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*  Mechanism of transfusion-related acute lung injury induced by HLA class II antibodies | Blood Journal
These findings indicate that HLA class II antibodies can bind to their cognate antigen(s) on the surface of monocytes and lead ... It is generally thought, although unproven, that either receptor cross-linking or direct activation of the receptor may lead to ... Oxidant-induced endothelial leak correlates with decreased cellular energy levels. Am Rev Respir Dis 1990;141(1):134-140. ... This finding was corroborated by a subsequent report on the release of leukotriene B4 (LTB4) from antigen-positive monocytes ...
  http://www.bloodjournal.org/content/117/2/669?sso-checked=true
*  NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration
... leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules. ... and antagonizing released cytokine products and/or their cognate receptors. To better understand how inflammasome formation is ... As a cellular property, the inflammasome is a powerful double-edged sword. Insufficient activation makes the immune system ... the latter of which is largely controlled by the membrane-bound degradation enzyme, neprilysin [62, 63]. Aβ's intrinsic ...
  https://www.hindawi.com/journals/mi/2015/690243/
*  Download The Narrow Path Of Freedom And Other Essays 2002
AND UNDERSTANDING 2013 repeats are Leukotrienes in the geometry overexpression or receptor receptors in the key response. These ... HRR receptors first in Binding both adaptive sets that form at ion transcription chains and light chains making in S or G2- ... The due project heterodimers of SUMO1, SUMO2, and SUMO3 initiate app that have cellular membrane antitumor families at the C- ... but their donor cognate result allows conserved and independently capping internalizes annotated when dolichyl-phospho-mannose ...
  http://erik-mill.de/books/download-The-Narrow-Path-of-Freedom-and-Other-Essays-2002.php
*  Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation
... leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules. ... SDC4 binds to fibroblast growth factors (FGF) and brings them to the FGF receptors on the cell surface. SDC4 is also a mediator ... it inhibited shedding of cognate substrates of ADAM17 (TNFα, TGFα, AREG, HB-EGF, and tumor necrosis factor receptor 1 (TNFR1) ... exosite-binding inhibitors have been made that spare TGF-alpha processing but inhibit other cellular shedding events. In ...
  https://www.hindawi.com/journals/mi/2017/9673537/
*  Chemokines (CCL3, CCL4, and CCL5) Inhibit ATP-Induced Release of IL-1β by Monocytic Cells
... leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules. ... Chemokines CCL3, CCL4, and CCL5 are known agonists of chemokine receptors CCR1, CCR3, and CCR5 [12]. CXCL16 binds to receptor ... These IC50 values are in the range of the EC50 values typical for the activation of their cognate receptors. CCL3 was selected ... we predict a prioritization of the chemotactic signal that enables cellular infiltration of the inflamed tissue but prevents IL ...
  https://www.hindawi.com/journals/mi/2017/1434872/
*  An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation
... leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules. ... Id2, inhibitor of DNA binding-2; Gata-3, Gata-binding protein 3; RORα, retinoic acid receptor-related orphan receptor-α; Eomes ... that are known to mediate NK cell cytotoxicity and production of cytokines upon recognition of cognate cellular and viral ... Following ligand binding, AhR dissociates from the chaperones and translocates to the nucleus, where it binds to its ...
  https://www.hindawi.com/journals/mi/2014/235460/
*  Eicosanoid receptor - Wikipedia
CysLT1 (Cysteinyl leukotriene receptor 1) - CYSLTR1;CYSLTR1 is the receptor for Leukotriene C4 and Leukotriene D4; in binds and ... Relaxant prostanoid receptors (IP, DP1, EP2, and EP4) raise cellular cAMP levels; contractile prostanoid receptors (TP, FP, and ... metabolize arachidonic acid to an eicosanoid which then binds cognate receptors on either its parent cell (acting as an ... Leukotriene B4 receptor) - LTB4R; BLT1 is the primary receptor for leukotriene B4. Relative potencies in binding to and ...
  https://en.wikipedia.org/wiki/Eicosanoid_receptor
*  OXGR1 - Wikipedia
GPR99 binds as is activated by LTE4 at concentrations far lower than the other major CysLT receptors, Cysteinyl leukotriene ... G protein-coupled receptor list: recommendations for new pairings with cognate ligands". Pharmacological Reviews. 65 (3): 967- ... Recent studies implicate GPR99 as a cellular receptor which is activated by LTE4 thereby causing these cells to contribute to ... the drug does not block the cysteinyl leukotriene receptor 2) (see cysteinyl leukotriene receptor 1#Clinical significance). The ...
  https://en.wikipedia.org/wiki/OXGR1
*  Download Terror, Terrorism, And The Human Condition 2004
separation VI triggers the most S67 binding promoter harboring ryanodine condition, an calcium submitted from its Binding with ... and membrane of cellular acids of formation, which serves increased from damage during cellular Virus and transports signaling ... DNA urea is loaded at clear receptors via ORC diseases. download Terror, Terrorism, and the Human 2008 includes adhesion to the ... The lead of the antimicrobial interconversion leukotriene into a biological cytoskeleton remains intended by the loop of type ...
  http://familie-walther.eu/photos/books/download-Terror%2C-Terrorism%2C-and-the-Human-Condition-2004.php
*  Patent US7455853 - Medical devices containing rapamycin analogs - Google Patents
... agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix ... Other examples of these agents include those that inhibit binding of cytokines or chemokines to the cognate receptors to ... In addition, these compounds antagonize cellular responses to several growth factors, and therefore possess antiangiogenic ... diseases caused by histamine or leukotriene-C4 release; Behcet's disease such as intestinal-, vasculo- or neuro-Behcet's ...
  http://www.google.com/patents/US7455853?dq=7,682,496
*  LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS - Patent application
LPA binding to its cognate GPCRs (LPA1, LPA2, LPA3, LPA4, LPA5, LPA6) activates intracellular signaling pathways to produce a ... leukotriene receptor antagonists, leukotriene formation inhibitors, leukotriene modulators, nasal decongestants, respiratory ... 0154] The cellular responses to LPA are mediated through the lysophosphatidic acid receptors. For example, LPA receptors ... TABLE-US-00002 TABLE 2 Compound LPA1 Binding LPA2 Binding LPA3 Binding No. IC50 IC50 IC50 1 A A A 2 A A A 3 A A A 4 A A A 5 A A ...
  http://www.patentsencyclopedia.com/app/20120258987
*  The Multiple Personalities of the Chemokine Receptor CCR7 in Dendritic Cells | The Journal of Immunology
Binding of the chemokine SLC/CCL21 to its receptor CCR7 increases adhesive properties of human mesangial cells. Kidney Int. 66 ... it also increases concomitantly the probability of productive interactions between Ag-loaded DCs and cognate T cells (24). In ... concomitantly increase the magnitude of the cellular immune response (29). In contrast, premature induction of DC death leads ... responses in the DCs for CCL19 or CCL21 are in line with other reports that show that the knocking down of the leukotriene C (4 ...
  http://www.jimmunol.org/content/176/9/5153
*  Plus it
... and the UL16-binding proteins (ULBP). While the cognate NKG2D receptor is normally associated with natural killer (NK) cells ... Interferon-gamma up-regulates expression of cysteinyl leukotriene type 2 receptors on eosinophils in asthmatic patients. Chest ... Damage-associated molecular patterns and cytotoxic cellular receptors. Study of eosinophil recruitment in solid tumors has ... cytokine receptors, immunoglobulin receptors, Toll-like pattern recognition receptors (TLR, PRR), and siglec-lectin receptors ( ...
  http://cancerimmunolres.aacrjournals.org/content/2/1/1
*  PAR Receptors - Page 2 - Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors
... whether Ivy may be carrying out additional cellular functions beyond c-type lysozyme binding. One interesting phenotypic ... well-defined functions DppA and OppA serve to bind peptides in the periplasm and transfer these nutrients to their cognate ABC ... leukotrienes) substances mediates many areas of asthma pathology [18 19 20 21 Eosinophil-independent systems can be found and ... The RNA binding protein Larp1 was originally shown to be involved * The androgen receptor (AR) cofactor p44/WDR77, which ...
  http://rectalcancersite.com/category/par-receptors/page/2/
*  Oxysterols are allosteric activators of the oncoprotein Smoothened.
Smo binds to nat-20(S)-OHC immobilized on beads Our pharmacological analyses suggested that Smo was the receptor for nat-20(S)- ... Most protein binding sites are exquisitely chiral and thus enantioselective for their cognate ligands. Though membrane lipids ... Oxysterols can induce the dramatic accumulation of Smo in the primary cilium15, a key change in sub-cellular localization that ... 10804983 - Pranlukast, a cysteinyl leukotriene antagonist, reduces serum eosinophil cationic prote.... 16660413 - Evidence that ...
  http://www.biomedsearch.com/nih/Oxysterols-are-allosteric-activators-oncoprotein/22231273.html
*  A Computational Approach to Finding Novel Targets for Existing Drugs
However, drugs are often able to bind to 'off-target' proteins due to similarities in the protein binding sites. If an off- ... We present here a large-scale computational approach that simulates three-dimensional binding between existing drugs and target ... Author Summary Most drugs are designed to bind to and inhibit the function of a disease target protein. ... non-cognate docking) because in the former case the protein is already in a specific ligand-bound conformation. Cognate-docking ...
  http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002139
*  Hypertonic Mannitol Loading of NF-κB Transcription Factor Decoys in Human Brain Microvascular Endothelial Cells Blocks...
Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia. Stroke. 1992;23:1337-1348. ... Excessive amounts of this decoy competed for NF-κB binding to prevent its translocation and binding to the cognate sequence in ... Inhibition of phorbol ester-induced cellular adhesion by competitive binding of NF-kB in vivo. Mol Cell Biol. 1993;13:6530-6536 ... Binding reactions were initiated by mixing 17 μL of binding buffer (Stratagen GelShift Assay kit), 5μL of protein extract ( ...
  http://stroke.ahajournals.org/content/31/5/1179
*  P2Y<sub>12</sub> receptor | P2Y receptors | IUPHAR/BPS Guide to...
P2Y receptors. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets. ... 2001) ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. J. Biol. Chem., 276 (11): 8608-15. [PMID: ... 2014) Agonist-bound structure of the human P2Y12 receptor. Nature, 509 (7498): 119-22. [PMID:24784220] ... receptor responsiveness to cysteinyl leukotrienes. PLoS ONE, 8 (3): e58305. [PMID:23472176] ...
  http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=328
*  T helper cell - Wikipedia
CD4, a co-receptor of the TCR complex, also binds to a different section of the MHC molecule. These interactions bring these ... "A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells". Proc Natl ... Cellular auto-immune disease occurs because the host antigen recognition systems fail, and the immune system believes, by ... and leukotriene to cause broncho-constriction, intestinal peristalsis, gastric fluid acidification to expel helminths. IL-5 ...
  https://en.wikipedia.org/wiki/T_helper_cell
*  Journal of Biological Chemistry | ACS Division of Biological Chemistry Website
After rundown of the Ca2+ signals following leukotriene receptor activation, stimulation of P2Y receptors evoked prominent ... Mechanistically, Bhlhe40 binds to the proximal E-boxes of Myogenin promoter and reduces the binding affinity and ... In cellular membranes, different lipid species are heterogeneously distributed forming domains with different characteristics. ... Our lab has shown that membrane heterogeneity affects the organization of cytochrome P450s and their cognate redox partner, the ...
  http://www.divbiolchem.org/category/publications/journal-of-biological-chemistry/page/46/
*  Chapter 317. Allergies, Anaphylaxis, and Systemic Mastocytosis | Harrison's Principles of Internal Medicine, 18e |...
Fc receptor for IgE, designated FcϵRI, also stabilizes the cellular expression of the receptor. FcϵRI is composed of one α, one ... Two receptors for LTB4, BLT1 and BLT2, mediate chemotaxis of human neutrophils. Two receptors for the cysteinyl leukotrienes, ... FK506 reveal binding to the ligand-specific immunophilin and attenuation of the calcium ion- and calmodulin-dependent serine/ ... The T cell response depends both on cognate recognition and on the cytokine microenvironment provided by the antigen-presenting ...
  http://accessmedicine.mhmedical.com/content.aspx?bookid=331§ionid=40727118
*  4 Information Related to Biologic Plausibility | Veterans and Agent Orange: Update 2008 | The National Academies Press
Receptor binding may result in release of other cytoplasmic proteins that alter the expres- sion or activity of other cell- ... Leukotriene A4 metabolites are endogenous ligands for the Ah receptor. Biochemistry 47(32):8445â 8455. Cohen SM, Arnold LL, ... â ¢ Elucidation of crosstalk between the AHR and receptors involved in regulation of cellular responses to stress (Burchiel et ... This heterodimer binds to its cognate DNA motifs and recruits the macromolecular complexes needed to initiate gene ...
  https://www.nap.edu/read/12662/chapter/6
*  T helper cell - Wikipedia
CD4, a co-receptor of the TCR complex, also binds to a different section of the MHC molecule. These interactions bring these ... "A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells". Proc Natl ... Cellular immune system. Maximizes the killing efficacy of the macrophages and the proliferation of cytotoxic CD8+ T cells. Also ... and leukotriene to cause broncho-constriction, intestinal peristalsis, gastric fluid acidification to expel helminths. IL-5 ...
  https://en.m.wikipedia.org/wiki/T_helper_cell
*  Frontiers | Mast Cells as Cellular Sensors in Inflammation and Immunity | Immunology
It appears that they have evolved as cellular sensors to discern their environment in order to initiate an appropriate ... It appears that they have evolved as cellular sensors to discern their environment in order to initiate an appropriate ... in adaptive immunity via the expression of Fc receptors that function as signaling modules that relay the antigen binding ... Mast cells also contribute to smooth muscle contractions either directly via prostaglandins and leukotrienes or via the ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2011.00037/full
*  Protocols and Video Articles Authored by Hong He (Translated to Hindi)
Binding of Gamide to the cholecystokinin-2 receptor activates small GTP-binding proteins of the Rho family (Rho, Rac, and Cdc42 ... Sep, 2005 , Pubmed ID: 16160912 Therapy for asthma often includes the combined use of glucocorticoids and leukotriene receptor ... Here we describe a form of evasion wherein the CD8(+) T cells are fully capable of recognizing their cognate antigen but their ... These effects of ARAP3 required a functional Rho GAP domain and were associated with reduced cellular levels of active RhoA and ...
  https://www.jove.com/author/Hong_He?language=Hindi