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*  Cerebral venous sinus thrombosis - Wikipedia
Cerebral venous sinus thrombosis (CVST) is the presence of acute thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain. Symptoms may include headache, abnormal vision, any of the symptoms of stroke such as weakness of the face and limbs on one side of the body, and seizures. The diagnosis is usually by computed tomography (CT/CAT scan) or magnetic resonance imaging (MRI) employing radiocontrast to demonstrate obstruction of the venous sinuses by thrombus. Treatment is with anticoagulants (medication that suppresses blood clotting), and rarely thrombolysis (enzymatic destruction of the blood clot). Given that there is usually an underlying cause for the disease, tests may be performed to look for these. The disease may be complicated by raised intracranial ...
  https://en.wikipedia.org/wiki/Cerebral_venous_sinus_thrombosis
*  Cerebral Venous Sinus Thrombosis Associated with Immune Thrombocytopenic Purpura: A Case Report | Acta Medica Philippina : The...
Discussion. Cerebral venous sinus thrombosis (CVST) is an uncommon type of stroke mechanism, accounting for ,1% of all strokes, with a higher incidence among females.5 Though progressive headache is the most frequent symptom, the clinical spectrum is protean, and includes focal deficits and seizures. The main sinuses affected are the superior sagittal and the lateral sinuses. In the former, venous infarcts are typically located near the midline, in the rolandic and parieto-occipital regions, similar in our patient's case. The obstruction results in increased venous pressure leading to disruption of the blood-brain barrier, and venous hemorrhage. In rare cases, patients with CVST may present as cortical subarachnoid hemorrhage on imaging, with the blood usually along the cortical convexity or ...
  http://actamedicaphilippina.com.ph/content/cerebral-venous-sinus-thrombosis-associated-immune-thrombocytopenic-purpura-case-report-1
*  Cerebral Venous Sinus Thrombosis Associated with Immune Thrombocytopenic Purpura: A Case Report | Acta Medica Philippina : The...
Philippine General Hospital, University of the Philippines Manila. Cerebral venous sinus thrombosis (CVST) constitutes a rare but serious stroke mechanism associated with hypercoaguable states. Immune thrombocytopenia (ITP) is a common hematologic disorder that results in an increased bleeding risk. CVST on the background of thrombocytopenia could be considered a clinical paradox. The co-existence of hyper and hypocoagulable states create management dilemmas. We present the case of an 18-year-old male hospitalized for sudden severe headache and seizures. Thrombosis of the sagittal sinus was confirmed with angiography. Work up of the persistently low platelet count revealed ITP. He was given medical decompression and steroids, with note of subsequent improvement in his functional status and platelet count.. Key Words: venous ...
  http://actamedicaphilippina.com.ph/content/cerebral-venous-sinus-thrombosis-associated-immune-thrombocytopenic-purpura-case-report
*  Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment. - Semantic...
Cerebral venous sinus thrombosis (CVST) is a rare clinicopathological entity. The incidence of CVST in children and neonates has been reported to be as high as 7 cases per million people, whereas in adults the incidence is 3-4 cases per million. The predisposing factors to this condition are mainly genetic and acquired prothrombotic states and infection. The clinical picture of CVST is nonspecific, highly variable, and can mimic several other clinical conditions. Diagnosis of CVST is established with the implementation of neuroimaging studies, especially MR imaging and venography. Identification and elimination of the underlying cause, anticoagulation, proper management of intracranial hypertension, and anticonvulsant prophylaxis constitute cornerstones of CVST treatment. Newer treatment strategies such as endovascular thrombolysis and decompressive craniectomy have been recently used in the treatment of patients with CVST ...
  https://www.semanticscholar.org/paper/Cerebral-venous-sinus-thrombosis-review-of-the-dem-Filippidis-Kapsalaki/6df7469bb807f716ee83fe876fa7e778025a7bec
*  "Role of surgery in cerebral venous sinus thrombosis" by S. Ather Enam
Cerebral venous sinus thrombosis (CVST) usually is taken care of by medical management or neuro-interventional vascular techniques. Some cases of CVST may take a malignant course if the intracranial pressure increases excessively. This increase in pressure is because of oedema in brain tissue due to impediment in venous return and/or intracerebral haemorrhage. Neurosurgical experience has shown remarkable recovery in these moribund patients if appropriate surgical intervention is done within reasonable time. Emergent decompressive craniotomy or other neurosurgical interventions are the only appropriate treatment in these malignant forms of CVST to prevent mortality and severe morbidity.
  https://ecommons.aku.edu/pakistan_fhs_mc_surg_surg/190/
*  Superior Sagittal Sinus Thrombosis and HIV | Annals of Internal Medicine | American College of Physicians
Although myriad neurologic complications have been reported in patients with HIV infection, thromboembolic phenomena have been limited to scattered reports. Most of these reports have been anecdotal and have implicated lupus anticoagulant, anticardiolipin antibody, and protein S deficiency (Although myriad neurologic complications have been reported in patients with HIV infection, thromboembolic phenomena have been limited to scattered reports. Most of these reports have been anecdotal and have implicated lupus anticoagulant, anticardiolipin antibody, and protein S deficiency (1-3). To our knowledge, cerebral venous sinuses thrombosis, a rare disease described as early as 1825, has not been described as an initial presentation of HIV.-3). To our knowledge, cerebral venous sinuses thrombosis, a rare disease ...
  http://annals.org/aim/article-abstract/715631/superior-sagittal-sinus-thrombosis-hiv
*  Endovascular Treatment of Dural Sinus Thrombosis With Rheolytic Thrombectomy and Intra-Arterial Thrombolysis | Stroke
We describe 2 cases of dural sinus thrombosis treated with the combination of rheolytic thrombectomy to recanalize the major intracranial sinuses and low-dose intra-arterial thrombolysis to lyse associated thromboses in cerebral veins. To our knowledge, this combination of therapies has not been previously described.. Because of the variable natural history of dural sinus thrombosis, it can be difficult to determine the extent to which aggressive therapy should be pursued. Both patients described here were young and otherwise healthy, with severe progressive neurological symptoms despite adequate anticoagulation with heparin. Both were also at risk of extending preexisting intracranial hemorrhages, so the thrombolytic dose was minimized after the AngioJet treatment. Furthermore, patient 2 had occlusion of both deep and superficial venous ...
  http://stroke.ahajournals.org/content/31/6/1420
*  Venous hypertensive encephalopathy secondary to venous sinus thrombosis and dural arteriovenous fistula | Practical Neurology
A 52-year-old man with a history of factor V Leiden thrombophilia, persistent headaches and papilloedema presented with worsening vision and confusion. MRI and MR angiography of the brain at the time of this presentation showed findings concerning for transverse sinus thrombosis and an associated dural arteriovenous fistula. Dural venous sinus thrombosis can lead to the formation of a dural arteriovenous fistula, which must be considered in the differential diagnosis for intracranial hypertension in patients with thrombophilia. ...
  http://pn.bmj.com/content/early/2017/05/16/practneurol-2017-001600
*  Solitaire FR device for treatment of dural sinus thrombosis | Journal of NeuroInterventional Surgery
Dural venous sinus thrombosis is a rare and potentially devastating disease. Several predisposing factors exist, including oral contraceptive therapy and colitis. First-line therapy consists of systemic anticoagulation. If first-line therapies fail, more aggressive endovascular therapies may be performed. We report our initial experience with the Solitaire FR device for treatment of refractory symptomatic dural venous sinus thrombosis.. ...
  http://jnis.bmj.com/content/early/2013/01/07/neurintsurg-2012-010543.rep
*  Venous Microembolic Signals Detected in Patients With Cerebral Sinus Thrombosis | Stroke
SSST is still a poorly understood disease with a quite variable prognosis. The severity of the clinical course seems to depend mainly on the acuity of thrombus formation and the capacity for compensation due to major venous vessels. High-dose heparin followed by oral anticoagulation is usually recommended.7 The duration of oral anticoagulation, however, is still open to discussion, since no clinical or technical parameter is known for determining the point when oral anticoagulation can be discontinued. The detection of MES indicates a new approach in the assessment of anticoagulation treatment. This method is now well established in arterial disorders. The predictive value is still debatable; however, one recently published prospective study indicates a positive correlation between the risk of ischemia and the rate of MES.8 Venous emboli have been detected with the use of duplex scanning in deep vein thrombosis of the legs. In a recently ...
  http://stroke.ahajournals.org/content/28/8/1607
*  Similar papers for Reversibility of severe sagittal sinus thrombosis with open surgical thrombectomy combined with local...
OBJECTIVE To explore the controversial issue of anticoagulant therapy and indications for surgery in association with severe sinus thrombosis. METHODS During the last 4 years, we have treated three patients with severe sinus thrombosis of the dural sinuses. All three patients received systemic anticoagulant therapy and, after experiencing neurological deterioration, underwent open thrombectomy and local thrombolysis. After the operation, aggressive intensive care was given and included cerebral perfusion monitoring, barbiturate administration, hyperventilation, and osmotherapy. The treatment was guided by repeated neuroradiological investigations. RESULTS All three patients returned to their normal lives. CONCLUSION Intracranial sinus thrombosis, even in the worst neurological state, should be treated ...
  https://www.semanticscholar.org/paper/Reversibility-of-severe-sagittal-sinus-thrombosis-Ekseth-Bostr%C3%B6m/7b193476fb207139db5d49cfbe057171a05ea1b0?tab=relatedPapers
*  NEOPLASTIC VENOUS OUTFLOW OBSTRUCTION; AN UNUSUAL CAUSE OF CEREBRAL VENOUS SINUS THROMBOSIS | Journal of Neurology,...
If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patient's written consent to publication and send them to the editorial office before submitting your response [Patient consent forms] ...
  http://jnnp.bmj.com/content/87/12/e1.118.responses
*  Non-invasive intracranial pressure monitoring with transcranial Doppler in a patient with progressive cerebral venous sinus...
In many intracranial disease states, monitoring of intracranial pressure (ICP) is essential to evaluate response to the therapeutic measures as well as estimation of prognosis. Although, direct estimation of ICP is reliable, it is invasive and not possible in all patients. Transcranial Doppler (TCD) ultrasonography is a bedside and noninvasive technique that provides reliable and real-time information about cerebral hemodynamics. We present a case of extensive and progressive cerebral venous sinus thrombosis in which TCD served as an excellent tool for monitoring ICP and the serial observations correlated closely with clinical status and ophthalmological findings.
  https://www.ndcn.ox.ac.uk/publications/480026
*  DanaT | MedLink Postscripts | Page 2
In this article, Dr. Mahendranath Moharir and Dr. Gabrielle deVeber of the University of Toronto discuss cerebral sinovenous thrombosis. The condition is often unrecognized in neonates and children due to nonspecific clinical features and challenges in radiographic diagnosis. Risk factors for cerebral sinovenous thrombosis in neonates are different from those in older children. Treatment with anticoagulants, a well-established practice in adults, is increasingly offered in children and, to a lesser extent, in neonates. The safety of anticoagulants and recanalization outcomes in cerebral sinovenous thrombosis has been established in children as well as in neonates based on consecutive cohort studies; however, its influence on neurologic outcome, particularly in neonates, has not been proven. The clinical ...
  http://medlink-blog.com/?author=1&paged=2
*  Most recent papers with the keyword Csvt | Read by QxMD
Turan Ö, Anuk-İnce D, Olcay L, Sezer T, Gülleroğlu K, Yılmaz-Çelik Z, Ecevit A. Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors. Turk J Pediatr 2017; 59: 71-75. Cerebral sinovenous thrombosis (CSVT) is a rare disease in the neonatal period and also the greatest risk of neonatal mortality and morbidity. In this report, we presented two cases with CSVT and different risk factors. One of these cases had methylenetetrahydrofolate reductase (MTHFR) C677T homozygous polymorphism and the other case had both MTHFR A1298C homozygous polymorphism, plasminogen activator inhibitor-1 (PAI-1) 4G/ 5G polymorphism and elevated lipoprotein a ...
  https://www.readbyqxmd.com/keyword/90399
*  Neuroradiology On the Net: gennaio 2008
Venous thrombosis may occur in any or all of the following venous structures: the venous sinuses, superficial cortical veins, or the deep venous system. Typically, superficial cortical vein thrombosis is only seen in the seen in the setting of venous sinus thrombosis, and thrombosis of the deep venous system is relatively rare (albeit very serious). Approximately 1% of all strokes occur secondary to venous sinus thrombosis, and the most frequently thrombosed sinuses are the superior sagittal sinus, followed by the transverse, sigmoid and cavernous sinuses. ...
  http://neuroradiologyonthenet.blogspot.com/2008_01_01_archive.html
*  Diagnostic Value of Multidetector-Row CT Angiography in the Evaluation of Thrombosis of the Cerebral Venous Sinuses | American...
The diagnosis of CVST has traditionally been made with conventional angiography (DSA).13,19 More recently, DSA has been superseded by MR imaging techniques as the method of choice. MR imaging with MR venography is now commonly considered the noninvasive "gold standard" in diagnosing thrombosis of the cerebral venous sinuses2,5,7,8,20-23 and also dominates the diagnostic arms in large international trials.6 However, because CT is still the technique of choice to rule out intracranial hemorrhage in most institutions, it is tempting to assess a CVST by using the same technique. Therefore, we propose MDCTA as an alternative diagnostic measure in CVST, which is faster, more widely accessible, and more cost-effective than MR imaging.. With the development of helical CT technology, CTA offered a new imaging technique to visualize the cerebral vascular circulation. CTA allowed the visualization of ...
  http://www.ajnr.org/content/28/5/946.long
*  Venous sinus thrombosis and haemorrhage | Radiology Case | Radiopaedia.org
A parenchymal haemorrhage, particularly in a younger patient, should trigger a careful scrutiny of relevant dural venous sinuses and cortical and deep veins for hyperdensity indicating thrombus, keeping in mind that acute thrombus only gradually ...
  https://radiopaedia.org/cases/venous-sinus-thrombosis-and-haemorrhage
*  imaging mathods | Noninvasive ICP
Authors: Mrfka M, Pistracher K, Schökler B, Wissa S, Kurschel-Lackner S.. We report on an unusual case of Idiopathic Intracranial Hypertension (IIH) in a woman of normal weight. Papilledema and increased intracranial pressure are symptoms of cerebral venous sinus thrombosis or idiopathic intrancranial hypertension. Because of the different treatment strategies, it is important to keep these two diseases separate. We show that the use of different imaging methods is an important tool in obtaining an effective diagnosis.. ...
  http://www.noninvasiveicp.com/taxonomy/term/187
*  Dural arteriovenous fistula post sinus thrombosis in puerperium | International Journal of Emergency Medicine | Full Text
A 28-year-old woman had a normal delivery (primipara) on January 15, 2009. On March 20, 2009, she suffered sudden onset of severe headache. Protein-S and protein-C levels were within the normal ranges. Computed tomography on admission showed no subarachnoid hemorrhage, and the patient was discharge with analgesic treatment. Four days later the patient presented again to our emergency department with increased headache, nauseas, vomiting and bruit of the head. In view of the history and clinical evolution, an urgent computerized tomography (CT) brain scan with intravenous contrast was done showing the empty delta sign; as magnetic resonance imaging (MRI) scan was not available at that time, computed tomography in venograms (Fig. 1a,b) was performed revealing occlusion of the superior sagittal sinus and the bilateral transverse sinus. The patient was referred to the Department of Neurosurgery where a cerebral angiography ...
  http://intjem.springeropen.com/articles/10.1007/s12245-010-0231-7
*  Acute treatment of cerebral venous and dural sinus thrombosis | SpringerLink
Management of thrombosis of the dural sinus and cerebral veins (CVT) includes treatment of the underlying condition, antithrombotic treatment, symptomatic treatment, and the prevention or treatment of
  https://link.springer.com/article/10.1007%2Fs11940-008-0014-0
*  Paediatric cerebral sinovenous thrombosis: findings of the International Paediatric Stroke Study | Archives of Disease in...
Results Of 170 children enrolled, 60% were male; median age 7.2 years (IQR 2.9-12.4). Headache, altered consciousness, focal deficits and seizures were common presenting clinical features. Infarction affected 37% and intracranial haemorrhage 31%. Risk factors included chronic disease in 50%; acute systemic illness or head/neck disorders 41%; prothrombotic state 20% and other haematological abnormality 19%. Discharge neurological status was normal in 48%, abnormal in 43% and unknown in 5%. Antithrombotic therapy was common, most often low molecular weight heparin was common, with significant regional variation in treatment practices. Mortality was low (4%) and was associated with no anticoagulation but not underlying chronic disease, anatomic extent of thrombosis or intracranial haemorrhage. Abnormal neurological status at discharge or death was associated with decreased level of consciousness at presentation and the presence of an identified prothrombotic state.. ...
  http://adc.bmj.com/content/100/2/174
*  Cerebral Vein and Dural Sinus Thrombosis in Elderly Patients | Stroke
Using the large data set of this prospective multicenter international study, we described a distinctive clinical presentation of CVT in patients aged ≥65 years. CVT in such elderly patients rarely presents as isolated intracranial hypertension syndrome, but depressed consciousness and altered mental status are common. The prognosis of elderly patients was worse than that of younger patients: only 49% recovered completely, whereas 22% were dependent and 27% had died at the end of follow-up.. Strengths of this study include: (1) large sample size and diversity of participating hospitals in different countries and continents, which diminishes potential inclusion bias; (2) diagnostic confirmation by robust methods in all cases; (3) 98.7% completeness of follow-up. There are, however, some potential limitations: differential effect of age in case ascertainment and previous disability in elderly patients. It is possible that younger subjects reporting of headache were investigated sooner and more ...
  http://stroke.ahajournals.org/content/36/9/1927
*  Theodor von Dusch - Wikipedia
Theodor von Dusch (17 September 1824 - 13 January 1890) was a German physician who was a native of Karlsruhe. He was the son of Baden statesman Alexander von Dusch (1789-1876). He studied medicine at the University of Heidelberg, where he had as instructors Jacob Henle (1809-1895), Karl von Pfeufer (1806-1869) and Maximilian Joseph von Chelius (1794-1876). He earned his doctorate in 1847, and was habilitated for medicine in 1854. In 1870 he became professor and director of the policlinic at Heidelberg. In the 1850s, with Heinrich G. F. Schröder (1810-1885), he demonstrated that a filter made of cotton-wool was effective in removing microbes such as bacteria from air. Dusch was the author of influential works involving thrombosis of cerebral sinuses ("On thrombosis of the cerebral sinuses"; translated into English in 1861), heart disease ...
  https://en.wikipedia.org/wiki/Theodor_von_Dusch
*  Plus it
In this study, the diagnostic accuracy of a combined, dynamic and static, contrast-enhanced MRV in CVT was compared with established MR and MRV sequences. Combo-4D MRV demonstrated the highest overall sensitivity (binary test) among the 4 assessed techniques for all thrombosed venous segments, with its overall accuracy (ROC analysis) being superior to T2W and GRE imaging, and equivalent to TOF MRV. Its overall specificity (binary test) was again superior to TOF MRV. Its incomplete overall sensitivity of 76% is most likely related to the inclusion of thrombosed cortical veins that are notoriously difficult to assess on MRV due to their high variability in number, size, and location.6,22 In dural venous sinus thrombosis alone, it showed the highest sensitivity (97%) and specificity (99%) among the 4 assessed techniques. Although only a trend toward superior accuracy was found on ROC analysis between combo-4D MRV (AUC of 0.99) ...
  http://www.ajnr.org/content/31/3/527