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*  Notch Signaling Limits Supporting Cell Plasticity in the Hair Cell-Damaged Early Postnatal Murine Cochlea
However, non-mammalian species regenerate lost auditory hair cells. In avians, supporting cells replace lost sensory hair cells ... 6) for outer hair cells. Such Vm values show that the recorded hair cell-like cells as well as control hair cells were healthy ... In contrast, 90% of hair cell-like cells in Notch inhibited hair cell-ablated cultures expressed the outer hair cell specific ... which re-enter the cell cycle in response to hair cell damage [2], [3], auditory supporting cells in the murine hair cell- ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3758270/?lang=en-ca
*  Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation. -...
Auditory hair cells spontaneously regenerate following injury in birds but not mammals. A better understanding of the molecular ... and the early hair cell marker myosin VI (red) (A). The apical surface of hair cells is to the left of the image and the neural ... The double-labeled cell is one that has been stimulated to divide and subsequently begin differentiating toward a hair cell ... Some new cells produced by miR181a transfection express the early hair cell marker myosin VI. ...
  https://www.ncbi.nlm.nih.gov/pubmed?term=20634979
*  David Roberson, MD | Boston Children's Hospital
Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epithelium. J Neurosci Res ... Light microscopic evidence that pre-mitotic transdifferentiation may give rise to new hair cells in regenerating avian auditory ... During my residency and for the first 8 years in Boston, I worked in basic science labs studying hair cell protection and ... Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo. J Neurosci. 2003 ...
  http://www.childrenshospital.org/doctors/david-roberson
*  cochlear Archives - Neuroscience News
By manipulating two genes, researchers have been able to regenerate immature auditory hair cells.... Read More... ... Success of Sensory Cell Regeneration Raises Hope for Hearing Restoration. Neuroscience News. April 11, 2017. ... Nerve Cells Warn Brain of Damage to the Inner Ear. Neuroscience News. November 9, 2015. ... According to a new study, some inner ear nerve cells can signal tissue damage to the brain.... Read More... ...
  http://neurosciencenews.com/neuroscience-terms/cochlear/
*  Audiology | Faculty | Department of Otolaryngology | CWRU
The senses of hearing and balance depend on hair cells. Auditory hair cells do not regenerate in mammals; their disappearance ... where he began his studies on mechanosensitivity of the sensory cells of the inner ear, the hair cells. Hair cells are receptor ... Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells. PLOS Biology. 2013. 11(6): ... Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell. 2010. 141(5):786- ...
  http://casemed.case.edu/Otolaryngology/faculty/stepanyan.php
*  Albert Edge | Harvard Catalyst Profiles | Harvard Catalyst
Regenerated synapses between postnatal hair cells and auditory neurons. J Assoc Res Otolaryngol. 2013 Jun; 14(3):321-9. PMID: ... Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. Stem Cell Reports. 2014 Mar 11; 2(3):311-22. ... Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells. Mol Cell Neurosci. 2007 Jan; 34(1):59-68 ... Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells. Cell Rep. 2017 ...
  https://connects.catalyst.harvard.edu/profiles/display/Person/60563
*  Previous Seminars | Physiology
Self-repair in mechanically-damaged non-regenerating auditory hair cells Alan Daugherty ... "In search of the hair cell mechanotransducer channel: the role of the transmembrane channel-like proteins". Gregory Frolenkov. ... Professor of Molecular & Cell Biology, University of Connecticut. "Altered programming of muscle-resident stem cells leads to ... Innate lymphoid cell in immunity Physiology Graduate Students 2/22/2017 Xiang-An Li, PhD Department of Pediatrics, University ...
  https://physiology.med.uky.edu/physiology-previous-seminars
*  二甲基亚砜,67-68-5,阿拉丁试剂网-阿拉丁aladdin
... birds regenerate auditory hair cells (HCs) after injury. During regeneration, mature non-sensory supporting cells (SCs) leave ... Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds ... Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. ... The human T-cell lymphotropic virus type 1 (HTLV-1) is the cause of adult T-cell leukemia and inflammatory diseases including ...
  http://www.aladdin-e.com/zh_cn/d103283.html
*  Affiliates | Virginia Merrill Bloedel Hearing Research Center
The discovery that non-mammalian vertebrates can regenerate new auditory and vestibular hair cells after damage suggests the ... In particular the auditory part called the organ of Corti which is made up of hair cells and support cells that are arranged in ... which are the progenitor cells that form new hair cells. Our efforts are aimed at characterizing properties of hair cell ... The final research program stems from the discovery that birds can regenerate inner ear receptor cells (hair cells) following ...
  https://depts.washington.edu/hearing/who-we-are/affiliates?field_last_name_value=&field_research_area_tid=All&page=1
*  MEMBS | News | Index
Jude Children's Research Hospital investigators have used genetic manipulation to regenerate auditory hair cells in adult mice ... 9, 2018 issue of Stem Cell Research a new method of creating human arterial endothelial cells from cord blood and adult ... ... Multipotent stromal cells are a hot topic in medical research. Scientists at the University of Bonn have now found a way to ... Scientists Identified "Anxiety Cells" in The Brain by Switching Them On and Off Feb 7, 2018 9:00 am ...
  http://membs.org/membs/news/index/
*  MEMBS | News
Jude Children's Research Hospital investigators have used genetic manipulation to regenerate auditory hair cells in adult mice ... Stem Cells & Cancer Stem Cells (195) New Discovery that Advances our Understanding of the Assembly of Kidney Building Blocks ... Stem cell scientists at Harvard University and Boston Children's Hospital have shown that the location of blood stem cells in ... For The First Time: New Device that can Isolate Fetal cells from Maternal Blood Cells. Aug 5, 2018 12:00 pm ...
  http://membs.org/membs/news
*  Untangling Brain Neuron Dysfunction in Parkinson's Disease and Dementia with Lewy Bodies
Jude Children's Research Hospital investigators have used genetic manipulation to regenerate auditory hair cells in adult mice ... The study appears today in the journal Cell Reports. Loss of auditory hair cells due to prolonged exposure to loud […] ... Biotechnology Cell Therapy Success of Sensory Cell Regeneration Raises Hope for Hearing Restoration. April 13, 2017. April 12, ... The nerve cells take up some of the fibrils. Inside the cells, the fibrils attract the soluble alpha-synuclein that naturally ...
  http://thebioconnection.com/untangling-brain-neuron-dysfunction-parkinsons-disease-dementia-lewy-bodies/
*  Molecular Mechanisms in Cochlear Regeneration - Research Projects - White Lab - University of Rochester Medical Center
Why don't mammals regenerate dying auditory cells? What signals can stimulate cochlear supporting cell proliferation, and what ... and forced expression of hair cell specific transcription factors in supporting cells can induce at least part of the hair cell ... Purified supporting cells become hair cells under certain cell culture conditions; there are drugs that induce immature ... I am also open to new ideas about how to induce hair cell differentiation in supporting cells. The second part addresses ...
  https://www.urmc.rochester.edu/labs/white/projects/molecular-mechanisms-in-cochlear-regeneration.aspx
*  Microarrays | Free Full-Text | The Transcriptomics to Proteomics of Hair Cell Regeneration: Looking for a Hair Cell in a...
... while all non-mammalian vertebrates examined can regenerate them. In an effort to find therapeutic targets for deafness and ... balance disorders, scientists have examined gene expression patterns in auditory tissues under different developmental and ... meta-analyses of these data may provide a better picture of pathways that are common to the process of hair cell regeneration ... are needed to better understand the process of hair cell regeneration. These technologies and some of the results of them are ...
  http://www.mdpi.com/2076-3905/2/3/186
*  Presbycusis - Wikipedia
Auditory hair cell loss is permanent damage due to the inability of these cells to regenerate. Therefore, deafness due to this ... Hair cell development is mediated by Notch signaling, which exerts lateral inhibition onto hair cells. Notch signaling in ... If the outer hair cells are damaged, they do not regenerate. This results in a loss of sensitivity of hearing, as well as an ... it contains hair cells with stereocilia, which extend to the tectorial membrane. The organ's outer hair cells play a ...
  https://en.wikipedia.org/wiki/Presbycusis
*  Frontiers | Making sense of Wnt signaling-linking hair cell regeneration to development | Frontiers in Cellular Neuroscience
... its activity governs sensory hair cell specification, cell cycle regulation, and hair cell orientation. In regenerating sensory ... its activity governs sensory hair cell specification, cell cycle regulation, and hair cell orientation. In regenerating sensory ... This review describes the current knowledge of the roles of Wnt signaling and Wnt-responsive cells in hair cell development and ... This review describes the current knowledge of the roles of Wnt signaling and Wnt-responsive cells in hair cell development and ...
  https://www.frontiersin.org/articles/10.3389/fncel.2015.00066/full
*  Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells. - PubMed - NCBI
Although hair cells can regenerate disrupted tip links and restore hearing, the molecular details of this process are unknown. ... Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells.. Indzhykulian AA1, Stepanyan R ... In terminally differentiated mammalian auditory hair cells, tip links are subjected to sound-induced forces throughout an ... Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells ...
  https://www.ncbi.nlm.nih.gov/pubmed/23776407
*  Hair cell - Wikipedia
Because hair cells of auditory and vestibular systems in birds and fish have been found to regenerate, their ability has been ... The human cochlea contains on the order of 3,500 inner hair cells and 12,000 outer hair cells at birth. The outer hair cells ... Nerve fiber innervation is much denser for inner hair cells than for outer hair cells. A single inner hair cell is innervated ... and inner hair cells. Damage to these hair cells results in decreased hearing sensitivity, and because the inner ear hair cells ...
  https://en.wikipedia.org/wiki/Hair_cell
*  Deaf people get gene tweak to restore natural hearing | New Scientist
Many other species, such as fish and birds, can regenerate the hair cells in their inner ear over time and create new auditory ... when researchers discovered that certain genes can transform the cells supporting the hair cells into both types of hair cell. ... Sound waves, amplified by the outer hair cells (shown above right), vibrate the inner hair cells, opening ion channels on their ... The Atoh1 gene should reach the supporting cells, instructing them to divide and form new hair cells. Results are expected ...
  https://www.newscientist.com/article/mg22229662-400-deaf-people-get-gene-tweak-to-restore-natural-hearing/
*  Somatostatin and gentamicin-induced auditory hair cell loss - Zurich Open Repository and Archive
OBJECTIVE/HYPOTHESIS: Hair cells of the mammalian auditory system do not regenerate, and therefore their loss leads to ... OBJECTIVE/HYPOTHESIS: Hair cells of the mammalian auditory system do not regenerate, and therefore their loss leads to ... Caelers, A; Monge, A; Brand, Y; Bodmer, D (2009). Somatostatin and gentamicin-induced auditory hair cell loss. Laryngoscope, ... Protection of auditory hair cells from gentamicin was tested using two different concentrations (1 microM and 5 microM, ...
  http://www.zora.uzh.ch/id/eprint/18734/
*  Math1 Gene Transfer Generates New Cochlear Hair Cells in Mature Guinea Pigs In Vivo | Journal of Neuroscience
Light microscopic evidence that direct transdifferentiation gives rise to new hair cells in regenerating avian auditory ... outer hair cells). Some of the nonsensory cells that replaced lost hair cells (arrow in second row, outer hair cell area) are ... Ectopic hair cells in the inner sulcus are adjacent to inner hair cells. Similar to inner hair cells, the neighboring ectopic ... The new hair cells exhibit the typical surface morphology of hair cells and stain for the hair cell-specific protein myosin ...
  http://www.jneurosci.org/content/23/11/4395.long
*  BGDB Face and Ear - Abnormalities - Embryology
Mammalian auditory hair cells do not spontaneously regenerate, once damaged or lost they are not replaced. Hearing loss due to ...
  https://embryology.med.unsw.edu.au/embryology/index.php/BGDB_Face_and_Ear_-_Abnormalities
*  Basilar papilla - Wikipedia
These auditory hair cells, unlike those in mammals, are known to spontaneously regenerate following injury, with experimental ... The basilar papilla is composed of cells called "hair cells" which are actually epithelial cells rather than true hairs. These ... The basilar papilla is the auditory sensory organ of lizards, amphibians, and birds, which is analogous to the Corti in mammals ... sensory cells, according to some studies, are related to the type II sensory cells in the vestibular epithelium of mammals. ...
  https://en.wikipedia.org/wiki/Basilar_papilla
*  Mass. Eye and Ear Researchers Regenerate Hair Cells, Restore Hearing | Mass. Eye and Ear
... because auditory hair cells in mammals, unlike those in birds or fish, do not regenerate once lost. Auditory hair cell ... These supporting cells turned into new hair cells upon treatment with the drug. Replacing hair cells improved hearing in the ... hair cells can be regenerated in an adult mammalian ear by using a drug to stimulate resident cells to become new hair cells, ... "We show that hair cells can be generated in a damaged cochlea and that hair cell replacement leads to an improvement in hearing ...
  https://www.masseyeandear.org/news/press-releases/2013/01/hair-cell-regeneration
*  Daudet Lab
... fish and birds can regenerate their hair cells throughout adult life. In these species, the supporting cells act as 'tissue ... This is because in the mammalian auditory organ, the full complement of hair cells is produced during embryonic development. In ... following hair cell loss. Supporting cells can i) re-enter the cell cycle to produce new hair cells and supporting cells, or ii ... cells and supporting cells, organised into a checkerboard-like pattern. Hair cells are essential for hearing and their loss ...
  http://www.ucl.ac.uk/ear/research/daudetlab