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*  Cancer Stem Cell News: January 2010
... the clonal evolution model, has recently been challenged by proponents of the cancer stem cell hypothesis. To investigate this ... we performed combined analyses of markers associated with cellular differentiation states and genotypic alterations in human ... Regulating Cancer Stem Cells the miR Way by Marcus E Peter, Cell Stem Cell 2010(Jan 8); 6(1): 4-6. [Commentary on Nat Cell Biol ... Cancer Stem Cell News A blog of news items related to cancer stem cells, with an emphasis on recent research and articles that ...
  http://cancerstemcellnews.blogspot.com/2010_01_01_archive.html
*  Abstract SY27-03: Breast cancer stem cell state transitions mediate therapeutic resistance | Cancer Research
The genetic evolution of cancer stem cells during carcinogenics and therapy highlights that both clonal evolution and ... Epigenetic regulation of gene expression occurs during normal cellular differentiation and during carcinogenesis generates ... Mol Cell 47, 570-584 (2012).. Citation Format: Max S. Wicha. Breast cancer stem cell state transitions mediate therapeutic ... Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts. Stem ...
  http://cancerres.aacrjournals.org/content/75/15_Supplement/SY27-03
*  Lung Cancer Stem Cell: New Insights on Experimental Models and Preclinical Data
... and clinical studies related to breast cancer, lung cancer, gastrointestinal cancer, skin cancer, head and neck cancer, ... paediatric oncology, neurooncology as well as genitourinary cancer. The journal provides a multidisciplinary forum for ... L. L. Campbell and K. Polyak, "Breast tumor heterogeneity: cancer stem cells or clonal evolution?" Cell Cycle, vol. 6, no. 19, ... Indeed, self-renewal, which drives tumorigenesis, and differentiation albeit aberrant that contributes to cellular ...
  https://www.hindawi.com/journals/jo/2011/549181/
*  Transit-Amplifying Cells in the Fast Lane from Stem Cells towards Differentiation
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... M. Loeffler and C. S. Potten, Stem Cells and Cellular Pedigrees-A Conceptual Introduction, Academyc Press, Manchester, UK, 1997 ... D. A. Gold and D. K. Jacobs, "Stem cell dynamics in Cnidaria: are there unifying principles?" Development Genes and Evolution, ...
  https://www.hindawi.com/journals/sci/2017/7602951/ref/
*  Lung Cancer Stem Cell: New Insights on Experimental Models and Preclinical Data
4. Campbell LL, Polyak K. Breast tumor heterogeneity: cancer stem cells or clonal evolution? Cell Cycle. 2007;6(19):2332-2338. ... Indeed, self-renewal, which drives tumorigenesis, and differentiation albeit aberrant that contributes to cellular ... and cancer stem cells. Nature. 2001;414(6859):105-111. [PubMed]. 2. Nowell PC. The clonal evolution of tumor cell populations. ... Normal stem cells and cancer stem cells: the niche matters. Cancer Research. 2006;66(9):4553-4557. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3010697/
*  Cancers | Free Full-Text | Epigenetics, Nervous System Tumors, and Cancer Stem Cells | HTML
... highlight emerging evidence that suggests epigenetic deregulation is a characteristic feature of so-called cancer stem cells ( ... We believe that better understanding how epigenetic mechanisms operate in neural cells and identifying the etiologies and ... one of the hallmarks of cancer. In this review, we describe the major epigenetic mechanisms (i.e., DNA methylation, histone and ... consequences of epigenetic deregulation in tumor cells and CSCs, in particular, are likely to promote the development of ...
  http://www.mdpi.com/2072-6694/3/3/3525/htm
*  Patient-derived xenograft models of breast cancer and their predictive power | Breast Cancer Research | Full Text
Here we review the utility of breast cancer PDX models to study the clonal evolution of tumors and to evaluate novel therapies ... Evaluating new targets using established cell lines is limited by the inexact correlation between responsiveness observed in ... Patient-derived xenografts (PDXs) generated from fresh tumor specimens recapitulate the diversity of breast cancer and reflect ... Despite advances in the treatment of patients with early and metastatic breast cancer, mortality remains high due to intrinsic ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0523-1
*  Cancer stem cell - Wikipedia
"Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution". Cell Press. 138 (5): 822-9. doi:10.1016/j.cell.2009.08.017 ... De-differentiation of mutated cells may create stem cell-like characteristics, suggesting that any cell might become a cancer ... Gao JX (2008). "Cancer stem cells: the lessons from pre-cancerous stem cells". Journal of Cellular and Molecular Medicine. 12 ( ... They examined cancer stem cell plasticity in which cancer stem cells can transition between non-cancer stem cells (Non-CSC) and ...
  https://en.wikipedia.org/wiki/Cancer_stem_cell
*  IJMS | Free Full-Text | Multidrug Resistance and Cancer Stem Cells in Neuroblastoma and Hepatoblastoma | HTML
It is known that cancer stem cells (CSCs) play a role as master regulators. Therefore, understanding the mechanisms that ... Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. ... Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of ... These defining requirements can be justified by a combination of CSC theory and a clonal evolution model. According to this ...
  http://www.mdpi.com/1422-0067/14/12/24706/htm
*  IJMS | Free Full-Text | Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review | HTML
Cancer stem cells (CSC) have recently been characterized as being responsible for resistance to radio/chemotherapies and ... Those CSCs express biomarkers such as cluster of differentiation 44 (CD44) and display high aldehyde dehydrogenase activity ... It has been demonstrated that ATRA can block the cell cycle, enhance apoptosis, and decrease gastric CSCs properties in GC cell ... Recent studies have started to show that ATRA also has an anti-tumoral role on solid cancers such as GC. The purpose of this ...
  https://www.mdpi.com/1422-0067/19/11/3388/htm
*  Sonia Prado | Phylogenomics Lab
Hypoxia Promotes Efficient Differentiation of Human Embryonic Stem Cells to Functional Endothelium. Stem Cells. 28(3):407-18. ... cabo verde cancer cancer evolution cape verde CONTRA conus deep coalescence duplication and loss forensic genetics gene ... myself as a molecular and cellular biologist whose scientific career has been strongly influenced by the biology of stem cells ... The influence of hypoxia on the differenciation capacities and immunosupresive properties of clonal mouse MSC lines. Immunology ...
  http://darwin.uvigo.es/sonia-prado/
*  Cancer stem cell metabolism | Breast Cancer Research | Full Text
According to this clonal evolution model, each cancer cell has a similar potential to grow a tumour. A second model, the cancer ... Therapeutic implications of cellular heterogeneity and plasticity in breast cancer. Cell Stem Cell. 2015;17(3):260-71.View ... with transitory bursts of ROS production that stimulate differentiation of CSCs towards their non-stem cancer cell counterparts ... Aguilar-Gallardo C, Simon C. Cells, stem cells, and cancer stem cells. Semin Reprod Med. 2013;31(1):5-13.View ArticlePubMed ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-016-0712-6
*  Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity | Genome Biology | Full Text
Here we review available techniques and future possibilities, arguing that the full potential of single-cell epigenetic studies ... Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene ... single-cell DNA sequencing has found evidence of clonal evolution in multiple cancer types, and has identified founder ... Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015;526:131-5.View Article ...
  https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0944-x
*  Roshini Abraham, PhD - AACC.org
She then joined the faculty, with a research focus on B cell clonal evolution and differentiation in the pathogenesis of ... hematopoietic stem cell transplantation, immunotherapy, and cancer vaccines.. She is also involved in teaching clinical ... where she is director of the cellular and molecular immunology section) at the Mayo Clinic in Rochester, MN.. During her ... The Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics ...
  https://www.aacc.org/Community/Awards/Hall-of-Fame/Bios/A-to-K/Abraham-Roshini.aspx
*  Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity | Springer for Research &...
Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene ... single-cell DNA sequencing has found evidence of clonal evolution in multiple cancer types, and has identified founder ... Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015;526:131-5.CrossRefPubMed ... Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell. ...
  https://rd.springer.com/article/10.1186/s13059-016-0944-x
*  Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity? | Breast Cancer Research ...
... for future progress in devising new and improved combinatorial therapeutic approaches for breast and other solid cancers. ... Paracrine signaling mechanisms play a critical role in both normal mammary gland development and breast cancer. Dissection of ... Though not mutually exclusive with the clonal selection hypothesis, the cancer stem cell hypothesis posits the existence of a ... Almendro V, Marusyk A, Polyak K: Cellular heterogeneity and molecular evolution in cancer. Ann Rev Pathol. 2013, 8: 277-302. ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3610
*  Aneuploidy in pluripotent stem cells and implications for cancerous transformation | SpringerLink
... human pluripotent stem cells (hPSCs) have emerged as a promising cell source for regenerative medicine, disease modeling and ... Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells. Hum Mol Genet 14:3129-3140 ... Modeling the evolution of culture-adapted human embryonic stem cells. Stem Cell Res 4:50-56CrossRefGoogle Scholar ... human pluripotent stem cells (hPSCs) culture adaptation aneuploidy cancer genetic changes ABBREVIATIONS. CNV. copy number ...
  https://link.springer.com/article/10.1007%2Fs13238-014-0073-9
*  Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression |...
Our analysis of mammary stem-like and stepwise cell differentiation, and an in-depth description of our findings in a breast ... To determine a possible association between mammary stem cells and breast cancer, a detailed characterization of the ... The transcriptional characterization of these mammary stem-like cells and their differentiation-induced gene expression ... transcriptome in mammary stem cells is essential. We have used a murine mammary epithelial stem-like cell line (HC11) and made ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr2256
*  Development & Differentiation | The EMBO Journal
Cellular turnover in skin compartments is synchronized during anagen‐associated growth, temporarily increasing stem cell ... The resulting clonal expansion of an entire circuit module is a likely mechanism of brain evolution. ... 6Department of Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA ... Reduced expression of cell fate regulator Prospero triggers an expansion of differentiation‐competent neural stem cells, giving ...
  http://emboj.embopress.org/collection/development-differentiation?page=2
*  Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in Cancer
M. Greaves and C. C. Maley, "Clonal evolution in cancer," Nature, vol. 481, no. 7381, pp. 306-313, 2012. View at Publisher · ... "Cancer stem cells-old concepts, new insights," Cell Death and Differentiation, vol. 15, no. 6, pp. 947-958, 2008. View at ... "New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer," Journal of Translational ... induced pluripotent stem cell-derived mesenchymal stem cells: progress toward safe clinical products," Stem Cells, vol. 30, no ...
  https://www.hindawi.com/journals/bmri/2013/430290/
*  Subventricular zone - Wikipedia
Brain Ventricular zone Neuroscience Neurogenesis Stem cell Neural stem cell Cellular differentiation Cerebral cortex Popp A, ... are stem cells that can be isolated from brain tumors by similar assays used for neuronal stem cells. In forming clonal spheres ... "Contributions to Drug Resistance in Glioblastoma Derived from Malignant Cells in the Sub-Ependymal Zone". Cancer Research. 75 ( ... Rakic, P (October 2009). "Evolution of the neocortex: a perspective from developmental biology". Nature Reviews. Neuroscience. ...
  https://en.wikipedia.org/wiki/Subventricular_zone
*  Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia | SpringerLink
... are situated at the apex of the haematopoietic differentiation hierarchy, ensuring the life-long supply of mature ... Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481:306-313PubMedPubMedCentralCrossRefGoogle Scholar ... current evidence suggests that pre-leukaemic cells are closely related to normal HSC and form a cellular reservoir where ... Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105-111PubMedCrossRef ...
  https://link.springer.com/article/10.1007%2Fs00109-017-1535-3
*  Leukemia Research Members | OSUCCC - James
... proteins function to prevent stress-induced apoptosis and clonal evolution of hematopoietic stem cells and progenitors. Dr. ... Precision Cancer Medicine Precision medicine enables cancer specialists to identify and target cancer cells. ... Shah's laboratory investigates the origin, development, and differentiation of hematopoietic stem cells (HSCs) to treat ... Her research focuses on cellular therapies for hematologic malignancies including engineered cell therapies for B cell ...
  https://cancer.osu.edu/research-and-education/research-programs/leukemia-research/leadership-and-members
*  Table of Contents | Cancer Research
Tumor and Stem Cell Biology RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells ... Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte-Endothelial Recognition to Foster ... Molecular and Cellular Pathobiology Detection of Pancreatic Cancer-Induced Cachexia Using a Fluorescent Myoblast Reporter ... These results show that Notch signaling not only supports the differentiation of tumor-associated macrophages, but also ...
  http://cancerres.aacrjournals.org/content/76/6
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and ... Cancer Biology, Issue 73, Medicine, Molecular Biology, Cellular Biology, Biomedical Engineering, Genetics, Oncology, ... This includes differentiation from a stem cell population, mitotic amplification, and meiosis. In addition, post-meiotic germ ... With the evolution of multi-photon imaging technology and three-dimensional reconstruction software, the ability to visualize ...
  https://www.jove.com/visualize/abstract/23300962/long-term-in-vivo-imaging-of-multiple-organs-at-the-single-cell-level