Items by Mrsny, Randall - Opus
The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial ... Adhesion proteins in cellular tight junctions: critical components in the modulation of paracellular permeability. Advanced ... Converting skin fibroblasts into hepatic-like cells by transient programming. Journal of Cellular Biochemistry. , 117 (3), pp. ... Local tissue distribution and cellular fate of vascular endothelial growth factor (VEGF) following intramuscular injection. ...http://opus.bath.ac.uk/view/person_id/2106.date.html
Expression of Glutathione Peroxidase and Glutathione Reductase and Level of Free Radical Processes under Toxic Hepatitis in Rats
Overexpression of these enzymes is required to increase cellular resistance to oxidative stress, which is one of the key issues ... N. Fedorova, State of the system of glutathione peroxidase-glutathione reductase in the stimulated to regenerate body and its ... i)Glutathione peroxidase (GP) and glutathione reductase (GR) system plays key role in organism defense under toxic hepatitis.( ... Expression of Glutathione Peroxidase and Glutathione Reductase and Level of Free Radical Processes under Toxic Hepatitis in ...https://www.hindawi.com/journals/jt/2013/870628/
Cardiotoxicity of MDMA
... and the cellular activities of glutathione peroxidase, glutathione reductase, and glutathione-S-transferase. No toxic effects ... glutathione (GSH), and glutathione disulfide (GSSG); intracellular Ca(2+), ATP, and ADP; ...https://www.mdma.net/cardiovascular/toxic-metab.html
Relationship between Antioxidant Enzyme Activities and Cardiac Susceptibility to Ischaemia and Reperfusion during Aging in Rats...
... glutathione peroxidase (GPx) and glutathione reductase (GRx) play key roles in the cellular defence systems against ROS under ... Glutathione Peroxidase Glutathione Reductase Antioxidant Enzyme Activity Glutathione Peroxidase Activity Myocardial Activity ... Assays of glutathione peroxidase. Meth. Enzymol. 105, 114-121 (1984).CrossRefGoogle Scholar ...https://link.springer.com/chapter/10.1007/978-1-4899-0167-5_40
Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice
... medical practitioners and pathologists working in the area of cellular pathology. The journal publishes original research ... Analytical Cellular Pathology is a peer-reviewed, Open Access journal that provides a forum for scientists, ... inhibition of cerebral thioredoxin reductase and glutathione peroxidase in mice after acute exposure," Molecular and Cellular ... Taken together, these sets of results indicate that (PhTe)2 is a xenobiotic that induces acute hepatitis and cellular death. ...https://www.hindawi.com/journals/acp/2015/784612/
Ascorbate | definition of ascorbate by Medical dictionary
... ascorbate peroxidase, glutathione reductase, glutathione peroxidase, dihydro ascorbat reductase .. Investigation of ... Plant defense systems to reduce the free oxygen in the cellular tissue and repair damaged tissue often can be in the role of ...https://medical-dictionary.thefreedictionary.com/ascorbate
... and organellar ascorbate peroxidase and glutathione reductase (Chew et al., 2003) transcript levels are known to respond to ... AOX anti-sense plant transcript levels of predicted mitochondrial components: fold change relative to wild type (TAIR cellular ... cytosolic and organellar glutathione reductase, and organellar ascorbate peroxidase (Table I). Transcript levels varied little ... Chew O, Whelan J, Millar AH (2003) Molecular definition of the ascorbate-glutathione cycle in Arabidopsis mitochondria reveals ...http://www.plantphysiol.org/content/139/4/1806
Selenium | Technology Trends
Selenium is a component of the antioxidant enzymes glutathione peroxidase and thioredoxin reductase (which indirectly reduce ... Selenium salts are toxic in large amounts, but trace amounts are necessary for cellular function in many organisms, including ...http://www.primidi.com/selenium
Effect of lemon verbena supplementation on muscular damage markers, proinflammatory cytokines release and neutrophils'...
... glutathione peroxidase and glutathione reductase. Supplementation with moderate levels of an antioxidant lemon verbena extract ... Nevertheless, exercise-derived ROS are essential to regulate cellular adaptation to exercise. Studies on antioxidant ... Flohe L, Gunzler WA (1984) Assays of glutathione peroxidase. Methods Enzymol 105:114-121PubMedCrossRefGoogle Scholar ... Goldberg DM, Spooner RJ (1983) Glutathione reductase. In: Bergmeyer HU, Bergmeyer J, Grabl M (eds) Methods of enzymatic ...https://link.springer.com/article/10.1007/s00421-010-1684-3
Nutrients | Free Full-Text | Protective Effect of Resveratrol on Biomarkers of Oxidative Stress Induced by Iron/Ascorbate in...
... glutathione peroxidase (GPX) activity; (vi) lipid peroxidation; (vii) and in vitro fertilization (IVF) capability. Spermatozoa ... Such enzymes include glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, low molecular weight ... Oxidative damage is considered the main indicator of a loss of cellular function caused by oxidative stress . Hence, ... Oxidized glutathione (GSSG) in the presence of glutathione reductase (GR) and NADPH is immediately changed to the reduced form ...http://www.mdpi.com/2072-6643/6/2/489/htm
Co-variation of glutathione transferase expression and cytostatic drug resistance in HeLa cells: establishment of class Mu...
... whereas the total glutathione concentration was unchanged and the glutathione peroxidase activity was increased. The results ... and other glutathione-linked enzymes in HeLa cells have been made in order to study their significance in cellular resistance ... The cytosolic concentrations of glutathione reductase and glyoxalase I were also lower in HR cells, ... Qualitative and quantitative analyses of glutathione, glutathione transferases (GSTs) ...http://www.biochemj.org/content/297/1/59
... glutathione peroxidase, and glutathione reductase as well as inhibiting the pro-oxidative enzyme, nitric-oxide synthase. ... The protective effects of melatonin and several other indoleamine antioxidants against cellular damage caused by carcinogens ... glutathione peroxidase, glutathione reductase, and catalase. Additionally, melatonin experimentally enhances intracellular ... Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX ...https://www.eattheapple.com/melatonin.htm
US Patent # 6,953,666. Biomarkers for oxidative stress - Patents.com
57:4965-4970): these include cellular and plasma glutathione peroxidases, phospholipid hydroperoxide glutathione peroxidase and ... against Aflatoxin B.sub.1 in the Rat is Associated with the Hepatic Expression of an Aldo-Keto Reductase and a Glutathione S- ... Ding, L. et al., Biochemical characterization of selenium-containing catalytic antibody as a cytosolic glutathione peroxidase ... 1991) "Eosinophil peroxidase: occurrence and biological function," in Peroxidases in Chemistry and Biology, Vol 1, Everse, J. ...http://patents.com/us-6953666.html
Hydrogen Peroxide H2O2 Therapy | Herbactive Health Clinic
Enzyme coatings are catalase, reductase, superoxide dismutase and glutathione peroxidase. Oxygen starved cells do not produce ... Proper cellular utilization of oxygen requires diets containing adequate amounts of unsaturated fatty acids. Most common ... Healthy cells manufacture and maintain an enzyme coating to protect them from cellular invasion by viruses and singlet oxygen. ...https://herbactive.co.uk/H2O2.php
Patent US5906811 - Intra-oral antioxidant preparations - Google Patents
This reaction may also be catalyzed by selenium as a cofactor to the enzyme glutathione peroxidase using reduced glutathione ( ... In turn, the GSSG is reduced back to GSH by the enzyme GSH reductase thereby maintaining abundant cellular GSH to scavenge free ... It is believed that selenium-GSH peroxidase catalyzes toxic hydrogen peroxidase in the presence of reduced glutathione. This ... particularly to increase cellular levels in glutathione depleted states. Certain diseases cause glutathione depletion from ...http://www.google.com/patents/US5906811?dq=patent:7076806
... glutathione peroxidase 1, and methionine sulfoxide reductase A was generally increased by RSG. Meanwhile, RSG did not affect ... Transcription of cellular antioxidant enzymes were concordantly regulated with RSG-induced mitochondrial biogenesis.. Increased ... Mitochondria produce ,95% of cellular ATP, required by adipocytes for triglyceride synthesis and adipokine synthesis and ... these transcripts in both db/db and HFD mice and induced transcription of mitochondrial structural proteins and cellular ...http://diabetes.diabetesjournals.org/content/56/7/1751
The Effect of an Aqueous Extract of Teucrium polium on Glutathione Homeostasis In Vitro: A Possible Mechanism of Its...
... glutathione redox state; and (3) glutathione peroxidase and glutathione reductase activities using a repeated measures ... The effects of an aqueous extract of T. polium on cellular integrity, glutathione redox state, and the activities of GPx and GR ... polium maintains intracellular glutathione levels by augmenting glutathione peroxidase and glutathione reductase activity in ... The Effect of an Aqueous Extract of T. polium on the Activities of Glutathione Peroxidase and Glutathione Reductase. Over the ...https://www.hindawi.com/journals/aps/2010/938324/
Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced bytert-butyl hydroperoxide |...
Experiment 2. Protective effect of Se-MeSeCys on the activity of glutathione peroxidase (GPx) and glutathione reductase (GR). ... and thioredoxin reductase, which are known to protect cellular components from oxidative damage [1, 2]. Although these ... and activity of the antioxidant enzymes glutathione peroxidase (GPx) and glutathione reductase (GR)-were evaluated. ... evaluation of the activity of the antioxidant enzymes GPx and glutathione reductase (GR) and determination of malondialdehyde ( ...https://link.springer.com/article/10.1007%2Fs00216-007-1626-z
Antiapoptotic Actions of Methyl Gallate on Neonatal Rat Cardiac Myocytes Exposed to H2O2
... cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a ... Open Access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of ... cellular basis is intimately linked to aging, cardiovascular disease, cancer, immune function, metabolism and neurodegeneration ... Oxidative Medicine and Cellular Longevity is a unique peer-reviewed, ...https://www.hindawi.com/journals/omcl/2014/657512/
Breeding drought tolerant cowpea: constraints, accomplishments, and future prospects | SpringerLink
... the antioxidative response in the form of superoxide reductase (SOD), glutathione reductase (GR), ascorbate peroxidase (AP), ... an integrated approach which combines cellular water relations, rooting characteristics, leaf area and biochemical and ... 2004). As mentioned in Table 2, genes involved in ABA biosynthesis, ascorbate peroxidase, glutathione reductase and transferase ... 2000). Among the detoxification systems two enzymes, glutathione reductase (GR) and ascorbate peroxidase (APX), play key roles ...https://link.springer.com/article/10.1007%2Fs10681-009-9893-8?LI=true
Response of antioxidant systems in oxygen deprived suspension cultures of rice ( Oryza sativa L.) | Springer for Research &...
... ascorbate peroxidase (APX), and glutathione reductase which occur in cells of rice plants exposed to anoxia stress in two ... Abiotic stresses have been reported to adversely affect cell division, damage cellular and organelle membranes. The signaling ... Goldberg DM, Spooner RJ (1983) Glutathione reductase. In: Bergmeyer HU (ed) Methods of enzymatic analysis, vol 3. Basel, pp 258 ... Peng M, Kuc J (1992) Peroxidase-generated hydrogen peroxide as a source of antifungal activity in vitro and on tobacco leaf ...https://rd.springer.com/article/10.1007/s10725-012-9668-4
Properties of Flavonoids Isolated from the Bark of Eysenhardtia polystachya and Their Effect on Oxidative Stress in...
... cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a ... Open Access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of ... cellular basis is intimately linked to aging, cardiovascular disease, cancer, immune function, metabolism and neurodegeneration ... Oxidative Medicine and Cellular Longevity is a unique peer-reviewed, ...https://www.hindawi.com/journals/omcl/2016/9156510/abs/
Redox Signaling as a Therapeutic Target to Inhibit Myofibroblast Activation in Degenerative Fibrotic Disease
We observed downregulation of the Se transporter SEPP1 and Se-containing ROS scavengers glutathione peroxidase 3 (GPX3) and ... T. A. Wynn, "Cellular and molecular mechanisms of fibrosis," Journal of Pathology, vol. 214, no. 2, pp. 199-210, 2008. View at ... M. S. Crane, A. F. Howie, J. R. Arthur, F. Nicol, L. K. Crosley, and G. J. Beckett, "Modulation of thioredoxin reductase-2 ... A key role for macrophages and transforming growth factor β (TGF-β)," Molecular and Cellular Endocrinology, vol. 124, no. 1-2, ...https://www.hindawi.com/journals/bmri/2014/131737/
An Overview of Seasonal Changes in Oxidative Stress and Antioxidant Defence Parameters in Some Invertebrate and Vertebrate...
... glutathione peroxidase; GR, glutathione reductase; , superoxide radicals; GSH, reduced glutathione; GSSG, oxidized glutathione. ... Figure 1: Schematic representation of cellular production of ROS, their impact on biomolecules, and their metabolism by ... Glutathione reductase (GR) plays a major role in generating reduced glutathione from oxidized glutathione by oxidizing NADPH. ... J. W. Eaton and J. W. Eaton, "Catalase, glutathione peroxidase and hydrogen peroxidase," Journal of Laboratory and Clinical ...https://www.hindawi.com/journals/scientifica/2016/6126570/
Cyclosporine-assisted adipose-derived mesenchymal stem cell therapy to mitigate acute kidney ischemia-reperfusion injury | Stem...
Expressions of antioxidant biomarkers at cellular (glutathione peroxidase, glutathione reductase, heme oxygenase-1 (HO-1)) and ... and cellular (CD68+) levels of IR kidney showed a similar pattern compared with that of creatinine in all groups (all P <0.05 ... Expressions of antioxidant biomarkers at cellular (glutathione peroxidase, glutathione reductase, heme oxygenase-1 (HO-1)) and ... Moreover, our IHC labeling technique was adopted to identify glutathione peroxidase (GPx)-positive, glutathione reductase (GR)- ...https://stemcellres.biomedcentral.com/articles/10.1186/scrt212