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*  Histamine-functionalized copolymer micelles as a drug delivery system in 2D and 3D models of breast cancer - Journal of...
pH responsible polymer drug delivery systems is a promising route to site specific delivery of drugs and offers the potential ... Our detailed in vitro experiments of the efficacy of drug delivery and the intracellular localization characteristics of this ... a key issue when designing NPs for drug delivery has been enhancing cellular uptake by promoting endo-lysosomal escape of the ... This combined with their ability to encapsulate a wide range of active compounds offers promise in the design of NPs for ...
  http://pubs.rsc.org/en/content/articlehtml/2015/tb/c4tb02051k
*  Patient safety - Wikipedia
Complete Safety Medication System A standardized bar code system for dispensing drugs might prevent 25% of drug errors. Despite ... Environment and design factors. In emergencies, patient care may be rendered in areas poorly suited for safe monitoring. The ... In addition to addressing quality and safety issues found in adult patients there are a few characteristics that are unique to ... Technology induced errors are significant and increasingly more evident in care delivery systems. This idiosyncratic and ...
  https://en.wikipedia.org/wiki/Patient_safety
*  IJMS | Free Full-Text | Conformational Changes in DNA upon Ligand Binding Monitored by Circular Dichroism | HTML
These studies show that CD spectroscopy is a powerful technique to monitor DNA conformational changes resulting from drug ... binding and also shows its potential to be a drug-screening platform in the future. ... which includes metal derivative complex of aureolic family drugs, actinomycin D, neomycin, cisplatin, and polyamine. It is ... which are attractive targets for the rational design of anticancer and antibiotic drugs. Most chemotherapeutic anticancer drugs ...
  http://www.mdpi.com/1422-0067/13/3/3394/htm
*  FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin | The Journal of Immunology
FcRn-dependent diversion of IgG and albumin away from lysosomal degradation is the basis for designing new or modified drugs ... The IgG Fc contains distinct Fc receptor (FcR) binding sites: the leukocyte receptors Fc gamma RI and Fc gamma RIIa bind to a ... FcRn binds IgG and albumin at acidic pH, which is characteristic of early and late endosomes, the proximal intestine during ... Transcytosis of IgG and its implications for drug delivery and vaccine development. In polarized cells, such as the epithelium ...
  http://www.jimmunol.org/content/194/10/4595
*  Biotechnology - Wikipedia
Such approaches promise the advent of "personalized medicine"; in which drugs and drug combinations are optimized for each ... In selective breeding, organisms with desirable characteristics are mated to produce offspring with the same characteristics. ... An example is the designing of an organism to produce a useful chemical. Another example is the using of enzymes as industrial ... As crops and fields became increasingly large and difficult to maintain, it was discovered that specific organisms and their by ...
  https://en.wikipedia.org/wiki/Biotechnology
*  Drug design - Wikipedia
... but biopolymer-based drugs (also known as biopharmaceuticals) produced through biological processes are becoming increasingly ... Structure-based drug design attempts to use the structure of proteins as a basis for designing new ligands by applying the ... These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition ... since drug interactions with off-target molecules may lead to undesirable side effects. Due to similarities in binding sites, ...
  https://en.wikipedia.org/wiki/Drug_design
*  Gaining Ground on Breast Cancer - Scientific American
The newest targeted therapies are helping doctors to tailor increasingly effective treatments to individual patients ... when the drug trastuzumab (Herceptin) was approved in 1998. The protein that trastuzumab was designed to attack, called HER2, ... drugs gives doctors more options for customizing treatment to cope with a tumor's particular suite of molecular characteristics ... The newest targeted therapies are helping doctors to tailor increasingly effective treatments to individual patients ...
  https://www.scientificamerican.com/article/gaining-ground-on-breast-cancer-2008-07/
*  Drug design - Wikipedia
... but biopolymer-based drugs (also known as biopharmaceuticals) produced through biological processes are becoming increasingly ... Structure-based drug design attempts to use the structure of proteins as a basis for designing new ligands by applying the ... These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition ... Leis S, Schneider S, Zacharias M (2010). "In silico prediction of binding sites on proteins". Current Medicinal Chemistry. 17 ( ...
  https://en.m.wikipedia.org/wiki/Drug_design
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Drug Design, optimization (mathematics), Amino Acids, Peptides, and Proteins, De novo protein and peptide design, Drug design, ... All these characteristics need to be considered when deciding on which approach to take for segmentation. The six different 3D ... Designing and Implementing Nervous System Simulations on LEGO Robots. Authors: Daniel Blustein, Nikolai Rosenthal, Joseph Ayers ... It is especially promising as a first-step tool to study the effects of drugs or mutations on basic behavioral patterns. The ...
  https://www.jove.com/visualize/abstract/25057813/a-push-pull-corf-model-simple-cell-with-antiphase-inhibition-improves
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*  Pharmacy - Wikipedia
... adverse drug reactions, and assess patient drug allergies while designing and initiating a drug therapy plan. Since the ... Pharmacogenomics: the study of the inheritance of characteristic patterns of interaction between drugs and organisms . ... and synthesis of new drug molecules (Medicinal Chemistry). Pharmaceutics: the study and design of drug formulation for optimum ... the study of the factors that control the concentration of drug at various sites in the body. Simply "What the body does to the ...
  https://en.wikipedia.org/wiki/Pharmacy
*  Designing a post-genomics knowledge ecosystem to translate pharmacogenomics into public health action.
After all, why design and innovate a product (for example, a pharmacogenomics test) if it were not to meet the needs of the ... While there is no doubt that these efforts remain crucial, and have moved genomics R&D increasingly to the Mode 2 knowledge ... Sites of knowledge production are confined (or cloistered) to academia or expert communities. Distributed science: ... The project has many of the characteristics of the much more open knowledge production systems that it is attempting to analyse ...
  http://www.biomedsearch.com/nih/Designing-post-genomics-knowledge-ecosystem/23194449.html
*  Turtle Island Native Network} • View topic - All About Life - Lifestyle and other news you can use
... online gaming sites, social networking sites, and hacking communities.. ###. About Journal of Addiction Medicine. The mission ... Sensory cues that are closely associated with drug intoxication (such as tastes and smells, or the sight of a tavern) have long ... This adjustment was necessary in order to deal with the same knotty problem that makes designing an effective and practical new ... In some parts of the world, solar is already economically superior, and the study predicts that it will become increasingly ...
  http://www.turtleisland.org/discussion/viewtopic.php?p=16341
*  Nanomaterials in medicine and pharmaceuticals: nanoscale materials developed with less toxicity and more efficacy : European...
So, the nanobased drug co-delivery systems have been designed for targeting the transporters concurrently delivering drugs for ... In addition, the drug release results indicate that PNiPAM/AA@SiO2 particles have pH responsive characteristics and higher ... Designing the future of nanomedicine: current barriers to targeted brain therapeutics by Herda, Luciana M./ Polo, Ester/ Kelly ... With continuous advances in new biomarkers and targeting ligands, it will be increasingly feasible to develop optimized ...
  https://www.degruyter.com/view/j/ejnm.2013.5.issue-2/ejnm-2013-0003/ejnm-2013-0003.xml
*  Mohammed Inayathullah | Stanford Medicine Profiles
Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening DRUG DESIGN DEVELOPMENT AND ... Sites whose effects were unique to Aβ40 include Lys16, Leu17, and Asn 27, whereas sites unique to Aβ42 include Phe20 and Ala21 ... We summarize here recent efforts to produce therapeutic drugs targeting Abeta assembly. A number of approaches are being used ... Even though these domains share the same gross amyloid structural characteristic, their proteasomal activities differ. We found ...
  https://med.stanford.edu/profiles/mohammed-inayathullah-nazir-ahmed
*  Full text] The new era of nanotechnology, an alternative to change cancer treatme | DDDT
... drug adsorption study and statistical optimization of drug loading by factorial design methodology. J Braz Chem Soc. 2016;27(4 ... These characteristics make them ideal carriers for drug delivery and targeting applications. They have the ability to interact ... It was shown that the optimal size for the drug delivery systems is between 1 and 100 nm. Small nanoparticles increasingly ... These carriers are attractive for drug designing due to their biodegradability, biocompatibility, low toxicity, ability to ...
  https://www.dovepress.com/the-new-era-of-nanotechnology-an-alternative-to-change-cancer-treatmen-peer-reviewed-fulltext-article-DDDT
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Drug treatment of whole animals is an essential tool in any model system for pharmacological and chemical genetic studies. ... Thus, designing relevant animal models of infection represents a key step in identifying host and pathogen specific mechanisms ... In the zebrafish (Danio rerio), IV injection of drugs has long been a challenge because of the small vessel diameter. This has ... We detail methodologies for the assessment of inflammation at local and systemic sites. The use of transgenic mice and defined ...
  https://www.jove.com/visualize/abstract/26010758/chronic-anatabine-treatment-reduces-alzheimer-s-disease-ad-like
*  The Genomic Era of Clinical Oncology: Integrated Genomic Analysis for Precision Cancer Care - FullText - Cytogenetic and Genome...
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this ... is one example of a bucket/basket trial design [Abrams et al., 2014; Redig and Jänne, 2015]. Additionally, other trial designs ... CMA can provide genome-wide CNV profiles characteristic to specific tumors. Medulloblastoma represents an example of such ... approved drugs or investigational therapies in the context of specific cancer types. These actionable or potentially actionable ...
  https://www.karger.com/Article/FullText/454655
*  european Industrial Pharmacy Issue 14 (September 2012) by European Industrial Pharmacists Group (EIPG) - issuu
Design drugs using the European Union Green Pharmacy concept with the end product and the impact to environment in mind; ... The targeted delivery of peptides and proteins to specific sites has been used to reduce the total dose of drug administered ... Smallfry is a Coventry-based industrial design and innovation consultancy that increasingly works in the healthcare industry, ... Thus, pharmaceuticals exhibit characteristics that are not typical of most chemicals found in nature. So how can they be ...
  https://issuu.com/eipg/docs/eip14sep12
*  Healthcare | Free Full-Text | Modeling Melanoma In Vitro and In Vivo | HTML
This has been achieved by designing 3D in vitro models of melanoma, such as melanoma spheroids embedded in extracellular matrix ... can be conducted to facilitate the selection of effective drugs, drug combinations, and dosing regimens for that specific ... Some cell lines metastasize spontaneously from these primary xenograft sites to distant sites such as the lung, so that this ... Patton, E.E.; Zon, L.I. The art and design of genetic screens: Zebrafish. Nat. Rev. Genet. 2001, 2, 956-966. [Google Scholar] [ ...
  http://www.mdpi.com/2227-9032/2/1/27/htm
*  Pharmaceuticals | Free Full-Text | From Single Target to Multitarget/Network Therapeutics in Alzheimer's Therapy | HTML
In this paper, we explore several drugs either in the clinic or under development for AD therapy in term of their design ... In contrast to the single-target drug approach, network medicines employ a holistic approach to restore network dysfunction by ... These drugs act as multi-target ligands and may serve as leads for further development as network medicines. ... This complexity challenges the dominant paradigm in drug discovery or a single-target drug for a single mechanism. Although ...
  http://mdpi.com/1424-8247/7/2/113/htm
*  Programming
This program will highlight various legal issues such as student and faculty privacy, social networking sites, drug testing/ ... This session showcases curricular design at five early-stage schools. These design elements are discussed for implications ... Designing an Innovative and Integrated Curriculum Based upon Core Competency Outcomes Mapping. Shariq Ali, Touro College of ... This session will present an update on anticancer drugs from discovery to the market. A review of conventional anticancer ...
  http://www.aacp.org/MEETINGSANDEVENTS/PASTMEETINGS/2009AM/Pages/Schedule.aspx
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Venous blood samples can be obtained at a number of sites in guinea pigs e.g., the saphenous and jugular veins, each technique ... In this paper we report on the design and use of an external fixator to study the healing of large segmental bone defects or ... Thus, designing relevant animal models of infection represents a key step in identifying host and pathogen specific mechanisms ... Originally published by Naal et al.1, we have adapted this degranulation assay for the screening of drugs and toxicants and ...
  https://www.jove.com/visualize/abstract/20370938/the-effects-30-month-dietary-intervention-on-bone-mineral-density
*  JCI - p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing
Mice and drug treatment. Trp53loxP/loxPPgrCre/+ mice were maintained by mating of Trp53loxP/loxP mice (FVB/129) with PgrCre/+ ... H and I) Putative p53 binding sites for Sesn2 in mouse and human. (J) Increases in luciferase activity of Sesn2 after treatment ... Rsv is an increasingly studied agent for its antioxidant and anticancer properties (55). It is reported to activate AMPK to ... Met upregulates AMPK signaling in p53d/d deciduae. The above results led us to explore the mechanism by which these drugs show ...
  https://www.jci.org/articles/view/87715
*  NCSALL: Youth in Adult Literacy Education Programs
NCSALL is also a leader in designing innovative professional development programs and in building support for research use. ... Characteristics of Young Dropouts. Most of the adult educators I interviewed described changes made in their programs to ... I made use of government documents available on-line from the Web sites of agencies such as the National Center for Education ... On the other hand, some staff suggested that increased use of drugs and violence in the schools was contributing to more ...
  http://www.ncsall.net/index.php@id=524.html