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*  Attenuated vascular reactivity in dogs with anteroventral third ventricle lesions. | Hypertension
Lesion of the anteroventral portion of the third cerebral ventricle causes hypernatremia, adipsia, and attenuation of the pressor response to intravenous administration of angiotensin II and norepinephrine. In addition, these lesions prevent the development of several experimental models of hypertension. In this study, a lesion of the third cerebral ventricle region was made in 14 dogs. In seven dogs in which hypernatremia developed the lesions included the organum vasculosum of the lamina terminalis; seven animals in which the circumventricular organ was spared by the lesion remained normonatremic. Vascular responsiveness of isolated right carotid artery rings to angiotensin II and phenylephrine was assessed 3 days after lesioning the anteroventral portion of the third cerebral ventricle. In endothelium-denuded ring vessels, vasoconstrictor responses to phenylephrine were significantly decreased in animals both with and without inclusion of the organum ...
  http://hyper.ahajournals.org/content/18/1/40
*  Dynamic features of postnatal subventricular zone cell motility: a two-photon time-lapse study. - Physiology, Anatomy and...
Neuroblasts migrate long distances in the postnatal subventricular zone (SVZ) and rostral migratory stream (RMS) to the olfactory bulbs. Many fundamental features of SVZ migration are still poorly understood, and we addressed several important questions using two-photon time-lapse microscopy of brain slices from postnatal and adult eGFP(+) transgenic mice. 1) Longitudinal arrays of neuroblasts, so-called chain migration, have never been dynamically visualized in situ. We found that neuroblasts expressing doublecortin-eGFP (Dcx-eGFP) and glutamic acid decarboxylase-eGFP (Gad-eGFP) remained within arrays, which maintained their shape for many hours, despite the fact that there was a wide variety of movement within arrays. 2) In the dorsal SVZ, neuroblasts migrated rostrocaudally as expected, but migration shifted to dorsoventral orientations throughout ventral regions of the lateral ventricle. 3) Whereas polarized bipolar morphology has been a gold standard for inferring migration in histologic sections,
  https://www.dpag.ox.ac.uk/publications/113410
*  Angiotensin II Increases Norepinephrine Turnover in the Anteroventral Third Ventricle of Spontaneously Hypertensive Rats |...
In the present study, we evaluated the involvement of norepinephrine neurons within the AV3V region in the central action of Ang II and found that norepinephrine turnover was increased by intracerebroventricular Ang II in SHR but not in WKY.. The role of norepinephrine neurons of the central nervous system in the development and maintenance of hypertension has been investigated either by measurement of tissue norepinephrine content or the activity of catecholamine synthesizing enzyme or by evaluation of norepinephrine turnover of the various nuclei. Norepinephrine content is either increased17 or decreased13 18 in the brain stem or hypothalamus of SHR. On the other hand, the activity of the norepinephrine-forming enzyme dopamine β-hydroxylase is decreased in hypothalamic nuclei of SHR. As regards norepinephrine turnover in hypertensive animals, Patel et al19 reported that norepinephrine turnover was decreased in the cortex of young SHR and increased in the hypothalamus of adult SHR. They also ...
  http://hyper.ahajournals.org/content/28/2/224
*  VENTRICULAR SYSTEM - WE ALL HAVE UNIQUE BRAINS
The ventricular system within the brain is located centrally and is composed of several parts, including the two lateral ventricles (otherwise known as the first and second ventricles), the third ventricle, the fourth ventricle, the central canal, the interventricular foramen and the cerebral aqueduct. In preserved specimens of brain, these spaces are hollow cavities.. What is the purpose of the ventricular system? The ventricular system is responsible for carrying around cerebrospinal fluid or CSF around the brain. The CSF is responsible for lubricating the brain and spinal cord within the skull and vertebrae, respectively.. How is CSF circulated?. The CSF is created within the choroid plexus, which is found in all components of the ventricular system except for the cerebral aqueduct. It then follows the following sequence of circulation:. ...
  http://weallhaveuniquebrains.com/brain_anatomy/ventricular_system/
*  Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III - Full Text View - ClinicalTrials.gov
The overall objective of this Phase III clinical trial is to obtain information from a population of 500 ICH subjects with intraventricular hemorrhage (IVH), representative of current clinical practice and national demographics of ICH regarding the benefit (or lack thereof) of IVH clot removal on subject function as measured by modified Rankin Scale (mRS). This application requests funding for five years to initiate a Phase III randomized clinical trial (RCT) testing the benefit of clot removal for intraventricular hemorrhage. The investigators propose to compare extraventricular drainage (EVD) use plus recombinant tissue plasminogen activator (rt-PA; Alteplase; Genentech, Inc., San Francisco, CA) with EVD+ placebo in the management and treatment of subjects with small intracerebral hemorrhage (ICH) and large intraventricular hemorrhage (IVH defined as ICH , 30 cc and obstruction of the 3rd or 4th ventricles by intraventricular blood clot ...
  https://clinicaltrials.gov/ct2/show/study/NCT00784134?show_locs=Y
*  Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III - Mayo Clinic
The overall objective of this Phase III clinical trial is to obtain information from a population of 500 ICH subjects with intraventricular hemorrhage (IVH), representative of current clinical practice and national demographics of ICH regarding the benefit (or lack thereof) of IVH clot removal on subject function as measured by modified Rankin Scale (mRS). This application requests funding for five years to initiate a Phase III randomized clinical trial (RCT) testing the benefit of clot removal for intraventricular hemorrhage. The investigators propose to compare extraventricular drainage (EVD) use plus recombinant tissue plasminogen activator (rt-PA; Alteplase; Genentech, Inc., San Francisco, CA and Boehringer Ingelheim, Inc., Ingelheim, Germany) with EVD+ placebo in the management and treatment of subjects with small intracerebral hemorrhage (ICH) and large intraventricular hemorrhage (IVH defined as ICH < 30 cc and obstruction of the 3rd or 4th ventricles by ...
  http://www.mayo.edu/research/clinical-trials/cls-20129002?&p=1
*  Plus it
The present studies were undertaken to determine the role of rostral periaqueductal gray (PAG) in mediating the pressor effect produced by intracerebroventricular (icv) injection of angiotensin II (ANG II, 200 ng). Two functionally and anatomically distinct sites were identified in rostral PAG: a dorsomedial site involved in the hemodynamic responses produced by electrical stimulation of the anteroventral third ventricle (AV3V) region and a ventromedial site required for the pressor response elicited by icv administration of ANG II. In Saffan-anesthetized rats, injection of lidocaine (LIDO, 4%) in dorsomedial PAG, but not in ventromedial PAG, significantly attenuated the decrease in hindquarter resistance (HQR) produced by electrical stimulation of the AV3V region, and the poststimulatory increase in mean arterial pressure (MAP) and HQR. The injection of LIDO in ventromedial PAG had no effect on the hemodynamic responses produced by electrical stimulation of the AV3V region in anesthetized rats ...
  http://ajpregu.physiology.org/content/265/5/R1052
*  Limited distribution of pertussis toxin in rat brain after injection into the lateral cerebral ventricles. - Semantic Scholar
In vivo administration of pertussis toxin is often used to study the involvement of guanine nucleotide binding proteins in signal transduction. Especially when it is administered in the brain the effect is often poor. This could be due to the fact that pertussis toxin does not reach the area of interest. To evaluate the extent to which pertussis toxin is distributed in rat brain after intraventricular injection, different techniques were used. Immunohistochemical studies with an antibody against pertussis toxin showed that immunoreactivity was limited to periventricular brain structures less than 0.5 mm from the lumen. The highest immunoreactivity was seen 16-24 h after injection. After 96 h the labeling was very weak. The proportion of guanine nucleotide binding proteins that were ADP-ribosylated by in vivo injection of pertussis toxin into the ventricles as assessed by in vitro [32P]-back-ADP-ribosylation was very low 48 h after the injection, in all regions studied. Direct injection of ...
  https://www.semanticscholar.org/paper/Limited-distribution-of-pertussis-toxin-in-rat-bra-Ploeg-Cintra/d6c91b35eb66a7be1f96933cf561f50b74fe0bb6
*  Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Yukari Shigemoto-Mogami, Kazue Hoshikawa, James E Goldman, Yuko Sekino, Kaoru Sato].
  https://www.sigmaaldrich.com/catalog/papers/24501362
*  Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis.
Abstract BACKGROUND: Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results. OBJECTIVE: To determ..
  https://www.omicsonline.org/references/neocortical-atrophy-third-ventricular-width-and-cognitive-dysfunction-in-multiple-sclerosis-1055885.html
*  Faculty | People | CSBi | Computational and Systems Biology at MIT
One unique feature of the vertebrate brain is that it is tubular. The lumen of the tube is filled with cerebrospinal fluid (CSF), and forms the brain ventricular system, a circulatory system within the brain. Ventricular abnormalities lead to devastating brain disorders such as anencephaly and hydrocephalus. The embryonic development and function of this system are poorly understood. We analyze embryonic brain ventricle development in the zebrafish, an excellent system, as imaging the brain at single cell resolution in living embryos is feasible, and as many brain ventricle mutants have been identified. Brain ventricles form over a six-hour period, during mid-somitogenesis, and require normal junctions and ion pump activity. Thus, mutants in nagie oko, which encodes a MAGUK family protein, with no clear midline and disrupted epithelial junctional protein expression fail to inflate their ventricles. In the snakehead mutant brain, the ...
  http://csbi.mit.edu/people/sive.html
*  11/22/2007 - Sawamoto Lab 澤本研究室
The Journal of Neuroscience, November 21, 2007, 27(47):12829-12838. Cyclin-Dependent Kinase 5 Is Required for Control of Neuroblast Migration in the Postnatal Subventricular Zone. Yuki Hirota, Toshio Ohshima, Naoko Kaneko, Makiko Ikeda, Takuji Iwasato, Ashok B. Kulkarni, Katsuhiko Mikoshiba, Hideyuki Okano, and Kazunobu Sawamoto. At the lateral wall of the lateral ventricles in the adult rodent brain, neuroblasts form an extensive network of elongated cell aggregates called chains in the subventricular zone and migrate toward the olfactory bulb. The molecular mechanisms regulating this migration of neuroblasts are essentially unknown. Here, we report a novel role for cyclin-dependent kinase 5 (Cdk5), a neuronal protein kinase, in this process. Using in vitro and in vivo conditional knock-out experiments, we found that Cdk5 deletion impaired the chain formation, speed, directionality, and leading process extension of the neuroblasts in a cell-autonomous manner. These findings suggest that ...
  http://k-sawamoto.com/2007/11/22/
*  Computational modeling of the cerebral ventricular cerebrospinal fluid system - Research Collection
ZEREBROSPINALFLÜSSIGKEIT (PHYSIOLOGIE, NEUROLOGIE); FLUIDDYNAMIK; KERNSPINRESONANZ-ABBILDUNGSVERFAHREN + KERNSPINRESONANZ-TOMOGRAPHIE (MEDIZINISCHE DIAGNOSTIK); MODELLRECHNUNG UND SIMULATION IN DER PHYSIOLOGIE; CEREBROSPINAL FLUID (PHYSIOLOGY, NEUROLOGY); FLUID DYNAMICS; NUCLEAR MAGNETIC RESONANCE IMAGING + NUCLEAR MAGNETIC RESONANCE TOMOGRAPHY (MEDICAL DIAGNOSTICS); MATHEMATICAL MODELING AND SIMULATION IN ...
  https://www.research-collection.ethz.ch/handle/20.500.11850/149768
*  Understanding Intraventricular Hemorrhage (IVH) in Preemies
Intraventricular hemorrhage (IVH) is a serious complication that can occur in premature infants. Learn more about IVH and related complications.
  https://www.verywell.com/intraventricular-hemorrhage-or-ivh-preemies-2748623
*  Physiological Disturbances Associated With Neonatal Intraventricular Hemorrhage - Full Text View - ClinicalTrials.gov
Annually, almost 5,000 extremely low birth weight (9 ounces to about 2 lbs) infants born in the US survive with severe bleeding in the brain (intraventricular hemorrhage); this devastating complication of prematurity is associated with many problems, including mental retardation, cerebral palsy, and learning disabilities, that result in profound individual and familial consequences. In addition, lifetime care costs for these severely affected infants born in a single year exceed $3 billion. The huge individual and societal costs underscore the need for developing care strategies that may limit severe bleeding in the brain of these tiny infants. The overall goal of our research is to evaluate disturbances of brain blood flow in these tiny infants in order to predict which of them are at highest risk and to develop better intensive care techniques that will limit severe brain injury.. ...
  https://clinicaltrials.gov/ct2/show/NCT00665769?recr=Open&cond=%22Hemorrhage%22&rank=17
*  Intraventricular Hemorrhage of Infancy | Reston Hospital Center
Learn more about Intraventricular Hemorrhage of Infancy at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
  https://restonhospital.com/hl/?/588188/IVH
*  PO-0696 Baseline Coagulation Times Do Not Influence Likelihood Of Intraventricular Haemorrhage (ivh) In Extremely Premature...
Results Infants with IVH (n = 30) had no significant difference in PT (p = 0.949), APTT (p = 0.405) and fibrinogen (p = 0.560) than those without IVH (n = 46). There was no association between IVH grade and APTT (p = 0.937). There was no significant difference in APTT in those with or without IVH, excluding infants with IVH on admission (p = 0.534). Of patients administered FP, there was no significant difference in IVH (p = 0.38). FP is frequently administered when APTT ,100 s. In this subgroup; IVH rates in those that received FP (n = 17) vs. those that did not (n = 4) was not significantly different (p = 0.447). There was no significant difference in IVH development in high risk (APTT ,100 s, Administered FP) vs. low risk infants (APTT ,100 s, No treatment), (p = 1.00) or when comparing infants with lesser degrees of coagulopathy (APTT 60 s-80 s vs. 80 s-100 s, p = 0.6334).. ...
  http://adc.bmj.com/content/99/Suppl_2/A482.1
*  The tumor cells invade the ventricular system.A- Septo- | Open-i
The tumor cells invade the ventricular system.A- Septo-Striatal section, phase contrast (tissue slides, 1X); B- The same Septo-Striatal section: Ki-67 (red) ove
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4380339_pone.0121707.g002&req=4
*  Ventricular System
The ventricular spaces in the various subdivisions of the brain reflects the fact that the ventricles are the adult derivatives of the open space of the embryonic neural tube. The two lateral ventricles, situated within the cerebrum, are relatively large and C-shaped, and roughly wraps around the dorsal aspects of the basal ganglia. In the lateral ventricles of the embryo the successive generation of neurons gives rise to the 6-layered structure of the neocortex, constructed from the inside out during development. ...
  http://science-naturalphenomena.blogspot.com/2009/05/ventricular-system.html
*  Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinsons disease - pdf descargar
Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinsons disease. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
  http://libros.duhnnae.com/2017/sep/150524215313-Longitudinal-whole-brain-atrophy-and-ventricular-enlargement-in-nondemented-Parkinsons-disease.php
*  Positive T wave overshoot as a sign of ventricular enlargement...
Positive T wave overshoot as a sign of ventricular enlargement.: A consecutive series of 86 patients with an inverted T wave showing terminal positivity (oversh
  https://www.mysciencework.com/publication/show/positive-t-wave-overshoot-sign-ventricular-enlargement-ebd6a475
*  Children's Hospital of The King's Daughters Health System
Periventricular leukomalacia (PVL) is a softening of white brain tissue near the ventricles. The ventricles are fluid-filled chambers in the brain. These are the spaces in the brain that contain the cerebrospinal fluid (CSF). The white matter is the inner part of the brain. It sends information between the nerve cells and the spinal cord, and from one part of the brain to another. PVL occurs because brain tissue has been injured or has died. A lack of blood flow to the brain tissue before, during, or after birth causes PVL. It is rarely possible to tell when or why this happens. PVL is sometimes linked to bleeding inside the brain (intraventricular hemorrhage). PVL can occur in babies who are born early (preterm or premature). ...
  http://www.chkd.org/Patients-and-Families/Health-Library/Content.aspx?contentTypeId=90&contentId=P02619
*  I Never Imagined: May 2009
One of the major risks for premature babies is Intraventricular Hemorrhage. The blood vessels in their brain are so delicate that they burst and bleeding occurs in the ventricles of the brain. This happened to Clayton on his fifth day of life. He had grades three and four bleeds (four being the worst). As the blood dissolves and breaks down in the ventricles, it starts to block the natural flow of cerebrospinal fluid (CSF). Normally the CSF flows from the ventricles down through the spinal cord and is absorbed by the body. This is a natural cycle that occurs in everyone's body. Clayton's body seemed to handle the bleeds well at first. His ventricles stayed a normal size for quite some time before we started to see problems. But after about a month, his ventricles started to enlarge because the CSF wasn't flowing out. The neurosurgeons started doing daily spinal taps to help move the CSF. ...
  http://ineverimagined.blogspot.com/2009/05/