Nasal chondrocytes (NC) are present in the hyaline cartilage of the nasal septum and in fact are the only cell type within the ... Similar to other chondrocytes from hyaline cartilage tissues in other locations in the human body, NC undergo a process of cell ... Although articular chondrocytes derived from older individuals have been shown to have a lower proliferation capacity than from ... Articular chondrocytes have typically been the cell type used for cartilage tissue engineering strategies for articular ...
The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated gene data at MGI are provided in Term Detail reports.
Pluripotent stem cell-derived chondrocytes for articular cartilage repair. Return to Grants ... Osteoarthritis Cartilage (2019): CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates ... Optimization of large-scale production, preservation and quality control of pluripotent stem cell-derived chondrocytes ... Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. (PubMed: ...
Dexa increased the apoptosis of canine tendon cells and chondrocytes in a time-dependent manner. In canine tendon cells and ... The results showed that Dexa could inhibit the proliferation of tendon cells and chondrocytes at increasing concentrations (0.1 ... Dexamethasone Induces Apoptosis in Proliferative Canine Tendon Cells and Chondrocytes World Small Animal Veterinary Association ... chondrocytes treated with 25 and 50 µg/ml concentration of Dexa the number of condensed apoptotic nuclei was significantly ...
The actions of inflammatory mediators in chondrocytes also result in a reduced collagen II expression in OA chondrocytes [27]. ... OA chondrocytes were incubated with IL-1β in the presence or absence of MV, EX or CM. Stimulation of OA chondrocytes with IL-1β ... Chondrocytes were stimulated with IL-1β (10 ng/ml) in presence or absence of MV (3.6x107 particles/ml), EX (7.2x107 particles/ ... OA chondrocytes. Knee specimens were obtained from patients diagnosed with advanced OA (27 women and 14 men, aged 65.6±12.0 ...
Within the gp130 cytokine family, OSM is a potent stimulus of chondrocyte responses, while IL-6 probably signals via trans- ... The results of this study highlight a key role for SOCS-3 in regulating chondrocyte responses during inflammatory arthritis. ... The gp130 cytokine-driven production of RANKL in chondrocytes may link chondrocyte activation and bone remodeling during ... Results: On chondrocytes from WT mice, gp130 and the oncostatin M (OSM) receptor were strongly expressed, whereas the ...
This pitfall may be due to the lack of understanding of the mechanisms underlying chondrocyte senescence. Therefore, our study ... Etoposide-induced senescence model may help investigate the initiation of cellular senescence in chondrocytes, and provide a ... On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced ... partial expression of senescence markers and does not allow us to conclude on its ability to induce senescence in chondrocytes ...
We provide evidence that tenocytes have a propensity to differentiate into hypertrophic chondrocyte-like cells to produce TNAP- ... Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline ... Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline ... Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline ...
... effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes ... effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes. ...
Wang P, Ye Y, Yuan W, Tan Y, Zhang S and Meng Q: Curcumin exerts a protective effect on murine knee chondrocytes treated with ... Gao ST, Yu YM, Wan LP, Liu ZM and Lin JX: LncRNA GAS5 induces chondrocyte apoptosis by down-regulating miR-137. Eur Rev Med ... Jiang S, Liu Y, Xu B, Zhang Y and Yang M: Noncoding RNAs: New regulatory code in chondrocyte apoptosis and autophagy. Wires RNA ... Tu J, Huang W, Zhang W, Mei J and Zhu C: The emerging role of lncRNAs in chondrocytes from osteoarthritis patients. Biomed ...
A proinflammatory chondrocyte model was created by treating the chondrocytes with lipopolysaccharide and was subsequently used ... A proinflammatory chondrocyte model was created by treating the chondrocytes with lipopolysaccharide and was subsequently used ... Efficient Generation of Chondrocytes From Bone Marrow-Derived Mesenchymal Stem Cells in a 3D Culture System : Protocol for a ... The chondrocytes exhibited reduced inflammation, as evidenced by the decreased tumor necrosis factor-α levels, in response to ...
Chondroprotective activity in human primary chondrocytes assessed as effect on IL-1beta-induced TIMP1 mRNA expression at 200 ug ...
The inhibitory doses had no adverse effect on the viability of chondrocytes. Mechanistic studies revealed no impact on the ... Here, we show that in primary human femoral head osteoarthritic and normal bovine chondrocytes, TWHF partially or completely ... F Extract Suppresses Proinflammatory Cytokine-Induced Expression of Matrix Metalloproteinase Genes in Articular Chondrocytes by ... F Extract Suppresses Proinflammatory Cytokine-Induced Expression of Matrix Metalloproteinase Genes in Articular Chondrocytes by ...
Chondrocyte apoptosis and expression of Bcl-2, Bax, Fas, and iNOS in articular cartilage in patients with Kashin-Beck disease. ... Chondrocyte apoptosis and expression of Bcl-2, Bax, Fas, and iNOS in articular cartilage in patients with Kashin-Beck disease. ... Chondrocyte apoptosis and expression of Bcl-2, Bax, Fas, and iNOS in articular cartilage in patients with Kashin-Beck disease. ... Chondrocyte apoptosis and expression of Bcl-2, Bax, Fas, and iNOS in articular cartilage in patients with Kashin-Beck disease. ...
Hyaluronate is associated with the cell surface of cultured Rous sarcoma virus-transformed chondrocytes. Detachment of these ... Cell-substratum attachment and cell surface hyaluronate of Rous sarcoma virus-transformed chondrocytes. Y Mikuni-Takagaki, Y ... Pericellular coat of chick embryo chondrocytes: structural role of hyaluronate. Binding of hyaluronate to the surface of ... It is proposed that the less readily released fraction is located between the transformed chondrocyte surface and substratum ...
Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes.. ... "Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes." ... "Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes." ... chondrocytes, osteoblasts, and adipocytes) and to test the hypothesis that primary differentiated cells exhibit distinct ...
Chondrocyte intracellular pH (pH(i)) is a powerful modulator of matrix synthesis and is principally regulated by Na(+)-H(+) ... The present study examines whether hypoxia can influence chondrocyte NHE activity and pH(i) over shorter timescales using the ... The conserved nature and rapidity of the response to hypoxia has considerable implications for chondrocyte homeostasis and ... exchange (NHE). In equine chondrocytes, NHE is inhibited when cells are incubated for 3 h at low O(2), leading to intracellular ...
The composition of cartilage reflects the net response of the chondrocytes to the prevailing loading pattern, with cartilage ... The mechanism of mechanotransduction is poorly understood; the chondrocytes appear to react to cartilage deformation and to the ... Mechanical load is an important regulator of chondrocyte metabolic activity. Changes in amplitude or frequency of the load can ... Mechanical load is an important regulator of chondrocyte metabolic activity. Changes in amplitude or frequency of the load can ...
"Chondrocytes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Chondrocytes" by people in this website by year, and whether " ... The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 ... Below are the most recent publications written about "Chondrocytes" by people in Profiles. ...
Chondrocytes were isolated from articular cartilage of ten patients with primary OA undergoing knee replacement surgery and six ... While hypertrophy of chondrocytes is a physiological process implicated in the longitudinal growth of long bones, hypertrophy- ... We identified several pathways and proteins to be associated with OA chondrocytes. This study provides evidence for further ... We analyzed the proteome of chondrocytes using high resolution mass spectrometry and quantified it by label-free quantification ...
... control provides a rapid and potentially important mechanism for controlling the synthetic responses of articular chondrocytes ... Cyclic mechanical load causes global translational arrest in articular chondrocytes: a process which is partially dependent ... Cyclic mechanical load causes global translational arrest in articular chondrocytes: a process which is partially dependent ... Animals, Cartilage, Articular, Cells, Cultured, Chondrocytes, Elongation Factor 2 Kinase, Extracellular Matrix Proteins, ...
Effects of Superoxide Dismutase 1 on cartilage chondrocyte metabolism: a protective mechanism against ankle osteoarthritis? ... Effects of Superoxide Dismutase 1 on cartilage chondrocyte metabolism: a protective mechanism against ankle osteoarthritis? The ...
Chondrocytes. Chondrocytes reside in lacunae within the cartilage matrix.. The lacunae provided a niche for the chondrocytes in ... Chondrocytes. Chondrocytes are mature cartilage cells.. Chondrocytes occupied tiny spaces within the firm cartilage structure. ... Chondrocytes. Chondrocytes play a key role in maintaining cartilage health.. Healthy chondrocytes ensured the cartilage ... Can chondrocytes produce the cartilage matrix?. While chondrocytes primarily maintain the matrix, they can revert to a matrix- ...
In vitro chondrocyte hypertrophy and mineralization assay. The hypertrophy and mineralization of chondrocyte was determined by ... Figure 1: Phenotype determination of mice primary chondrocyte. (A) The morphology of normal passage two primary chondrocytes. ( ... To evaluate chondrocyte degeneration, we investigated the function of ECM replacement of chondrocytes under IL-1β stimulation ... Phenotypic determination of primary chondrocytes. The morphology of primary chondrocytes (passage 2) is shown in Figure 1A. The ...
The cartilage-specific transcription factor Sox9 regulates AP-2 epsilon expression in chondrocytes ... The cartilage-specific transcription factor Sox9 regulates AP-2 epsilon expression in chondrocytes ... transcription factor Sox9 regulates AP-2 epsilon expression in chondrocytes. FEBS Journal, 276(9), 2494-2504. ...
The aim of this study was to identify and characterize the expression profile of miRNAs in normal and OA chondrocytes and to ... Chondrocytes were moved to aggregate culture and evaluated using histological and qPCR techniques. miRNAs were isolated and ... Amongst these 7 human miRNAs, 1 was up-regulated in OA chondrocytes (hsa-miR-483-5p) and 6 were up-regulated in normal ... We have identified 7 miRNAs differentially expressed in OA and normal chondrocytes. Our potential miRNA target predictions and ...
Pediatric auricular chondrocytes gene expression analysis in monolayer culture and engineered elastic cartilage; Ruszymah BH, ... Stem cell genes are poorly expressed in chondrocytes from microtic cartilage. *Growth kinetic study on normal and microtic ... Pediatric auricular chondrocytes gene expression analysis in monolayer culture and engineered elastic cartilage. ... Specific attentions were to characterize pediatric auricular chondrocyte growth in a combination culture medium and to assess ...
Home Exome pubmed: wnt1 WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes ... In the present study, we determined the expression of WISP-2 in healthy and OA human chondrocytes. WISP-2 expression is ... We demonstrated that recombinant human WISP-2 protein reduced IL-1β-mediated chondrocyte catabolism, that IL-1β and WNT/b- ... WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes pubmed: wnt1 2023-05-31 ...
Autologous Chondrocyte Implantation (ACI) is a procedure suitable for larger cartilage defects in the knee (larger than 2 by 3 ... Autologous Chondrocyte Implantation (ACI) is a procedure suitable for larger cartilage defects in the knee (larger than 2 by 3 ...
he most advanced cartilage repair techniques is the articular chondrocyte implantation (ACI), which leads to a normally ... The Basics of Articular Chondrocyte Implantation (ACI). by afarber / Monday, 27 October 2014 / Published in Knee Surgery ... During the second procedure, the surgeon clears the damaged cartilage and implants the cultured chondrocytes. This is usually ... The most advanced cartilage repair techniques is the articular chondrocyte implantation (ACI), which leads to a normally ...