*  Pure proximal deletion of chromosome 21 and kyphosis.
We report on two unrelated patients with a proximal deletion of the long arm of chromosome 21. The deletion encompassed 14.5Mb ... Chromosome Breakage. Chromosome Deletion*. Chromosomes, Human, Pair 21 / genetics*. Female. Humans. Kyphosis / genetics*. Male ... 7558019 - Integration of the physical and genetic linkage map for human chromosome 13.. 10406899 - Secondary chromosome changes ... We report on two unrelated patients with a proximal deletion of the long arm of chromosome 21. The deletion encompassed 14.5Mb ...
  http://www.biomedsearch.com/nih/Pure-proximal-deletion-chromosome-21/17890169.html
*  Michael Cascio - Publications - Oregon Health & Science University
Chromosomes, Human, Pair 21 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytogenetics Genetic Markers ... Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration. Cascio, M., Xing, Y., Gong ... Cytogenetic Variation of B-Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21 (iAMP21): A Multi- ...
  https://ohsu.pure.elsevier.com/en/persons/michael-cascio/publications/
*  Chromosome 21 (human) - Wikipedia
... working on the Human Genome Project announced that they had determined the sequence of base pairs that make up this chromosome ... Gilbert F (1997). "Disease genes and chromosomes: disease maps of the human genome. Chromosome 21". Genet Test. 1 (4): 301-6. ... after chromosome 22. The following are some of the gene count estimates of human chromosome 21. Because researchers use ... The following is a partial list of genes on human chromosome 21. For complete list, see the link in the infobox on the right. ...
  https://en.wikipedia.org/wiki/Chromosome_21_(human)
*  "Familial and sporadic Alzheimer's disease: neuropathology cannot exclu" by Carol F. Lippa, Ann M. Saunders et al.
... six AD patients with mutations of chromosome 21 (codon 717 of the beta-amyloid percursor protein gene), and 11 sporadic AD (SAD ... Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 21; Gene Frequency; Humans; Linkage (Genetics); Middle Aged; Mutation; ... patients with linkage to chromosome 14, six AD patients with mutations of chromosome 21 (codon 717 of the beta-amyloid ...
  https://escholarship.umassmed.edu/neuro_pp/300/
*  "Change-point analysis of paired allele-specific copy number variation " by Yinglei Lai
For a cancer study, it is common to collect data for paired normal and tumor samples. Then, two types of paired data can be ... Chromosomes, Human, Pair 20--genetics; Chromosomes, Human, Pair 21--genetics; DNA, Neoplasm; Neoplasms--genetics; Polymorphism ... For a cancer study, it is common to collect data for paired normal and tumor samples. Then, two types of paired data can be ... Lai, Y. (2012). Change-point analysis of paired allele-specific copy number variation data. Journal of Computational Biology, ...
  https://hsrc.himmelfarb.gwu.edu/biostatscenter_facpubs/36/
*  Loss of RUNX1/ETO Triggers C/EBPα-Driven Reorganizatio | Open-i
Chromosome Mapping. *Chromosomes, Human, Pair 21. *Chromosomes, Human, Pair 8. *Core Binding Factor Alpha 2 Subunit/metabolism ... Health and Human Services • 8600 Rockville Pike,Bethesda,MD 20894 Privacy • Accessibility • Freedom of Information Act • ... Health and Human Services • 8600 Rockville Pike,Bethesda,MD 20894 Privacy • Accessibility • Freedom of Information Act • ... p , 0.05, **p , 0.01 by paired Student's t test.(D) UCSC genome browser screenshot showing the binding pattern of RUNX1/ETO, C/ ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4487811_nihms703543f7&req=4
*  Radiation hybrid mapping - Wikipedia
The RH procedure was used to map 14 DNA probes from a region of human chromosome 21 spanning 20 megabase pairs. Deloukas, Panos ... If two given DNA markers are far apart on the initial chromosome, then it is likely that they will appear in distinct fragments ... First of all, desired chromosomes are broken into several segments with X-rays, after which they are implanted in rodent cells ... Radiation hybrid mapping (also known as RH mapping) is a technique for mapping mammalian chromosomes. Radiation hybrid mapping ...
  https://en.wikipedia.org/wiki/Radiation_hybrid_mapping
*  dementia facts, information, pictures | Encyclopedia.com articles about dementia
It has been known since 1993 that a specific form of a gene (the APOE gene) on human chromosome 19 is a genetic risk factor for ... In 1999, a mutated gene that produces the amyloid responsible for FBD was discovered on human chromosome 13. Studies of this ... Doctors are not sure what causes CJD, although in some cases it appears to have been passed from human to human by contaminated ... three forms of human chromosome 21 instead of a pair) often develop early-onset AD. ...
  http://encyclopedia.com/medicine/psychology/psychology-and-psychiatry/dementia
*  Are cancers newly evolved species? - Healthcanal.com : Healthcanal.com
... one of the 23 pairs of human chromosomes. All cancer cells are aneuploid, Duesberg said, though proponents of the mutation ... Staining chromosomes with different dyes highlights the orderly nature of the normal human karyotype (left), that is, humans ... Each cell has precisely two copies of 22 chromosomes and one copy of each sex chromosome, demonstrating that human cells have a ... "If humans changed their karyotype - the number and arrangement of chromosomes - we would either die or be unable to mate, or in ...
  https://www.healthcanal.com/cancers/19150-are-cancers-newly-evolved-species.html
*  acute myelogenous leukemia without maturation fab m1 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Chromosomes, Human, Pair 11 / genetics. Chromosomes, Human, Pair 5 / genetics. Chromosomes, Human, Pair 7 / genetics. Gene ... Twenty-one cases, including ours, of myelodysplastic syndromes and acute myelogenous leukemia with MLL amplification present in ... MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 7. Leukemia, Myeloid, Acute / ... MeSH-major] Chromosomes, Human, Pair 15. Chromosomes, Human, Pair 17. Leukemia, Myeloid, Acute / genetics. Leukemia, ...
  http://www.bmlsearch.com/?kwr=acute+myelogenous+leukemia+without+maturation+fab+m1+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Robertsonian translocation - Wikipedia
In humans, Robertsonian translocations generally occur in the five acrocentric chromosome pairs, namely 13, 14, 15, 21 and 22. ... or non-homologous chromosomes (i.e. two different chromosomes, not belonging to a homologous pair). A feature of chromosomes ... This type of translocation is cytologically visible, and can reduce chromosome number (from 23 to 22 pairs, in humans) if the ... The nonrandom participation of human acrocentric chromosomes in Robertsonian translocations. Annals of Human Genetics 1989;53: ...
  https://en.wikipedia.org/wiki/Robertsonian_translocation
*  Tackling the genetic onset of Down syndrome
The most common cause of this 'trisomy' on HC21 is the failure of the chromosome pair to divide in an egg cell-often linked to ... Down syndrome (DS) is caused by the erroneous replication of human chromosome 21 (HC21), which results in three copies of the ... Chromosome 21 is the smallest of the 23 pairs of chromosomes in humans, yet it is responsible for Down syndrome-the most common ... Human Molecular Genetics 13, 1333-1340 (2004). 2. Amano, K., Fujii, M., Arata, S., Tojima, T., Ogawa, M., Morita, N., Shimohata ...
  https://www.innovations-report.com/html/reports/life-sciences/tackling-genetic-onset-syndrome-148060.html
*  C21orf62 - Wikipedia
... in humans, is encoded by the C21orf62 gene. C21orf62 is found on human chromosome 21, and it is thought to be expressed in ... The C21orf62 gene is 4132 base pairs in length and contains five exons. The mRNA sequence of C21orf62 in humans has one known ... C21orf62 in humans has higher cysteine and lower valine concentrations than expected compared to other human proteins. This ... The C21orf62 protein in humans has a sequence that is 219 amino acids in length. The primary sequence of C21orf62 in humans has ...
  https://en.wikipedia.org/wiki/C21orf62
*  Rhesus macaque - Wikipedia
The PRAME family has 26 members on human chromosome 1. In the macaque, it has eight, and has been very simple and stable for ... but do have peaceful relationships with the offspring of their consort pairs. Manson and Parry found that free-ranging rhesus ... coming to rely on handouts or refuse from humans. They adapt well to human presence, and form larger troops in human-dominated ... So, macaque, chimpanzee, and human chromosomes are mosaics of each other. Surprisingly, some normal gene sequences in healthy ...
  https://en.wikipedia.org/wiki/Rhesus_macaque
*  Chromosome 22 (human) - Wikipedia
Chromosome 22 is one of the 23 pairs of chromosomes in human cells. Humans normally have two copies of chromosome 22 in each ... Chromosome 22 was the first human chromosome to be fully sequenced. Chromosome 22 was originally identified as the smallest ... Chromosome 22 is the second smallest human chromosome (chromosome 21 being smaller), spanning about 49 million DNA base pairs ... See also: Category:Genes on human chromosome 22. The following is a partial list of genes on human chromosome 22. For complete ...
  https://en.wikipedia.org/wiki/Chromosome_22_(human)
*  Genome gains at chromosome 21q21/22 segment leads to co-amplification of Down Syndrome Critical Regions and known oncogenes in...
Chromosomes, Human, Pair 21, Humans, Cord Blood Stem Cell Transplantation, Karyotyping, Gene Amplification, Oncogenes, Adult, ... Genome gains at chromosome 21q21/22 segment leads to co-amplification of Down Syndrome Critical Regions and known oncogenes in ... Genome gains at chromosome 21q21/22 segment leads to co-amplification of Down Syndrome Critical Regions and known oncogenes in ...
  https://www.ndorms.ox.ac.uk/publications/262926
*  Researchers document second case of 'Down syndrome' in chimps | EurekAlert! Science News
... in humans. The report1 on Kanako, a 24-year-old female chimp born into captivity, was led by Satoshi Hirata of Kyoto University ... Human cells normally contain 23 pairs of chromosomes, for a total of 46. Down syndrome occurs when a person's cells contain a ... apes have 24 pairs of chromosomes, for a total of 48. Trisomy 22 is diagnosed when the cells of apes such as chimpanzees, ... These symptoms are also common in human Down syndrome. Kanako's heart condition was only picked up in 2014 during a routine ...
  https://www.eurekalert.org/pub_releases/2017-02/s-rds022117.php
*  Female Down's syndrome karyotype - Stock Image C007/2031 - Science Photo Library
Humans usually have 46 chromosomes in total, arranged into 23 pairs. Down's syndrome, also called trisomy 21, is caused by the ... The XX chromosome pair at centre right indicates that this person is female. Males have an XY chromosome pair instead (the ... presence of three copies of chromosome 21 (bottom left). Down's syndrome results in mental retardation and flattened facial ... empty space for a Y chromosome is at bottom right). - Stock Image C007/2031 ...
  http://www.sciencephoto.com/media/135022/view
*  myths & misconceptions
There are 46 chromosomes which are arranged in 23 pairs in each cell in the human body. In 95% of DS cases, pair #21 has three ... DS is an abnormality of the chromosome makeup in the body. It is still not known exactly what causes this error, but it is not ... Of all the genetic disorders with chromosome abnormalities, Down s Syndrome has the highest rateof occurrence. *Some 7,000 ... chromosomes instead of the normal two. This is known as disjunction, and is not linked to any hereditary factors. THe remaining ...
  http://www.pirchei.co.il/specl_ed/down/archives/myths.htm
*  The Genetic Language: The Old, Old Testament. , page 3
23 pairs of human chromosomes. 23 degrees of tilt from the Earth's axis to neutral up and down. I guess we were meant to be ... Question: (stupid perhaps); is there a harmonic value to the human body/brain/nerve system?. Everything alive and not alive ... Together, they have 46 letters, just like the seed of human life. o_O ... General Chit Chat • 21 • : enlightenedservant * The nightmare of slavery should make us appreciate the blessings of today. ...
  http://www.abovetopsecret.com/forum/thread1029618/pg3
*  BLIMP-1 and STAT3 Counterregulate MicroRNA-21 during Plasma Cell Differentiation | The Journal of Immunology
In these primer pairs, the number in the primer name designates the genomic coordinate on human chromosome 17 (miR-21) or ... Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10: 1957-1966. ... Use of human samples was approved by the Leeds East Research Ethics Committee (REC reference 07/Q1206/47). The Abs used for ... Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression. Blood 112: 1804-1812. ...
  http://www.jimmunol.org/content/189/1/253.long
*  RUFY2 - Wikipedia
The human RUFY2 gene is located on the long (q) arm of chromosome 10 at region 21 band 3, from base pair 70,100,864 to base ... There are 18 predicted exons in the human gene with 13 alternative transcripts. 8,180 base pairs upstream of RUFY2 is the ... RUN and FYVE domain containing 2 (RUFY2) is a protein that in humans is encoded by the RUFY2 gene. The RUFY2 gene is named for ... pair 70,167,051 on the reverse strand (Build GRCh37/hg19) (map). The gene produces a 2,080 base pair mRNA. ...
  https://en.wikipedia.org/wiki/RUFY2
*  New Methods Offer Insight into Regulatory DNA
... human genome regions. The second was 35million base-pairs of chromosome 21 sequence: three copies of chromosome 21 lead to Down ... The third was a region of chromosome 20 - 10 million base-pairs - that is known to be associated with diabetes and obesity. In ... The project focused on three regions of the human genome. The first, called the ENCODE regions, and about 30 million base-pairs ... Through the Human Genome Project, the HapMap Project and other efforts, we are beginning to identify genes that are modified in ...
  http://www.innovations-report.com/html/reports/life-sciences/report-53062.html
*  Human genetic variation - Wikipedia
Chromosome abnormalities are detected in 1 of 160 live human births. Apart from sex chromosome disorders, most cases of ... The human nucleotide diversity is estimated to be 0.1% to 0.4% of base pairs. A difference of 1 in 1,000 amounts to ... According to a 2000 study of Y-chromosome sequence variation, human Y-chromosomes trace ancestry to Africa, and the descendants ... No two humans are genetically identical. On average, in DNA sequence, each human is 99.5% similar to any other human. Even ...
  https://en.wikipedia.org/wiki/Human_genetic_variation
*  Down syndrome facts, information, pictures | Encyclopedia.com articles about Down syndrome
Humans have 46 chromosomes arranged into 23 pairs. Chromosomes contain the genetic information necessary to direct the ... chromosome appears as a third chromosome attached to the 21st of the 23 pairs of chromosomes normally present in the human ... an extra chromosome in the 21st pair (altogether, they have 47 chromosomes instead of the normal 46); four percent have ... causing both chromosomes from a pair to get packaged together. If the sex cell with the extra chromosome is fertilized by a sex ...
  http://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/down-syndrome