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*  Haller Main - Medizinische Universität Innsbruck
... in surfactant secreting pulmonary alveolar type II pneumocytes. Dietl, P., Haller, T., and Frick, M. Cell calcium 52, 296-302 ... 2014: Nontoxic impact of PEG-coated gold nanospheres on functional pulmonary surfactant-secreting alveolar type II cells. ... Stem Cells Differentiate into Functional Alveolar Type II-Like Cells that Synthesize and Secrete Pulmonary Surfactant Complexes ... immortalized mouse type II and isolated rat alveolar type II cells. Wemhoner, A., Jennings, P., Haller, T., Rudiger, M., and ...
  https://www.i-med.ac.at/dpmp/physiologie/research/haller/
*  Alveolar macrophage - Wikipedia
... cells that form the structure of an alveolar wall. Type II pneumocyte (Great Alveolar) cells that secrete pulmonary surfactant ... There are three major alveolar cell types in the alveolar wall (pneumocytes): Type I pneumocyte (Squamous Alveolar) ... An alveolar macrophage (or dust cell) is a type of macrophage found in the pulmonary alveolus, near the pneumocytes, but ... The lungs are especially sensitive and prone to damage, thus to avoid collateral damage to type 1 and type II pneumocytes, ...
  https://en.wikipedia.org/wiki/Alveolar_macrophage
*  Perinatal Physiology - Pediatrics - Merck Manuals Professional Edition
The lungs continually produce fluid-a transudate from pulmonary capillaries plus surfactant secreted by type II pneumocytes. ... However, neonatal T cells do not function as effectively as adult T cells. For example, neonatal T cells may not respond ... Fairly well-developed alveoli and type II surfactant-producing pneumocytes are present around the 25th wk and continue to ... and 4 surface-active proteins all stored in lamellar inclusions in type II pneumocytes, reduces high surface tension, which ...
  http://www.merckmanuals.com/en-ca/professional/pediatrics/perinatal-physiology/perinatal-physiology
*  Pulmonary surfactant | definition of pulmonary surfactant by Medical dictionary
What is pulmonary surfactant? Meaning of pulmonary surfactant medical term. What does pulmonary surfactant mean? ... Looking for online definition of pulmonary surfactant in the Medical Dictionary? pulmonary surfactant explanation free. ... pulmonary surfactant. A lipoprotein secreted by type II alveolar cells that decreases the surface tension of the fluid lining ... It is during this stage that type II pneumocytes increase production of pulmonary surfactant Lung development continues for ...
  https://medical-dictionary.thefreedictionary.com/pulmonary+surfactant
*  Exam III Flashcards by Antonio White | Brainscape
What pulmonary cells secrete surfactant? Clara cells and type II alveolar cells. ... they serve as stem cells for type I and type II pneumocytes ... What two types of cells are present at the islets of langerhan ... recognize peptide fragments of foreign proteins bound to MHC class II on the surface of cells. ... it is used for stimulation of dendritic cells needed for the maturation of single positive T cells. ...
  https://www.brainscape.com/flashcards/exam-iii-4609546/packs/6402534
*  Pulmonary surfactant - Wikipedia
Pulmonary surfactant is a surface-active lipoprotein complex (phospholipoprotein) formed by type II alveolar cells. The ... or reabsorbed into the lamellar structures of type II pneumocytes. Up to 90% of surfactant DPPC (dipalmitoyl ... Alveolar surfactant has a half life of 5 to 10 hours once secreted. It can be both broken down by macrophages and / ... There are a number of types of pulmonary surfactants available. Synthetic pulmonary surfactants Colfosceril palmitate (Exosurf ...
  https://en.wikipedia.org/wiki/Pulmonary_surfactant
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
This study demonstrates localization of LCAD to human alveolar type II pneumocytes, which synthesize and secrete pulmonary ... Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types, and in engineered cells ... The changes in lung mechanics were found to be due to pulmonary surfactant dysfunction. Large aggregate surfactant isolated ... in apoptotic cells (neurons, pulmonary artery endothelial cells) and mouse lung under inflammatory/oxidative stress conditions ...
  https://www.jove.com/visualize?author=Yulia+Y+Tyurina
*  3β-Hydroxysteroid dehydrogenase - Wikipedia
This is significant because cortisol induces type II pneumocytes of the lungs to synthesize and secrete pulmonary surfactant; ... of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells". J. Biol. ... type I) and HSD3B2 (type II). The type I isoenzyme is expressed in placenta and peripheral tissues, whereas the type II 3β-HSD ... A deficiency in the type II form through mutations in HSD3B2 is responsible for a rare form of congenital adrenal hyperplasia. ...
  https://en.wikipedia.org/wiki/3%CE%B2-Hydroxysteroid_dehydrogenase
*  Tissue Differentiation of ESC into Lung Cells and Functional Validation | Springer for Research & Development
Of these, the alveolar epithelial gas exchange surface consists of two cell... ... The pulmonary system is composed of a variety of epithelial cell populations residing in distinct anatomical locations. ... the type I and type II pneumocytes, also known as alveolar epithelial type I and type II (AEI and AEII) cells, that comprise ~ ... Functions of AEII cells include the secretion and reuptake of pulmonary surfactant (Fehrenbach 2001), regulation of alveolar ...
  https://rd.springer.com/chapter/10.1007/978-81-322-2053-4_4
*  Plus it
Type-II pneumocytes can proliferate and generate both type-II and type-I cells. Moreover, they can secrete a number of ... while mice transfection with soluble TGF type-II receptors significantly attenuates the degree of apoptosis and pulmonary ... molecules, such as surfactant-associated products, cytokines and growth factors, enzymes and matrix proteins 1. ... Alveolar epithelial cells. Alveolar epithelium contains a continuous layer of two cell types: the flattened type-I pneumocytes ...
  http://erj.ersjournals.com/content/32/6/1631
*  Idiopathic pulmonary fibrosis - Wikipedia
... pneumocytes), which line the majority of the alveolar surface. When type I AECs are damaged or lost, it is thought that type II ... the hyperplastic type II AECs die and the remaining cells spread and undergo a differentiation process to become type I AECs. ... Genetic associations include mutations in pulmonary surfactant proteins A1, A2, C (SFTPA1, SFTPA2B) and mucin (MUC5B). A ... fibroblasts accumulate in these areas of damage and differentiate into myofibroblasts that secrete collagen and other proteins ...
  https://en.wikipedia.org/wiki/Idiopathic_pulmonary_fibrosis
*  Frontiers | Biomarkers for Bronchopulmonary Dysplasia in the Preterm Infant | Pediatrics
... and overlapping symptoms with other diseases such as pulmonary hypertension (PH). Due to the current lack of effective ... and overlapping symptoms with other diseases such as pulmonary hypertension (PH). Due to the current lack of effective ... Differentiation of the epithelial cells into type I and II pneumocytes occurs, and type II cells begin to produce surfactant. ... is a glycoprotein preferentially expressed and secreted by type II pneumocytes and bronchial epithelial cells, whose expression ...
  https://www.frontiersin.org/articles/10.3389/fped.2016.00033/full
*  Lung tissue remodeling in the acute respiratory distress syndrome
... destruction of pneumocytes types I and II (PI and PII) and pulmonary surfactant denaturation, followed subsequently by alveolar ... The fibroblasts migrate to the injured areas and are stimulated to secrete collagen and other matrix proteins. These cells also ... There is proliferation of type II pneumocytes to cover the damaged epithelial surface, followed by differentiation into type I ... They are synthetized by many types of lung cells, including condroblasts, miofibroblasts and smooth muscle cells. (33) ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-35862003000400013&lng=es&nrm=iso
*  Pulmonary Histology Flashcards by Antonio White | Brainscape
Clara cells and type II alveolar cells secrete what? A surfactant. It reduces the surface tension on alveolar surfaces.. Type ... The basal lamina of which pneumocyte is sometimes fused with the basal lamina of nearby capillaries? ... Type I and Type II alveolar cells.. Type I covers the largest surface area.. Type II is cuboidal and serves as stem cells of ... You note that a particular type of cell is present as the ciliated columnar cells decrease. What type of cell have you found? ...
  https://www.brainscape.com/flashcards/pulmonary-histology-4486430/packs/6402534
*  Alveolar2 collapse | definition of alveolar2 collapse by Medical dictionary
a characteristic of pulmonary epithelial cells is their capacity to undergo metaplasia from one cell type to another. Called ... Their function is to secrete surfactant in response to injury and the renewal and repair of the alveolar wall. Called also ... Called also membranous pneumocytes. Type 2 cells are cuboidal and cover much less of the alveolar surface than do type 1 cells ... alveolar2 cell. cover the alveolar surface. Type 1 cells are flattened and extended, offering maximum opportunity for oxygen ...
  https://medical-dictionary.thefreedictionary.com/alveolar2+collapse
*  Acute Respiratory Distress Syndrome and Extracorporeal Membrane Oxygenation - Next Generation Combat Medic
Damage and death of the type II alveolar pneumocytes leads to surfactant issues, which further compromise alveolar gas exchange ... ARDS results from inflammation-associated increases in pulmonary vascular permeability, edema and epithelial cell death. The ... It activated by pneumocyte injury, which attracts the alveolar macrophages. In response, the macrophages secrete chemicals that ... There are several types of ECMO, but most likely, you will see two in the military on combat casualties. ...
  https://nextgencombatmedic.com/2017/08/25/acute-respiratory-distress-syndrome-and-extracorporeal-membrane-oxygenation/
*  Recombinant SP-A for the treatment or prevention of pulmonary infection and inflammation - Patent # 7135452 - PatentGenius
... thereon are useful for the prevention or treatment of pulmonary infection and inflammation. ... Recombinant surfactant protein A and pharmaceutical compositions based ... It is synthesized by alveolar type II pneumocytes and secreted as tightly packed lamellar bodies into the alveoli (King, R. J ... Surfactant protein A inhibits T cell proliferation via its collagen-like tail and a 210-kDa receptor. Oct. 1998, Am. J. Physiol ...
  http://www.patentgenius.com/patent/7135452.html
*  ACADL - Wikipedia
... this protein was shown to be localized to the human alveolar type II pneumocytes, which synthesize and secrete pulmonary ... Mice that were lacking LCAD (-/-) had dysfunctional or reduced amounts of pulmonary surfactant, which is required to prevent ... "Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5". Diabetes. 61 (1): 166-74. ... "Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction". The Journal of Biological ...
  https://en.wikipedia.org/wiki/ACADL
*  Fetal and neonatal samples of a precursor surfactant protein B inversely related to gestational age | BMC Pediatrics | Full Text
Pulmonary surfactant is synthesized by type II pneumocytes and secreted into the airways of the lung beginning at 24 weeks ... Cell-free plasma, urine and amniotic fluid were stored at -20°C until C-pro-SPB analysis. The samples were batched and run ... Determining surfactant proteins in body fluids may aid in monitoring the course of pulmonary diseases, such as pulmonary ... C-ProSP-B is a transient intermediate in the synthesis of SP-B that does not accumulate in type II pneumocytes [3]. ...
  https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-13-164
*  Preceptor Research Interest and Trainee Opportunities
The pulmonary surfactant is a mixture of phospholipids and protein synthesized, packaged, and secreted exclusively by type 2 ... Procedures to simultaneously identify all promising areas in a genome scan while controlling for overall type I and type II ... He also has a NIH sponsored grant to study a c-kit mast cell inhibitor, imatinib, in severe asthma in collaboration with ... pneumocytes that line the distal airways. This mixture forms a monolayer at the air-liquid interface in the alveolus that ...
  https://biostatistics.wustl.edu/education/post-doctoral-research-training-in-genetic-epidemiology/preceptor-research-interest-and-trainee-opportunities/
*  Adult respiratory distress syndrome information from Wikipedia - RightDiagnosis.com
Dysfunction of type I pulmonary epithelial cells may also be present, with a reduction in surfactant production. Elevated ... Moreover, edema and decreased surfactant production by type II pneumocytes may cause whole alveoli to collapse, or to ... secreted by local epithelial and endothelial cells.. Neutrophils and some T-lymphocytes quickly migrate into the inflamed lung ... Pulmonary: barotrauma (volutrauma), pulmonary embolism (PE), pulmonary fibrosis, ventilator-associated pneumonia (VAP). ...
  https://www.rightdiagnosis.com/a/adult_respiratory_distress_syndrome/wiki.htm
*  Fetal Circulation Flashcards by Carolyn Holt | Brainscape
Distal airways develop and epithelial cells subdivide into:. - Type 1 pneuomocytes~ which are necessary for gas exchange. - ... The increased pulmonary blood flow increases the pulmonary venous return which raises the pressure in the left atrium ... What are the two main functions of surfactant? To reduce surface tension in the alveoli, allowing them to expand more easily. ... It is composed of 90% lipids and 10% protein and secreted in to lung fluid from around 22 weeks ...
  https://www.brainscape.com/flashcards/fetal-circulation-1744730/packs/3228945
*  Histology and Pathology Flashcards by Alaina Francis | Brainscape
surfactant - type 1 pneumocyte epithelia - basal lamina of type 1 pneumocyte - CT - basal lamina of endothelium - endothelial ... cuboidal epithelium with some cilia - clara cells - one or two layers of SM - no goblet cells ... cuboidal cells, often in the ange between alveoli with short microvilli and lamellar bodies which secrete surfactant to reduce ... decreased pulmonary compliance due to haemorrhage and loss of surfactant ...
  https://www.brainscape.com/flashcards/histology-and-pathology-2132306/packs/3811955
*  Protocols and Video Articles Authored by Shioko Kimura (Translated to Hindi)
... was negative in Type II cell hyperplasias and adenomas. However, it was expressed in alveolar Type II cell carcinomas and Clara ... Hop functions in the developing pulmonary airway, acting downstream of Nkx2.1 and GATA6, to negatively regulate surfactant ... of FSH-secreting cells and 47 % of LH-secreting cells. In addition, SCGB3A2 dramatically inhibited LH and FSH mRNA expression ... Both SCGB3A2 and NKX2-1 are expressed in airway epithelial cells and the latter also in alveolar Type II cells. NKX2-1 has been ...
  https://www.jove.com/author/Shioko_Kimura?language=Hindi
*  Module A2: Upper Airway Anatomy & Physiology - ppt download
Objectives Classify epithelial tissue based on cell type and tissue layers. Identify location of tissue epithelium in the ... Type II cells that secrete surfactant) 21 Simple Squamous Epithelium. PRIMARY FUNCTION - GAS EXCHANGE Alveoli (Type I ... pneumocytes) Pulmonary capillaries 22 Upper Airway Anatomy Nose Oral Cavity Pharynx Throat ... 13 Epithelial Cell Type Squamous Cells Cuboidal Cells Columnar Cells 14 HISTOLOGY 101 Lots of Surface Area aka Pavement, Sunny- ...
  http://slideplayer.com/slide/3381618/