Int J Dev Biol - A network of growth and transcription factors controls neuronal differentation and survival in the developing...
Neurogenesis is highly regulated by a network of extrinsic and intrinsic factors, whose participation in auditory neurogenesis ... Inner ear neurons develop from the otic placode and connect hair cells with central neurons in auditory brain stem nuclei. Otic ... ABSTRACT Inner ear neurons develop from the otic placode and connect hair cells with central neurons in auditory brain stem ... otic neurogenesis, IGF-I, FGF, inner ear, auditory ganglion, cochlear microarray. *Corresponding author e-mail: email@example.com ...http://www.ijdb.ehu.es/web/paper/072373hs/a-network-of-growth-and-transcription-factors-controls-neuronal-differentation-and-survival-in-the-developing-ear
Frontiers | Spontaneous Neuronal Activity in Developing Neocortical Networks: From Single Cells to Large-Scale Interactions |...
... programmed cell death, cellular differentiation, formation of local and long-range axonal connections, synaptic plasticity or ... programmed cell death, cellular differentiation, formation of local and long-range axonal connections, synaptic plasticity or ... the auditory brainstem suggest that inner hair cells act as pacemakers for spontaneous burst activity in more central auditory ... 2015). Spontaneous activity of cochlear hair cells triggered by fluid secretion mechanism in adjacent support cells. Cell 163, ...https://www.frontiersin.org/articles/10.3389/fncir.2016.00040/full
Frontiers | GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing | Frontiers in Neural...
In the inner ear, the cochlear hair cells in GC-B KO mice were nevertheless similar to those from wildtype mice, justified by ... Furthermore, late sound-evoked brainstem responses were significantly delayed in GC-B KO mice. This delay in sound response was ... In the inner ear, the cochlear hair cells in GC-B KO mice were nevertheless similar to those from wildtype mice, justified by ... However, efferent cholinergic feedback to inner and outer hair cells was reduced in GC-B KO mice, linked to very likely reduced ...https://www.frontiersin.org/articles/10.3389/fncir.2018.00065/full
Structural and functional effects of acoustic exposure in goldfish: evidence for tonotopy in the teleost saccule | BMC...
It is not known whether the auditory hair cells of fishes possess a similar tonotopic organization in the saccule, which is ... The hair cell bundles were counted at 19 specific locations in each saccule to determine the extent and location of hair cell ... All sound-exposed fish exhibited significant hair cell and hearing loss following sound exposure. The location of hair cell ... and there was a significant linear relationship between hair cell loss and hearing loss. The pattern of hair cell loss as a ...https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-12-19
Age-Related Cochlear Synaptopathy: An Early-Onset Contributor to Auditory Functional Decline | Journal of Neuroscience
Cochlear hair cell and neuronal function was assessed via distortion product otoacoustic emissions and auditory brainstem ... of spiral ganglion cells degenerate well before their cell bodies (and central axons), as suggested by Figure 5C. Similar ... All acoustic information is carried from the hair cells to the brainstem via the bipolar sensory neurons of the auditory nerve ... 2008) in The senses: a comprehensive reference, Perspectives on auditory neuropathy: disorders of inner hair cell, auditory ...http://www.jneurosci.org/content/33/34/13686.long
Cochlear nerve - Wikipedia
The central axons form synaptic connections with cells in the cochlear nucleus of the brainstem. The cell bodies of the ... The peripheral axons of auditory nerve fibers form synaptic connections with the hair cells of the cochlea via ribbon synapses ... Each type I axon innervates only a single inner hair cell, but each inner hair cell is innervated by up to 30 such nerve fibers ... across the cell body (or soma) and continue to propagate along the central axon. In this respect, auditory nerve fibers are ...https://en.wikipedia.org/wiki/Cochlear_nerve
CG-MED-49 Auditory Brainstem Responses (ABRs) and Evoked Otoacoustic Emissions (OAEs) for Hearing Disorders
Auditory neuropathy: A type of hearing impairment where outer hair cell function is normal but neural transmission in the ... A diagnostic ABR provides information such as "no response", thresholds prediction, auditory neuropathy, or central auditory ... Auditory Brainstem Response (ABR). Auditory Evoked Potential (AEP). Brainstem Auditory Evoked Potential (BAEP). Brainstem ... brainstem evoked auditory potential (EAP), brainstem auditory evoked potential (BAEP), brainstem auditory evoked response (BAER ...https://www.unicare.com/medicalpolicies/guidelines/gl_pw_c160719.htm
Frontiers | Non-Monotonic Relation between Noise Exposure Severity and Neuronal Hyperactivity in the Auditory Midbrain |...
Mulders WH, Ding D, Salvi R, Robertson D. Relationship between auditory thresholds, central spontaneous activity, and hair cell ... Central tinnitus and lateral inhibition: an auditory brainstem model. Hear Res (1996) 97:75-83. doi:10.1016/S0378-5955(96)80009 ... Central Auditory System Stage of the Model. The central auditory system stage comprises a neuronal circuit where projection ... The model is based on previous models of the effects of loss of inner and outer hair cells and damage to hair cell stereocilia ...https://www.frontiersin.org/articles/10.3389/fneur.2016.00133/full
Sensorineural hearing loss - Wikipedia
... or the auditory tracts of the brainstem. If higher levels of the auditory tract are affected this is known as central deafness ... Sensory hearing loss often occurs as a consequence of damaged or deficient cochlear hair cells.[disputed - discuss] Hair cells ... Thus, an increase in firing rate of the auditory neurons connected to the hair cell occurs. On the other hand, the bending of ... Thus, a decrease in firing rate of the auditory neurons connected to the hair cell occurs. OHCs are unique in that they are ...https://en.wikipedia.org/wiki/Sensorineural_hearing_loss
Tinnitus Today June 2001 Vol 26, No 2 | Tinnitus | Auditory System
with the loss of outer hair cells. In addition, dam- age to inner hair cells that was caused by higher dosages reduced the ... can reduce the central auditory response to sound and may offer promise in reducing tinnitus. James Kaltenbach, Ph.D., ofWayne ... nucleus - in the auditory portion of the brainstem. However, Drs. Alan Lockwood and Richard Salvi's research with people who ... hyperactivity-may be caused by outer hair cell damage, and that the effect may be offset or reversed by inner hair cell damage ...https://www.scribd.com/document/115051544/Tinnitus-Today-June-2001-Vol-26-No-2
Newborn hearing screening in Western Australia | The Medical Journal of Australia
It only measures outer hair-cell function in the cochlea. Babies with central hearing loss can have normal cochlear function ... Auditory brainstem response is a modified electroencephalogram recording of brain activity in response to auditory stimuli ... Automated auditory brainstem responses (AABR). The detection of AABR is more specific, but the test takes more time and is more ... Universal newborn hearing screening with automated auditory brainstem response: a multisite investigation. J Perinatol 2000; 20 ...https://www.mja.com.au/journal/2002/177/4/newborn-hearing-screening-western-australia
Sensory Systems/Vestibular System - Wikibooks, open books for an open world
Each utricle has about 30'000 hair cells, and each saccule about 16'000. The otoliths are located at the central part of the ... Regular and Irregular Haircells. While afferent haircells in the auditory system are fairly homogeneous,those in the ... On the other hand, Miles and Lisberger argued that the brainstem neurons targeted by the Purkinje cells are the site of ... The displacement is sensed by the hair cells. The bending of the hairs then polarizes the cell and induces afferent excitation ...https://en.wikibooks.org/wiki/Sensory_Systems/Vestibular_System
Supra-Threshold Hearing and Fluctuation Profiles: Implications for Sensorineural and Hidden Hearing Loss | SpringerLink
An important topic in contemporary auditory science is supra-threshold hearing. Difficulty hearing at conversational speech ... Mechanoelectrical transduction in auditory hair cells. In: Eatock RA, Fay RR (eds) Vertebrate hair cells. Springer, New York, ... Schofield BR (2011) Central descending auditory pathways. In: Ryugo DK, Fay RR, Popper AN (eds) Auditory and vestibular ... either directly or via other brainstem nuclei, relay fluctuation profiles to the inferior colliculus (IC). IC neurons are ...https://link.springer.com/article/10.1007%2Fs10162-018-0669-5
Sensory Neuroscience: Hearing and speech - Wikibooks, open books for an open world
Innervation patterns of the two types of hair cells. *Genesis of auditory nerve fiber tuning and the roles of the two hair cell ... Central auditory nervous system *Structural and functional organization. *Brainstem-evoked potentials in audiological & ...https://en.wikibooks.org/wiki/Sensory_Neuroscience:_Hearing_and_speech
Hearing - Biology Encyclopedia - cells, body, human, process, system, different, life, structure
Hair cells themselves do not make the impulses that are transmitted to the central nervous system (CNS); they stimulate nerve ... In the CNS, the information is transmitted both to the brainstem, which controls reflex activity, and to the auditory cortex, ... hair cells are anchored on the basilar membrane, which forms the roof of the vestibular duct. The tips of the hair cells are in ... pushes the hair cells against the tectorial membrane, bending the 'hairs' (stereocilia). When stereocilia are bent, the hair ...http://www.biologyreference.com/Gr-Hi/Hearing.html
Binaural fusion - Wikipedia
... where hair cells transform the mechanical signal into an electrical signal. The auditory nerve, also called the cochlear nerve ... doi:10.1007/s00381-002-0604-1. Twefik, Ted L. "Auditory System Anatomy". Masterton, R.B. (1992). "Role of the central auditory ... Action potentials originate in the hair cells of the cochlea and propagate to the brainstem; both the timing of these action ... it encounters the hair cells that line the basilar membrane of the cochlea in the inner ear. The cochlea receives auditory ...https://en.wikipedia.org/wiki/Binaural_fusion
Ear - wikidoc
Hair cells are also the receptor cells involved in balance, although the hair cells of the auditory and vestibular systems of ... Sound waves are perceived by the brain through the firing of nerve cells in the auditory portion of the central nervous system ... The nerve impulses travel from the left and right ears through the eighth cranial nerve to both sides of the brain stem and up ... The microscopic "hairs" of these cells are structural protein filaments that project out into the fluid. The hair cells are ...http://wikidoc.org/index.php/Ear
Cognitive neuroscience of music - Wikipedia
The hair cells in the cochlea release neurotransmitter as a result, causing action potentials down the auditory nerve. The ... and the auditory thalamus. By phase- and mode-locking in this way, the auditory brainstem is known to preserve a good deal of ... A widely postulated mechanism for pitch processing in the early central auditory system is the phase-locking and mode-locking ... This tonotopy is in general maintained up to primary auditory cortex in mammals, however it is often found that cells in ...https://en.wikipedia.org/wiki/Cognitive_neuroscience_of_music
Hearing Evaluation in Children
... may involve a specific part of the cochlea such as the inner hair cells, outer hair cells, or both. It usually exists at birth ... Central auditory evoked potential (CAEP) test. This test is similar to the ABR, and uses the same tiny earphones and small ... Auditory brainstem response (ABR) test. For this test, tiny earphones are placed in the ear canals and small electrodes ( ... A normal recording suggests that the outer hair cells are working well. But in some cases, a hearing loss may still happen if ...http://kidshealth.org/en/parents/hear.html?view=ptr&WT.ac=p-ptr
Superior olivary complex - Wikipedia
... which innervates cochlear outer hair cells. These cells contain electromotile fibers, and act as mechanical amplifiers/ ... The GABAergic projections from the DNLL form a major source of GABA in the auditory brainstem, and project bilaterally to the ... The LSO projects bilaterally to the central nucleus of the inferior colliculus (ICC). Ipsilateral projections are primarily ... Made up of a heterogeneous population of cells, this nucleus projects to many auditory nuclei, and forms the medial ...https://en.wikipedia.org/wiki/Superior_olivary_complex
V, VII Pair of Cranial Nerves | Vertigo | Vestibular System
From these receptors receive signals bipolar cells, located in the vestibular site of internal auditory passage. The central ... central acoustic nuclei and their pathways. Hair cell of Corti's organ of the cochlea are specialized acoustic receptors, which ... half of the brain stem) contralaterally of central type (often in conjunction with central hemiparesis and paresis of the hand ... central paresis pons) of extremities Auditory hallucinations, auditory aura (noise, melody, voice) Temporal lobe, Heschl gyrus ...https://www.scribd.com/document/34869778/V-VII-Pair-of-Cranial-Nerves
Information from cochlear potentials and genetic mutations helps localize the lesion site in auditory neuropathy | Genome...
... abnormality of auditory brainstem potentials and preserved outer hair-cell activities. Furthermore, AN can be identified either ... Mol Biol Cell. 2004, 15: 5001-5011. 10.1091/mbc.E04-04-0294.PubMedPubMed CentralView ArticleGoogle Scholar. ... Starr A, Zeng F, Michalewski H, Moser T: Perspectives on auditory neuropathy: disorders of inner hair cell, auditory nerve, and ... no detailed information of cochlear nerve and hair-cell activities can be provided by auditory brainstem response recording ...https://genomemedicine.biomedcentral.com/articles/10.1186/gm212
Amanda Marie Lauer, M.S., Ph.D.
... focuses her research on the perceptual and central nervous system consequences of hearing lo... ... Lina, I. A., Lauer, A. M. (2013). Rapid measurement of auditory filter shape in mice using the auditory brainstem response and ... Lauer, A. M., Fuchs, P. A., Ryugo, D. K., Francis, H. W. (2012). Efferent synapses return to inner hair cells in the aging ... Amanda Lauer, Ph.D., focuses her research on the perceptual and central nervous system consequences of hearing loss. The ...https://www.hopkinsmedicine.org/profiles/results/directory/profile/0349560/amanda-lauer
Gene Report for G00001817 - Genes2Cognition Neuroscience Research Programme
Conclusions: Auditory nerve involvement in the presence of normal cochlear outer hair cell activity is asymptomatic in one of ... Absent or abnormal ABRs were consistent with slowing of conduction along auditory nerve and/or brainstem auditory pathway. Wave ... may reflect the ability of central mechanisms to compensate for the slowly developing auditory nerve abnormalities. ... inhibits cell cycle progression in small cell lung carcinoma (SCLC) cells. We also demonstrated that SCLC cells express both ...http://www.genes2cognition.org/db/Gene/G00001817
GMS | 76th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery | Expression of the plasticity...
... focusing on the nuclei of the auditory brainstem. C-Fos expressing cells in the anteroventral cochlear nucleus (AVCN), the ... by direct electrical stimulation of the auditory nerve after deafness caused by the degeneration of the cochlear hair cells. ... Expression of c-Fos has been observed in central auditory neurons of various regions after acoustic or electrical stimulation ... Expression of the plasticity marker c-Fos in auditory brainstem projection neurons of the rat after electrical intacochlear ...http://www.egms.de/static/en/meetings/hno2005/05hno029.shtml