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*  Identification and Regulation of c-Myb Target Genes in MCF-7 Cells | BMC Cancer | Full Text
The c-myb gene is a cellular proto-oncogene from which the v-myb oncogenes expressed by two avian leukemia viruses are derived ... This result is different than hematopoietic cells, in which c-Myb protein is largely or exclusively in the nucleus [30]. Time ... c-Myc associates with more than 4,000 genes [23], estrogen receptor alpha associates with more than 10,000 genes [24] and ... a proto-oncogene. EPB41 encodes the erythrocyte protein band 4.1, which was first identified in erythroid cells but is also ...
  https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-30
*  A stochastic model of oncogene expression and the relevance of this model to cancer therapy | Theoretical Biology and Medical...
... assessment of the amount of cellular death or growth inhibition that result from the ablation of an oncogene's protein product ... if the oncogene or set of oncogenes contributing maximally to a tumor cell's survival can be identified, such oncogene(s) are ... Oncogenes become part of the cellular machinery, block apoptosis and differentiation or promote proliferation and give rise to ... A mathematical model is presented that describes cellular phenotypic entropy as a function of cellular proliferation and/or ...
  https://tbiomed.biomedcentral.com/articles/10.1186/1742-4682-3-5
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... that leukemia in gene therapy treated patients originated from provirus induced overexpression of a neighboring proto-oncogene ... Hematopoietic stem cells (HSCs) are used clinically for transplantation treatment to rebuild a patient's hematopoietic system ... both at the mRNA and protein level. For protein analysis, flow cytometry is a powerful analytical tool for assessing quality of ... Cellular Biology, Issue 41, iPS, pluripotent, stem cells, cell culture, medium, media, feeder-free, Geltrex, human ...
  https://www.jove.com/visualize/abstract/22132178/generation-induced-pluripotent-stem-cells-from-cd34-cells-across
*  Regulation of MicroRNA Biogenesis: A miRiad of mechanisms | Cell Communication and Signaling | Full Text
... mature microRNA are generated through a series of coordinated processing events mediated by large protein complexes. It is ... non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development ... The proto-oncogene c-Myc is a helix-loop-helix leucine zipper transcription factor which regulates ~10 to 15% of human genes to ... The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells. Blood. ...
  https://biosignaling.biomedcentral.com/articles/10.1186/1478-811X-7-18
*  ERG Is a Megakaryocytic Oncogene | Cancer Research
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 1987; 49: ... These data suggest that ERG is a hematopoietic oncogene that may play a direct role in myeloid leukemia pathogenesis. [Cancer ... The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy. Leukemia 2008; 22: 521-9. ... 7, 8). In both EWS-ERG and TLS-ERG, the fusion protein contains a truncated form of ERG that retains the ETS domain. A ...
  http://cancerres.aacrjournals.org/content/69/11/4665.full
*  Rac regulates the interaction of fascin with protein kinase C in cell migration | Journal of Cell Science
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol. 5, 3610-3616. ... Rosenberg, M. and Ravid, S. (2006). Protein kinase Cgamma regulates myosin IIB phosphorylation, cellular localization, and ... Shirsat, N. V., Pignolo, R. J., Kreider, B. L. and Rovera, A. (1990). A member of the ras gene superfamily is expressed ... Rac2 is restricted to haematopoietic cells (Shirsat et al., 1990) and antibodies specific for Rac3 are unavailable. In this ...
  http://jcs.biologists.org/content/121/17/2805
*  Method for treating a metastatic carcinoma using a conditionally lethal gene - Patent # 5997859 - PatentGenius
... construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity ... Mansour et al., "Disruption Of The Proto-Oncogene int-2 In Mouse Embryo Derived Stem Cells: A General Strategy for Targeting ... or a genetic disease by preventing the cellular synthesis of critical proteins neededfor cell growth. Examples of such ... Stanton, et al., "Nucleotide sequence comparison of normal and translocated murine c-myc genes," Nature 310: 423-425, 1984... ...
  http://www.patentgenius.com/patent/5997859.html
*  SYNERGISTIC TREATMENT OF CELLS THAT EXPRESS EPHA2 AND ERBB2 - Patent application
... transcriptional activity of known genes such as proto-oncogenes (e.g., fos, myc) or cell cycle markers; cell viability can be ... linkage to a cellular ligand or other protein, etc. A derivative of a membrane permeable sequence polypeptide may be modified ... deliver the mdr 1 gene to hematopoietic stem cells in order to make the stem cells more resistant to chemotherapy. Other ... protein A-based immune modulator, protein kinase C inhibitor, protein kinase C inhibitors, microalgal, protein tyrosine ...
  http://www.patentsencyclopedia.com/app/20100254996
*  EPCAM APTAMER FOR DETECTION OF CANCER STEM CELLS - DEAKIN UNIVERSITY
EpCAM acts by inducing proliferation with a direct impact on cell cycle control upregulating the proto-oncogene c-myc and ... such as non-cellular fractions of blood, saliva, or urine, that can be used to measure gene expression levels. Biological ... The surviving expression levels were normalised as the ratio of survivin protein expression levels to that of β-actin protein. ... The best known example of adult cell renewal by the differentiation of stem cells is the hematopoietic system. Developmentally ...
  http://www.freepatentsonline.com/y2015/0197755.html
*  Plus it
eIF4E is a proto-oncogene that promotes translation of several genes essential for cellular proliferation (cyclin D1, c-Myc, ... These observations were supported by ELISA analysis of cyclin D1 and c-Myc protein levels. Furthermore, treatment with these ... Our in vitro and in vivo data demonstrate the potential of briciclib in targeting eIF4E for hematopoietic and solid cancers and ... and ELISA assays were used to evaluate cellular viability, survival, and protein expression levels. Results: Briciclib and ON ...
  http://cancerres.aacrjournals.org/content/75/15_Supplement/1649
*  Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44+/CD24-) in MCF-7 by Upregulating Mucin1 and EpCAM
... upregulating the proto-oncogene c-myc and Cyclins A and E, and transducing signals into the cell nucleus through the Wnt ... Steller H. Mechanisms and genes of cellular suicide. Science. 1995;267:1445-9 ... Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2. Pharmacol Ther. 2002; ... For example, hematopoietic stem cells (HSCs) are responsible for the generation and regeneration of circulating blood cells, ...
  http://www.jcancer.org/v06p1049.htm
*  Induction of Apoptosis by Flavopiridol in Human Neuroblastoma Cells Is Enhanced under Hypoxia and Associated With N-myc Proto...
Bruick RK Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA 2000;97: ... Our aim was to investigate flavopiridol effects on advanced-stage, N-myc proto-oncogene (MYCN)-amplified human neuroblastomas ... Total cellular RNA was purified from LAN-5 and GI-LI-N cells with the TriZOL RNA reagent (Life Technologies), according to the ... Parker BV, Kaur G, Nieves-Neira W, et al Early induction of apoptosis in hematopoietic cell lines after exposure to ...
  http://clincancerres.aacrjournals.org/content/10/24/8704
*  Roeland Nusse | Stanford Medicine Profiles
Wingless (wg), the Drosophila homologue of the mouse Wnt-1 proto-oncogene, is a segment polarity gene essential in each segment ... a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains ... The ~50 genes upregulated early after Wnt addition include the previously known Wnt targets Cyclin D1, MYC, ID2 and betaTRCP. ... The purified Wnt3a protein induces self-renewal of haematopoietic stem cells, signifying its potential use in tissue ...
  https://med.stanford.edu/profiles/roeland-nusse
*  USE OF DIBENZOFURANONE DERIVATIVES TO INHIBIT KINASES - Patent application
... expression of the Wnt target gene. These target genes also include several proto-oncogenes. An increased CK2 activity can lead ... 0138] Filhol, O. and Cochet, C. (2009) Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a ... Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization ... for example c-myc or TAL-1, is over-expressed, this considerably strengthened the pathogenic phenotype compared with the ...
  http://www.patentsencyclopedia.com/app/20130225674
*  c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland | BMC Biology | Full Text
During lactation, lower levels of ribosomal RNAs and proteins were present and translation was generally decreased in mutant ... Generation of c-myc fl/fl mice carrying the mammary gland-specific WAPiCre transgene resulted in c-Myc loss in alveolar ... We have demonstrated that c-Myc plays multiple roles in the mouse mammary gland during pregnancy and lactation. c-Myc loss ... First, c-Myc-deficient alveolar cells had a slower proliferative response at the start of pregnancy, causing a delay but not a ...
  https://preview-bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-7-63
*  RegenerativeMedicine.net - Article Archives
Surface chemistry for cytosolic gene delivery and photothermal transgene expression by gold nanorods Cellular prion protein ( ... regulates sensitivity of breast cancer cells to HER2 inhibition via FOXO/c-Myc axis Sleep disruption impairs haematopoietic ... as an RNAi-based therapy for glioblastoma Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene ... gene fission and rational gene fusion to discover near-infrared fluorescent protein fragments that report on protein protein ...
  http://regenerativemedicine.net/NewsletterArchives.asp?qEmpID=25275&qCat=RMJ
*  Sixteenth Annual Pezcoller Symposium | Cancer Research
Adult stem cells of the hematopoietic and neuronal tissues express the proto-oncogene bmi-1, a member of the polycomb family ... The secreted frizzled related protein (SFRP) gene family, which encodes for proteins that act as antagonists to the frizzled ... and empower preclinical models for gene and cellular therapy. The question was asked whether an HSC could be identified ... myc and through repression of the Ink4a/Arf tumor-prevention fail-safe mechanism. Conversely, Bmi1 deficiency, as seen in bmi1 ...
  http://cancerres.aacrjournals.org/content/64/22/8474.full
*  Browse our AKT ELISA Kits
... proto-oncogene c-Akt , rac protein kinase alpha , AKT1 kinase , protein kinase B-alpha , proto-oncogene c-AKT , related to A ... The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and ... cellular cytoskeletal beta-actin , beta-actin , gamma non-muscle actin , beta actin , RAC protein kinase alpha RAC-PK alpha , ... and C-myc (show MYC ELISA Kits) levels in SMMC-7721 cells. ... in the mesenchymal stem cells regulates hematopoietic stem cell ...
  http://www.antibodies-online.com/pi3k-akt-signaling-pathway-4/akt-elisa-kit-1844/
*  Cardiomyocyte Cell Cycle Regulation | Circulation Research
The c-myc proto-oncogene regulates cardiac development in transgenic mice. Mol Cell Biol. 1990; 10: 3709-3716. ... Inducible gene targeting in postnatal myocardium by cardiac-specific expression of a hormone-activated Cre fusion protein. Circ ... Proliferation dynamics of cellular elements in the differentiating mouse myocardium. Tsiotologiya. 1968; 10: 1391-1409. ... Absence of cardiac differentiation in hematopoietic stem cells transplanted into normal and injured hearts. Circulation. 2001; ...
  http://circres.ahajournals.org/content/90/10/1044
*  Applications of microarray technology in breast cancer research | Breast Cancer Research | Full Text
... including the MYC and PIM1 proto-oncogenes and genes for immediate early transcription factors, kinases and phosphatases. ... as well as many other genes involved in muscle function [53]. BRCA1 encodes a protein that has been implicated in the cellular ... Sets of genes that were predominant in either fetal or adult hematopoietic cells were also identified. The cytosine ... These include DNA replication and repair genes, apoptosis genes and genes involved in cellular responses to polycyclic aromatic ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr291
*  Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation | Stem Cell...
... including proto-oncogene c-MYC. Expression of reprogramming factors could prevent proper differentiation of iPS cells, while ... B) Total cellular RNA from WT-iPS, SLE-iPS and ADPKD-iPS clones was isolated and analyzed for endogenous pluripotency genes by ... episomal vectors or introduction of reprogramming proteins, RNAs or miRNAs [35-41]. We have recently reprogrammed patient's ... Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors. Mol Ther. 2009, ...
  https://stemcellres.biomedcentral.com/articles/10.1186/scrt89
*  Hitchhiker's Guide to the Galaxy on Chromosomal translocation
RET proto-oncogene[14] on chromosome 10. PTC (Papillary Thyroid Cancer) - Placeholder for any of several other genes/proteins[ ... c-myc on chromosome 8,. gives the fusion protein lymphocyte-proliferative ability. [email protected] (immunoglobulin heavy ... Hematopoeitic malignancies". Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Elsevier Health Sciences. pp. 1371 ... cellular variant of mesoblastic nephroma. TEL on chromosome 12. TrkC receptor on chromosome 15 ...
  http://hitchhikersgui.de/Chromosomal_translocation
*  Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks | SpringerLink
Nanbru C, Lafon I, Audigier S et al (1997) Alternative translation of the proto-oncogene c-myc by an internal ribosome entry ... Yip-Schneider MT, Horie M, Broxmeyer HE (1995) Transcriptional induction of pim-1 protein kinase gene expression by interferon ... a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29. J Virol 42:773-779PubMedPubMedCentral ... An N, Kraft AS, Kang Y (2013) Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice. J Hematol Oncol 6:12PubMed ...
  https://link.springer.com/article/10.1007/s10495-016-1289-3
*  Targets
Proto-oncogene c-Fos. FOS Tchem. Transcription Factor. -4.12726. 13094.7. 961. Myc proto-oncogene protein. MYC Tbio. ... Gene. Development Level. Target Family. Log Novelty Pubmed Score Antibody Count Knowledge Availability ... Cellular tumor antigen p53. TP53 Tchem. Transcription Factor. -4.71557. 51004.8. 5255. 1/79. ... Hematopoietic stem cell. 370 , 370 Ovary. 342 , 342 Artery. 327 , 327 Ganglion. 322 , 322 ...
  https://pharos.nih.gov/idg/targets?facet=Jensen-TM+Tissue/Cervical+cancer+cell+line
*  Transcription factor‐mediated reprogramming toward hematopoietic stem cells | The EMBO Journal
Myc demonstrated the requirement of the Myc genes in the exit from stem cell state as well as preventing apoptosis of HSCs. ... Transcriptional regulation of cellular identity. TFs dictate the specific gene expression pattern necessary for a cell to ... Epigenetic regulation of protein‐coding and microRNA genes by the Gfi1‐interacting tumor suppressor PRDM5. Mol Cell Biol 27: ... McCormack MP, Young LF, Vasudevan S, de Graaf CA, Codrington R, Rabbitts TH, Jane SM, Curtis DJ (2010) The Lmo2 oncogene ...
  http://emboj.embopress.org/content/early/2015/02/20/embj.201490804