulfides, but ... Williams, M.S.; Henkart, P.A. Role of reactive oxygen intermediates in TCR-induced death of T cell blasts and hybridomas. J. ... Sinha, R.; Said, T.K.; Medina, D. Organic and inorganic selenium compounds inhibit mouse mammary cell growth in vitro by ... Consumers' Health-Related Motive Orientations and Reactions to Claims about Dietary Calcium ...http://www.mdpi.com/2072-6643/5/1/97/htm
Acetylcysteine - Wikipedia
"L-Cysteine, N-acetyl- - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005 ... Gu F, Chauhan V, Chauhan A (Jan 2015). "Glutathione redox imbalance in brain disorders". Current Opinion in Clinical Nutrition ... The thiol (sulfhydryl) group confers antioxidant effects and is able to reduce free radicals. ... The effect was similar to that observed following a 3-week exposure to an oxygen-deprived environment (chronic hypoxia). The ...https://en.m.wikipedia.org/wiki/N-acetylcysteine
Antioxidant - Wikipedia
... reactive oxygen species also have useful cellular functions, such as redox signaling. Thus, the function of antioxidant systems ... as antioxidants collectively are a diverse group of compounds with different reactivities to various reactive oxygen species. ... It has been claimed that the α-tocopherol form is the most important lipid-soluble antioxidant, and that it protects membranes ... Besides ascorbate, medically important conditional pro-oxidants include uric acid and sulfhydryl amino acids such as ...https://en.wikipedia.org/wiki/Free_radical_scavenger
Imidazoline .alpha.-adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and...
... with at least one NO or NO.sub.2 moiety and compounds that donate, transfer or release nitric oxide or elevate levels of ... The kit of claim 43, wherein the compound that stimulates nitric oxide synthesis is L-arginine or OH-arginine.. 46. A method of ... wherein A.sub.2 is oxygen or sulfur.. Another embodiment of the invention includes substituted compounds of the formula VI: ## ... sulfhydryl condensation), carbon and nitrogen. The invention also provides compositions comprising one or more of such ...http://www.patentgenius.com/patent/6514934.html
Patent US6359004 - Manipulating nitrosative stress to upregulate nitrosative stress defenses - Google Patents
... contains 1 to 10 carbon atoms. In another invention herein, mammals in need of increased nitrosative stress defenses are ... helminth and/or mammal to nitric oxide related compound or to NO+ or NO−, especially redox active metal catalysts, preferably ... Claims(2). What is claimed is: 1. A method of upregulation of nitrosative stress defense mechanism in a patient in need of such ... He is taken to the hyperbaric chamber and given 100% oxygen with 80 ppm (part/million) NO in 3 atmospheres of absolute pressure ...http://www.google.com/patents/US6359004?dq=4168396
Patent US7468458 - Accelerants for the modification of non-natural amino acids and non-natural ... - Google Patents
The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non- ... Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and ... Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing ... Examples of isotopes that can be incorporated into the present compounds include isotopes of hydrogen, carbon, nitrogen, oxygen ...http://www.google.com/patents/US7468458
Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com
A method as claimed in claim 31 wherein said agent further comprises a therapeutic compound. 36. A method as claimed in claim ... Examples of reactive moieties capable of reaction with sulfhydryl groups include .alpha.-haloacetyl compounds of the type X--CH ... Oxygen-containing contrast media also represent potentially useful paramagnetic MR contrast agents.  Furthermore, in the ... The reversible nature of this covalent bond means that bubble flow can be controlled by altering the redox environment. ...http://www.patents.com/us-20050002865.html
Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury |...
Chernorudskiy AL, Zito E. Regulation of calcium homeostasis by ER redox: a close-up of the ER/mitochondria connection. J Mol ... Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci. 2010;35( ... Besides that, stem cells inhibit inflammatory effects that further damage nearby cells and remove toxic compounds accumulated ... Wilkerson DC, Sankar U. Mitochondria: a sulfhydryl oxidase and fission GTPase connect mitochondrial dynamics with pluripotency ...https://link.springer.com/article/10.1186/s13287-018-0832-2
Environmental Determinants of Chronic Disease and Medical Approaches: Recognition, Avoidance, Supportive Therapy, and...
Metals such as lead and cadmium, and many halogenated compounds (e.g., flame retardants, nonstick compounds, stain repellents, ... This is a direct effect of pesticides designed to bind with receptors, or of toxic metals that bind with protein sulfhydryl ... C. De Luca, M. G. Scordo, E. Cesareo et al., "Biological definition of multiple chemical sensitivity from redox state and ... carbon monoxide supplanting oxygen on hemoglobin, or heavy metals supplanting zinc on glutathione), and overall a toxicant ...https://www.hindawi.com/journals/jeph/2012/356798/
Patent US6693122 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google Patents
... and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived ... at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived ... claim 40. , wherein the compound of claim 1. and the compound that donates, transfers, or releases nitric oxide, induces the ... is oxygen then Q is not -NO2; and the compounds of Formula (I) must contain at least one nitrite, nitrate, thionitrite or ...http://www.google.com/patents/US6693122?dq=6978253
Patente US20020143188 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google Patentes
... and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived ... at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived ... claim 81. , wherein the compound of claim 2. and the compound that donates, transfers, or releases nitric oxide, or induces the ... is oxygen then Q is not -NO2; and the compounds of Formula (I) must contain at least one nitrite, nitrate, thionitrite or ...http://www.google.es/patents/US20020143188
US20080292618A1 - Intranuclear protein transduction through a nucleoside salvage pathway - Google Patents
Also provided are methods of treating a patient having an autoimmune disorder involving administering to the patient a compound ... claim 8. , wherein the drug compound is selected from the group consisting of α-glucosidase, α-L-iduronidase, α-galactosidase A ... or an agent that alters the redox state of a tissue. The agent that treats or inhibits hypoxia may be excess oxygen, TSC, or ... Alternatively, molecules such asamino-sulfhydryl cross-linking reagents which are cleavable under mildly acidic conditions may ...https://patents.google.com/patent/US20080292618A1/en
Arsenic poisoning - Wikipedia
DMA(III) is able to form reactive oxygen species (ROS) by reaction with molecular oxygen. Resulting metabolites are the ... Organic arsenic compounds tend to be eliminated in the urine in unchanged form, while inorganic forms are largely converted to ... Arsenic, especially +3 As, binds to single, but with higher affinity to vicinal sulfhydryl groups, thus reacts with a variety ... Robert Mugabe's successor as President of Zimbabwe, Emmerson Mnangagwa has claimed he was poisoned with arsenic at a rally. His ...https://en.wikipedia.org/wiki/Arsenic_poisoning
US5932538A - Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses -...
... and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO + ) or nitroxyl (NO ... C07D-HETEROCYCLIC COMPOUNDS * C07D405/00-Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as ... The composition of claim 18, wherein the compound comprising at least one O2 N--O--, O2 N--N--, O2 N--S-- or O2 N--C-- group is ... sulfhydryl condensation), carbon and nitrogen. The invention also provides compositions comprising such compounds in a ...https://patents.google.com/patent/US5932538?oq=flatulence
Lactoperoxidase - Wikipedia
A combination of lactoperoxidase, glucose, glucose oxidase (GOD), iodide and thiocyanate is claimed to be effective in the ... The oxidation of thiocyanate and the nature of the inhibitory compound". Biochem. J. 100 (2): 382-8. PMC 1265146 . PMID 5338806 ... The ability of lactoperoxidase to propagate a chain reaction leading to oxygen consumption and intracellular hydrogen peroxide ... Thomas EL, Aune TM (May 1978). "Lactoperoxidase, peroxide, thiocyanate antimicrobial system: correlation of sulfhydryl ...https://en.wikipedia.org/wiki/Lactoperoxidase
N-Acetylcysteine | Phoenix Rising ME / CFS Forums
Some claim that by the time glutathione is digested and into the bloodstream it is no longer glutathione. They claim that it is ... NAC, cysteine and glutathione contain sulfur in the form of sulfhydryl groups. Sulfhydryl groups directly react with many ... NAC directly detoxifies reactive oxygen mutagens such as superoxide, hydrogen peroxide, and singlet oxygen, and inhibits ... compounds and excess oxidizers that enter cells. The harmful compounds that have been conjugated with glutathione then pass ...https://forums.phoenixrising.me/index.php?threads/n-acetylcysteine.18899/
Identification, characterization and purification of porcine Quiescin Q6-Sulfydryl Oxidase 2 protein | BMC Veterinary Research ...
However, unlike isoform 1, scarce information is available for isoform 2, likely due to its lower expression level and lack of ... Two isoforms (isoform 1 and 2) from Quiescin Q6-Sulfydryl Oxidase protein family have been identified in the male reproductive ... Coppock DL, Thorpe C. Multidomain flavin-dependent sulfhydryl oxidases. Antioxid Redox Signal. 2006;8(3-4):300-11.View Article ... The last domain represents the oxidative site for the catalysis of the thiol/disulfide redox pool to molecular oxygen via/ ...https://0-bmcvetres-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12917-017-1125-1
US Patent # 6,953,666. Biomarkers for oxidative stress - Patents.com
... and normal dietary phenolic compounds (e.g., caffeic acid) that generate oxidants by redox cycling (Ames, B. N. et al. (1993 ... The method of claim 32, wherein said organism is a mammal. 35. The method of claim 32, wherein said organism is a human.. ... 215:767-775). In principle, all of these reactive oxygen species (ROS) and reactive non-oxygen species are strong enough to ... with a body fluid containing an oxidized sulfhydryl amino acid; then at least partially purifying the oxidized sulfhydryl amino ...http://patents.com/us-6953666.html
1993) redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. ... with thiols in the presence of oxygen. These compounds are naturally occurring in vivo, stabilize NO and potentiate its ... It was claimed that even low molecular weight RSNOs such as CysNO are unlikely to permeate cell membranes readily because they ... the 4B was incubated with 5 mM NEM for 10 min to alkylate the sulfhydryl group; the NEM-treated 4B (NEM-4B) was then thoroughly ...http://jpet.aspetjournals.org/content/284/2/526