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*  Phenotypic Definition of the Progenitor Cells with Erythroid Differentiation Potential Present in Human Adult Blood
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... "Human erythroid cells produced ex vivo at large scale differentiate into red blood cells in vivo," Nature Biotechnology, vol. ... cells mostly BFU-E (87%) and and cells were not tested due to low numbers. Under HEMA conditions, , , and cells generated EBs ...
  https://www.hindawi.com/journals/sci/2011/602483/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Cellular Biology, Issue 53, Human hematopoietic stem cells, erythropoiesis, red blood cells, lentivirus, knockdown, ... These cells are pluripotent meaning they have the capacity to differentiate into all cell lineages 1. Both hMSCs and iPS cells ... erythroid cells at given stages of differentiation 3-5. However transformed cell lines can only partially mimic erythroid cells ... cells, human mesenchymal stem cells (hMSC) and induced pluripotent stem (iPS) cells. HEK 293 cells are derived from human ...
  https://www.jove.com/visualize/abstract/20169072/soluble-erythropoietin-receptor-contributes-to-erythropoietin
*  Stem cell Research
... red blood cells are specifically designed to carry oxygen through the blood. All humans start out as only one cell. This cell ... This process is called differentiation. Stem cells are cells that haven't differentiated yet. They have the ability to divide ... it can either remain a stem cell or turn into a differentiated cell, such as a muscle cell or a red blood cell. ... Stem cell Research. Stem cells are undifferentiated, or "blank," cells. This means they're capable of developing into cells ...
  https://www.omicsonline.org/conferences-list/stem-cell-research
*  Cellular differentiation - Wikipedia
... cells in an adult human has its own copy or copies of the genome except certain cell types, such as red blood cells, that lack ... Such cells, called somatic cells, make up most of the human body, such as skin and muscle cells. Cells differentiate to ... Hematopoietic stem cells (adult stem cells) from the bone marrow that give rise to red blood cells, white blood cells, and ... The cells of the inner cell mass go on to form virtually all of the tissues of the human body. Although the cells of the inner ...
  https://en.wikipedia.org/wiki/Cellular_differentiation
*  Optical stretcher - Wikipedia
... red blood cells and different types of white blood cells. In this study, it was shown that the white blood cell types show ... Hematopoietic stem cells residing in the bone marrow differentiate into different types of blood cells to produce human blood ... An exemplary study in stem cell research sheds light on the process of cell differentiation: ... 2012). "Viscoelastic Properties of Differentiating Blood Cells Are Fate- and Function-Dependent". PLoS ONE. 7 (9): e45237. ...
  https://en.wikipedia.org/wiki/Optical_stretcher
*  Study redefines how stem cells make blood - The San Diego Union-Tribune
... says study with implications for understanding how blood cancers form. ... Hematopoiesis takes fewer steps from stem cell to adult blood cells than standard theory, ... The study proposes that hematopoietic stem cells take only a few steps to differentiate into adult red and white blood cells. ... A model of the changes in human My-Er-Mk differentiation across developmental time points. The standard model is shown at top ...
  http://www.sandiegouniontribune.com/business/biotech/sdut-blood-stem-cells-notta-hematopoietic-dick-2015nov05-htmlstory.html
*  NIGMS Funds New Stem Cell Centers
... to genetically modify stem cells and will study the molecular signals that cause them to differentiate into red blood cells.. ... differentiation and genetic alteration of human embryonic stem cells. The group will focus on developing methods ... More information about NIGMS initiatives related to human embryonic stem cells is available at Stem Cell Initiatives. More ... Human embryonic stem cells have properties that make them uniquely valuable for studying virtually any cellular process. ...
  https://www.nigms.nih.gov/News/results/Pages/08092005.aspx
*  Monocyte - Wikipedia
Monocytes are a type of leukocyte, or white blood cell. They are the largest type of leukocyte and can differentiate into ... and differentiation into macrophages or dendritic cells to effect an immune response. In an adult human, half of the monocytes ... immune-mediated disease granulomatous disease atherosclerosis necrosis red blood cell regeneration viral fever sarcoidosis A ... 2010). "Nomenclature of monocytes and dendritic cells in blood". Blood. 116 (16): e74-e80. doi:10.1182/blood-2010-02-258558. ...
  https://en.wikipedia.org/wiki/Monocyte
*  Kupffer cell - Wikipedia
There they complete their differentiation into Kupffer cells. Red blood cells are broken down by phagocytic action, where the ... CRIg is conserved in mice and humans and is a critical component of the innate immune system. Kupffer cell activation is ... Their development begins in the yolk sac where they differentiate into fetal macrophages. Once they enter the blood stream, ... Cell. 124 (5): 915-27. doi:10.1016/j.cell.2005.12.039. PMID 16530040. Michael D. Wheeler (2004). "Endotoxin and Kupffer Cell ...
  https://en.wikipedia.org/wiki/Kupffer_cell
*  Hematopoiesis from Pluripotent Stem Cells | Thermo Fisher Scientific - DE
Explore hematopoiesis from pluripotent stem cells and find antibodies to detect some of its target proteins, including IL-3, GM ... hematopoietic stem cells differentiate into red blood cells, white blood cells, platelets). Unipotent cells produce only one ... muscle stem cells). During blood-cell development, pluripotent HSC undergo either self-renewal or differentiation into ... Pluripotent cells are capable of forming virtually all of the possible tissue types found in human beings. Multipotent stem ...
  http://www.thermofisher.com/de/de/home/life-science/antibodies/antibodies-learning-center/antibodies-resource-library/cell-signaling-pathways/hematopoiesis-pluripotent-stem-cells.html
*  Factor found to balance medically useful stem cell qualities
A key protein controls stem cell properties that could make them more useful in regenerative medicine, according to a study led ... time to turn them into replacements for say misshapen red blood cells seen in sickle cell anemia or abnormal white blood cells ... Since 2006, researchers have been able of take differentiated specialized cells, like skin cells, and transform them into ... which are good cell models for the study of processes seen in human stem cells. ...
  https://www.medicalnewstoday.com/releases/301843.php
*  Toward a Better Understanding of Blood Cell Differentiation | Cell And Molecular Biology
Publishing in Nature, their work chall , Cell And Molecular Biology ... Researchers at ETH Zurich used a cutting edge microscopy technique to investigate how stem cells become blood cells. ... red blood cells transport oxygen while white blood cells play a major role in the immune system. How exactly stem cells are ... in a process called differentiation. Stem cells are less differentiated, and are what gives rise to the various specific cell ...
  https://www.labroots.com/trending/cell-and-molecular-biology/3692/understanding-blood-cell-differentiation
*  N-methyl-d-aspartate receptors in human erythroid precursor cells and in circulating red blood cells contribute to the...
... was previously shown in rat red blood cells (RBCs) and in a UT-7/Epo human myeloid cell line differentiating into erythroid ... mortality of cells at the stage of basophilic and polychromatic erythroblasts (Fig. 3B). Cells at later differentiation stages ... Ion channels in human red blood cell membrane: actors or relics? Blood Cells Mol Dis 46: 261-265, 2011. ... Stimulation of human red blood cells leads to Ca2+-mediated intercellular adhesion. Cell Calcium 50: 54-61, 2011. ...
  http://ajpcell.physiology.org/content/305/11/C1123
*  Propofol at Clinically Relevant Concentrations Increases Neuronal Differentiation But Is Not Toxic to Hippocampal Neural...
Propofol in whole blood is largely bound to red blood cells and albumin, leaving only about 1-3% free in the plasma for ... Increasing doses of propofol exposure for 6 h under differentiating conditions caused cell damage and release of lactate ... the dose of propofol required in rodents is higher than that required in humans to achieve an equal level of anesthesia. All of ... in differentiating precursor cells. Neural precursor cells were plated in differentiation medium with propofol for 6 h, then ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1925970
*  Phys.org - liver(... continued page 6)
Embryonic stem cells (ESCs) have the potential to form more than 200 distinct cell types in the human body. Although ESCs can ... Erythropoietin (EPO)-a key regulator of red blood cell production-is widely used for treating certain cancers and anemia ... Minimizing the cellular contaminants that plague the differentiation of pluripotent stem cells. ... differentiate into any specialized tissue, scientists are still unsure of how to coax these pluripotent ... ...
  https://phys.org/tags/liver/page6.html
*  JCI - Pharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model
Stained red blood cells were imaged and divided into 4 differentiation stages: stage I, basophilic erythroblast; stage II, ... Undifferentiated and differentiated red blood cells were identified and counted according to their staining pattern and ... U2OS cells (human bone osteosarcoma cells) were stably transfected with pTol2-Luc, pTol2-hif1aa 5′UTR-Luc, pTol2-hif1ab 5′UTR- ... and red blood cell production. Currently, there are no effective treatments available for VHL disease. Here, using an animal ...
  https://www.jci.org/articles/view/73665
*  Stem Cell Basics by Mai2xs - issuu
Title: Stem Cell Basics, Author: Mai2xs, Name: Stem Cell Basics, Length: 8 pages, Page: 1, Published: 2008-04-02 ... Hematopoietic stem cell - A stem cell from which all red and white blood cells develop. Human embryonic stem cell - A type of ... D. How are embryonic stem cells stimulated to differentiate?. Figure 1. Directed differentiation of mouse embryonic stem cells ... cardiac muscle cells and skeletal muscle cells. Brain stem cells may differentiate into: blood cells and skeletal muscle cells ...
  https://issuu.com/mai2xs/docs/stem_cell_basics
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Stem Cell Biology, Issue 61, Human embryonic stem cells, Endothelial cells, Pancreatic differentiation, Co-culture ... differentiate into oligopotent progenitors, committed precursors and mature red blood cells 1. This process is regulated for a ... Cellular Biology, Issue 53, Human hematopoietic stem cells, erythropoiesis, red blood cells, lentivirus, knockdown, ... Endothelial Cell Co-culture Mediates Maturation of Human Embryonic Stem Cell to Pancreatic Insulin Producing Cells in a ...
  https://www.jove.com/visualize/abstract/22022577/nuclear-grp75-binds-retinoic-acid-receptors-to-promote-neuronal
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Cellular Biology, Issue 53, Human hematopoietic stem cells, erythropoiesis, red blood cells, lentivirus, knockdown, ... The in vitro differentiation of ES cells towards a hematopoietic cell fate is useful when studying cell populations that are ... differentiate into oligopotent progenitors, committed precursors and mature red blood cells 1. This process is regulated for a ... and In vivo Monitoring of Human NK Cells from Human Embryonic Stem Cells (hESCs) and Induced Pluripotent Stem Cells (iPSCs) ...
  https://www.jove.com/visualize/abstract/23349713/co-culture-hematopoietic-stemprogenitor-cells-with-human-osteblasts
*  Hematopoietic stem cell niche - Wikipedia
Many human blood cells, such as red blood cells (RBCs), immune cells, and even platelets all originate from the same progenitor ... There are 2 types of hematopoiesis that occur in humans: Primitive hematopoiesis - blood stem cells differentiate into only a ... Hematopoiesis involves a series of differentiation steps from one progenitor cell to a more committed cell type, forming the ... cell, the hematopoietic stem cell (HSC). As these cells are short-lived, there needs to be a steady turnover of new blood cells ...
  https://en.wikipedia.org/wiki/Hematopoietic_stem_cell_niche
*  Stem cell transplantation for articular cartilage repair - Wikipedia
... red blood cells, platelets, and nucleated cells. The adult stem cell fraction is present in the nucleated cells of the marrow. ... "Ex vivo expansion and pluripotential differentiation of cryopreserved human bone marrow mesenchymal stem cells". J Zhejiang ... Most of these cells are CD34+ heme progenitors (destined to differentiate into blood components), while very few are actually ... Most of the adult bone marrow consists of blood cells in various stages of differentiation. These marrow components can be ...
  https://en.wikipedia.org/wiki/Stem_cell_transplantation_for_articular_cartilage_repair
*  Structural Biochemistry/Nucleic Acid/DNA/Transgenic Animals - Wikibooks, open books for an open world
... red blood cells, etc. Mesenchymal stem cells actually produce a whole variety of cell types including bone cells, fat cells, ... such as heart muscle cells differentiating into brain cells. This type of differentiation is better known as ... Ethical conflicts with stem cells?. The main concern with stem cells has to do with the human embryonic stem cells, which has ... a white blood cell, brain cell, etc.. How are stem cells set apart from other types of cell?. There are two primary properties ...
  https://en.wikibooks.org/wiki/Structural_Biochemistry/Nucleic_Acid/DNA/Transgenic_Animals
*  High mobility group box 1 orchestrates tissue regeneration via CXCR4 | JEM
After incubation with red blood cell lysis buffer (Z314; Promega), cells were preplated on one 150-mm uncoated dish for 2 h. ... C1q and HMGB1 reciprocally regulate human macrophage polarization. Blood. 128:2218-2228. doi:10.1182/blood-2016-05-719757. ... For the differentiation assay, cells were plated after 4 d in culture on Matrigel-coated slides in 12-well plates (105 cells/ ... On injury, satellite cells get activated, proliferate, differentiate, and fuse to form new myofibers. To further investigate ...
  http://jem.rupress.org/content/215/1/303
*  Division of Hematology: Research: Janis L. Abkowitz
A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319:825-828, 2008 ... Catlin SN, Busque L, Gale R, Guttorp P and Abkowitz JL The replication rate of human hematopoietic stem cells in vivo. Blood ... Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones ... Abkowitz s research is understanding the molecular and cellular events that control red cell differentiation. Given her recent ...
  http://depts.washington.edu/hemeweb/research/abkowitz.htm
*  1.3 Cell Differences (p40-43) Cell Development All cells start their
Specialized Cells Structure and Function Muscle Cells Nerve Cells (Neurons) Red Blood Cells Bone Cells Skin Cells ... Cell Differentiation ___________________________________________: This is the series of events through which ... They might be used to _____________________ or _____________________damaged tissues in humans. Specialized Cells Each different ... Scientists are very interested in studying how stem cells differentiate. ...
  https://studyres.com/doc/8097308/1.3-cell-differences--p40-43--cell-development-all-cells-