*  Neocentromere - Wikipedia
Centromeres are well-associated with specific proteins that are involved in the formation of the kinetochore and the mitotic ... So far, this suggests that the repetitive sequences may play a fundamental but not necessary role in centromere formation. ... for kinetochore formation. This expands the scope of the centromere's function to include regulating the function of the ... and regional centromeres. Whereas point centromeres are defined by sequence, regional and holocentromeres are epigenetically ...
  https://en.wikipedia.org/wiki/Neocentromere
*  Frontiers | Identification and Characterization of Switchgrass Histone H3 and CENH3 Genes | Plant Science
CENH3, the major histone protein found in centromeres, along with canonical H3 and other histones, plays an important role in ... CENH3, the major histone protein found in centromeres, along with canonical H3 and other histones, plays an important role in ... CENH3 is specifically present at centromeres and is essential for centromere and kinetochore formation in all organisms ( ... Alignment of the CDS sequences with the genomic DNA sequences for all of the switchgrass histone H3 genes allowed us to ...
  https://www.frontiersin.org/articles/10.3389/fpls.2016.00979/full
*  Books - Lane Medical Library - Stanford University School of Medicine
The centromere is a specialized chromatin domain that is required for kinetochore formation and chromosomal attachment to the ... In higher eukaryotes, centromere identity is independent of the underlying DNA sequence and is thought to be propagated through ... Importantly, TH17 cells drive the formation of TH17-promoting DCs (DCTh17), whereas TH1 and TH2 cells drive the formation of ... DSB-2 localizes to chromatin during the time of break formation, suggesting it acts to promote competence for DSB formation. ...
  http://lane.stanford.edu/biomed-resources/eb.html?a=r&page=2&proxy-links=false
*  Prokaryotic cytoskeleton - Wikipedia
... like the kinetochore and centromere respectively. Lately a actin-like ParM homolog has been found in a gram-positive bacterium ... According to Shih et al., MinC inhibits the formation of the septum by prohibiting the polymerization of the Z-ring. MinC, MinD ... It has the highest sequence similarity to eukaryotic actins of any known actin homologue. Crenactin has been well characterized ... ParR acts like the kinetochore complex, and parC acts like the centromere of the chromosome. F plasmid segregation occurs in a ...
  https://en.wikipedia.org/wiki/Prokaryotic_cytoskeleton
*  Centromere - Wikipedia
... but which can form on other DNA sequences as well. The signal for formation of a regional centromere appears to be epigenetic. ... spindle fibers attach to the centromere via the kinetochore. Centromeres were first thought to be genetic loci that direct the ... In regional centromeres, DNA sequences contribute to but do not define function. Regional centromeres contain large amounts of ... Point centromeres are smaller and more compact. DNA sequences are both necessary and sufficient to specify centromere identity ...
  https://en.wikipedia.org/wiki/Centromere
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... regions are highly divergent among species and it remains to be determined how centromere DNA directs kinetochore formation. ... Centromeres are specified by sequence-independent epigenetic mechanisms in most organisms. Rarely, centromere repositioning ... To test the function of these centromere sequences, we conditionally removed the centromere from the Z chromosome using genetic ... Although the role of the centromere is conserved throughout evolution, the DNA sequences associated with centromere ...
  https://www.jove.com/visualize?author=Asao+Fujiyama
*  CENPH - Wikipedia
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid ... CENP-H shows sequence similarity to the Schizosaccharomyces pombe kinetochore protein Fta3 which is a subunit of the Sim4 ... to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore ... "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes". Hum Mol Genet. 9 (19): ...
  https://en.wikipedia.org/wiki/CENPH
*  DiVA - Search result
... core is the base for formation of the kinetochore structure whereas the flanking region is important for sister centromere ... The amino acid sequence of eEF2 is highly conserved in different organisms. eEF2 from S. cerevisiae contains 842 amino acids. ... The declustering of centromeres in mis6 cells correlated with loss the Ndc80 kinetochore marker protein from the centromeres. ... pombe centromeres in interphase is similar to that of human centromeres. Here we demonstrate that S. pombe centromeres are ...
  http://www.diva-portal.org/smash/resultList.jsf?dswid=0&searchType=SUBJECT&language=en&onlyFullText=false&af=%5B%5D&aq=%5B%5B%7B%22categoryId%22%3A%2211552%22%7D%5D%5D
*  Chromosome Centromeres Are Inherited Epigenetically - Redorbit
... attaches to the centromeres. In most organisms the position of the centromere is not determined by the DNA sequence. Scientists ... Centromeres provide a platform for the development of a protein complex known as the kinetochore. During cell division, the ... The histone protein CenH3 is both necessary and sufficient to trigger the formation of centromeres and pass them on from 1 ... In most organisms the position of the centromere is not determined by the sequence of the DNA building blocks, i.e. the DNA ...
  http://www.redorbit.com/news/science/1112415890/chromosome-centromeres-are-inherited-epigenetically/
*  C8orf58 (protein) - Wikipedia
CENPH (Centromere Protein H) plays a critical role in centromere structure, kinetochore formation, and sister chromatid ... There is a kozak consensus sequence present, which confirms it is a protein coding sequence. C8orf58 Isoform 1 has a molecular ... UniProt NCBI GEO Profiles Expasy Bioinformatics Resource Portal IntAct Molecular Interaction Database Centromere protein H ...
  https://en.wikipedia.org/wiki/C8orf58_(protein)
*  Molecular Cytogenetic Mapping of Chromosomal Fragments and Immunostaining of Kinetochore Proteins in Beta
K. Nagaki, Z. Cheng, S. Ouyang et al., "Sequencing of a rice centromere uncovers active genes," Nature Genetics, vol. 36, no. 2 ... An important step during the formation of a functional kinetochore is the phosphorylation of the pericentromeric histone H3 [29 ... Kinetochore Proteins in the B. vulgaris Hybrid PRO1. There is no conserved DNA sequence responsible for the centromeric ... Modification of the proteins in the active kinetochore on B. vulgaris and PRO1 centromeres was demonstrated by immunostaining. ...
  https://www.hindawi.com/journals/ijpg/2009/721091/
*  What's hot today: Current papers in developmental biology and gene function
Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division. J Cell Biol [Epub ahead of print ... Even though centromeres are essential for genome stability, the underlying centromeric DNA is highly variable in sequence and ... and is required for correct localization of the centromere-defining proteins CENP-A and CENP-C, as well as outer kinetochore ... αTubulin 67C and Ncd are essential for establishing a cortical microtubular network and formation of the Bicoid mRNA gradient ...
  http://www.sdbonline.org/sites/fly/aimain/model-organisms-november2014.htm
*  Protocols and Video Articles Authored by Andreas Houben (Translated to German)
No centromere-specific DNA sequence has been found for any holocentric organism studied so far. It was proposed that ... 2014 , Pubmed ID: 24887084 In eukaryotes, centromeres are the assembly sites for the kinetochore, a multi-protein complex to ... A cell-cycle-dependent shuffling of multiple centromeric units results in the formation of functional (poly)centromeres during ... flanking 400 kb of identified sequence and central unknown sequences. Cytogenetic and sequence analyses revealed that the LOA ...
  https://www.jove.com/author/Andreas_Houben?language=German
*  Robin Allshire - Wikipedia
"Sequence features and transcriptional stalling within centromere DNA promote establishment of CENP-A chromatin". PLoS Genet. 11 ... "Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation". J Cell Biol. ... He has investigated how RNA interference (RNAi) mediates heterochromatin formation and shown that splicing fators contribute to ... "A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres". Mol. Cell ...
  https://en.wikipedia.org/wiki/Robin_Allshire
*  Mitogen-Activated Protein Kinase | Broad-Spectrum Antiviral Activity of the IMP Dehydrogenase Inhibitor
The site of kinetochore formation is usually defined by a region of the chromosome the centromere. Without functional ... For most eukaryotes the centromere is much larger and is not defined by a particular DNA sequence. For both simple and more ... In budding yeast classic experiments defined the centromere as a small (~125 bp) sequence-specified region of DNA (Clarke and ... Background Sequencing from the individual genome has identified many chromosome copy. Background Sequencing from the individual ...
  http://hr010.net/category/mitogen-activated-protein-kinase/
*  Anti-MAD2 antibody (ab70385) | Abcam
Chromosome , centromere , kinetochore. Cytoplasm. Cytoplasm , cytoskeleton , spindle pole. Recruited by MAD1L1 to unattached ... Formation of a heterotetrameric core complex containing two molecules of MAD1L1 and of MAD2L1 in the closed conformation ... Sequence similarities. Belongs to the MAD2 family.. Contains 1 HORMA domain.. * Domain ... Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the ...
  http://www.abcam.com/mad2-antibody-ab70385.html
*  Centromere protein B - Wikipedia
Centromere protein B is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is ... "Human centromere protein B induces translational positioning of nucleosomes on alpha-satellite sequences". The Journal of ... "Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells". Chembiochem. 9 (1): 77-92. doi:10.1002/ ... Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, ...
  https://en.wikipedia.org/wiki/Centromere_protein_B
*  Home | The EMBO Journal
Kinetochore assembly at the budding yeast point centromere involves the sequence‐specific centromere binding factor 3 (CBF3), ... One of two flexible Gal4 DNA binding domains in the Cep3 homodimer gets stabilised and inactivated upon core complex formation. ... A new tiling‐based method maps functional domains across a panel of long non‐coding RNAs, identifying sequence motifs that ... The CBF3 core can specifically bind centromeric DNA sequences, dependent on dephosphorylation of a yeast‐specific Skp1 loop. ...
  http://emboj.embopress.org/front.current-issue
*  Cohesin - Wikipedia
... mono-orientation of sister kinetochores during meiosis I, non-homologous centromere coupling, chromosome architecture and ... A few cohesin rings are found in chromosome arms that have AT-rich DNA sequences indicating that DNA sequence may be an ... The two rings are connected to each other through formation of a bridge that holds the two sister chromatids together. The ... Proteins that are essential for sister chromatid cohesion, such as Smc3 and Scc1, do not regulate the formation of covalent ...
  https://en.wikipedia.org/wiki/Cohesin
*  Differential localization of the centromere-specific proteins in the major centromeric satellite of Arabidopsis thaliana |...
... the 180 bp sequences and from anti-HTR12 overlapped completely at the kinetochore regions or outer layers of the centromeres ( ... Potential roles of centromeric retrotransposons in centromere formation have been discussed (Cheng and Murata, 2003; Gindullis ... since it interacts directly with centromere DNA and replaces histone H3 at the kinetochore region of active centromeres ( ... CENH3 was also detected at the kinetochore regions of the centromere and colocalized with centromere-specific tandem repeat ...
  http://jcs.biologists.org/content/117/14/2963.full
*  Anti-BubR1/bub1b antibody (ab28193)
Chromosome , centromere , kinetochore. Cytoplasm , cytoskeleton , centrosome. Cytoplasmic in interphase cells. Associates with ... Sequence similarities. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.. Contains 1 ... Note=Defects in BUB1B are associated with tumor formation.. Defects in BUB1B are the cause of premature chromatid separation ... The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore ...
  https://www.abcam.com/bubr1-antibody-ab28193.html
*  1hlv - Proteopedia, life in 3D
... arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore ... The human centromere protein B (CENP-B), one of the centromere components, specifically binds a 17 bp sequence (the CENP-B box ... Centromere protein References *↑ Tanaka Y, Nureki O, Kurumizaka H, Fukai S, Kawaguchi S, Ikuta M, Iwahara J, Okazaki T, ... 1hlv is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided ...
  http://proteopedia.org/wiki/index.php/1hlv
*  CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly | Journal of Cell Science
2015). DNA sequence-specific binding of CENP-B enhances the fidelity of human centromere function. Dev. Cell 33, 314-327. doi: ... The results of the present study strongly support our notion that centromere formation and heterochromatin formation (e.g. ... Kinetochores assemble on centromere chromatin marked by nucleosomes containing the centromere-specific histone H3 variant CENP- ... 2015). Genetic and epigenetic regulation of centromeres: a look at HAC formation. Chromosome Res. 23, 87-103. doi:10.1007/ ...
  http://jcs.biologists.org/content/128/24/4572
*  Anti-Bub3 Antibody
Chromosome, centromere, kinetochore . Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the ... Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates ... Sequence Similarities. Belongs to the WD repeat BUB3 family. Subcellular Localization. Nucleus. ... Bub3 directs the localization of Bub1 at the kinetochore in order to activate the SAC. Bub3 also acts as a regulator in that it ...
  https://www.bosterbio.com/anti-bub3-antibody-pa1645.html
*  Artificial chromosome vector - The General Hospital Corporation
... the centromere of a higher eukaryote, particularly a plant, the telomere itself, the centromere ... The DNA sequences found at the centromere (CEN sequences) presumably play a role in specifying kinetochore assembly. ... The present invention discloses a novel method for isolating the ARS sequences which involves the formation of minichromosome ... 4 shows the DNA sequence of the pAtT4 insert. Insert sequences are shown in larger font and flanking vector sequences displayed ...
  http://www.freepatentsonline.com/5270201.html