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*  The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse | Journal of...
We also show that BCR-induced MTOC polarization requires the dynein motor protein as well as IQGAP1, a scaffolding protein that ... 2013). Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage. J. Cell Biol. 202, ... Enter multiple addresses on separate lines or separate them with commas.. You are going to email the following The Rap1-cofilin ... Other actin-microtubule crosslinking proteins (e.g. spectraplakins; Suozzi et al., 2012), plus-end-binding proteins (e.g. EB1, ...
  http://jcs.biologists.org/content/130/6/1094?rss=1
*  Centrosome cycle - Wikipedia
Second, the centrosomes are separated via microtubules motor proteins. Centrosome disorientation refers to the loss of ... 23] In early mitosis, several motor proteins drive the separation of centrosomes. With the onset of prophase, the motor protein ... Centrosomes are the major microtubule organizing center (MTOC) in mammalian cells. Failure of centrosome regulation can cause ... These include: centrosome duplication during the G1 phase and S Phase, centrosome maturation in the G2 phase, centrosome ...
  https://en.wikipedia.org/wiki/Centrosome_cycle
*  Prophase - Wikipedia
... powered by centrosome associated motor proteins. Interdigitated interpolar microtubules from each centrosome interact with each ... Microtubules involved in the interphase scaffolding break down as the replicated centrosomes separate. The movement of ... Interpolar microtubules from both centrosomes interact, joining the sets of microtubules and forming the basic structure of the ... Microtubule activity in each centrosome is increased due to recruitment of γ-tubulin. Replicated centrosomes from interphase ...
  https://en.wikipedia.org/wiki/Prophase
*  Expression of the Mitotic Motor Protein Eg5 in Postmitotic Neurons: Implications for Neuronal Development | Journal of...
... related members of the bimC family are critical for generating forces on microtubules that separate the duplicated centrosomes ... Might other motor proteins generate forces on microtubules in the neuron, and if so, might such forces be relevant to axonal ... motor protein. Microtubules are essential for the differentiation of axons and dendrites. Throughout the axon and in the distal ... Specifically, motor proteins can generate forces on microtubules, and thereby move them into specific locations within the cell ...
  http://www.jneurosci.org/content/18/19/7822
*  NIOSHTIC-2 Publications Search - 20037238 - Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic...
... as well as the motor proteins that separate the chromosomes during cell division. Disruption of centrosomes and mitotic ... Proteins; Mitosis; Author Keywords: Genotoxic; mitotic spindle; microtubule; carbon nanotube; aneuploid ... The similarity of carbon nanotubes to microtubules suggests a potential to interact with cellular biomolecules, such as the ... the long thin tubular-shaped carbon nanotubes have a striking similarity to cellular microtubules. ...
  https://www.cdc.gov/niosh/nioshtic-2/20037238.html
*  Chapter 6 A Tour of the Cell
... large motor proteins extending from one microtubule doublet to adjacent doublet  ATP hydrolysis drives changes in dynein shape ... in mitotic spindle to separate chromosomes  in animal cells: microtubules made in centrosome Centrioles  pair w/in each ... protein made for use in cytosol kept separate from those meant for export  transport vesicles carry new secretory protein/ ... html Microtubule Functions  shape & support cell (compression-resistant role)  serve as tracks other organelles with motor ...
  http://slidegur.com/doc/164059/chapter-6-a-tour-of-the-cell
*  Thrombopoietin-induced Polyploidization of Bone Marrow Megakaryocytes Is Due to a Unique Regulatory Mechanism in Late Mitosis |...
1996) Kinesin proteins: a phylum of motors for microtubule-based motility. BioEssays 18:207-218, pmid:8867735.. ... The sets of centromeres were located close to each centrosome, and none of the sets of chromosomes was separated completed. We ... MKLP1 is a plus end-directed human kinesein-related motor protein that bundles antiparallel microtubules and slides them past ... One possibility is that factors regulating anaphase B, such as microtubule motor proteins, might be involved in this ...
  http://jcb.rupress.org/content/139/2/449
*  Aurora A kinase - Wikipedia
... a microtubule-associated protein that stabilizes centrosomal microtubules and Kinesin 5, a motor protein involved in the ... Therefore, without proper expression of Aurora A, the cell's centrosomes are never able to separate. Aurora A also assures ... In the absence of Aurora A mad2, a protein that normally dissipates once a proper kinetochore-microtubule connection is made, ... During mitosis, a mitotic spindle is assembled by using microtubules to tether together the mother centrosome to its daughter. ...
  https://en.wikipedia.org/wiki/Aurora_A_kinase
*  Kinetochore - Wikipedia
Other proteins in the kinetochore attach it to the microtubules (MTs) of the mitotic spindle. There are also motor proteins, ... As mitosis progresses, both centrosomes separate to establish the mitotic spindle. In this way, the spindle in a mitotic cell ... This movement is probably mediated by the motor activity towards the "minus" (-) of the motor protein cytoplasmic dynein, which ... KNL/KBP proteins (kinetochore-null/KNL-binding protein), MIS proteins and CENP-F. Together with the constitutive components, ...
  https://en.wikipedia.org/wiki/Kinetochore
*  2.5: Structure and Function: Protein Function II - Biology LibreTexts
In this section we begin our discussion of a subclass of proteins that catalyze reactions releasing energy and convert it into ... These motor proteins facilitate the movement of materials inside of cells along microtubule "rails". These motor proteins are ... Individual units get arranged in microtubule organizing centers (MTOCs), an example of which is the centrosome. Centrosomes are ... Chromosomes must be separated in mitosis and meiosis.. The proteins dynein and kinesin (Figure 2.106) are necessary for ...
  https://bio.libretexts.org/TextMaps/Biochemistry/Book%3A_Biochemistry_Free_For_All_
*  Mitosis - Wikipedia
The two centrosomes polymerize tubulin to help form a microtubule spindle apparatus. Motor proteins then push the centrosomes ... The new envelope forms around each set of separated daughter chromosomes (though the membrane does not enclose the centrosomes ... The centrosome is the coordinating center for the cell's microtubules. A cell inherits a single centrosome at cell division, ... A number of polar microtubules find and interact with corresponding polar microtubules from the opposite centrosome to form the ...
  https://en.wikipedia.org/wiki/Mitosis
*  An Introduction to Molecular Biology/Cell Cycle - Wikibooks, open books for an open world
... involves both the elongation of overlapping microtubules and the use of two distinct sets of motor proteins: one pulls ... The centrosomes will be pushed apart to opposite ends of the cell nucleus by the action of molecular motors acting on the ... anaphase is when the chromatids separate from each other and move to opposit ends of the cell When the chromatids are fully ... Kinesin proteins that are attached to polar microtubules push the microtubules past one another. A second force involves the ...
  https://en.wikibooks.org/wiki/An_Introduction_to_Molecular_Biology/Cell_Cycle
*  Spindle checkpoint - Wikipedia
These kinetochore-derived microtubules, along with kinesin motor proteins in the outer kinetochore, facilitate interactions ... As mitosis progresses, both centrosomes separate to generate the mitotic spindle. In this way, the mitotic spindle has two ... The activated GTP-bound form of Ran releases microtubule-stabilizing proteins, such as TPX2, from protein complexes in the ... These proteins keep the SAC activated until they are removed and the correct kinetochore-microtubule attachment is made. Even a ...
  https://en.wikipedia.org/wiki/Spindle_checkpoint
*  Symmetric and asymmetric mitotic segregation patterns influence Wolbachia distribution in host somatic tissue | Journal of Cell...
The role of microtubules and motor proteins in Bradyrhizobium movement has not been determined and no other bacteria have been ... 2A). A subset of bacteria moved rapidly between separating sister centrosomes (duplicated centrosomes associated with the same ... A Wsp-Gst fusion protein was expressed in E.coli. E. coli proteins were separated on a SDS gel, the Wsp-Gst fusion protein was ... After centrosome duplication, the new centrosome moves basally, but does not establish robust astral microtubules. Wolbachia do ...
  http://jcs.biologists.org/content/122/24/4570.long
*  The Tree of Life: The power of Open Access II - Posting my open access papers in my blog
2000) Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: ... Along these lines, there has also been an expansion in other motor proteins. For example, there are 78 kinesins, more than in ... Thus it appears many of the paralogous genes in T. thermophila are the results of separate small duplication events. ... including the regulation of centrosome maturation [151] and flagellar excision [152]. We identified 39 NRKs in T. thermophila, ...
  https://phylogenomics.blogspot.com/2007/03/power-of-open-access-ii-posting-my-open.html
*  Eukaryote - Conservapedia
Vesicles traffic along the microtubules under the influence of motor proteins such as kinesin (which transports items from the ... The microtubules are composed of tubulin, and are organised by a microtubule organising centre (the centrosome and centrioles ... Consequently, disrupted ER 'microsomes' can be separated using density gradient centrifugation. Other proteins are destined for ... The first are the actin microfilaments, which, with the motor protein myosin, form the muscles of the cytoskeleton (and in ...
  http://www.conservapedia.com/Eukaryota
*  Centrosomin
... and motor proteins may be responsible for tethering the microtubules into confined poles. Morphologically, these centrosome- ... Apc1 protein localized to centrosomes in GSCs and spermatogonia during late G2/prophase, after centrosomes were fully separated ... a microtubule nucleating protein, or centrosomin, a protein that recruits γ-tubulin to the centrosome. In these RNAi-treated ... based on microtubule arrays containing bundled microtubules. Thus, the mother centrosomes may maintain interphase microtubule ...
  http://www.sdbonline.org/sites/fly/cytoskel/centrosomin4.htm
*  Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation | JCB
This process is mediated by cytoplasmic microtubules and by cytoplasmic dynein, a microtubule motor protein complex (Ding et al ... Aliquots of the cell extracts, each containing 80 µg of total protein, were separated on an SDS-PAGE gel. GFP-tagged proteins ... The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus. Cell. 115:825-836. ... 8 B). An interaction between Sad1 and Bqt1 mediates the association of the Sad1-Kms1 complex and associated microtubule motor ...
  http://jcb.rupress.org/content/187/3/413/
*  The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK | JCB
The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line. J. Cell ... mitotic spindle; kinetochore; microtubule; centrosome, poleward flux. Introduction. The spindle is a microtubule-based ... Total cell protein was separated by size using SDS-PAGE and blotted with Kif2a-, MCAK-, and tubulin-specific antibodies. (B-E) ... Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle defects in mitosis. J. Cell Sci. 107:859- ...
  http://jcb.rupress.org/content/166/4/473.long
*  Cytokinesis signaling visualized in vitro, using Xenopus cell-free system
Microtubules grew out as asters from artificial centrosomes and met to organize antiparallel overlap zones. These zones blocked ... The CPC was transported to overlap zones, which required two motor proteins, Kif4A and a Kif20A paralog. Using supported lipid ... Cytokinesis, when two daughter cells are physically separated from one another, is the final stage of cell division. How ... During animal cell division, the cleavage furrow is positioned by microtubules that signal to the actin cortex at the cell ...
  http://www.xenbase.org/entry/doNewsRead.do?id=167
*  Measuring the Forces of Biology | Science at Rensselaer
Then the microtubules - aided by proteins and motor proteins - begin to shorten and move, pulling the chromosomes toward the ... centrosomes, until the two sets have been separated.. To learn more about the mechanics, Forth investigates the forces exerted ... creating bundles of microtubules and cross-links between them. PRC1 works along with a motor protein, which slides microtubules ... and motor proteins use chemical energy to push and pull materials along microtubules, or move the microtubules themselves. ...
  https://science.rpi.edu/biology/news/measuring-forces-biology
*  Chromosome Segregation and Kinetochore research - Istituto Europeo di Oncologia
... a dynamic array of centrosomes (spindle poles), microtubules and microtubule-associated proteins. Sister chromatid alignment is ... motor proteins and spindle regression move the chromosomes into the daughter cells, generating offspring with a correct number ... However, the rDNA locus separates at the end of anaphase. This is because cells must actively transcribe rDNA to generate ... Assays include co-IPs, in vitro protein-centromere binding studies using gel retardation analysis, in vitro protein ...
  https://www.ieo.it/it/ricerca/Ricerca-di-base/Dipartimento-di-Oncologia-Sperimentale/Chromosome-Segregation-and-Kinetochore-research-Unit/
*  Regulated offloading of cytoplasmic dynein from microtubule plus ends to the cortex. - Semantic Scholar
Conversely, shortening the 'neck' sequence between the tail and motor domains precludes offloading from the microtubule plus ... Mutants with an engineered peptide inserted between the tail domain and the motor head retain wild-type motor activity but ... These findings provide direct support for an active microtubule-mediated delivery process that appears to be regulated by a ... Here we show that yeast dynein offloads from microtubule plus ends to the daughter cell cortex. ...
  https://www.semanticscholar.org/paper/Regulated-offloading-of-cytoplasmic-dynein-from-to-Markus-Lee/8d86e604ef44642413c16f37991b83f87997009a
*  Microtubule organizing center - Wikipedia
The polarity of the microtubules is important for cellular transport, as the motor proteins kinesin and dynein typically move ... γ-tubulin is a protein located at the centrosome that nucleates the microtubules by interacting with the tubulin monomer ... which separate the chromosomes during cell division. The MTOC is a major site of microtubule nucleation and can be visualized ... Organization of the microtubules at the MTOC, or centrosome in this case, is determined by the polarity of the microtubules ...
  https://en.wikipedia.org/wiki/Microtubule_organizing_center