Eicosanoid - Wikipedia
12R type) forms R chirality products, i.e. 12R-HpETE and 12R-HETE. Similarly, ALOXE3 (i.e. epidermis-type lipoxygenase 3 or ... Lipoxygenases (LOXs): 5-Lipoxygenase (5-LOX or ALOX5) initiates the metabolism of arachidonic acid to 5- ... Interestingly, cPLA2 may also release the lysophospholipid that becomes platelet-activating factor. Next, the free fatty acid ... COX, the lipoxygenases, and the phospholipases are tightly controlled-there are at least eight proteins activated to coordinate ...https://en.wikipedia.org/wiki/Eicosanoid
Lipoxygenase - Wikipedia
Epidermis-type lipoxygenase (ALOXE3), also termed eLOX3 and lipoxygenase, epidermis type. Unlike other lipoxygenases, ALOXE3 ... platelet type platelet lipoxygenase (or 12-lipoxygenase, platelet type) 12-LOX, and 12-LO. It metabolizes arachidonic acid to ... Most lipoxygenases catalyze the formation of initially formed hydroperoxy products that have S chirality. Exceptions to this ... There are several lipoxygenase structures known including: soybean lipoxygenase L1 and L3, coral 8-lipoxygenase, human 5- ...https://en.wikipedia.org/wiki/Lipoxygenase
Metabolites | Free Full-Text | Targeted Chiral Analysis of Bioactive Arachidonic Acid Metabolites Using Liquid-Chromatography...
HPETE through a human platelet-type 12(S)-LOX  or 12(R)-HPETE through a human skin-type 12(R)-LOX . A 2electrons ... depending upon their chirality and regiochemistry, the EETs can inhibit the platelet aggregation [73,87]. Finally, a recent ... 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J. ... 5-Lipoxygenases-Mediated Metabolism of Arachidonic Acid in Human Lymphoblastic Cell Line. 5-LOX metabolism is thought to be ...http://www.mdpi.com/2218-1989/2/2/337/htm