... urinary CXCL10 corresponded with BKV, but not CMV viremia (p=0.02). These urine CXCL10 findings were confirmed in the ... Serum and urinary CXCL10 ELISA was performed. An independent validation set was evaluated for urine CXCL10: normal histology (n ... Elevated urinary CXCL10 reflected inflammation within the tubulointerstitial (urinary CXCL10/creatinine 1.23ng/mmol vs. 0.46ng/ ... Finally, serum CXCL10 was elevated with BKV and CMV viremia but was not associated with microvascular or vascular inflammation ...

BUD and FORM suppress RV-induced chemokines and growth factors in bronchial epithelial cells in a concentration-dependent, ... Chemokine CXCL10 / biosynthesis * Chemokines / biosynthesis * Drug Synergism * Epithelial Cells / metabolism* * Epithelial ... Conclusion: BUD and FORM suppress RV-induced chemokines and growth factors in bronchial epithelial cells in a concentration- ... CXCL8 and CXCL10 in both cell types as well as VEGF in NHBE only. Combination treatment also resulted in an enhanced ...

Given that CXCL10 mediates chemoattraction of activated lymphocytes, it is counterintuitive that this chemokine correlates with ... of CXCL10. These data offer what we believe to be the first evidence for CXCL10 antagonism in human disease and identify a ... Recent studies identified the chemokine CXCL10 (also known as IP-10) as an important negative prognostic biomarker. ... Herein, we offer new insight into this paradox and provide evidence that CXCL10 in the plasma of patients chronically infected ...

CCL2 and CXCL10 are chemokines expressed in MS lesions, which are thought to be pivotal in chemoattraction of T cells and ... Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis. ... DENNEY, Helen Ann. (2008). Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis. ... MMP2 N-terminally cleaved four residues from CCL2, and five from CXCL10. C-terminal truncation of CXCL10 was observed with MMPs ...

The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. CXCL10 is secreted by ... C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine ... Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD (August 2002). "The CXCR3 binding chemokine IP-10/CXCL10: structure ... CXCL10 in plasma is mirrored by intrahepatic CXCL10 mRNA, and both strikingly predict the first days of elimination of HCV RNA ...

CXC chemokine ligand 10 (CXCL10) is a CXC chemokine family protein that transmits signals by binding to its specific receptor, ... CXC motif chemokine ligand 10 (CXCL10) and its receptor CXC motif chemokine receptor 3 (CXCR3), play important roles in the ... C-C motif chemokine ligand 5 (CCL5), C-X-C motif chemokine ligand 9 and 10 (CXCL9, CXCL10)) and programmed death-ligand 1 (PD- ... CXCL10 is also known as an interferon-γ-inducible chemokine involved in various biological phenomena, including chemotaxis of ...

Chemokines and their receptors play essential roles in immunology during inflammation and in homeostasis. ... Chemokines are a class of secreted molecules that induce chemotaxis (migration) of target cells. ... CXCL10. b. b. a. b. b. b. b. b. b. b. b. b. b. b. b. b. b. b. b. ... Chemokine Receptor Biology poster. Order your copy of our ... Chemokines are also involved in the orchestration of wound healing.. For more information on inflammatory chemokines, see the ...

Results indicated that the most consistently elevated chemokines in the circulation across several studies were CXCL10 (n = 15 ... Prominent CXCR3 signaling is due to increased expression of CXCL9, CXCL10, CXCL11, and CXCL4. Of these, CXCL10 seems to display ... Because most studies have focused on a small number of chemokines, future broad chemokine profile studies are suggested; they ... chemokine levels in the skin were measured for CXCL10 (n = 9), CXCL9 (n = 7), CXCL11 (n = 4), CCL5 (n = 2), CCL20 (n = 2), ...

CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]. 6373 CXCL11; C-X-C motif chemokine ligand 11 [KO:K12672]. ... The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After ... Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for ... In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, ...

We previously reported that the IFN-γ-induced chemokine CXCL10 is expressed in lesional... ... CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo Friday, February 14, 2014 ... Keratinocyte-Derived Chemokines Orchestrate T-Cell Positioning in the Epidermis during Vitiligo and May Serve as Biomarkers of ... report that CXCL10 expression reflects subtle inflammation in normal-appearing skin but not in stable depigmented lesions, ...

CXCL10, and CCL25, whereas CCL21, CCL27 and CXCL12 were lower. Migration assays showed that MAIT cells and EM T cells migrated ... We have characterized the T cell composition and chemokine profile in paired intervillous and peripheral blood samples from ... The levels of several chemokines were significantly higher in intervillous compared to peripheral blood, including macrophage ... The levels of several chemokines were significantly higher in intervillous compared to peripheral blood, including macrophage ...

View Human CXCL10/IP-10/CRG-2 Alexa Fluor® 647-conjugated Antibody (IC266R-100UG) datasheet. ... A chemokine receptor specific for CXCL10 and Mig has been cloned and shown to be highly expressed in IL-2-activated T- ... C7; chemokine (C-X-C motif) ligand 10; CRG2; CRG-2; CXCL10; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10 ... The amino acid sequence of CXCL10 identified the protein as a member of the chemokine alpha subfamily that lacks the ELR domain ...

Cxcl10. C-X-C motif chemokine ligand 10. increases expression. ISO. KRN 7000 results in increased expression of CXCL10 protein ...

... neutrophil infiltration into the lungs will produce high levels of chemokines, such as C-X-C motif chemokine 10 (CXCL10), which ... CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir ... Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol. 2004;136(1):95-103. ...

... and chemokines. Chemokines such as CXCL10 (IP-10) and CXCL9 may inhibit cancer development. In addition, adhesion molecules, ...

Targeting CXCL10 Chemokine Signaling in Breast Cancer Metastasis. 000. 2. NIH. 11/3/2023. $76,750. ...

... chemokine C-X-C-motif chemokine 10 (CXCL10), tumor necrosis factor alpha (TNF-α), IL-1 receptor antagonist (IL-1ra), FMS-like ... The fold changes of TNF-α (a), MCP-1 (b), CXCL10 (c), and IL-1Ra (d) are shown. . ... The levels of other cytokines, including CXCL-10 (Figure 3(c)) and IL-1Ra (Figure 3(d)), remained essentially unchanged. VEGF ... The plasma expression of relevant cytokines and chemokines. The cytokine levels of plasma samples collected at 2, 4, and 6 ...

1) "CXCL10 is a classic interferon-stimulated gene and one of the more potent cytokines or chemokines associated with cGAS- ... The researchers also identified the chemokine CXCL10 in circulating blood as a novel biomarker for radiation-induced cardiac ... CXCL10 levels were significantly higher among patients who experienced decreases in global longitudinal strain, an early ... Wild-type mice treated with radiation therapy also had significantly higher circulating levels of CXCL10 than control mice. ( ...

In addition, polyI:C elicited measurably elevated levels of a number of these cyto/chemokines, specifically CXCL10 and CCL5 at ... Serum chemokine and cytokine expression.. Serum chemokines and cytokines were measured using a Luminex bead 9-plex assay, and ... CXCL10, IL-6 and TNF-α but not SAA3 at 4 hr, then the same set of cyto/chemokines but including SAA3 at 8 hr. These comparisons ... such as CXCL10.. We have added in a discussion of the relevance of our identified chemokines in the context of vaccination as ...

CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]. 6187 RPS2; ribosomal protein S2 [KO:K02981]. ...

... most importantly CXCL chemokines (in particular CXCL9, CXCL10, and CXCL11) via JAK-STAT signaling (12, 45). CXCL chemokines are ... CXCL10, CXCL11) (78). Notably, CXCL10 is of particular importance as it is considered the chemokine that determines the ... receptors on keratinocytes in an autocrine loop and mediates increased expression of proinflammatory chemokines such as CXCL10 ... Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: an amplification cycle triggering cutaneous lupus ...

... chemokine (C-C motif) ligand 2 (CCL2; monocyte chemotactic protein-1 [MCP - 1]), IL-6, and CXCL10 (interferon gamma-induced ... AChR-acetylcetylcholine receptor; CCR-chemokine receptor; HSV-herpes simplex virus; NCAM-neural cell adhesion molecule; NGFR- ... AChR-acetylcetylcholine receptor; CCR-chemokine receptor; HSV-herpes simplex virus; NCAM-neural cell adhesion molecule; NGFR- ... acute encephalopathy may be associated with viral infections and increased plasma concentrations of chemokine (CXC motif) ...

IFNs induce the expression of various chemokines, such as CXCL10 (also called IP-10), and mice lacking CXCL10 have increased ... C-E) Levels of Ifnb1 mRNA (C), Cxcl10 mRNA (D), and CXCL10 protein (E) expression before infection and at 2 or 4 dpi. (F and G ... A) CXCL10 protein levels in heart at 4 dpi. (B and C) Number of CVB3 genomes in heart (B) and liver (C) at 8 dpi. (D) Levels of ... hearts had lower levels of Cxcl10 mRNA and CXCL10 protein expression at 4 dpi compared with Par1+/+ hearts (Figure 1, D and E ...

Chemokine production and chemokine receptor expression by human glioma cells: Role of CXCL10 in tumour cell proliferation.. ... Regulation of chemokine receptor expression in human microglia and astrocytes.. Journal of Neuroimmunology, 136(1-2) pp. 84-93 ... Chemokines control fat accumulation and leptin secretion by cultured human adipocytes.. Molecular and cellular endocrinology, ... Expression of chemokines and their receptors by human brain endothelium: Implications for multiple sclerosis.. Journal of ...

High-dose hydrocortisone reduces expression of the pro-inflammatory chemokines CXCL8 and CXCL10 in SARS coronavirus-infected ... Pum, A.; Ennemoser, M.; Adage, T.; Kungl, A.J. Cytokines and Chemokines in SARS-CoV-2 Infections-Therapeutic Strategies ...

... the cytokines and chemokines (Cxcl10, Cxcl9, and Cxcr3) were found to be up-regulated (Table S1) in the phenotype. These ... Some of the up-regulated genes such as Bcl3, Cxcl10, and Cxcr3; miRNAs (miR-497, miR-574, miR-138) and TFs (IRF8, STAT6, CCDN1 ... By releasing cytokines, chemokines, and growth factors, the bone microenvironment inhibits colonization of cancer cells in ... In breast cancer bone metastasis, most immunological molecules such as chemokines, cytokines, and lipid metabolism molecules ...

In COVID-19, chemokines like CCL2, CCL3, and CXCL10 attract several immune cell types. Discover the scope of each of these ... Chemokines can maintain normal homeostasis within tissues or call cells into action to investigate injuries and invading ... Learn about the concepts and principles of our LEGENDplex™ multiplexing assays and how they can aid in cytokine and chemokine ...

... support that TA/PVPON-containing encapsulated islets are effective in suppressing pro-inflammatory CCL5 and CXCL10 chemokine ... Tannic Acid-Containing Nanothin Coatings Dampen Innate Immune-Derived Pro-Inflammatory Chemokine Synthesis ... TA/PVPON would similarly blunt the production of pro-inflammatory chemokines involved in recruiting immune cells to the site of ... Tannic Acid-Containing Nanothin Coatings Dampen Innate Immune-Derived Pro-Inflammatory Chemokine Synthesis ...

Stimulation with SARS-CoV-2 spike protein or LPS triggered exaggerated prostanoid-, type I IFN-, and chemokine responses in ... The induction of IFN-induced genes (e.g. CXCL10, CXCL11, MPEG1) was increased in S-protein-stimulated post COVID-19 MDM (Fig. ... 2: S-protein-induced type I IFN and chemokine responses are exaggerated in post COVID-19 MDM.. ... Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19. J. Allergy Clin. ...